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The map label for this gene is aceK [H]

Identifier: 78049514

GI number: 78049514

Start: 4542876

End: 4544615

Strand: Reverse

Name: aceK [H]

Synonym: XCV3958

Alternate gene names: 78049514

Gene position: 4544615-4542876 (Counterclockwise)

Preceding gene: 78049515

Following gene: 78049513

Centisome position: 87.76

GC content: 63.05

Gene sequence:

>1740_bases
ATGAGCCATCCACCCTTGCCACCACAATCCGAGCGCCGCGCGCTGGCGATCGCCCAGGCCGTGTACGAAGCGTTCGAGGA
CTATCACGCGCGCTTTTCCGAAATCACCGCACGCGCCAAGCAGCGGTTCGAAACACGCGACTGGAGCGGCGCGCGCGAAG
ACGCGGTAGCGCGCATCGCGCTGTACGACCAATACATCGCCGAATGCATGTTGCGCCTGCGTGCAGTACTGCTGGGCCAG
GCGCACGATCGCGCGCTGTGGATGCGTGCGCGCGATCATTACGCCGCCTTGCTGAGCGGGTTGATCGACCAGGAGTTGTA
CAAGACGTTCTACAACACCCTGACCCGGCGCTACTTCGGTACCCACGGCGTCGATGCCGATATCGAATTCATCGCCCTGG
ATATCGAACCGACCGACGCCATCACCGTGCCTGTTGCGCGCCACACCTATGCGGTCTCGCCCGGCCGCCTGACCGACATG
CTGGTGCGGGTGCTCGGCGACTACGCGTTCGCCGTACCGTATACGCACCGCACCCGCTGCGCGGCCGCCATCGCGGTGCG
TCTGCTCGACGATCTTGCGCATTGGGGCGAGCATCCGGTGCGCAGCGTGGAATTACTGGAGACGGTGTTCTATCGCGAGC
GGCGCGCGTATCTGGTCGGACGCGTGTTCGGCGAACATCGCTTTTCGCCGTGCGTGATCGCGCTGATCAACGACGAGGCG
GGCCTGCGCGCCGAAGCGGTGTTGACCCGGCGCAGCGATGTCGCGCAATTGTTCAGTAACTCGCGTAGCTATTTTCAAGC
CGACCTGTCCACTGTCGGCGACGCGGTGGTGTTCCTGCGCAGCCTGCTCACCCACAAGCCGGTCGATGAGCTATACACGA
TGCTGGGTCGCGCCAAACAGGGCAAGACCGAGCGTTACCGCACGTTTTTCAGTCATTTTCAGGCGCATCCGTCCGAACAG
CTGGTGCACGCCGACGGCACTCCCGGCATGGTCATGGTGGTGTTTACGCTGCCCAGTTATCCGCTGGTCTTCAAACTCAT
TCGCGACCGCTTTGCGTATCCCAAAACCATGAGCCGCGCGCAGGTAGAGGGCAAGTACGAGCTGGTCTTCCAGCTCGACC
GCATCGGCCGCCTGCTCGACGCGCAGCCGTATCGCTTCCTGCGCTTCCCCAAGGCGCGCTTCTCACCGGCGTTGCTGCAA
GAACTGCAGACCAGCTGCGCGATGAGCCTGAGCGAAGACGGCGACGATGTCCTGATCGCACTGTGCTATGTGCAGCGCCG
GTTGCGCCCGTTGAATTTGTACCTGCGCGAACAATTGCCCGAAGCCGCGCATGCCGCAGCGCTGGACTACGGCCAGGCCA
TCAAGGACATGGCGCGCAACAACATCTTTCCTGGCGACATGCTGCTGAAGAATTTCGGCATTACCCGCCATCAGCGCGCG
GTGTTCTACGACTACGACGAGCTATGCCTGATCACCGAATGCAACTTCCGCGATTGGCCAGTGCCCACCACTTACGAAGA
ACAGATGGCCGCAGAACCCTGGTTCCATGTCGGCCCGCGCGACGTCTTTCCCGAGCGCTTCGCCTTGTTCATGGGCCTGC
CCGCCTCGCAACTGGAAGCGGTCAAGCACCAGCACCCGGAACTGTTCGACCCACGCTGGTGGCGCGACCTGCAGAGCCGG
CTGCGCGAAGACGATTATCCCGACACCCCGCCCTATGCGGAGTCGCGCAGGCTGGCGTAG

Upstream 100 bases:

>100_bases
CCTGGCTGCAGGGCCAGGCGCGCGAACACGCCGCGCATGCGCAGCAGGCGACCGCCATACCACTTGCCGCGCGCCGCAAG
CGCTCCGGGACACTGCCGCC

Downstream 100 bases:

>100_bases
CGATTTACCGGCAGCGGCAACACTGGTACAACGCACGCTACATCATCAGGGAGTGCGGTCATGCAATGGAAGCAGCGTTT
CAGTCTTGGCATCTTGCTGG

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSHPPLPPQSERRALAIAQAVYEAFEDYHARFSEITARAKQRFETRDWSGAREDAVARIALYDQYIAECMLRLRAVLLGQ
AHDRALWMRARDHYAALLSGLIDQELYKTFYNTLTRRYFGTHGVDADIEFIALDIEPTDAITVPVARHTYAVSPGRLTDM
LVRVLGDYAFAVPYTHRTRCAAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRVFGEHRFSPCVIALINDEA
GLRAEAVLTRRSDVAQLFSNSRSYFQADLSTVGDAVVFLRSLLTHKPVDELYTMLGRAKQGKTERYRTFFSHFQAHPSEQ
LVHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRAQVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQ
ELQTSCAMSLSEDGDDVLIALCYVQRRLRPLNLYLREQLPEAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRA
VFYDYDELCLITECNFRDWPVPTTYEEQMAAEPWFHVGPRDVFPERFALFMGLPASQLEAVKHQHPELFDPRWWRDLQSR
LREDDYPDTPPYAESRRLA

Sequences:

>Translated_579_residues
MSHPPLPPQSERRALAIAQAVYEAFEDYHARFSEITARAKQRFETRDWSGAREDAVARIALYDQYIAECMLRLRAVLLGQ
AHDRALWMRARDHYAALLSGLIDQELYKTFYNTLTRRYFGTHGVDADIEFIALDIEPTDAITVPVARHTYAVSPGRLTDM
LVRVLGDYAFAVPYTHRTRCAAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRVFGEHRFSPCVIALINDEA
GLRAEAVLTRRSDVAQLFSNSRSYFQADLSTVGDAVVFLRSLLTHKPVDELYTMLGRAKQGKTERYRTFFSHFQAHPSEQ
LVHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRAQVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQ
ELQTSCAMSLSEDGDDVLIALCYVQRRLRPLNLYLREQLPEAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRA
VFYDYDELCLITECNFRDWPVPTTYEEQMAAEPWFHVGPRDVFPERFALFMGLPASQLEAVKHQHPELFDPRWWRDLQSR
LREDDYPDTPPYAESRRLA
>Mature_578_residues
SHPPLPPQSERRALAIAQAVYEAFEDYHARFSEITARAKQRFETRDWSGAREDAVARIALYDQYIAECMLRLRAVLLGQA
HDRALWMRARDHYAALLSGLIDQELYKTFYNTLTRRYFGTHGVDADIEFIALDIEPTDAITVPVARHTYAVSPGRLTDML
VRVLGDYAFAVPYTHRTRCAAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRVFGEHRFSPCVIALINDEAG
LRAEAVLTRRSDVAQLFSNSRSYFQADLSTVGDAVVFLRSLLTHKPVDELYTMLGRAKQGKTERYRTFFSHFQAHPSEQL
VHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRAQVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQE
LQTSCAMSLSEDGDDVLIALCYVQRRLRPLNLYLREQLPEAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRAV
FYDYDELCLITECNFRDWPVPTTYEEQMAAEPWFHVGPRDVFPERFALFMGLPASQLEAVKHQHPELFDPRWWRDLQSRL
REDDYPDTPPYAESRRLA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=566, Percent_Identity=34.8056537102473, Blast_Score=338, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 66816; Mature: 66685

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPPLPPQSERRALAIAQAVYEAFEDYHARFSEITARAKQRFETRDWSGAREDAVARIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LYDQYIAECMLRLRAVLLGQAHDRALWMRARDHYAALLSGLIDQELYKTFYNTLTRRYFG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
THGVDADIEFIALDIEPTDAITVPVARHTYAVSPGRLTDMLVRVLGDYAFAVPYTHRTRC
CCCCCCCEEEEEEEECCCCCEEECEECCEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHH
AAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRVFGEHRFSPCVIALINDEA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
GLRAEAVLTRRSDVAQLFSNSRSYFQADLSTVGDAVVFLRSLLTHKPVDELYTMLGRAKQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GKTERYRTFFSHFQAHPSEQLVHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRA
CCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHH
QVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQELQTSCAMSLSEDGDDVLIA
HCCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LCYVQRRLRPLNLYLREQLPEAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRA
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCE
VFYDYDELCLITECNFRDWPVPTTYEEQMAAEPWFHVGPRDVFPERFALFMGLPASQLEA
EEECCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHCHHHHHHHHCCCHHHHHH
VKHQHPELFDPRWWRDLQSRLREDDYPDTPPYAESRRLA
HHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHPPLPPQSERRALAIAQAVYEAFEDYHARFSEITARAKQRFETRDWSGAREDAVARIA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LYDQYIAECMLRLRAVLLGQAHDRALWMRARDHYAALLSGLIDQELYKTFYNTLTRRYFG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
THGVDADIEFIALDIEPTDAITVPVARHTYAVSPGRLTDMLVRVLGDYAFAVPYTHRTRC
CCCCCCCEEEEEEEECCCCCEEECEECCEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHH
AAAIAVRLLDDLAHWGEHPVRSVELLETVFYRERRAYLVGRVFGEHRFSPCVIALINDEA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
GLRAEAVLTRRSDVAQLFSNSRSYFQADLSTVGDAVVFLRSLLTHKPVDELYTMLGRAKQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
GKTERYRTFFSHFQAHPSEQLVHADGTPGMVMVVFTLPSYPLVFKLIRDRFAYPKTMSRA
CCHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHH
QVEGKYELVFQLDRIGRLLDAQPYRFLRFPKARFSPALLQELQTSCAMSLSEDGDDVLIA
HCCCHHHHHHHHHHHHHHHCCCCHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LCYVQRRLRPLNLYLREQLPEAAHAAALDYGQAIKDMARNNIFPGDMLLKNFGITRHQRA
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCE
VFYDYDELCLITECNFRDWPVPTTYEEQMAAEPWFHVGPRDVFPERFALFMGLPASQLEA
EEECCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHCHHHHHHHHCCCHHHHHH
VKHQHPELFDPRWWRDLQSRLREDDYPDTPPYAESRRLA
HHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]