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The map label for this gene is gcvPB [H]

Identifier: 78044158

GI number: 78044158

Start: 426795

End: 428255

Strand: Direct

Name: gcvPB [H]

Synonym: CHY_0492

Alternate gene names: 78044158

Gene position: 426795-428255 (Clockwise)

Preceding gene: 78044154

Following gene: 78044055

Centisome position: 17.77

GC content: 47.09

Gene sequence:

>1461_bases
ATGGGAAGCTATCCTCTGATTTTTGAATTATCTAAAGAAGGAAGAACCGGCTTTGAGCTTCCTGAGTTGGATGTTCCCGC
TAAAGATATCAATAATCTCATTCCTGAAGAAATGCAAAGGAAAACCGAACCGGACCTCCCGGAAGTGGCTGAAGTAGATG
TGGTTCGTCATTATGTGGGCTTATCCCGGCGGAATTTTGGCGTGGATAACGGCTTTTATCCTCTGGGAAGCTGTACGATG
AAGTATAACCCCAAGATTAACGAAGACACTTCAAGGCTTGCCGGTTTTGCTGAACTTCATCCCTATGTGCCGGAGGAACT
TGCTCAAGGGGCTTTAGAGCTGCTGTACGATGCGGAACAGTACCTTAAAGAAATTACCGGCATGGATCGTTTTACTTTCC
AGCCGGCGGCGGGAGCCCACGGAGAATTTACCGGATTGATGATAATAAAAGCCTACTTGGAGAAAAAGGGCGAGAAGCGG
ACAAAAGTTATCGTTCCCGATTCTGCCCACGGTACCAACCCGGCAACCGCTGCCATGTGCGGTTTTAATGTGATTTCCAT
TAAGTCCAATGAACGGGGACTGGTAGACCCGGAGGAACTGGCAAAAGTTTTGGATAAAGAGGTTGCAGCATTAATGCTTA
CCAACCCCAATACCCTGGGACTTTTTGAAGAAGAAATTGTAAAAATTGCCAAAATGGTCCATGATGTCGGCGGGCTACTG
TACTATGATGGAGCTAACTTAAATGCCATTATGGGGGTAACCCGCCCGGGAGATATGGGCTTTGATGTCATGCACATTAA
CCTTCATAAAACTTTTTCCACTCCCCACGGCGGCGGTGGACCCGGTTCCGGACCGGTAGGGGTTAAAGCCCATTTAGCCG
AGTTCCTGCCGGTACCGGTGGTGGAGAAAGACGGAGATCGGTACTACTTTAATTACAACCTGCCCAATTCCATCGGCAAA
GTAAGGACCTTCTACGGCAACTTCCTGGTAGTGGTTAAAGCTTATACTTACTTAAAAGCTTTAGGTGGCGAAGGCCTTAC
CGATGTCAGCCAAAAAGCTGTTTTAAACGCTAACTATTTAAGAGAAAAGCTTAAAAAATACTTCTATCTGCCCTATGACC
GGCTCTGCAAGCACGAGTTTGTCCTGTCCGGTAAGTGGCAGAAGGAAAAAGGGGTTCGGACTTTAGATATTGCTAAACGT
CTGTTGGACTATGGAGTTCACCCACCGACCATTTACTTCCCGCTTATTGTTGATGAAGCGTTGATGATTGAGCCCACGGA
AACCGAGTCCAAGGAAACTTTAGACCGGTTTATTGAGGTAATGATTGCAATAAGCCGGGAAGTAGAGGAAAATCCCGAAC
TTCTCCATGAAGCTCCCCACGTCACCCCGGTGAAGCGGCTGGATGAGGTGGGTGCAGCGAGAAATCCAATTTTGAGGTGG
AGTAAAGATTGGCAAAAATAA

Upstream 100 bases:

>100_bases
TTTATCCGGAGTTAGCACCCGCTTTAATGATTGCGGTTACGGAAAAACGCACCCGGGAAGAAATTGACAATCTGGTGGAA
GTACTGGGAGGTGACCGGTA

Downstream 100 bases:

>100_bases
CTTTCGTTTATCCCCATAAAACCAAACCGGTTACCGTTACCGGCCCCCACTGTGCCTTAAACTGTGCCCACTGTGGGGGC
CATTATTTAAAAAGTATGCT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MGSYPLIFELSKEGRTGFELPELDVPAKDINNLIPEEMQRKTEPDLPEVAEVDVVRHYVGLSRRNFGVDNGFYPLGSCTM
KYNPKINEDTSRLAGFAELHPYVPEELAQGALELLYDAEQYLKEITGMDRFTFQPAAGAHGEFTGLMIIKAYLEKKGEKR
TKVIVPDSAHGTNPATAAMCGFNVISIKSNERGLVDPEELAKVLDKEVAALMLTNPNTLGLFEEEIVKIAKMVHDVGGLL
YYDGANLNAIMGVTRPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPVPVVEKDGDRYYFNYNLPNSIGK
VRTFYGNFLVVVKAYTYLKALGGEGLTDVSQKAVLNANYLREKLKKYFYLPYDRLCKHEFVLSGKWQKEKGVRTLDIAKR
LLDYGVHPPTIYFPLIVDEALMIEPTETESKETLDRFIEVMIAISREVEENPELLHEAPHVTPVKRLDEVGAARNPILRW
SKDWQK

Sequences:

>Translated_486_residues
MGSYPLIFELSKEGRTGFELPELDVPAKDINNLIPEEMQRKTEPDLPEVAEVDVVRHYVGLSRRNFGVDNGFYPLGSCTM
KYNPKINEDTSRLAGFAELHPYVPEELAQGALELLYDAEQYLKEITGMDRFTFQPAAGAHGEFTGLMIIKAYLEKKGEKR
TKVIVPDSAHGTNPATAAMCGFNVISIKSNERGLVDPEELAKVLDKEVAALMLTNPNTLGLFEEEIVKIAKMVHDVGGLL
YYDGANLNAIMGVTRPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPVPVVEKDGDRYYFNYNLPNSIGK
VRTFYGNFLVVVKAYTYLKALGGEGLTDVSQKAVLNANYLREKLKKYFYLPYDRLCKHEFVLSGKWQKEKGVRTLDIAKR
LLDYGVHPPTIYFPLIVDEALMIEPTETESKETLDRFIEVMIAISREVEENPELLHEAPHVTPVKRLDEVGAARNPILRW
SKDWQK
>Mature_485_residues
GSYPLIFELSKEGRTGFELPELDVPAKDINNLIPEEMQRKTEPDLPEVAEVDVVRHYVGLSRRNFGVDNGFYPLGSCTMK
YNPKINEDTSRLAGFAELHPYVPEELAQGALELLYDAEQYLKEITGMDRFTFQPAAGAHGEFTGLMIIKAYLEKKGEKRT
KVIVPDSAHGTNPATAAMCGFNVISIKSNERGLVDPEELAKVLDKEVAALMLTNPNTLGLFEEEIVKIAKMVHDVGGLLY
YDGANLNAIMGVTRPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPVPVVEKDGDRYYFNYNLPNSIGKV
RTFYGNFLVVVKAYTYLKALGGEGLTDVSQKAVLNANYLREKLKKYFYLPYDRLCKHEFVLSGKWQKEKGVRTLDIAKRL
LDYGVHPPTIYFPLIVDEALMIEPTETESKETLDRFIEVMIAISREVEENPELLHEAPHVTPVKRLDEVGAARNPILRWS
KDWQK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=499, Percent_Identity=38.2765531062124, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1789269, Length=432, Percent_Identity=41.2037037037037, Blast_Score=289, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17535605, Length=427, Percent_Identity=41.6861826697892, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI32564013, Length=381, Percent_Identity=43.3070866141732, Blast_Score=273, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323843, Length=490, Percent_Identity=41.2244897959184, Blast_Score=325, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24645648, Length=412, Percent_Identity=42.4757281553398, Blast_Score=293, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54395; Mature: 54264

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSYPLIFELSKEGRTGFELPELDVPAKDINNLIPEEMQRKTEPDLPEVAEVDVVRHYVG
CCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHC
LSRRNFGVDNGFYPLGSCTMKYNPKINEDTSRLAGFAELHPYVPEELAQGALELLYDAEQ
CCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YLKEITGMDRFTFQPAAGAHGEFTGLMIIKAYLEKKGEKRTKVIVPDSAHGTNPATAAMC
HHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
GFNVISIKSNERGLVDPEELAKVLDKEVAALMLTNPNTLGLFEEEIVKIAKMVHDVGGLL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCEE
YYDGANLNAIMGVTRPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPVPV
EECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCC
VEKDGDRYYFNYNLPNSIGKVRTFYGNFLVVVKAYTYLKALGGEGLTDVSQKAVLNANYL
EECCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
REKLKKYFYLPYDRLCKHEFVLSGKWQKEKGVRTLDIAKRLLDYGVHPPTIYFPLIVDEA
HHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEHEEECCE
LMIEPTETESKETLDRFIEVMIAISREVEENPELLHEAPHVTPVKRLDEVGAARNPILRW
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHCCCCCCCEEC
SKDWQK
CCCCCC
>Mature Secondary Structure 
GSYPLIFELSKEGRTGFELPELDVPAKDINNLIPEEMQRKTEPDLPEVAEVDVVRHYVG
CCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHC
LSRRNFGVDNGFYPLGSCTMKYNPKINEDTSRLAGFAELHPYVPEELAQGALELLYDAEQ
CCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YLKEITGMDRFTFQPAAGAHGEFTGLMIIKAYLEKKGEKRTKVIVPDSAHGTNPATAAMC
HHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHH
GFNVISIKSNERGLVDPEELAKVLDKEVAALMLTNPNTLGLFEEEIVKIAKMVHDVGGLL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCEE
YYDGANLNAIMGVTRPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVGVKAHLAEFLPVPV
EECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCC
VEKDGDRYYFNYNLPNSIGKVRTFYGNFLVVVKAYTYLKALGGEGLTDVSQKAVLNANYL
EECCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
REKLKKYFYLPYDRLCKHEFVLSGKWQKEKGVRTLDIAKRLLDYGVHPPTIYFPLIVDEA
HHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEHEEECCE
LMIEPTETESKETLDRFIEVMIAISREVEENPELLHEAPHVTPVKRLDEVGAARNPILRW
EEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHCCCCCCCEEC
SKDWQK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]