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The map label for this gene is hisQ [H]

Identifier: 78065759

GI number: 78065759

Start: 1225183

End: 1225872

Strand: Direct

Name: hisQ [H]

Synonym: Bcep18194_A4287

Alternate gene names: 78065759

Gene position: 1225183-1225872 (Clockwise)

Preceding gene: 78065758

Following gene: 78065760

Centisome position: 33.17

GC content: 63.77

Gene sequence:

>690_bases
GTGTTCCTTTACGGCTTTGGTCCTGTCCTCTGGGCCGGCACCGTGCAGACCATCGAGCTGTCGGTGCTGTCGCTCGCCAC
TGCGGTGGCGCTGGGGCTGATCGGCGCGGTGGCGAAGCTGTCGCACAACCGGGTGCTGCGAGCGATCGCGACCGGTTATA
CGACGCTGATCCGCTCGGTGCCCGATCTCGTCCTGATGCTGCTGTTGTTCTACAGCATCCAGATCTGGCTGAACCAGTTC
ACCGACTTCGTCGGCTGGGACCAGATCGACATCGACCCGTTCGTGGCCGGCGTGCTGACGCTCGGCTTCATCTACGGCGC
GTACTTCACCGAGACGTTCCGCGGCGCGTTCCTGTCGGTGCCGCGCGGCCAGCTCGAAGCCGGTGCGGCTTACGGGATGA
GCGGCGCACGCGTGTTCGCGCGGATCATGTTTCCGCAGATGATGCGCTTCGCGCTGCCCGGGATCGGGAACAACTGGCAG
GTGCTCGTGAAGGCGACCGCGCTGGTGTCGATCATCGGCCTCGCGGACGTCGTGAAGGCCGCGCAGGACGCCGGCAAGAG
CACGTTCAACATGTTCTTCTTCATCCTCGTCGCGGCGCTGATCTATCTCGCGATCACGACCGTTTCCAACCTCGTGCTGA
TCCAGCTCGAGAAGCGTTATTCCATGGGCGTGCGGCACGCAGATCTATGA

Upstream 100 bases:

>100_bases
AAGGTGGTTTGAGGCAATCAATTTCGCTTGCGACTATCCGCGTCAGCCCGGCGCGGGACAGGCATACGCGTCGGCAACCA
TTCCAACTCTGGAGACGCGC

Downstream 100 bases:

>100_bases
TCGAGATTCTCCAGGAATTCGGCCAGGCGTTCCTTTACTGGGACGGCCAGCGCCTCTCCGGCCTCGCGGTGACGCTGTGG
CTGCTCGTCGCGTCGATTTC

Product: ABC polar amino acid transporter, inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAIATGYTTLIRSVPDLVLMLLLFYSIQIWLNQF
TDFVGWDQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLSVPRGQLEAGAAYGMSGARVFARIMFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIQLEKRYSMGVRHADL

Sequences:

>Translated_229_residues
MFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAIATGYTTLIRSVPDLVLMLLLFYSIQIWLNQF
TDFVGWDQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLSVPRGQLEAGAAYGMSGARVFARIMFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIQLEKRYSMGVRHADL
>Mature_229_residues
MFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAIATGYTTLIRSVPDLVLMLLLFYSIQIWLNQF
TDFVGWDQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLSVPRGQLEAGAAYGMSGARVFARIMFPQMMRFALPGIGNNWQ
VLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIQLEKRYSMGVRHADL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=227, Percent_Identity=63.4361233480176, Blast_Score=288, Evalue=2e-79,
Organism=Escherichia coli, GI1787087, Length=216, Percent_Identity=36.5740740740741, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1787030, Length=215, Percent_Identity=30.6976744186047, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788226, Length=221, Percent_Identity=29.8642533936652, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788645, Length=229, Percent_Identity=30.5676855895196, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1786874, Length=182, Percent_Identity=30.2197802197802, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082239, Length=220, Percent_Identity=25.9090909090909, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787086, Length=220, Percent_Identity=26.8181818181818, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25001; Mature: 25001

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAIATGYTTLIRSV
CEEEECCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDLVLMLLLFYSIQIWLNQFTDFVGWDQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLSV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRGQLEAGAAYGMSGARVFARIMFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKA
CCCHHHCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIQLEKRYSMGVRHADL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCCCC
>Mature Secondary Structure
MFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAIATGYTTLIRSV
CEEEECCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PDLVLMLLLFYSIQIWLNQFTDFVGWDQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLSV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRGQLEAGAAYGMSGARVFARIMFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKA
CCCHHHCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQDAGKSTFNMFFFILVAALIYLAITTVSNLVLIQLEKRYSMGVRHADL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]