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The map label for this gene is lpxB [H]

Identifier: 78047021

GI number: 78047021

Start: 1647120

End: 1648439

Strand: Reverse

Name: lpxB [H]

Synonym: XCV1465

Alternate gene names: 78047021

Gene position: 1648439-1647120 (Counterclockwise)

Preceding gene: 78047022

Following gene: 78047020

Centisome position: 31.83

GC content: 67.95

Gene sequence:

>1320_bases
ATGAAGGAAATCGGGAATCGGGAGTCGGGAATCGTGGACGGTCAGCGCAACGGCGCGTCGGTCGGCAGCGACCCGACTGC
GCTGCCGATTCCCCATTCCCCACTCCCCATTCCCGGCGCGCATGCGCGCCCTCCCCGCATCGCGCTGATCGCTGGCGAGG
CCTCTGGCGACATCCTGGGCGCGGGACTGATCGAGCAGCTGCGGCTGCGCTATCCGAATGCCGAATTCGTCGGCATCGGT
GGCGATGCGATGCGTGGCGTCGGTTGCCAGACCTGGTTCGATGCCAGCGAGCTGGCGGTGATGGGCCTGACCGAGGTGCT
GCGGCATTTGCCGCGCCTGCTCAAGCTGCGCAGCGCGTTCCGCGAGCGGGTGCTGGCGTGGAAGCCGGACGTGTTCATCG
GCATCGACGCGCCGGATTTCAACCTCCCGGTGGAACGCTGGCTCAAGCAGCGCGGGATCAAGACCGTGCACTACGTCAGC
CCGTCGGTGTGGGCGTGGCGCGAGAAGCGTGCCGAAAAAATCGGCGTCAGCGCCGATCTGGTGCTGTGCCTGTTTCCGAT
GGAACCGCCGATCTACGCCAGGCATGGCGTGGACGCCCGTTTTGTCGGCCACCCGATGGCCGACGATATCGCCTACCAGG
CCGACCGCGCAGCGGCGCGCGCAACGCTGGGCCTGTCCGCCTCCAGCACCGTCCTGGCAGTGTTGCCGGGCAGCCGGCAC
GGCGAAATCAGCCGGCTCGGCGACACCTTTTTCCAGGCCGCATGGCTGGTGTCCGAGCACCTGCCCAACCTGCACGTGCT
GGTACCGGCCGCCAATCCGGGCTGCAAGCAACTGCTGGCCGAGCAGCTCTCACGCTCGTCGCTGCCGGTGATGCGCTCCC
ACCTGCTCGACGGCCAGGCACGCACTGCGATGCTGGCCGCCGACGTGGTGCTGCTGGCCTCCGGCACCGCCACGCTGGAA
GCGATGCTGGTCAAGCGCCCGATGGTGGTGGGCTACAAGGTCGCACCGCTCACCTACCGCATCGTCAAGCTGCTGGGCCT
GCTCAAGGTCAACCGCTACGCCCTGCCCAATATCCTGGCCAATGACGACCTGGCGCCGGAACTGATGCAGGACGACTGCG
CCCCCGAGCGCCTGTGCGTGGCGCTGCTGGACTGGTTCAAACACCCCGACAAGGTCGCCGCCCTGCAACCGCGCTACCTG
GCCCTGCATGCGCAGTTGCGCCGCGACGCGTCGGCGCGGGCAGCGGATGCGGTGGCCGGGCTGCTGGAAGGCAGGGATTC
GGAGGTCGGGATTTGGGATTCGGCAGGAGCGAAGGCATGA

Upstream 100 bases:

>100_bases
TGGCCGATGCCAAGCTGCAGCTGGCCGAACAGGCCAAGAGCAGCGAGGATGTGCGCGGCATGCTCGAGTTCATCGAAGCG
GCAGAACGGCCGTTGTTACG

Downstream 100 bases:

>100_bases
AAATCATTGCTTTAGGCACCCAAGCCGATAGCGCCGACGCTGAGGCGCGCCAGTCGCCCTTGTTTGACCAATCCCAAATC
CCGAATGTCGAATCCCGGCG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKEIGNRESGIVDGQRNGASVGSDPTALPIPHSPLPIPGAHARPPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIG
GDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVS
PSVWAWREKRAEKIGVSADLVLCLFPMEPPIYARHGVDARFVGHPMADDIAYQADRAAARATLGLSASSTVLAVLPGSRH
GEISRLGDTFFQAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLE
AMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCAPERLCVALLDWFKHPDKVAALQPRYL
ALHAQLRRDASARAADAVAGLLEGRDSEVGIWDSAGAKA

Sequences:

>Translated_439_residues
MKEIGNRESGIVDGQRNGASVGSDPTALPIPHSPLPIPGAHARPPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIG
GDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVS
PSVWAWREKRAEKIGVSADLVLCLFPMEPPIYARHGVDARFVGHPMADDIAYQADRAAARATLGLSASSTVLAVLPGSRH
GEISRLGDTFFQAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLE
AMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCAPERLCVALLDWFKHPDKVAALQPRYL
ALHAQLRRDASARAADAVAGLLEGRDSEVGIWDSAGAKA
>Mature_439_residues
MKEIGNRESGIVDGQRNGASVGSDPTALPIPHSPLPIPGAHARPPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIG
GDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVS
PSVWAWREKRAEKIGVSADLVLCLFPMEPPIYARHGVDARFVGHPMADDIAYQADRAAARATLGLSASSTVLAVLPGSRH
GEISRLGDTFFQAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLE
AMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCAPERLCVALLDWFKHPDKVAALQPRYL
ALHAQLRRDASARAADAVAGLLEGRDSEVGIWDSAGAKA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=379, Percent_Identity=47.4934036939314, Blast_Score=337, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 47535; Mature: 47535

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIGNRESGIVDGQRNGASVGSDPTALPIPHSPLPIPGAHARPPRIALIAGEASGDILG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
AGLIEQLRLRYPNAEFVGIGGDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAF
HHHHHHHHHCCCCCCEEECCCHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRAEKIGVSADL
HHHHHEECCCEEEEECCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEE
VLCLFPMEPPIYARHGVDARFVGHPMADDIAYQADRAAARATLGLSASSTVLAVLPGSRH
EEEEECCCCCCEECCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GEISRLGDTFFQAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQA
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCH
RTAMLAADVVLLASGTATLEAMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILA
HHHHHHHHHHHEECCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCHHHCCCHHC
NDDLAPELMQDDCAPERLCVALLDWFKHPDKVAALQPRYLALHAQLRRDASARAADAVAG
CCCCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHH
LLEGRDSEVGIWDSAGAKA
HHCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MKEIGNRESGIVDGQRNGASVGSDPTALPIPHSPLPIPGAHARPPRIALIAGEASGDILG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
AGLIEQLRLRYPNAEFVGIGGDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAF
HHHHHHHHHCCCCCCEEECCCHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRAEKIGVSADL
HHHHHEECCCEEEEECCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEE
VLCLFPMEPPIYARHGVDARFVGHPMADDIAYQADRAAARATLGLSASSTVLAVLPGSRH
EEEEECCCCCCEECCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GEISRLGDTFFQAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQA
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHCCCCH
RTAMLAADVVLLASGTATLEAMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILA
HHHHHHHHHHHEECCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCHHHCCCHHC
NDDLAPELMQDDCAPERLCVALLDWFKHPDKVAALQPRYLALHAQLRRDASARAADAVAG
CCCCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHH
LLEGRDSEVGIWDSAGAKA
HHCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]