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The map label for this gene is mvaB [H]

Identifier: 78047453

GI number: 78047453

Start: 2144467

End: 2145363

Strand: Reverse

Name: mvaB [H]

Synonym: XCV1897

Alternate gene names: 78047453

Gene position: 2145363-2144467 (Counterclockwise)

Preceding gene: 78047454

Following gene: 78047452

Centisome position: 41.43

GC content: 67.89

Gene sequence:

>897_bases
ATGAGCGACTTCGTCCGCATTGTCGAAGTTGGCCCACGCGATGGCCTGCAAAACGAAGCGCAGCCGATCGCCACTGCCGA
CAAGATCGCGTTGATCGATCAACTCTCGGCCACCGGGCTGCGCACGATCGAAGCAACCAGCTTCGTCAGCCCGCGCTGGG
TACCGCAGCTGGCCGACGCCGCCGAGGTGTTTGCCGGCATCGCGCAGGTGCCGGGCATCGCATATCCGGTGCTGGTGCCC
AACCTGCAGGGCTACGAACGCGCACGCGCGGCCGGGGCGCAGGAAGTGGCGGTCTTCACCGCGGCGTCGGAGGCGTTTAA
TCGCACCAATACCAACGCCGGCATCGACGAATCGATCGAACGCTTTCGGCCGATCCTGCAGCAGGCCGCGCTCGATGGTG
TGCGCGTGCGCGGCTACGTCTCCACCGTGCTGGGCTGCCCGTACCAGGGCGAAGTGCCGGTGGCCGATGTGGTCGATGTG
GCGCAACGTCTGCACGCACTCGGCTGCTATGAAATCTCGCTGGGCGACACCATTGGCGTAGGCACGCCGGTCAAGGCGCG
TCAGATGCTGGCCGCGGTGGCGCAGGCGGTGCCGATGCAGGCGTTGGCGGTGCATTTCCACGATACCTATGGGCAGGCGC
TGGCCAATATCGCCGCATGCCTGGAGCAAGGCGTACGCGTGATCGATGCGGCCGTGTCCGGTGCGGGCGGCTGCCCGTAT
GCCAGGGGCGCCAGCGGCAACGTCGCCAGCGAAGACGTGGTGTACCTGTTGCAGGGGCTGGGCATGCCCACCGGCATCGA
CCTGCCTGCCCTGGCCCGCACCGGCCGCTGGCTGGCGCAGCTGCTCGGTCGCGACACCGGCAGCAAGGTCGGCAAGGCGT
TGGCTGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
TTCCGATGTCCCTGGTTTCCTTGTCCACGCATTCGGCCGCCACCACGCACGCGGTTGCGGCGATGCCTGCACGACGTCAT
GCGCGCTGCGATGTGAGCGC

Downstream 100 bases:

>100_bases
GGTTTTCCTGCCCGCGCAATCGTGCATCACCGACCACCGCGATCACGCAGGGGCTTGGGCTAGAATTGCCGACCGCTCCG
CCGATCGTTCGTTTGCCGCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADAAEVFAGIAQVPGIAYPVLVP
NLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIERFRPILQQAALDGVRVRGYVSTVLGCPYQGEVPVADVVDV
AQRLHALGCYEISLGDTIGVGTPVKARQMLAAVAQAVPMQALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLAQLLGRDTGSKVGKALAAAG

Sequences:

>Translated_298_residues
MSDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADAAEVFAGIAQVPGIAYPVLVP
NLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIERFRPILQQAALDGVRVRGYVSTVLGCPYQGEVPVADVVDV
AQRLHALGCYEISLGDTIGVGTPVKARQMLAAVAQAVPMQALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLAQLLGRDTGSKVGKALAAAG
>Mature_297_residues
SDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADAAEVFAGIAQVPGIAYPVLVPN
LQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIERFRPILQQAALDGVRVRGYVSTVLGCPYQGEVPVADVVDVA
QRLHALGCYEISLGDTIGVGTPVKARQMLAAVAQAVPMQALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPYA
RGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLAQLLGRDTGSKVGKALAAAG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=289, Percent_Identity=58.477508650519, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=55.2901023890785, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=55.2901023890785, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI260654708, Length=289, Percent_Identity=39.4463667820069, Blast_Score=181, Evalue=7e-46,
Organism=Escherichia coli, GI1786261, Length=204, Percent_Identity=25.9803921568627, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17510563, Length=292, Percent_Identity=50.3424657534247, Blast_Score=312, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24582381, Length=289, Percent_Identity=62.6297577854671, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30961; Mature: 30829

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADA
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHH
AEVFAGIAQVPGIAYPVLVPNLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIE
HHHHHHHHHCCCCCCCEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
RFRPILQQAALDGVRVRGYVSTVLGCPYQGEVPVADVVDVAQRLHALGCYEISLGDTIGV
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCC
GTPVKARQMLAAVAQAVPMQALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLAQLLGRDTGSKVGKALAAAG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDFVRIVEVGPRDGLQNEAQPIATADKIALIDQLSATGLRTIEATSFVSPRWVPQLADA
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHH
AEVFAGIAQVPGIAYPVLVPNLQGYERARAAGAQEVAVFTAASEAFNRTNTNAGIDESIE
HHHHHHHHHCCCCCCCEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
RFRPILQQAALDGVRVRGYVSTVLGCPYQGEVPVADVVDVAQRLHALGCYEISLGDTIGV
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCC
GTPVKARQMLAAVAQAVPMQALAVHFHDTYGQALANIAACLEQGVRVIDAAVSGAGGCPY
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ARGASGNVASEDVVYLLQGLGMPTGIDLPALARTGRWLAQLLGRDTGSKVGKALAAAG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]