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The map label for this gene is gcvPA

Identifier: 78044154

GI number: 78044154

Start: 425461

End: 426795

Strand: Direct

Name: gcvPA

Synonym: CHY_0491

Alternate gene names: 78044154

Gene position: 425461-426795 (Clockwise)

Preceding gene: 78044435

Following gene: 78044158

Centisome position: 17.72

GC content: 47.79

Gene sequence:

>1335_bases
TTGAAATATACTCCCCATACCCCGGACGAAGTCCGGGAAATGTTAAGTAGCCTTGGCTTAAGTAGCATCGAGGAATTGTT
TTCGGACATCCCGGAAGAGGTTAAACTTAAAAGGCCCTTAAATCTCCCTTCCGGGATGTCGGAATTGGAAGTAAAGAAAC
ACCTGGCAAACTTAGCGGCTAAAAACGGTTCGGCGGATAAGTATACCGTTTTCTTGGGAGCAGGGGTATACGACCATTAT
GTCCCGGCGGTGGTCAACCACATTTTGCTGCGCTCGGAGTTCTATACCGCTTATACTCCTTACCAGGCGGAAATGAGCCA
GGGAGTTTTACAGTCGATCTTTGAATATCAGACCATGATTTGCGAACTAACCGGTCTTGACATCACCAATGCCTCGATGT
ATGATGGCGGTTCGGCTTTGGCTGAAGCCGCTCTGATGGCGGTAAGCCAAACCCGGAGAGATAAAGTTTTGGTGTTAGCC
ACCGTTCATCCCGAGTACCGAAGTGTGGTAAAAACCTACACCTGGGGCCCGGAAATTGAGGTAGTAGAAGTGCCCTATAA
AAGCGGTACCGTTGACCTGGAAAAATTAGAAGAACTAATAGACGATAAAACTGCCGCGGTCCTGGTGCAACATCCAAACT
TCTTTGGCCAATTAGAACCGGTTGAGGAAATCAGCCGGTTGATTCATGCCCAAAAAGGCCTTTTGGTGGTGGCAGTAGAC
CCCATTTCCCTGGGTATTTTAAAACCGCCCGCGGAATACGGCGCTGATATTGCTGTGGGTGATGGGCAGGCTCTGGGTAA
TGGCCTTGCTTTTGGTGGTCCGCACCTTGGCTTTTTTGCCGCCCGGAAGGATTTAGCCCGCCGGATGCCGGGACGCCTCG
TAGGTTTAACTACCGATAAAGAGGGTAATCGCGGCTTTGTTTTAACCTTGCAGGCGCGGGAGCAGCATATTCGGCGGGAA
AAGGCAACTTCCAATATCTGCAGTAACCAGGCTTTAAATGCCTTAGCCGCAACCGTTTATCTGGCTACTGTTGGCAAGAA
GGGATTAAAAGAAATTGCTCTGCAAAGCTTACAAAAAGCCCATTATGCTTTTGAACGTTTAATTGGTGAAGGTTACGAAC
CTTTATTTAGCGGACCGTTCTTTAAAGAGTTTGTGGTAAAAGTTAAAAATGAAGAAGAAATTACCCAAAAACTTCTAAAA
CATCATATTTTGGCGGGGCCGGGTATCAGCCGTTTTTATCCGGAGTTAGCACCCGCTTTAATGATTGCGGTTACGGAAAA
ACGCACCCGGGAAGAAATTGACAATCTGGTGGAAGTACTGGGAGGTGACCGGTAA

Upstream 100 bases:

>100_bases
GGGTGGATGATTAAAGTGGAAATTAGTAACGAAGCGGAGTTAGACGAACTGCTCTCCCCCGAAGATTACGAAAAACTTCT
GGAAGAGGAAGGAGAGTAAT

Downstream 100 bases:

>100_bases
TGGGAAGCTATCCTCTGATTTTTGAATTATCTAAAGAAGGAAGAACCGGCTTTGAGCTTCCTGAGTTGGATGTTCCCGCT
AAAGATATCAATAATCTCAT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKYTPHTPDEVREMLSSLGLSSIEELFSDIPEEVKLKRPLNLPSGMSELEVKKHLANLAAKNGSADKYTVFLGAGVYDHY
VPAVVNHILLRSEFYTAYTPYQAEMSQGVLQSIFEYQTMICELTGLDITNASMYDGGSALAEAALMAVSQTRRDKVLVLA
TVHPEYRSVVKTYTWGPEIEVVEVPYKSGTVDLEKLEELIDDKTAAVLVQHPNFFGQLEPVEEISRLIHAQKGLLVVAVD
PISLGILKPPAEYGADIAVGDGQALGNGLAFGGPHLGFFAARKDLARRMPGRLVGLTTDKEGNRGFVLTLQAREQHIRRE
KATSNICSNQALNALAATVYLATVGKKGLKEIALQSLQKAHYAFERLIGEGYEPLFSGPFFKEFVVKVKNEEEITQKLLK
HHILAGPGISRFYPELAPALMIAVTEKRTREEIDNLVEVLGGDR

Sequences:

>Translated_444_residues
MKYTPHTPDEVREMLSSLGLSSIEELFSDIPEEVKLKRPLNLPSGMSELEVKKHLANLAAKNGSADKYTVFLGAGVYDHY
VPAVVNHILLRSEFYTAYTPYQAEMSQGVLQSIFEYQTMICELTGLDITNASMYDGGSALAEAALMAVSQTRRDKVLVLA
TVHPEYRSVVKTYTWGPEIEVVEVPYKSGTVDLEKLEELIDDKTAAVLVQHPNFFGQLEPVEEISRLIHAQKGLLVVAVD
PISLGILKPPAEYGADIAVGDGQALGNGLAFGGPHLGFFAARKDLARRMPGRLVGLTTDKEGNRGFVLTLQAREQHIRRE
KATSNICSNQALNALAATVYLATVGKKGLKEIALQSLQKAHYAFERLIGEGYEPLFSGPFFKEFVVKVKNEEEITQKLLK
HHILAGPGISRFYPELAPALMIAVTEKRTREEIDNLVEVLGGDR
>Mature_444_residues
MKYTPHTPDEVREMLSSLGLSSIEELFSDIPEEVKLKRPLNLPSGMSELEVKKHLANLAAKNGSADKYTVFLGAGVYDHY
VPAVVNHILLRSEFYTAYTPYQAEMSQGVLQSIFEYQTMICELTGLDITNASMYDGGSALAEAALMAVSQTRRDKVLVLA
TVHPEYRSVVKTYTWGPEIEVVEVPYKSGTVDLEKLEELIDDKTAAVLVQHPNFFGQLEPVEEISRLIHAQKGLLVVAVD
PISLGILKPPAEYGADIAVGDGQALGNGLAFGGPHLGFFAARKDLARRMPGRLVGLTTDKEGNRGFVLTLQAREQHIRRE
KATSNICSNQALNALAATVYLATVGKKGLKEIALQSLQKAHYAFERLIGEGYEPLFSGPFFKEFVVKVKNEEEITQKLLK
HHILAGPGISRFYPELAPALMIAVTEKRTREEIDNLVEVLGGDR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=347, Percent_Identity=41.7867435158501, Blast_Score=255, Evalue=6e-68,
Organism=Escherichia coli, GI1789269, Length=446, Percent_Identity=32.0627802690583, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535605, Length=393, Percent_Identity=38.4223918575064, Blast_Score=251, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6323843, Length=454, Percent_Identity=35.2422907488987, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24645648, Length=346, Percent_Identity=41.6184971098266, Blast_Score=272, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_CARHZ (Q3AET5)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359349.1
- ProteinModelPortal:   Q3AET5
- SMR:   Q3AET5
- STRING:   Q3AET5
- GeneID:   3727270
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_0491
- NMPDR:   fig|246194.3.peg.976
- TIGR:   CHY_0491
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   CHYD246194:CHY_0491-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48909; Mature: 48909

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTPHTPDEVREMLSSLGLSSIEELFSDIPEEVKLKRPLNLPSGMSELEVKKHLANLAA
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
KNGSADKYTVFLGAGVYDHYVPAVVNHILLRSEFYTAYTPYQAEMSQGVLQSIFEYQTMI
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHH
CELTGLDITNASMYDGGSALAEAALMAVSQTRRDKVLVLATVHPEYRSVVKTYTWGPEIE
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCEE
VVEVPYKSGTVDLEKLEELIDDKTAAVLVQHPNFFGQLEPVEEISRLIHAQKGLLVVAVD
EEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEEC
PISLGILKPPAEYGADIAVGDGQALGNGLAFGGPHLGFFAARKDLARRMPGRLVGLTTDK
CCEECCCCCCHHHCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
EGNRGFVLTLQAREQHIRREKATSNICSNQALNALAATVYLATVGKKGLKEIALQSLQKA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
HYAFERLIGEGYEPLFSGPFFKEFVVKVKNEEEITQKLLKHHILAGPGISRFYPELAPAL
HHHHHHHHCCCCCCHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MIAVTEKRTREEIDNLVEVLGGDR
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKYTPHTPDEVREMLSSLGLSSIEELFSDIPEEVKLKRPLNLPSGMSELEVKKHLANLAA
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
KNGSADKYTVFLGAGVYDHYVPAVVNHILLRSEFYTAYTPYQAEMSQGVLQSIFEYQTMI
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHH
CELTGLDITNASMYDGGSALAEAALMAVSQTRRDKVLVLATVHPEYRSVVKTYTWGPEIE
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCCEE
VVEVPYKSGTVDLEKLEELIDDKTAAVLVQHPNFFGQLEPVEEISRLIHAQKGLLVVAVD
EEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEEC
PISLGILKPPAEYGADIAVGDGQALGNGLAFGGPHLGFFAARKDLARRMPGRLVGLTTDK
CCEECCCCCCHHHCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
EGNRGFVLTLQAREQHIRREKATSNICSNQALNALAATVYLATVGKKGLKEIALQSLQKA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
HYAFERLIGEGYEPLFSGPFFKEFVVKVKNEEEITQKLLKHHILAGPGISRFYPELAPAL
HHHHHHHHCCCCCCHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
MIAVTEKRTREEIDNLVEVLGGDR
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA