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The map label for this gene is bcd2 [H]

Identifier: 78044080

GI number: 78044080

Start: 1209161

End: 1210306

Strand: Direct

Name: bcd2 [H]

Synonym: CHY_1350

Alternate gene names: 78044080

Gene position: 1209161-1210306 (Clockwise)

Preceding gene: 78043322

Following gene: 78045205

Centisome position: 50.35

GC content: 42.76

Gene sequence:

>1146_bases
ATGGATTTTCGTTTATCCGAAGAACACGAATTATTACGACAAACGGTAAGAGATTTTGCCGAAAAAGAAGTAGCACCTTC
AGCAGCCGAAAGGGACGAACAAGAAAGATTTGATCGGGAAATCTTTAAGAAAATGGCCGAATTGGGATTAACAGGCATTC
CCTGGCCGGAAGAATACGGTGGGGCCGGCATGGATTACATTGCTTATGCCATAGCAGTGGAAGAACTTTCCCGGGTTTGC
GCCTCCACGGGAGTAACGTTATCCGCCCATGTCTCTTTAGGTAGTTTCCCCATTTATAAATACGGTACGGAAGAACAAAA
GCAAAAATATTTAAAACCACTGGCTTTGGGAGAAAAACTTGGTGCTTTTGGTCTCACCGAGCCTTCTGCCGGTAGCGATG
CCGGTTCCCTAAAAACTACTGCTGTCCGGGATGGCGATTATTACATTTTAAACGGGTCAAAAATTTTCATAACGAATGGT
GGGGAAGCGGAAATCTATGTAGTTTTTGCTACCGTCGATAAATCTAAAGGACACAGAGGAATTTCCGCTTTTATTGTTGA
AAAAGGGACCCCGGGCTTTTCTTTCGGTAAGAAAGAAAAGAAGTTAGGCATTCGTTCCTCTCCAACGGTGGAGTTAGTAT
TTGAAAACTGCAGAATTCCCAAAGAAAATCTTTTAGGAGAGGAAGGTCAGGGGTTTAAAATTGCCTTATCTACTTTAGAT
GGCGGACGCATCGGTATTGCTGCTCAGGCTGTAGGTATTGCCCAGGGAGCTTATGAAGCTGCTGTAAAATATGCCAAGGA
AAGAACCCAGTTCGGAAAGCCCATAGCTGAATTTCAAGGAGTAAGTTTTGTTTTAGCGGATATGGCAACTAAAATCCAGG
CGGCAAGGTTGTTAGTTTATCATGCTGCCTGGCTTGAATCAAACAATCTGCCCTATGGTAAGGCAGCGGCAATGGCTAAA
CTTTTTGCTTCGGAAACGGCAATGGAAGTAACTACAAAAGCCGTGCAAATTTTCGGAGGCTATGGTTATACCCGTGAATA
TCCTGTAGAACGAATGATGAGAGATGCTAAAATCACCGAAATTTATGAAGGTACCAGTGAAGTACAAAGAATAGTTATTT
CTTCGTATATCTTAAAGGAGTTTTAA

Upstream 100 bases:

>100_bases
CTATTTTTGCTCTTTTAGCCCTAATTTTAAAATGGCATTAATTTTGCTAAAAGTTTTAATTGTAAGAAATTTTTTTAAAA
ATTATAGGGAGGGGATTTAT

Downstream 100 bases:

>100_bases
TTGGTATAATAATCCTGTATAAGACTAAAGCAGAGGAGGAGCCTAATGCCAGCAACACCTTCAGCAGAATACCAAAAAAA
ACTGGTAGATGTAGACCACG

Product: butyryl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDFRLSEEHELLRQTVRDFAEKEVAPSAAERDEQERFDREIFKKMAELGLTGIPWPEEYGGAGMDYIAYAIAVEELSRVC
ASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKLGAFGLTEPSAGSDAGSLKTTAVRDGDYYILNGSKIFITNG
GEAEIYVVFATVDKSKGHRGISAFIVEKGTPGFSFGKKEKKLGIRSSPTVELVFENCRIPKENLLGEEGQGFKIALSTLD
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVYHAAWLESNNLPYGKAAAMAK
LFASETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITEIYEGTSEVQRIVISSYILKEF

Sequences:

>Translated_381_residues
MDFRLSEEHELLRQTVRDFAEKEVAPSAAERDEQERFDREIFKKMAELGLTGIPWPEEYGGAGMDYIAYAIAVEELSRVC
ASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKLGAFGLTEPSAGSDAGSLKTTAVRDGDYYILNGSKIFITNG
GEAEIYVVFATVDKSKGHRGISAFIVEKGTPGFSFGKKEKKLGIRSSPTVELVFENCRIPKENLLGEEGQGFKIALSTLD
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVYHAAWLESNNLPYGKAAAMAK
LFASETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITEIYEGTSEVQRIVISSYILKEF
>Mature_381_residues
MDFRLSEEHELLRQTVRDFAEKEVAPSAAERDEQERFDREIFKKMAELGLTGIPWPEEYGGAGMDYIAYAIAVEELSRVC
ASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKLGAFGLTEPSAGSDAGSLKTTAVRDGDYYILNGSKIFITNG
GEAEIYVVFATVDKSKGHRGISAFIVEKGTPGFSFGKKEKKLGIRSSPTVELVFENCRIPKENLLGEEGQGFKIALSTLD
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVYHAAWLESNNLPYGKAAAMAK
LFASETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITEIYEGTSEVQRIVISSYILKEF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=55.1724137931034, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=43.7665782493369, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=43.236074270557, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=41.4698162729659, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=41.8666666666667, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=41.8666666666667, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI226958414, Length=351, Percent_Identity=41.025641025641, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=43.8746438746439, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=40.8488063660477, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=40.8488063660477, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=36.2433862433862, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=33.6870026525199, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=34.1597796143251, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI48976061, Length=346, Percent_Identity=33.2369942196532, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI211971008, Length=346, Percent_Identity=33.2369942196532, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI38505218, Length=389, Percent_Identity=26.7352185089974, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI218563752, Length=243, Percent_Identity=27.5720164609054, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=32.1989528795811, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=33.7662337662338, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI87082384, Length=283, Percent_Identity=27.208480565371, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081702, Length=311, Percent_Identity=27.3311897106109, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=44.4444444444444, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=43.236074270557, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=42.7821522309711, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=44.6753246753247, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=43.9276485788114, Blast_Score=308, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=40.9574468085106, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=40.9448818897638, Blast_Score=290, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=50, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=40.7303370786517, Blast_Score=250, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=33.5106382978723, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=44.7368421052632, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=37.0909090909091, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=290, Percent_Identity=41.0344827586207, Blast_Score=203, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=30.4582210242588, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=30.188679245283, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17531909, Length=245, Percent_Identity=34.2857142857143, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562446, Length=324, Percent_Identity=31.1728395061728, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=183, Percent_Identity=31.6939890710383, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=27.8195488721804, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=266, Percent_Identity=27.8195488721804, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=53.315649867374, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=48.9417989417989, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=43.7665782493369, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=42.8191489361702, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=40.9921671018277, Blast_Score=280, Evalue=9e-76,
Organism=Drosophila melanogaster, GI281363737, Length=390, Percent_Identity=38.974358974359, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=32.0209973753281, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI281365206, Length=411, Percent_Identity=24.5742092457421, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585193, Length=411, Percent_Identity=24.5742092457421, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585195, Length=411, Percent_Identity=24.5742092457421, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585191, Length=411, Percent_Identity=24.5742092457421, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41761; Mature: 41761

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRLSEEHELLRQTVRDFAEKEVAPSAAERDEQERFDREIFKKMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GAGMDYIAYAIAVEELSRVCASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
GAFGLTEPSAGSDAGSLKTTAVRDGDYYILNGSKIFITNGGEAEIYVVFATVDKSKGHRG
CCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCEEEEECCCCEEEEEEEEEEECCCCCCC
ISAFIVEKGTPGFSFGKKEKKLGIRSSPTVELVFENCRIPKENLLGEEGQGFKIALSTLD
EEEEEEECCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCHHHCCCCCCCCEEEEEEECC
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
HAAWLESNNLPYGKAAAMAKLFASETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQRIVISSYILKEF
HHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFRLSEEHELLRQTVRDFAEKEVAPSAAERDEQERFDREIFKKMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GAGMDYIAYAIAVEELSRVCASTGVTLSAHVSLGSFPIYKYGTEEQKQKYLKPLALGEKL
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
GAFGLTEPSAGSDAGSLKTTAVRDGDYYILNGSKIFITNGGEAEIYVVFATVDKSKGHRG
CCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCEEEEECCCCEEEEEEEEEEECCCCCCC
ISAFIVEKGTPGFSFGKKEKKLGIRSSPTVELVFENCRIPKENLLGEEGQGFKIALSTLD
EEEEEEECCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCHHHCCCCCCCCEEEEEEECC
GGRIGIAAQAVGIAQGAYEAAVKYAKERTQFGKPIAEFQGVSFVLADMATKIQAARLLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
HAAWLESNNLPYGKAAAMAKLFASETAMEVTTKAVQIFGGYGYTREYPVERMMRDAKITE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQRIVISSYILKEF
HHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]