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The map label for this gene is cobD [H]

Identifier: 78048875

GI number: 78048875

Start: 3796855

End: 3797769

Strand: Reverse

Name: cobD [H]

Synonym: XCV3319

Alternate gene names: 78048875

Gene position: 3797769-3796855 (Counterclockwise)

Preceding gene: 78048876

Following gene: 78048874

Centisome position: 73.34

GC content: 70.05

Gene sequence:

>915_bases
ATGCTGCTGGTGACTGCCACCGTTGCCGTGCTGCTGGATTTGCTGCTCGGCGAGCCGCGGCGCGGACATCCGCTGGTGTT
GTTCGGCACCTGGGCGCAACGTATCGAAGCGCGCCTGCACCGCAACCGTCGCAGCGTGGGCATCCTGGCGTGGTGCATGA
GCGTGTTGCCGTTGACCTGTATCGCTGCAGTGGTGCAATGGGGGCTGTGGTGCGTGTCGCCCTGGGCGGCGGCCGCGTTC
GCCGCGATCACGCTGTATCTGGCGCTGGGCCTGCGTAGCCTGGGCGAACACGCACAAGCGGTGATCGATGCGCTGCAGGT
CACTGATCTGCCTGCCGCCCGCGCTGCAGTGGGTCGTATCGTCAGCCGCGATACGGCTGTGCTGGACGCCACCCAAGTCG
CTGCCGCAGCGACCGAGTCGGTCTTGGAAAACGGCAGCGACGCCGTGTTCGCCGCACTGTTCTGGGGCGTCGCGCTGGGC
GCACCGGGCGCGGTGTTGTACCGGCTGTCCAATACGCTGGATGCCATGTGGGGCTATCGCACGCCGCGCTACGTCAACTT
CGGCTGGGCCGCGGCGCGCATCGACGATGCGTTGAACTGGTTGCCGGCGCGGCTGACCGCAGCGACCTACGCCGTGCTGG
GCCGCACCCGTGCGGGCATGCGCTGCGCGTGGCGGCAGGGACGCGGCTGGAAGAGCCCCAATGCCGGCCCCGTGATGGCG
GCGGGCGCAGGCGCGCTGCATGTCCGATTGGGCGGGCCTGCGCCGTACCACGGCCATTGGCAGCCGCGCCCCGCGCTGGG
CGAGGGCGCGGCAGCAAGCGCAAACAGCGTGCAACGCGCATTGCGGCTGGTGCGTGCCGGGGTCGCGTTCTGGCTGCTGC
TGGGCGCGCTGGTAACCGCGCTGGCGATGCGATGA

Upstream 100 bases:

>100_bases
ATCAAGGCGCAACTCGGCATCGAGCTGTAGCCGTGGGCGTGCGCGCGCAATGCCTTGCATGGCTCGGCATGTTGGCTGGC
ATGCGCCGGGACTGCACGCC

Downstream 100 bases:

>100_bases
TCGGCACGCGGATGGCCTGGCGTTTCACCAACACGCACCGGCGCACCGTTCACGCCGGCGCAGGTAGCGCCGCTCCATTA
CCGGGAGTGCGCAATGCTTG

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLLVTATVAVLLDLLLGEPRRGHPLVLFGTWAQRIEARLHRNRRSVGILAWCMSVLPLTCIAAVVQWGLWCVSPWAAAAF
AAITLYLALGLRSLGEHAQAVIDALQVTDLPAARAAVGRIVSRDTAVLDATQVAAAATESVLENGSDAVFAALFWGVALG
APGAVLYRLSNTLDAMWGYRTPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTRAGMRCAWRQGRGWKSPNAGPVMA
AGAGALHVRLGGPAPYHGHWQPRPALGEGAAASANSVQRALRLVRAGVAFWLLLGALVTALAMR

Sequences:

>Translated_304_residues
MLLVTATVAVLLDLLLGEPRRGHPLVLFGTWAQRIEARLHRNRRSVGILAWCMSVLPLTCIAAVVQWGLWCVSPWAAAAF
AAITLYLALGLRSLGEHAQAVIDALQVTDLPAARAAVGRIVSRDTAVLDATQVAAAATESVLENGSDAVFAALFWGVALG
APGAVLYRLSNTLDAMWGYRTPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTRAGMRCAWRQGRGWKSPNAGPVMA
AGAGALHVRLGGPAPYHGHWQPRPALGEGAAASANSVQRALRLVRAGVAFWLLLGALVTALAMR
>Mature_304_residues
MLLVTATVAVLLDLLLGEPRRGHPLVLFGTWAQRIEARLHRNRRSVGILAWCMSVLPLTCIAAVVQWGLWCVSPWAAAAF
AAITLYLALGLRSLGEHAQAVIDALQVTDLPAARAAVGRIVSRDTAVLDATQVAAAATESVLENGSDAVFAALFWGVALG
APGAVLYRLSNTLDAMWGYRTPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTRAGMRCAWRQGRGWKSPNAGPVMA
AGAGALHVRLGGPAPYHGHWQPRPALGEGAAASANSVQRALRLVRAGVAFWLLLGALVTALAMR

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 32292; Mature: 32292

Theoretical pI: Translated: 11.30; Mature: 11.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVTATVAVLLDLLLGEPRRGHPLVLFGTWAQRIEARLHRNRRSVGILAWCMSVLPLTC
CEEHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IAAVVQWGLWCVSPWAAAAFAAITLYLALGLRSLGEHAQAVIDALQVTDLPAARAAVGRI
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSRDTAVLDATQVAAAATESVLENGSDAVFAALFWGVALGAPGAVLYRLSNTLDAMWGYR
HHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
TPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTRAGMRCAWRQGRGWKSPNAGPVMA
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEE
AGAGALHVRLGGPAPYHGHWQPRPALGEGAAASANSVQRALRLVRAGVAFWLLLGALVTA
ECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMR
HHCC
>Mature Secondary Structure
MLLVTATVAVLLDLLLGEPRRGHPLVLFGTWAQRIEARLHRNRRSVGILAWCMSVLPLTC
CEEHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IAAVVQWGLWCVSPWAAAAFAAITLYLALGLRSLGEHAQAVIDALQVTDLPAARAAVGRI
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSRDTAVLDATQVAAAATESVLENGSDAVFAALFWGVALGAPGAVLYRLSNTLDAMWGYR
HHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
TPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTRAGMRCAWRQGRGWKSPNAGPVMA
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEE
AGAGALHVRLGGPAPYHGHWQPRPALGEGAAASANSVQRALRLVRAGVAFWLLLGALVTA
ECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA