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The map label for this gene is fabG2 [H]

Identifier: 78047452

GI number: 78047452

Start: 2143559

End: 2144329

Strand: Reverse

Name: fabG2 [H]

Synonym: XCV1896

Alternate gene names: 78047452

Gene position: 2144329-2143559 (Counterclockwise)

Preceding gene: 78047453

Following gene: 78047451

Centisome position: 41.41

GC content: 67.06

Gene sequence:

>771_bases
ATGCAGCCATCTTCTGTTCTTGCCATCGTCACCGGCGGCGTTTCCGGCCTCGGCCTGGCGGTCGCACAGCGTCTGGTGGT
CGACGGCGGCAAGGTCGCGTTGTTCGATGTCAACGCCGACAAGGCCGAGTCGGCGCTGGCGCTGCTCGGTGCCGGCAACG
CGCATTACTTCGCCACCGATGTCACCGACGAAGCGCAGGTGGCCGCCAATGTGGCGCAGGCTGCACAGGCGCTGGGCGGG
CTCAACCTGGTGGTGAATTGCGCCGGCATCCTGGGCGCCGGTCGCGTGCTGGGCAAGGAAGCGCCGATGCCGTTGGCCAC
CTTCCGCAACACCGTGCTGGTGAATCTGGTCGGCAGCTTCAACGTGGCCAAGGCCGCTGCCGATGTCATGCAACACAACA
CCGCCGGCGATGACGGCGAGCGCGGCGTGATCGTCAATACCGCCTCGGTGGCGGCATTCGAGGGCCAGATCGGCCAGGCA
GCGTATGCGGCAAGCAAAGGCGGCGTGGTCGGCATGACCTTGCCGATGGCACGCGAACTGGCGCGCTTCGGTATCCGCGT
GATGACGATCGCGCCGGGCGTGTTCTGGACCCCGATGGTCGACGGCATGCCCGAGGCCGTGCAGCAATCGCTGGCCGCCT
CCATCCCGTTCCCCTCGCGTCTGGGCCAGCCCGACGAATACGCCGACACCGTCGCCTTCATCCTGCGCAACCGCTACCTC
AACGGCGAAGTGATTCGCCTGGACGGCGGCGTGCGGTTGGTACCCAAGTAG

Upstream 100 bases:

>100_bases
CGCGATCACGCAGGGGCTTGGGCTAGAATTGCCGACCGCTCCGCCGATCGTTCGTTTGCCGCCAACACCGGCCACCAACG
CTATTTTAGGGAACCACCGC

Downstream 100 bases:

>100_bases
CGGGGATTGGGGAATCGGGAATGGGGAATCGTAACGGCGCCCTGCTCTCAGCACCCCGGCCCCGGCTTTTTCGATTTCCC
ATTCCCTACTCCCGATTCCC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MQPSSVLAIVTGGVSGLGLAVAQRLVVDGGKVALFDVNADKAESALALLGAGNAHYFATDVTDEAQVAANVAQAAQALGG
LNLVVNCAGILGAGRVLGKEAPMPLATFRNTVLVNLVGSFNVAKAAADVMQHNTAGDDGERGVIVNTASVAAFEGQIGQA
AYAASKGGVVGMTLPMARELARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
NGEVIRLDGGVRLVPK

Sequences:

>Translated_256_residues
MQPSSVLAIVTGGVSGLGLAVAQRLVVDGGKVALFDVNADKAESALALLGAGNAHYFATDVTDEAQVAANVAQAAQALGG
LNLVVNCAGILGAGRVLGKEAPMPLATFRNTVLVNLVGSFNVAKAAADVMQHNTAGDDGERGVIVNTASVAAFEGQIGQA
AYAASKGGVVGMTLPMARELARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
NGEVIRLDGGVRLVPK
>Mature_256_residues
MQPSSVLAIVTGGVSGLGLAVAQRLVVDGGKVALFDVNADKAESALALLGAGNAHYFATDVTDEAQVAANVAQAAQALGG
LNLVVNCAGILGAGRVLGKEAPMPLATFRNTVLVNLVGSFNVAKAAADVMQHNTAGDDGERGVIVNTASVAAFEGQIGQA
AYAASKGGVVGMTLPMARELARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
NGEVIRLDGGVRLVPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=252, Percent_Identity=51.5873015873016, Blast_Score=237, Evalue=8e-63,
Organism=Homo sapiens, GI83715985, Length=252, Percent_Identity=48.015873015873, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=36.9230769230769, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=34.6938775510204, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI31542939, Length=242, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI59889578, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=27.1653543307087, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4503817, Length=197, Percent_Identity=27.9187817258883, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=30.078125, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=30.7392996108949, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=28.968253968254, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=33.8582677165354, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=31.2, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=28.3018867924528, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=30.9160305343511, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=27.4131274131274, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=28.4, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=29.0697674418605, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=44.4, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=32.2834645669291, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=33.8645418326693, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=32.3076923076923, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=25.7936507936508, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=272, Percent_Identity=27.5735294117647, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=25.4681647940075, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=26, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=202, Percent_Identity=30.1980198019802, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=26.0700389105058, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=226, Percent_Identity=25.6637168141593, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=50.199203187251, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=36.9477911646586, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=30.2788844621514, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24665243, Length=205, Percent_Identity=30.2439024390244, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221331218, Length=205, Percent_Identity=30.2439024390244, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI23397609, Length=265, Percent_Identity=30.5660377358491, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24665247, Length=206, Percent_Identity=30.5825242718447, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221331216, Length=206, Percent_Identity=30.5825242718447, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26228; Mature: 26228

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSSVLAIVTGGVSGLGLAVAQRLVVDGGKVALFDVNADKAESALALLGAGNAHYFATD
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHEEEEEECCCCEEEEEC
VTDEAQVAANVAQAAQALGGLNLVVNCAGILGAGRVLGKEAPMPLATFRNTVLVNLVGSF
CCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHCCCCCCCHHHHHCEEEEEEECCC
NVAKAAADVMQHNTAGDDGERGVIVNTASVAAFEGQIGQAAYAASKGGVVGMTLPMAREL
HHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHCCCCEEEEEHHHHHHH
ARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
HHCCEEEEEECCCCEECCCCCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCC
NGEVIRLDGGVRLVPK
CCEEEEECCCEEECCC
>Mature Secondary Structure
MQPSSVLAIVTGGVSGLGLAVAQRLVVDGGKVALFDVNADKAESALALLGAGNAHYFATD
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHEEEEEECCCCEEEEEC
VTDEAQVAANVAQAAQALGGLNLVVNCAGILGAGRVLGKEAPMPLATFRNTVLVNLVGSF
CCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHCCCCCCCHHHHHCEEEEEEECCC
NVAKAAADVMQHNTAGDDGERGVIVNTASVAAFEGQIGQAAYAASKGGVVGMTLPMAREL
HHHHHHHHHHHCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHCCCCEEEEEHHHHHHH
ARFGIRVMTIAPGVFWTPMVDGMPEAVQQSLAASIPFPSRLGQPDEYADTVAFILRNRYL
HHCCEEEEEECCCCEECCCCCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCC
NGEVIRLDGGVRLVPK
CCEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]