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The map label for this gene is mazG [H]

Identifier: 78048755

GI number: 78048755

Start: 3636689

End: 3637693

Strand: Reverse

Name: mazG [H]

Synonym: XCV3199

Alternate gene names: 78048755

Gene position: 3637693-3636689 (Counterclockwise)

Preceding gene: 78048756

Following gene: 78048754

Centisome position: 70.25

GC content: 66.07

Gene sequence:

>1005_bases
ATGTCTCAGACCCCTTCCACCGGCGATATCCAGCAGCTGTTGCACTTGATGGCGCGTCTGCGCGATCGCGAACACGGCTG
TCCCTGGGATGTACAGCAGACCTTCGCCAGCATCGCGCCGTACACCATCGAAGAAGCCTACGAGGTGGCCGATGCGATCG
ACCGCAACGACCTGGCTGGCCTGCGCGACGAGTTGGGCGACCTGTTGCTGCAGGTGGTCTTCCATTCGCAAATGGCGGCC
GAGCAGGGAGCGTTCGGCTTCGCCGACGTGGTCGCCACGCTCAGCGACAAGCTCATACGTCGACACCCGCATGTGTTCGC
CGCGCAACCGGCGGCCGATGCGCAGGCGGTGAGCACCAACTGGGAGCAGATCAAGCGCGAAGAGCGTCGTGCCGCTGGCA
ACCAGGACGACTCCGCACTTGCCGGCATCGCGCGCGGGCTGCCGGAATGGCAGCGCTCCACCAAACTGCAGTCGCGCGCG
GCGCGCGTGGGTTTCGATTGGCCCGGCCCGGTGCCGGTGTTGGAAAAACTGCAGGAAGAAATCGAAGAGTTGCGCGTGGA
ATTCGCACGCGGCCCGGTGGCCGACAATCAGGCCCGGCTGGAAGACGAATTGGGCGATGTGTTGTTTGTCTGCGCCAATC
TGGCGCGCCATGCCAAGGTGGATGTCGGCGCCGCGTTGCGGCACGCCAACCTGAAATTCGAACGTCGCTTTCGTGCGATG
GAAGCGCGGGCGCGTGCTGCCGGCACGTCGTTGAACGCGTTGTCGCTGGGCGAACAGGAAGCGTTATGGCAACAGGTCAA
ACGCGAGGAGCGCAGCGGCGATGTGCCGGCCATCGACGGTTCCGCGGGCGACGCATCGGCCTTGCACGCCCCGCTGTCCC
ACGCACCGCCTGTAGACAGCGCTGCCGGCAGTGACCCGTCCGTTGGCGGTGAGGCTTCCCGCAGCGCACCGGGGTATCAA
ACCGGCCCTGATGGCGCCGCCTCCGATACGCCCCGGCCGGCATGA

Upstream 100 bases:

>100_bases
TGCCGCGCGCCGTTGCGGTGTGCAACGGCCGCTTACGTCGCTTGCCTCGCGTGGGACATGCGCCTGCGGCGCACTCACTC
AGAGGTTCCAGGAATACACG

Downstream 100 bases:

>100_bases
CGATCGCGCCGACCACGCTACTGCTGTTTGCCGCGACGGCGCTCGCCGAGTTGGTCGGTTGCTACCTGCCTTATCTCTGG
CTGCGCAAAGGGGGCAGCAT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSQTPSTGDIQQLLHLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHSQMAA
EQGAFGFADVVATLSDKLIRRHPHVFAAQPAADAQAVSTNWEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRA
ARVGFDWPGPVPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
EARARAAGTSLNALSLGEQEALWQQVKREERSGDVPAIDGSAGDASALHAPLSHAPPVDSAAGSDPSVGGEASRSAPGYQ
TGPDGAASDTPRPA

Sequences:

>Translated_334_residues
MSQTPSTGDIQQLLHLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHSQMAA
EQGAFGFADVVATLSDKLIRRHPHVFAAQPAADAQAVSTNWEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRA
ARVGFDWPGPVPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
EARARAAGTSLNALSLGEQEALWQQVKREERSGDVPAIDGSAGDASALHAPLSHAPPVDSAAGSDPSVGGEASRSAPGYQ
TGPDGAASDTPRPA
>Mature_333_residues
SQTPSTGDIQQLLHLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAGLRDELGDLLLQVVFHSQMAAE
QGAFGFADVVATLSDKLIRRHPHVFAAQPAADAQAVSTNWEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRAA
RVGFDWPGPVPVLEKLQEEIEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAME
ARARAAGTSLNALSLGEQEALWQQVKREERSGDVPAIDGSAGDASALHAPLSHAPPVDSAAGSDPSVGGEASRSAPGYQT
GPDGAASDTPRPA

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=261, Percent_Identity=54.7892720306513, Blast_Score=268, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 36057; Mature: 35926

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTPSTGDIQQLLHLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAG
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
LRDELGDLLLQVVFHSQMAAEQGAFGFADVVATLSDKLIRRHPHVFAAQPAADAQAVSTN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHCC
WEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRAARVGFDWPGPVPVLEKLQEE
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EARARAAGTSLNALSLGEQEALWQQVKREERSGDVPAIDGSAGDASALHAPLSHAPPVDS
HHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
AAGSDPSVGGEASRSAPGYQTGPDGAASDTPRPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQTPSTGDIQQLLHLMARLRDREHGCPWDVQQTFASIAPYTIEEAYEVADAIDRNDLAG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
LRDELGDLLLQVVFHSQMAAEQGAFGFADVVATLSDKLIRRHPHVFAAQPAADAQAVSTN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHCC
WEQIKREERRAAGNQDDSALAGIARGLPEWQRSTKLQSRAARVGFDWPGPVPVLEKLQEE
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IEELRVEFARGPVADNQARLEDELGDVLFVCANLARHAKVDVGAALRHANLKFERRFRAM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EARARAAGTSLNALSLGEQEALWQQVKREERSGDVPAIDGSAGDASALHAPLSHAPPVDS
HHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
AAGSDPSVGGEASRSAPGYQTGPDGAASDTPRPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]