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The map label for this gene is proC [H]

Identifier: 78065292

GI number: 78065292

Start: 716412

End: 717224

Strand: Reverse

Name: proC [H]

Synonym: Bcep18194_A3816

Alternate gene names: 78065292

Gene position: 717224-716412 (Counterclockwise)

Preceding gene: 78065293

Following gene: 78065287

Centisome position: 19.42

GC content: 71.09

Gene sequence:

>813_bases
ATGAAAATCGCATTCATCGGCGGCGGCAACATGGCCGCGGCCCTGATCGGCGGCCTGATCAAGCGCGGCGTTGCCGCTGA
CGGCCTGTATGCCATCGACGTCAACGAAGAGGTGCGCGCGCGCGCCGCCCAGCAGTTCGGCGTGCACACCGGCGCGGCCA
TCGACGCGACGCTCGCCGACTACGACGCGGTCGTGCTCGCGGTGAAGCCGCAGGTGCTGAAGGACGTCGCGCAGGCGCTC
GCGCCGCACCTGAAGTCGCAGCTCGTGATCAGCATCGCGGCCGGCATTCGCGGCACGGACCTCGCGCGCTGGCTCGGCGG
CTACGACCGCATCGTGCGCACGATGCCGAACACGCCCGCGCTCGTCGGCATGGGCGTGACGGGCCTCACCGCGCTGCCGG
GCGTCGACGCGGCGGGCCGCGAACTCGCATCGAACGTGCTCGGCGCGGTCGGCGAGATCGTGTGGTTCGACGACGAGTCG
AAGCTCGACGCCGTCACCGCGATCTCGGGCAGCGGCCCCGCGTACGTGTTCTATTTCATCGAAGCGCTGCAGGAAGCCGC
GCGCCAGCTCGGCATGAACGACGAACAGGGGCGCGCACTCGCGGTCGCGACGTTCACGGGCGCCGCACAACTCGCCGCGC
AATCGGGCGAGCCCGCGAGCGTGCTGCGCGAACGCGTGACGTCGAAGGGCGGCACGACGGCCGCCGCGCTCGCGTCGTTC
GACGCGCAAGGCGTGAAGGATGCGATCGTGCGCGGCGCGCTTGCAGCCGAGGCACGCGCGAAGGAAATGGGCGACGAGCT
CGGCCGCGCGTAA

Upstream 100 bases:

>100_bases
CGTGCGCGTCGGCACCGCGATCTTCGGCGCGCGCGATTACTCGCACTAAACGCCGCCTCCCTTACGCCCTACCGTTCACT
CACTCGCTCATTCGGACATC

Downstream 100 bases:

>100_bases
GCGCGCCGGGGCGGTGCCGGCCCGGTGCGCTCTGCGCCGCACGGGCCGCCCCCTTTGCCTTGCTCAACCAACAAAAAAAG
CGGCCCAGGCCGCTTTTTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKIAFIGGGNMAAALIGGLIKRGVAADGLYAIDVNEEVRARAAQQFGVHTGAAIDATLADYDAVVLAVKPQVLKDVAQAL
APHLKSQLVISIAAGIRGTDLARWLGGYDRIVRTMPNTPALVGMGVTGLTALPGVDAAGRELASNVLGAVGEIVWFDDES
KLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALASF
DAQGVKDAIVRGALAAEARAKEMGDELGRA

Sequences:

>Translated_270_residues
MKIAFIGGGNMAAALIGGLIKRGVAADGLYAIDVNEEVRARAAQQFGVHTGAAIDATLADYDAVVLAVKPQVLKDVAQAL
APHLKSQLVISIAAGIRGTDLARWLGGYDRIVRTMPNTPALVGMGVTGLTALPGVDAAGRELASNVLGAVGEIVWFDDES
KLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALASF
DAQGVKDAIVRGALAAEARAKEMGDELGRA
>Mature_270_residues
MKIAFIGGGNMAAALIGGLIKRGVAADGLYAIDVNEEVRARAAQQFGVHTGAAIDATLADYDAVVLAVKPQVLKDVAQAL
APHLKSQLVISIAAGIRGTDLARWLGGYDRIVRTMPNTPALVGMGVTGLTALPGVDAAGRELASNVLGAVGEIVWFDDES
KLDAVTAISGSGPAYVFYFIEALQEAARQLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALASF
DAQGVKDAIVRGALAAEARAKEMGDELGRA

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=31.0606060606061, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=28.2527881040892, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=28.2527881040892, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=28.2051282051282, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=34.3173431734317, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=33.8289962825279, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=29.9295774647887, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=203, Percent_Identity=31.0344827586207, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=34.8484848484849, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=30.5454545454545, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=36.094674556213, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27616; Mature: 27616

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGGGNMAAALIGGLIKRGVAADGLYAIDVNEEVRARAAQQFGVHTGAAIDATLAD
CEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHC
YDAVVLAVKPQVLKDVAQALAPHLKSQLVISIAAGIRGTDLARWLGGYDRIVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
LVGMGVTGLTALPGVDAAGRELASNVLGAVGEIVWFDDESKLDAVTAISGSGPAYVFYFI
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCCEEEECCCCCCHHHHHH
EALQEAARQLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHH
DAQGVKDAIVRGALAAEARAKEMGDELGRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFIGGGNMAAALIGGLIKRGVAADGLYAIDVNEEVRARAAQQFGVHTGAAIDATLAD
CEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHC
YDAVVLAVKPQVLKDVAQALAPHLKSQLVISIAAGIRGTDLARWLGGYDRIVRTMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
LVGMGVTGLTALPGVDAAGRELASNVLGAVGEIVWFDDESKLDAVTAISGSGPAYVFYFI
EEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCCEEEECCCCCCHHHHHH
EALQEAARQLGMNDEQGRALAVATFTGAAQLAAQSGEPASVLRERVTSKGGTTAAALASF
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHH
DAQGVKDAIVRGALAAEARAKEMGDELGRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]