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The map label for this gene is pdhA [H]

Identifier: 78046032

GI number: 78046032

Start: 537314

End: 538402

Strand: Reverse

Name: pdhA [H]

Synonym: XCV0476

Alternate gene names: 78046032

Gene position: 538402-537314 (Counterclockwise)

Preceding gene: 78046033

Following gene: 78046031

Centisome position: 10.4

GC content: 67.58

Gene sequence:

>1089_bases
ATGAGCGTAGCCGCGCAGTTCCAGATCGACTATCTGCAATACATGGACGCGGACGGCCAATGGGTCCGCGACGACCTTCC
GGCCGACGCCGCCAACCCGCAACAGCTGCTCGCCCTGTTCAAGCGCATGTTGTTCGTGCGCACCTTCGACACCAAGTCAG
TGGCCCTGCAGCGCACCGGCAAGCTGGGCACCTACGCGGCCTGCATCGGCCACGAAGCCACGCATGTGGGCATCGGCGCT
TCGATGCGCAGCGGCGATGTGTTCGCGCCCAGCTACCGCGAATACGGCACCATGTTCGAACGCGGCGTGCGCCCGCGCGA
TGTGCTGCTGTACTGGGGCGGCGACGAGCGCGGCAGCGACTATCCGCGCGATGCCGATGCGGCGATCGACTTCCCGATCT
GCGTGCCCATTTCCACCCAGTGCCTGCACGCCGCCGGCTCGGCGCTGTCGTTCAAGCTGCAGGGCAAACCGCAGGTTGCG
GTGGCCTGCTGCGGCGACGGTGGCAGCTCCAAGACCGACTTCTATGCCGCGCTCAATTCGGCCGGCGCCTACAAGCTGCC
GCTGATCCTGTGCGTGATCAATAACGGCTGGGCGATCTCGGTGCCGCGCTCGGCGCAGACCGGCGCGCAGACGCTTGCGC
AGAAGGGCCTGGCCGGCGGCCTGCAGTGCCTGCAGGTGGACGGCAACGATCTGGTTGCCGTGCTCGAAGCCATGCGTCAG
GCACGCGTGCGCGCACTGGCCGGCGATGGCGGCACGGTGATCGAGTTTTTGACCTATCGCCTGTCCGACCACACCACCGC
CGACGACGCGCGGCGCTATCGCGGCGAAGAAGAGGTCAAGCAGGGCTGGGCGCGCGAACCGCTGCTGCGCCTGCGCCGCT
ACCTCACCGCGCAAGGCCTGTGGGACGCCGCCCAGGAAGACGCCTGGAAGGCCGAATGCAGCGCGCGCGTGGACGAAGAG
GTCAACGCCTATCTCAACACGCCGGTGCAGCCGGTCGAAGCGATGTTCGATTACCTCTACGGCGACCCGCCGGCCGAGTT
GCTGGCACAGCGCGCCGAGGTGATGGCGCTGGAGTCGCGCCATGGATGA

Upstream 100 bases:

>100_bases
AGCATGATTGTCTGCTGCGGTGCAGGACAGCGTTTTGCTTCGCCGTCCTTAACATGGCAACTCATATCATTTGAAACTTC
TTGATGAAGGTGTCGTCGCA

Downstream 100 bases:

>100_bases
GCTCACCCATGTGCCCGCAGACACCTCGCAGCACGCCAGTGCCCCTTACAACGCTGCGGCAACGCGCGGAGAGATCGCCA
TGAGTTCGCCCATCACCCTG

Product: putative pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSVAAQFQIDYLQYMDADGQWVRDDLPADAANPQQLLALFKRMLFVRTFDTKSVALQRTGKLGTYAACIGHEATHVGIGA
SMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKPQVA
VACCGDGGSSKTDFYAALNSAGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLQCLQVDGNDLVAVLEAMRQ
ARVRALAGDGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGLWDAAQEDAWKAECSARVDEE
VNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESRHG

Sequences:

>Translated_362_residues
MSVAAQFQIDYLQYMDADGQWVRDDLPADAANPQQLLALFKRMLFVRTFDTKSVALQRTGKLGTYAACIGHEATHVGIGA
SMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKPQVA
VACCGDGGSSKTDFYAALNSAGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLQCLQVDGNDLVAVLEAMRQ
ARVRALAGDGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGLWDAAQEDAWKAECSARVDEE
VNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESRHG
>Mature_361_residues
SVAAQFQIDYLQYMDADGQWVRDDLPADAANPQQLLALFKRMLFVRTFDTKSVALQRTGKLGTYAACIGHEATHVGIGAS
MRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSDYPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKPQVAV
ACCGDGGSSKTDFYAALNSAGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLQCLQVDGNDLVAVLEAMRQA
RVRALAGDGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGLWDAAQEDAWKAECSARVDEEV
NAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESRHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=363, Percent_Identity=31.404958677686, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI258645172, Length=366, Percent_Identity=31.1475409836066, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI4505685, Length=325, Percent_Identity=26.7692307692308, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI291084742, Length=325, Percent_Identity=26.7692307692308, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI291084744, Length=332, Percent_Identity=25.6024096385542, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4885543, Length=310, Percent_Identity=24.8387096774194, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI86563355, Length=334, Percent_Identity=35.3293413173653, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI86563357, Length=334, Percent_Identity=35.3293413173653, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI32564172, Length=321, Percent_Identity=24.6105919003115, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17536047, Length=321, Percent_Identity=24.6105919003115, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=26.517571884984, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355903, Length=357, Percent_Identity=31.3725490196078, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24639744, Length=291, Percent_Identity=27.1477663230241, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28571106, Length=291, Percent_Identity=27.1477663230241, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639740, Length=291, Percent_Identity=27.1477663230241, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639746, Length=255, Percent_Identity=28.6274509803922, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639748, Length=290, Percent_Identity=25.5172413793103, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39545; Mature: 39414

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAAQFQIDYLQYMDADGQWVRDDLPADAANPQQLLALFKRMLFVRTFDTKSVALQRTG
CCCCHHEEHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KLGTYAACIGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSD
CCCHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
YPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKPQVAVACCGDGGSSKTDFYAALNS
CCCCCCCEECCEEECCCCHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHCC
AGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLQCLQVDGNDLVAVLEAMRQ
CCCEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
ARVRALAGDGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCH
WDAAQEDAWKAECSARVDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESR
HHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
HG
CC
>Mature Secondary Structure 
SVAAQFQIDYLQYMDADGQWVRDDLPADAANPQQLLALFKRMLFVRTFDTKSVALQRTG
CCCHHEEHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCC
KLGTYAACIGHEATHVGIGASMRSGDVFAPSYREYGTMFERGVRPRDVLLYWGGDERGSD
CCCHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCC
YPRDADAAIDFPICVPISTQCLHAAGSALSFKLQGKPQVAVACCGDGGSSKTDFYAALNS
CCCCCCCEECCEEECCCCHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHCC
AGAYKLPLILCVINNGWAISVPRSAQTGAQTLAQKGLAGGLQCLQVDGNDLVAVLEAMRQ
CCCEEEEEEEEEECCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
ARVRALAGDGGTVIEFLTYRLSDHTTADDARRYRGEEEVKQGWAREPLLRLRRYLTAQGL
HHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCH
WDAAQEDAWKAECSARVDEEVNAYLNTPVQPVEAMFDYLYGDPPAELLAQRAEVMALESR
HHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
HG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA