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The map label for this gene is sahH [H]

Identifier: 78046412

GI number: 78046412

Start: 975437

End: 976879

Strand: Reverse

Name: sahH [H]

Synonym: XCV0856

Alternate gene names: 78046412

Gene position: 976879-975437 (Counterclockwise)

Preceding gene: 78046421

Following gene: 78046406

Centisome position: 18.86

GC content: 63.48

Gene sequence:

>1443_bases
ATGAACGCTGTCACAAAGATCACCCCGCACACCGACTACAAGATTGCCGACATCTCCCTGGCCGATTGGGGCCGCAAGGA
GCTGGACATCGCCGAGCACGAAATGCCGGGCCTGATGTCGATCCGCCGCAAGCATGCGCAGACCAAGCCGCTGAAGGACG
TCCGCATCACCGGCTCGCTGCACATGACCATCCAGACCGCCGTGCTGATCGAAACGCTCAAGGACATCGGCGCCGATGTG
CGCTGGGCCTCGTGCAACATCTTCTCCACCCAGGACCACGCCGCCGCTGCGATCGCCGCGACCGGCACCCCCGTGTTCGC
CTGGAAGGGCGAGACGCTGGAAGAGTACTGGGACTGCACCCTGGACGCGCTGACCTTCACCCTGCCCGACGGCACCCTCA
CCGGCCCGGAGCTGGTGGTGGACGACGGTGGCGACGTCACCCTGCTGATCCACAAGGGCTATGAGCTCGAGAACGGCAGC
ACCTGGGTGGACGAGCCGGCCTCCTCGCACGAAGAGGGCGTCATCAAGGCGTTGCTCAAGCGCGTGGCCGTCGAGCGCCC
GGGCTACTGGGGCCGCGTGGTCAAGGACTGGAAGGGCGTCTCCGAAGAAACCACCACCGGCGTGCACCGCCTGTACCAGA
TCGCCGAAGCCGGCAAGCTGCTGATCCCGGCCATCAACGTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACCTGTAC
GGCTGCCGCGAGTCGCTGGCCGATGGCCTCAAGCGCGCGATGGACGTGATGCTTGCCGGCAAGGTTGCCGTGGTCTGCGG
CTACGGCGATGTCGGCAAGGGCAGCGCCGCCTCGCTGCGCGCCTATGGCGCCCGCGTGATCGTCACCGAAATCGACCCGA
TCTGCGCATTGCAGGCGTCGATGGAAGGCTTCGAAGTCAACACCATCGAATCCACCCTGGGCCGGGCCGACATCTATGTC
ACCACCACCGGCAACAAGGACATCATCACCGTCGAGCACCTGCAGGCGATGAAGGACCAGGCCATCGTCTGCAACATCGG
CCACTTCGACAACGAGATCCAGGTCGATGCGCTCAAGGCGCTGAAGGACGTGCAGAAGATCAACATCAAGCCGCAGGTGG
ACAAGTACGTGTTCCCCAACGGCAACGCGATCTTCCTGCTGGCCGATGGCCGCCTGGTGAACCTGGGCTGCGCCACCGGC
CACCCGAGCTTCGTGATGTCCAACTCGTTCGCCAACCAGACCCTGGCTCAGATCGACCTGTGGGAAAAGCGCGACACCTA
CGAAAAGAAGGTCTACATCCTGCCCAAGCACCTGGATGAAGAAGTTGCGCGTCTGCACCTGGAAAAGATCGGCGTGAAGC
TGACCACCCTCACCAAGGACCAGGCCGATTACCTCGGCGTGCCGGTGGAAGGCCCGTTCAAGCCGGATCATTACCGCTAC
TGA

Upstream 100 bases:

>100_bases
ACTGCACCACAGGTGCAGGTACACGGCCAGGCTCGACCAGCAGTTACCGTTCAACGGCGCCCGGCATTGCAGACATTCGT
TTGCCTACCGGAGCCATTGC

Downstream 100 bases:

>100_bases
GACGTGGGCGCACGTTCGCCCATCCTCGACAGTGTCAATCAACGGGCGCCGCAAGGCGCCCGTTGTGCTTCAAGGCCATG
ATCGGCACGACGTCGAAGCT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGS
TWVDEPASSHEEGVIKALLKRVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRADIYV
TTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVPVEGPFKPDHYRY

Sequences:

>Translated_480_residues
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGS
TWVDEPASSHEEGVIKALLKRVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRADIYV
TTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVPVEGPFKPDHYRY
>Mature_480_residues
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGADV
RWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGS
TWVDEPASSHEEGVIKALLKRVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRADIYV
TTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKALKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATG
HPSFVMSNSFANQTLAQIDLWEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVPVEGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=59.8290598290598, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=446, Percent_Identity=58.9686098654709, Blast_Score=501, Evalue=1e-142,
Organism=Homo sapiens, GI298286489, Length=471, Percent_Identity=46.7091295116773, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI195539337, Length=471, Percent_Identity=46.7091295116773, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI24308043, Length=471, Percent_Identity=46.7091295116773, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI195539349, Length=471, Percent_Identity=46.7091295116773, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI21361647, Length=471, Percent_Identity=46.072186836518, Blast_Score=414, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506425, Length=471, Percent_Identity=60.0849256900212, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320882, Length=486, Percent_Identity=58.0246913580247, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=468, Percent_Identity=62.1794871794872, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24656245, Length=459, Percent_Identity=47.7124183006536, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553387, Length=470, Percent_Identity=46.5957446808511, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45553385, Length=469, Percent_Identity=46.4818763326226, Blast_Score=401, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52824; Mature: 52824

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSL
CCCCEECCCCCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCEEEEECEE
HMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCT
EEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCEEEEECCCCHHHHHCCE
LDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVDEPASSHEEGVIKALLK
EEEEEEECCCCCCCCCEEEEECCCCEEEEEECCEEECCCCEECCCCCCCCHHHHHHHHHH
RVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
HHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQAS
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHC
MEGFEVNTIESTLGRADIYVTTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKA
CCCEEEEHHHHHCCCEEEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCCHHHHHHH
LKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATGHPSFVMSNSFANQTLAQIDL
HHHHHHCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHEEC
WEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVPVEGPFKPDHYRY
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCEEEEEEECCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNAVTKITPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSL
CCCCEECCCCCCEEEEEEECCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCEEEEECEE
HMTIQTAVLIETLKDIGADVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCT
EEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCEEEEECCCCHHHHHCCE
LDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVDEPASSHEEGVIKALLK
EEEEEEECCCCCCCCCEEEEECCCCEEEEEECCEEECCCCEECCCCCCCCHHHHHHHHHH
RVAVERPGYWGRVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLY
HHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
GCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQAS
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHC
MEGFEVNTIESTLGRADIYVTTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALKA
CCCEEEEHHHHHCCCEEEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCCCHHHHHHH
LKDVQKINIKPQVDKYVFPNGNAIFLLADGRLVNLGCATGHPSFVMSNSFANQTLAQIDL
HHHHHHCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHEEC
WEKRDTYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVPVEGPFKPDHYRY
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCEEEEEEECCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]