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The map label for this gene is fadB [H]

Identifier: 77748627

GI number: 77748627

Start: 2355218

End: 2357590

Strand: Reverse

Name: fadB [H]

Synonym: XAC2013

Alternate gene names: 77748627

Gene position: 2357590-2355218 (Counterclockwise)

Preceding gene: 21242758

Following gene: 21242756

Centisome position: 45.55

GC content: 64.48

Gene sequence:

>2373_bases
ATGTCCAACCCGTTGCTAGTCCGTCGTGCCGCCGTGCTCGGTGCCGGCGTCATGGGCGCGCAGATCGCCGCCCACCTCAC
CAATGCCGGTGTCGACACCGTGTTGTTCGACCTGCCTGCCAAGGAAGGCCCGGCCGACGGCATCGTACTCAAGGCGATCG
CCAATCTCGGCAAGCTGAGCCCAGCCCCGCTCGCCAGCAAGGCGCTGGCCGAGGCGATCACGCCAGCCAACTACGAGAGC
GGTCTGGAGCAACTGCGCGACTGCGATCTGATCATCGAAGCGATCGCCGAACGCATGGACTGGAAGCAGGACCTGTACAA
GAAGATCGCCCCGTTCGTCTCTGAGCATGCAGTGCTGGCATCCAATACCTCCGGCCTGGGCATCAACAAGCTGTCGGATG
TGCTGCCCGAGCAGCTGCGCCATCGTTTTTGCGGCGTGCACTTCTTCAACCCGCCGCGCTACATGCACCTGGCCGAGTTG
ATTCCGGCCAAGGGCACCGACAAGGCCGTGCTCGAGGGCCTGGAAGCCTTCCTGGTCACCACGCTCGGCAAGGGCGTGGT
GTATGCCAAGGACACGCCGAACTTCATCGGCAACCGCATCGGCGTGTTCTCGATCCTGTCCACCATCCATCACACGCAGG
AATTCGGCCTGGGCTTCGACGAAGTCGATGCGCTGACCGGCCCGCTGGTCGGCCGTCCCAAGTCGGCCACCTACCGCACC
TCCGATGTGGTCGGCCTGGACACCATGGCGCACGTCATCAAGACCATGGGCGACACCTTGCCGGACGACCCGTGGCATCA
GTATTTCAAGTCGCCGAAGTGGCTGGAGGCGCTGATCGCCAAGGGCGCGCTGGGCCAGAAGGTCGGGGCCGGCATCTTCC
GCAAGGTCGGCAAGGACATCGTGGTGCTGGACCTGCACGAGCAGGACTACCGCGCCGCCGATCGCAGTGCCGCGCCGGAA
GTGGTCGAGATCCTAAAGATCAAGAATCCGGCCGAGAAGTTCGCCAAGCTGCGCGAGAGCCAGCATCCGCAGGCGCAGTT
CCTGTGGGCGAGCTTCCGCGACCTGTTCCACTACAGCGCCTTCCATCTGGCCGATATCGCCGAGACCGCACGCGATGTGG
ATCTGGCGATTCGCTGGGGCTACGGTTGGTCGCTGGGCCCGTTCGAGACCTGGCAGGCAGCCGGCTGGAAGCAGGTGGCG
CAGTGGATCGCCGAAGACATCTCCAACGGCAAGAGCATGAGCAGCGCACCGTTACCTAACTGGGTGTTCGACGGTCGCGA
TGGCGTGCATGGCGCCGAAGGCTCGTATAGCCCGGCGCGCGACGCCAAGCTGCCGCGCTCGTCGCTGCCGGTGTACAAAC
GCCAGCGCTTCCCCGATCCGTTGCTTGGCGAGCAGTTCTCGCCGGGCGAAACCGTGTTCGAAAACGACGGCGTGCGCATG
TGGCACGACGGCGACGACATCGCGGTGGTCAGCTTCAAGACCAAGATGAACACCGTTTCCGACCACGTGCTCAACGGCTT
GCAGGACGTCGTTGGCCGCGCCGAGAAGGACTTCGCTGGCCTGGTGATCTGGCAGCAGAAGGAGCCCTTCTCCGCCGGCG
CCGATCTGGCCGGCGCGCTCGGCCTGCTGCAGGCTGGCAAGGTCGATGCCTTCGAAGCATTGGTCGCCAATTTCCAGGCC
ACCAGCCAGCGCATCAAGTACGCGCAGGTGCCGGTGATCTCGGCCGTGCGCGGCTTGGCACTGGGCGGCGGTTGCGAGTT
CCAGATGCACAGCGCCAAGACGGTGGCCTCGCTGGAGAGCTACATCGGCTTGGTCGAAGCTGGCGTCGGCCTGCTGCCGG
CCGGCGGCGGCCTGAAGGAAATCGCGGTACGTGCATCGATCGCCGCAGGCCCGGGCGGCGACGTGTTTGCCGAGCTCAAA
AAGACCTTCGAAACCGTGGCAATGGCCAAGGTCTCCAACTCGGCGGTCAATGCCAAGGAACTGGGCCTGCTGCGCGCCAC
CGACAAAGTGGTGTTCAACAGCTACGAGAGCCTGCACATCGCCAAGGCCGAAGCGCGCGCACTGGCCGAGGGCGGCTACC
GCGCCCCGCTGCCGGCACGCCATATCCAGGTTGCCGGCGACGTCGGCATCGCCACCTTCAAGATGCTGCTGGTCAACATG
CTGGAAGGTCGCTTCATCAGCGAATACGACTATGAAATCGCCAGCCGCATCGCCACGGTGGTGTGCGGTGGCGAAGTCGA
TCGCGGCGCGCTGGTCGATGAAGAATGGCTGCTCAAGCTGGAGCGCAAGCACTTCGTCGAACTGGCCCAGCAGGAAAAGA
CCCAGGCCCGGATTGGGCACATGTTGAAGACGGGCAAGCCGTTGAGGAACTGA

Upstream 100 bases:

>100_bases
CGACCACCGCGCGCGCGCGGCGCGAGAACTCATTCGTTTCGCGGAACCCGGTTTCCGTGCTCATTCCACACCGTAAACGT
TCCACAAGAGGCCTATCGCT

Downstream 100 bases:

>100_bases
GAATCGGGAGCGGGGAATCGGGAATGGGTAAAAGCCCAGCCTACTCCCCGCTTCTCCCAATTATCTGCCGGGTGATGAAG
ATGGCGAACCCAGGCGAATC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MSNPLLVRRAAVLGAGVMGAQIAAHLTNAGVDTVLFDLPAKEGPADGIVLKAIANLGKLSPAPLASKALAEAITPANYES
GLEQLRDCDLIIEAIAERMDWKQDLYKKIAPFVSEHAVLASNTSGLGINKLSDVLPEQLRHRFCGVHFFNPPRYMHLAEL
IPAKGTDKAVLEGLEAFLVTTLGKGVVYAKDTPNFIGNRIGVFSILSTIHHTQEFGLGFDEVDALTGPLVGRPKSATYRT
SDVVGLDTMAHVIKTMGDTLPDDPWHQYFKSPKWLEALIAKGALGQKVGAGIFRKVGKDIVVLDLHEQDYRAADRSAAPE
VVEILKIKNPAEKFAKLRESQHPQAQFLWASFRDLFHYSAFHLADIAETARDVDLAIRWGYGWSLGPFETWQAAGWKQVA
QWIAEDISNGKSMSSAPLPNWVFDGRDGVHGAEGSYSPARDAKLPRSSLPVYKRQRFPDPLLGEQFSPGETVFENDGVRM
WHDGDDIAVVSFKTKMNTVSDHVLNGLQDVVGRAEKDFAGLVIWQQKEPFSAGADLAGALGLLQAGKVDAFEALVANFQA
TSQRIKYAQVPVISAVRGLALGGGCEFQMHSAKTVASLESYIGLVEAGVGLLPAGGGLKEIAVRASIAAGPGGDVFAELK
KTFETVAMAKVSNSAVNAKELGLLRATDKVVFNSYESLHIAKAEARALAEGGYRAPLPARHIQVAGDVGIATFKMLLVNM
LEGRFISEYDYEIASRIATVVCGGEVDRGALVDEEWLLKLERKHFVELAQQEKTQARIGHMLKTGKPLRN

Sequences:

>Translated_790_residues
MSNPLLVRRAAVLGAGVMGAQIAAHLTNAGVDTVLFDLPAKEGPADGIVLKAIANLGKLSPAPLASKALAEAITPANYES
GLEQLRDCDLIIEAIAERMDWKQDLYKKIAPFVSEHAVLASNTSGLGINKLSDVLPEQLRHRFCGVHFFNPPRYMHLAEL
IPAKGTDKAVLEGLEAFLVTTLGKGVVYAKDTPNFIGNRIGVFSILSTIHHTQEFGLGFDEVDALTGPLVGRPKSATYRT
SDVVGLDTMAHVIKTMGDTLPDDPWHQYFKSPKWLEALIAKGALGQKVGAGIFRKVGKDIVVLDLHEQDYRAADRSAAPE
VVEILKIKNPAEKFAKLRESQHPQAQFLWASFRDLFHYSAFHLADIAETARDVDLAIRWGYGWSLGPFETWQAAGWKQVA
QWIAEDISNGKSMSSAPLPNWVFDGRDGVHGAEGSYSPARDAKLPRSSLPVYKRQRFPDPLLGEQFSPGETVFENDGVRM
WHDGDDIAVVSFKTKMNTVSDHVLNGLQDVVGRAEKDFAGLVIWQQKEPFSAGADLAGALGLLQAGKVDAFEALVANFQA
TSQRIKYAQVPVISAVRGLALGGGCEFQMHSAKTVASLESYIGLVEAGVGLLPAGGGLKEIAVRASIAAGPGGDVFAELK
KTFETVAMAKVSNSAVNAKELGLLRATDKVVFNSYESLHIAKAEARALAEGGYRAPLPARHIQVAGDVGIATFKMLLVNM
LEGRFISEYDYEIASRIATVVCGGEVDRGALVDEEWLLKLERKHFVELAQQEKTQARIGHMLKTGKPLRN
>Mature_789_residues
SNPLLVRRAAVLGAGVMGAQIAAHLTNAGVDTVLFDLPAKEGPADGIVLKAIANLGKLSPAPLASKALAEAITPANYESG
LEQLRDCDLIIEAIAERMDWKQDLYKKIAPFVSEHAVLASNTSGLGINKLSDVLPEQLRHRFCGVHFFNPPRYMHLAELI
PAKGTDKAVLEGLEAFLVTTLGKGVVYAKDTPNFIGNRIGVFSILSTIHHTQEFGLGFDEVDALTGPLVGRPKSATYRTS
DVVGLDTMAHVIKTMGDTLPDDPWHQYFKSPKWLEALIAKGALGQKVGAGIFRKVGKDIVVLDLHEQDYRAADRSAAPEV
VEILKIKNPAEKFAKLRESQHPQAQFLWASFRDLFHYSAFHLADIAETARDVDLAIRWGYGWSLGPFETWQAAGWKQVAQ
WIAEDISNGKSMSSAPLPNWVFDGRDGVHGAEGSYSPARDAKLPRSSLPVYKRQRFPDPLLGEQFSPGETVFENDGVRMW
HDGDDIAVVSFKTKMNTVSDHVLNGLQDVVGRAEKDFAGLVIWQQKEPFSAGADLAGALGLLQAGKVDAFEALVANFQAT
SQRIKYAQVPVISAVRGLALGGGCEFQMHSAKTVASLESYIGLVEAGVGLLPAGGGLKEIAVRASIAAGPGGDVFAELKK
TFETVAMAKVSNSAVNAKELGLLRATDKVVFNSYESLHIAKAEARALAEGGYRAPLPARHIQVAGDVGIATFKMLLVNML
EGRFISEYDYEIASRIATVVCGGEVDRGALVDEEWLLKLERKHFVELAQQEKTQARIGHMLKTGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=296, Percent_Identity=31.7567567567568, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI296179427, Length=313, Percent_Identity=31.629392971246, Blast_Score=124, Evalue=5e-28,
Organism=Homo sapiens, GI20127408, Length=303, Percent_Identity=28.0528052805281, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI261878539, Length=321, Percent_Identity=24.9221183800623, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI68989263, Length=321, Percent_Identity=24.9221183800623, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790281, Length=325, Percent_Identity=26.7692307692308, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI1787661, Length=453, Percent_Identity=24.7240618101545, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1788682, Length=215, Percent_Identity=27.4418604651163, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17549919, Length=300, Percent_Identity=28.6666666666667, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17553560, Length=291, Percent_Identity=27.4914089347079, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=298, Percent_Identity=29.5302013422819, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25144276, Length=293, Percent_Identity=31.740614334471, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508953, Length=293, Percent_Identity=31.740614334471, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=293, Percent_Identity=30.7167235494881, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508951, Length=293, Percent_Identity=31.740614334471, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985923, Length=268, Percent_Identity=26.865671641791, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=257, Percent_Identity=26.0700389105058, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921000, Length=337, Percent_Identity=30.2670623145401, Blast_Score=85, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583077, Length=337, Percent_Identity=30.2670623145401, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583079, Length=337, Percent_Identity=30.2670623145401, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 85610; Mature: 85479

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLVRRAAVLGAGVMGAQIAAHLTNAGVDTVLFDLPAKEGPADGIVLKAIANLGKLS
CCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHHHCCCC
PAPLASKALAEAITPANYESGLEQLRDCDLIIEAIAERMDWKQDLYKKIAPFVSEHAVLA
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEE
SNTSGLGINKLSDVLPEQLRHRFCGVHFFNPPRYMHLAELIPAKGTDKAVLEGLEAFLVT
CCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
TLGKGVVYAKDTPNFIGNRIGVFSILSTIHHTQEFGLGFDEVDALTGPLVGRPKSATYRT
HHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
SDVVGLDTMAHVIKTMGDTLPDDPWHQYFKSPKWLEALIAKGALGQKVGAGIFRKVGKDI
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCE
VVLDLHEQDYRAADRSAAPEVVEILKIKNPAEKFAKLRESQHPQAQFLWASFRDLFHYSA
EEEEECCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FHLADIAETARDVDLAIRWGYGWSLGPFETWQAAGWKQVAQWIAEDISNGKSMSSAPLPN
HHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCC
WVFDGRDGVHGAEGSYSPARDAKLPRSSLPVYKRQRFPDPLLGEQFSPGETVFENDGVRM
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEECCCCEEE
WHDGDDIAVVSFKTKMNTVSDHVLNGLQDVVGRAEKDFAGLVIWQQKEPFSAGADLAGAL
EECCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHH
GLLQAGKVDAFEALVANFQATSQRIKYAQVPVISAVRGLALGGGCEFQMHSAKTVASLES
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEECCHHHHHHHHH
YIGLVEAGVGLLPAGGGLKEIAVRASIAAGPGGDVFAELKKTFETVAMAKVSNSAVNAKE
HHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LGLLRATDKVVFNSYESLHIAKAEARALAEGGYRAPLPARHIQVAGDVGIATFKMLLVNM
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCHHHHHHHHHHHH
LEGRFISEYDYEIASRIATVVCGGEVDRGALVDEEWLLKLERKHFVELAQQEKTQARIGH
HCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLKTGKPLRN
HHHCCCCCCC
>Mature Secondary Structure 
SNPLLVRRAAVLGAGVMGAQIAAHLTNAGVDTVLFDLPAKEGPADGIVLKAIANLGKLS
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHHHHHHCCCC
PAPLASKALAEAITPANYESGLEQLRDCDLIIEAIAERMDWKQDLYKKIAPFVSEHAVLA
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEE
SNTSGLGINKLSDVLPEQLRHRFCGVHFFNPPRYMHLAELIPAKGTDKAVLEGLEAFLVT
CCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
TLGKGVVYAKDTPNFIGNRIGVFSILSTIHHTQEFGLGFDEVDALTGPLVGRPKSATYRT
HHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCC
SDVVGLDTMAHVIKTMGDTLPDDPWHQYFKSPKWLEALIAKGALGQKVGAGIFRKVGKDI
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCE
VVLDLHEQDYRAADRSAAPEVVEILKIKNPAEKFAKLRESQHPQAQFLWASFRDLFHYSA
EEEEECCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FHLADIAETARDVDLAIRWGYGWSLGPFETWQAAGWKQVAQWIAEDISNGKSMSSAPLPN
HHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCC
WVFDGRDGVHGAEGSYSPARDAKLPRSSLPVYKRQRFPDPLLGEQFSPGETVFENDGVRM
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEECCCCEEE
WHDGDDIAVVSFKTKMNTVSDHVLNGLQDVVGRAEKDFAGLVIWQQKEPFSAGADLAGAL
EECCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHH
GLLQAGKVDAFEALVANFQATSQRIKYAQVPVISAVRGLALGGGCEFQMHSAKTVASLES
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEECCHHHHHHHHH
YIGLVEAGVGLLPAGGGLKEIAVRASIAAGPGGDVFAELKKTFETVAMAKVSNSAVNAKE
HHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LGLLRATDKVVFNSYESLHIAKAEARALAEGGYRAPLPARHIQVAGDVGIATFKMLLVNM
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCCHHHHHHHHHHHH
LEGRFISEYDYEIASRIATVVCGGEVDRGALVDEEWLLKLERKHFVELAQQEKTQARIGH
HCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLKTGKPLRN
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]