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The map label for this gene is lpxA [H]

Identifier: 78047022

GI number: 78047022

Start: 1648436

End: 1649227

Strand: Reverse

Name: lpxA [H]

Synonym: XCV1466

Alternate gene names: 78047022

Gene position: 1649227-1648436 (Counterclockwise)

Preceding gene: 78047023

Following gene: 78047021

Centisome position: 31.85

GC content: 65.78

Gene sequence:

>792_bases
ATGCGCGATTCAACACCTTTGATTCATCCGACGGCGGTCATCGATCCATCGGCAACGCTGGCAGACGACGTCCGCGTCGG
CGCCTTCTCGTTGATCGGCGCCGATGTGCAGATCGGGGCGGGCACCGAGGTGGGGCCACACTGCTCGATCCACGGCCCGA
CCCGGATCGGCCGCAACAACCGCTTCATCGGCCACGCCGCGATCGGCGGCGAACCGCAGGACAAGAAGTACGCTGGCGAG
CGCACCGAACTGGTGATCGGCGACGGCAACGTGATCCGCGAATTCGTCACCATCAATCGCGGCACCGGCGGCGGCGGCGG
CGTCACCGTGGTCGGCAACGACAACTGGATGCTGGCCTATACGCACGTGGCGCACGACTGCCATGTGGGCAACCACTGCG
TGTTTTCCAACAACACCACGCTCGCCGGCCACGTCACCGTGGGCGACTACGTGATCATCAGCGGCTTTGCCGGCGCGCAT
CAGTTTTGCCGGATCGGCGCGCATGCCTTCCTGGGCATGGGCGCGCTGACCAATGGCGACGTCCCGCCGTTCACCATGGT
GGGCAGCGACTCGCTGGGGCGTCCGCGCGGCATCAATAGCGAAGGGCTCAAGCGTCGCGGTTTCGACGCCGAACGCATTA
CCGCGATCAAGCGCGCCTACCGCACGCTGTACGTGGCCGGCCTGCCGCTGGCCGATGCCAAGCTGCAGCTGGCCGAACAG
GCCAAGAGCAGCGAGGATGTGCGCGGCATGCTCGAGTTCATCGAAGCGGCAGAACGGCCGTTGTTACGATGA

Upstream 100 bases:

>100_bases
TGCTTCTACGGCGAGGCCAAGGTCGATGGCGAAGTGGTGGCCAGTGCCGAGGTGATGTGCGCCGGCGCCAGGTAATCACC
CGCTTTCGGAGTAAGACACG

Downstream 100 bases:

>100_bases
AGGAAATCGGGAATCGGGAGTCGGGAATCGTGGACGGTCAGCGCAACGGCGCGTCGGTCGGCAGCGACCCGACTGCGCTG
CCGATTCCCCATTCCCCACT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGE
RTELVIGDGNVIREFVTINRGTGGGGGVTVVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAH
QFCRIGAHAFLGMGALTNGDVPPFTMVGSDSLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
AKSSEDVRGMLEFIEAAERPLLR

Sequences:

>Translated_263_residues
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGE
RTELVIGDGNVIREFVTINRGTGGGGGVTVVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAH
QFCRIGAHAFLGMGALTNGDVPPFTMVGSDSLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
AKSSEDVRGMLEFIEAAERPLLR
>Mature_263_residues
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNNRFIGHAAIGGEPQDKKYAGE
RTELVIGDGNVIREFVTINRGTGGGGGVTVVGNDNWMLAYTHVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAH
QFCRIGAHAFLGMGALTNGDVPPFTMVGSDSLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
AKSSEDVRGMLEFIEAAERPLLR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=263, Percent_Identity=45.2471482889734, Blast_Score=237, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27851; Mature: 27851

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNN
CCCCCCCCCCEEEECCCCCHHCCCCCCEEEEECCEEEECCCCCCCCCEEECCCCEECCCC
RFIGHAAIGGEPQDKKYAGERTELVIGDGNVIREFVTINRGTGGGGGVTVVGNDNWMLAY
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHEEEEEEEECCCCCCCCEEEEECCCEEEEE
THVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAHQFCRIGAHAFLGMGALTNGD
EEEECCCCCCCEEEECCCCEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
VPPFTMVGSDSLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
CCCEEEECCCCCCCCCCCCHHCHHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
AKSSEDVRGMLEFIEAAERPLLR
HCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRDSTPLIHPTAVIDPSATLADDVRVGAFSLIGADVQIGAGTEVGPHCSIHGPTRIGRNN
CCCCCCCCCCEEEECCCCCHHCCCCCCEEEEECCEEEECCCCCCCCCEEECCCCEECCCC
RFIGHAAIGGEPQDKKYAGERTELVIGDGNVIREFVTINRGTGGGGGVTVVGNDNWMLAY
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHEEEEEEEECCCCCCCCEEEEECCCEEEEE
THVAHDCHVGNHCVFSNNTTLAGHVTVGDYVIISGFAGAHQFCRIGAHAFLGMGALTNGD
EEEECCCCCCCEEEECCCCEEEEEEEECCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
VPPFTMVGSDSLGRPRGINSEGLKRRGFDAERITAIKRAYRTLYVAGLPLADAKLQLAEQ
CCCEEEECCCCCCCCCCCCHHCHHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
AKSSEDVRGMLEFIEAAERPLLR
HCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]