Click here to switch to the map view.

The map label for this gene is relA [H]

Identifier: 78048800

GI number: 78048800

Start: 3705275

End: 3707446

Strand: Reverse

Name: relA [H]

Synonym: XCV3244

Alternate gene names: 78048800

Gene position: 3707446-3705275 (Counterclockwise)

Preceding gene: 78048809

Following gene: 78048799

Centisome position: 71.59

GC content: 67.86

Gene sequence:

>2172_bases
GTGTCCACCGCTGTGACCAGTTCCTCATTTGATCGTCTGCAGGCGCTGCTGCAGCGGCCTGCCGTGGCCTCGATCGCGCC
GGCAGTGCGCGACGCGCTGGCGCAGGCCTGGCAGGACCTGCCGCCTACGCAGACCGATCGCGTGCCGTGGGCATTGCTCG
GCGACACCCTGGATGCATTGGCGCTGCTGGCCGCCGACGAAGCCACCCTGATTGCGGCGTTGCTGTTCGACTTGTCTGCC
TTGCGCGGCGCGATCGCGGGCCTGCCGTGGCAACCGGCGGAGCGGCGGGTGGCGGTAGAAGGCCTGTTGGACGGCCTGGA
TGCAGCCGATCAGGTCTGGGCGCTGCATGCCGGACGCGAGGCCGGGCGCAACAGCGAAGGGTTGCGGCGTCTGCTGCTTT
CCATCATCCACGACCTGCGCGTGGTGCCGATCCTGCTGGCACGGCAGCTGGCGCGCATGCGCGTGGCCGATCGCCTGAGC
GAAGATGAGCGCCGCGCGCTGGCCCAGCTCACGCGCGACATCCACGCGCCGCTGGCCAACCGGCTGGGCATCTGGCAGGT
GAAGTGGGAGTTGGAGGACCTGGCATTCCGGCATCTGGAGCCGGAGACCTATCGCCGCATCGCCCGCGAAGTGGACGAAA
CCCGCGTGGCGCGCGAGCGCTACCTGGAAGCGGTCAAGCGCACCCTGTCGGCAGCGCTTGCCCAGCAGGGCCTGCGCGCA
GAGGTGAGCGGACGGCCGAAGCACATCTACAGCATCTGGCGAAAGATGCAGAAGAAGCGGCTGTCGTTCGATCAGCTGTA
CGACATCCGCGCGGTGCGGGTCATGGTCGAGGACGTGGCGGCGTGCTATGCCGCGCTGGGGGCGGTGCATTCGTTGTGGG
CGCCGGTGCCGAGCGAGTTCGACGATTACATCGCCCGGCCCAAGGCCAACGACTACCGCTCGTTGCATACCGCGGTGGTC
GGCCCGGAAGGGCGCACGATCGAAATCCAGATCCGTACCTTCGAAATGCACGCCCAGGCCGAACTCGGCGTGGCTGCGCA
CTGGAAATACAAGGAAGGCGGCAAGGGCGGCGAAAAAGCGTTCGATCGCAAGATTTTGTGGATGCGCCAGCTGCTGGAGC
AGGTGCAGGAGGGCGAGCATGGCGAACTGGCCGGCGCGCTGGATGCCGAGCTGATCGAAGACCGCGTGTATGCGCTCACC
CCCAAGGGCGAGGTGATCGATCTGCCGCAAGGTGCCACGCCGCTGGATTTTGCGTATCACGTGCACACCATGGTCGGGCA
TCGCTGCCGTGGCGCACGCGTCAACGACCGCATCGTGCCGCTGACCTACCGGCTGCGCAGCGGCGACCGCGTGGAAATCA
TGACCGCCAAGGAAGCGGACCCGCGCCGCGATTGGCTGCTGGCCTCCAACGGCTTTCTGGCCAGCGGGCGCTCGCGCGAC
AAGGTACGCGCCTGGTTCCACAAGCTGGACCGCGCGCGCAATGTGCAGGCGGGCAAGGACTTGCTCGATCGCGAGCTCAA
GCGCCTGGGCCTGCAGCATGCGGATCTGAGCGTGGCCGCGCGCAAATTCCACGCCGAAAACGTCGACGAGCTGTATATCC
AGGTCGCCCTGGGCGATACCGGCCCGAACCAGGTCAGCCGTGCGTTGCTGGAAGCCGAACGTGCCGCGTCCCAGCCGGCG
GTACCGGCGCCCCCGCGGCCGACCGCGCGGCGCGATGGATTGGGGAAATCCAAATTCACCGTCGAGGGAGTGGGCAATTT
GCTGGTGCAGTTGGCGCGTTGCTGCCAGCCGGTGGCCGGCGAACCGATTGCCGGCTATCTCACCCGCGGTCGCGGCATCA
CCGTGCACCGCACCGACTGTGCGGCACTGGCGCGCCTGGCCGCCGCCCACCCGCAGCGCGTGTTGCCGGTGGAGTGGGGC
AAGGCCGGCAGCGGCTACGAAGTGGATGTGCAGGTGCGCGCGGTGGACCGCCGCTGGCTGCTCAAGGACATCACCAACCT
GATCGCCCAGGAAGACGCGCACGTGCTGGAAATCAACAGCGACAACGTGCGCGATACCGGCAGGGCGCAGCTACGGCTGC
GCTTGAAGGTCAGCGATTACGACCAGCTGTCCGGCCTGCTCGGCAAGCTGGATGCGCTGCCCGGCGTGAGCGAGGTGCGG
CGGCTGGGCTGA

Upstream 100 bases:

>100_bases
GCGCGTCCTCCCGCACGGCGAGCGCCGCGGTAAAACGCGTTGTGGAGAAGGTGACGCGCACGTTACCGTAGTCGTCAGCC
TCCCGTTGTTGCCCGCCGCC

Downstream 100 bases:

>100_bases
GGACGCCGCGCACCTGGCAAGAGCACGCGGTTGAAAACAGACAGCACATGAAAGAGGTGAGCTGTGCTTGCCTGACGATT
CCCGATTCCCGATTCCCGAT

Product: guanosine 3',5'-bis-pyrophosphate synthetase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 723; Mature: 722

Protein sequence:

>723_residues
MSTAVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLPPTQTDRVPWALLGDTLDALALLAADEATLIAALLFDLSA
LRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLS
EDERRALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQGLRA
EVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVEDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLHTAVV
GPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALT
PKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGRSRD
KVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENVDELYIQVALGDTGPNQVSRALLEAERAASQPA
VPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWG
KAGSGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGVSEVR
RLG

Sequences:

>Translated_723_residues
MSTAVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLPPTQTDRVPWALLGDTLDALALLAADEATLIAALLFDLSA
LRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLS
EDERRALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQGLRA
EVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVEDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLHTAVV
GPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALT
PKGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGRSRD
KVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENVDELYIQVALGDTGPNQVSRALLEAERAASQPA
VPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWG
KAGSGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGVSEVR
RLG
>Mature_722_residues
STAVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLPPTQTDRVPWALLGDTLDALALLAADEATLIAALLFDLSAL
RGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGREAGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLSE
DERRALAQLTRDIHAPLANRLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQGLRAE
VSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVEDVAACYAALGAVHSLWAPVPSEFDDYIARPKANDYRSLHTAVVG
PEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKAFDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTP
KGEVIDLPQGATPLDFAYHVHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGRSRDK
VRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENVDELYIQVALGDTGPNQVSRALLEAERAASQPAV
PAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAGEPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWGK
AGSGYEVDVQVRAVDRRWLLKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGVSEVRR
LG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=685, Percent_Identity=43.9416058394161, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1790082, Length=672, Percent_Identity=34.375, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 80389; Mature: 80258

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLPPTQTDRVPWALLGDTLDAL
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ALLAADEATLIAALLFDLSALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGRE
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHH
AGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLSEDERRALAQLTRDIHAPLAN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQGLRA
CCCEEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVEDVAACYAALGAVHSLWAPVPSEF
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DDYIARPKANDYRSLHTAVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKA
HHHHCCCCCCCHHHHHHEEECCCCCEEEEEEEEEEEEHHHCCCEEEEECCCCCCCCCHHH
FDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTPKGEVIDLPQGATPLDFAYH
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCHHHHHH
VHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGRSRD
HHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCCCEECCCCHH
KVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENVDELYIQVALGDT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCC
GPNQVSRALLEAERAASQPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAG
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCC
EPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWGKAGSGYEVDVQVRAVDRRWL
CCHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEEEEEHHHHHH
LKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGVSEVR
HHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCHHHHH
RLG
HCC
>Mature Secondary Structure 
STAVTSSSFDRLQALLQRPAVASIAPAVRDALAQAWQDLPPTQTDRVPWALLGDTLDAL
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
ALLAADEATLIAALLFDLSALRGAIAGLPWQPAERRVAVEGLLDGLDAADQVWALHAGRE
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHH
AGRNSEGLRRLLLSIIHDLRVVPILLARQLARMRVADRLSEDERRALAQLTRDIHAPLAN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLGIWQVKWELEDLAFRHLEPETYRRIAREVDETRVARERYLEAVKRTLSAALAQQGLRA
CCCEEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EVSGRPKHIYSIWRKMQKKRLSFDQLYDIRAVRVMVEDVAACYAALGAVHSLWAPVPSEF
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DDYIARPKANDYRSLHTAVVGPEGRTIEIQIRTFEMHAQAELGVAAHWKYKEGGKGGEKA
HHHHCCCCCCCHHHHHHEEECCCCCEEEEEEEEEEEEHHHCCCEEEEECCCCCCCCCHHH
FDRKILWMRQLLEQVQEGEHGELAGALDAELIEDRVYALTPKGEVIDLPQGATPLDFAYH
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCHHHHHH
VHTMVGHRCRGARVNDRIVPLTYRLRSGDRVEIMTAKEADPRRDWLLASNGFLASGRSRD
HHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCEEEECCCCEECCCCHH
KVRAWFHKLDRARNVQAGKDLLDRELKRLGLQHADLSVAARKFHAENVDELYIQVALGDT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCC
GPNQVSRALLEAERAASQPAVPAPPRPTARRDGLGKSKFTVEGVGNLLVQLARCCQPVAG
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCC
EPIAGYLTRGRGITVHRTDCAALARLAAAHPQRVLPVEWGKAGSGYEVDVQVRAVDRRWL
CCHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCEECCCCCCCCEEEEEEEEEHHHHHH
LKDITNLIAQEDAHVLEINSDNVRDTGRAQLRLRLKVSDYDQLSGLLGKLDALPGVSEVR
HHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCHHHHH
RLG
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]