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The map label for this gene is pdhB [H]

Identifier: 78046031

GI number: 78046031

Start: 536251

End: 537321

Strand: Reverse

Name: pdhB [H]

Synonym: XCV0475

Alternate gene names: 78046031

Gene position: 537321-536251 (Counterclockwise)

Preceding gene: 78046032

Following gene: 78046030

Centisome position: 10.38

GC content: 67.32

Gene sequence:

>1071_bases
ATGGATGAGCTCACCCATGTGCCCGCAGACACCTCGCAGCACGCCAGTGCCCCTTACAACGCTGCGGCAACGCGCGGAGA
GATCGCCATGAGTTCGCCCATCACCCTGATCGAAGCCATCACCCAGGCGCTAGCCTGGGAGCTGGAACACGACCCCGCGG
TACTGGTGCTGGGCGAGGATGTCGGCGTCAACGGTGGCGTGTTTCGTGCCACCGCCGGCCTGCAGCAACGCTTCGGCAGC
GACCGCGTGCTGGACACGCCGCTGGACGAAACCACCATCGCCGGGCTGAGCGTCGGGCTGGCCGCGCAAGGCATGAAGCC
GGTGGCCGAAGCGCAGTTCGACGGCTTCGTGTATCCGATGGTCGACCATCTGATCTGCCACGCCGCCCGCCTGCGCAACC
GCACCCGTGGCCGCCTGCATTGCCCGATGGTGCTGCGCGTGCCGTGGGGCGGTGGCATCCGCGCGCCGGAACATCACAGC
GAAGCCAACGAAGCCATCTTCACCAACGTGCCGGGCCTGCGCGTGGTGCTGCCGTCCTCGCCGCAGCGCGCCTACGGCCT
GCTGCTGGCCGCCATCCGCGACCCGGATCCGGTCATCTACATGGAGCCCAAGCGCATCTATCGCCAGTACAAGGAAGTGG
TGGCCAACGATGGGCAAGCGCTGCCGCTGGATGTGTGCTTCGTGTTGCGCGACGGCACCGATGTCACCCTAGTGACCTGG
GGCGCGCAGGTGAAAGAGGCGCTGGAAGCGGCCGACAAACTCGCTGGCGAAGGCATCAGCGCCGAAGTCATCGACGTGGC
CACGTTGCGCCCGCTGGACTTCGACACCATCGCCGAATCGGTGGCCAAGACCGGCCGCTGCGTGATCGTGCAGGAAGCCC
CGCGCACCGCCGGTTTCGGTGCGGAAATCGCCGCGCGCCTGGCCGAACAGTCGATGTACGACCTGGTGGCGCCAGTGGAA
CGCGTCACCGGTTACGACACGCATATCCCGCTGTTCCGGCTGGAAATGAAGTTCCTGCCGAGCGTGGAGCGCATCGTCGC
CGCGGCACGTCGCGCGGTGGCTGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGGTGCAGCCGGTCGAAGCGATGTTCGATTACCTCTACGGCGACCCGCCGGCCGAGTTGCTGGCACAGCGCGCCGAGGT
GATGGCGCTGGAGTCGCGCC

Downstream 100 bases:

>100_bases
TATGCGCGCCCGTCTGCTTTGCGACCATCGCGCCGCCTACGCCAACCCGGTCCGCTTCCAGGCAGGCCAGCAGGTCGGCG
TGGGCGTGCGCGACGAAGAA

Product: putative pyruvate dehydrogenase E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDELTHVPADTSQHASAPYNAAATRGEIAMSSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGS
DRVLDTPLDETTIAGLSVGLAAQGMKPVAEAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHS
EANEAIFTNVPGLRVVLPSSPQRAYGLLLAAIRDPDPVIYMEPKRIYRQYKEVVANDGQALPLDVCFVLRDGTDVTLVTW
GAQVKEALEAADKLAGEGISAEVIDVATLRPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVE
RVTGYDTHIPLFRLEMKFLPSVERIVAAARRAVAAG

Sequences:

>Translated_356_residues
MDELTHVPADTSQHASAPYNAAATRGEIAMSSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGS
DRVLDTPLDETTIAGLSVGLAAQGMKPVAEAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHS
EANEAIFTNVPGLRVVLPSSPQRAYGLLLAAIRDPDPVIYMEPKRIYRQYKEVVANDGQALPLDVCFVLRDGTDVTLVTW
GAQVKEALEAADKLAGEGISAEVIDVATLRPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVE
RVTGYDTHIPLFRLEMKFLPSVERIVAAARRAVAAG
>Mature_356_residues
MDELTHVPADTSQHASAPYNAAATRGEIAMSSPITLIEAITQALAWELEHDPAVLVLGEDVGVNGGVFRATAGLQQRFGS
DRVLDTPLDETTIAGLSVGLAAQGMKPVAEAQFDGFVYPMVDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHS
EANEAIFTNVPGLRVVLPSSPQRAYGLLLAAIRDPDPVIYMEPKRIYRQYKEVVANDGQALPLDVCFVLRDGTDVTLVTW
GAQVKEALEAADKLAGEGISAEVIDVATLRPLDFDTIAESVAKTGRCVIVQEAPRTAGFGAEIAARLAEQSMYDLVAPVE
RVTGYDTHIPLFRLEMKFLPSVERIVAAARRAVAAG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=330, Percent_Identity=40.9090909090909, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI34101272, Length=330, Percent_Identity=40.9090909090909, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=34.4615384615385, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=33.2307692307692, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=42.0245398773006, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=37.5, Blast_Score=210, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6319698, Length=343, Percent_Identity=35.8600583090379, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI160714832, Length=317, Percent_Identity=41.3249211356467, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI160714828, Length=317, Percent_Identity=41.3249211356467, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21358145, Length=341, Percent_Identity=37.8299120234604, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24650940, Length=341, Percent_Identity=37.8299120234604, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24650943, Length=111, Percent_Identity=35.1351351351351, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650945, Length=111, Percent_Identity=35.1351351351351, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38372; Mature: 38372

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELTHVPADTSQHASAPYNAAATRGEIAMSSPITLIEAITQALAWELEHDPAVLVLGED
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECC
VGVNGGVFRATAGLQQRFGSDRVLDTPLDETTIAGLSVGLAAQGMKPVAEAQFDGFVYPM
CCCCCCEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
VDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHSEANEAIFTNVPGLRVVLPSS
HHHHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCC
PQRAYGLLLAAIRDPDPVIYMEPKRIYRQYKEVVANDGQALPLDVCFVLRDGTDVTLVTW
CCHHHHHHHHEECCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEC
GAQVKEALEAADKLAGEGISAEVIDVATLRPLDFDTIAESVAKTGRCVIVQEAPRTAGFG
CHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCC
AEIAARLAEQSMYDLVAPVERVTGYDTHIPLFRLEMKFLPSVERIVAAARRAVAAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDELTHVPADTSQHASAPYNAAATRGEIAMSSPITLIEAITQALAWELEHDPAVLVLGED
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECC
VGVNGGVFRATAGLQQRFGSDRVLDTPLDETTIAGLSVGLAAQGMKPVAEAQFDGFVYPM
CCCCCCEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
VDHLICHAARLRNRTRGRLHCPMVLRVPWGGGIRAPEHHSEANEAIFTNVPGLRVVLPSS
HHHHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCC
PQRAYGLLLAAIRDPDPVIYMEPKRIYRQYKEVVANDGQALPLDVCFVLRDGTDVTLVTW
CCHHHHHHHHEECCCCCEEEECHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEC
GAQVKEALEAADKLAGEGISAEVIDVATLRPLDFDTIAESVAKTGRCVIVQEAPRTAGFG
CHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCC
AEIAARLAEQSMYDLVAPVERVTGYDTHIPLFRLEMKFLPSVERIVAAARRAVAAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]