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The map label for this gene is fadA [H]

Identifier: 21242756

GI number: 21242756

Start: 2353856

End: 2355061

Strand: Reverse

Name: fadA [H]

Synonym: XAC2012

Alternate gene names: 21242756

Gene position: 2355061-2353856 (Counterclockwise)

Preceding gene: 77748627

Following gene: 77748626

Centisome position: 45.5

GC content: 66.09

Gene sequence:

>1206_bases
ATGAGCAAACAGATTCAAGAAGCCTACATCGTCGCCGCCACACGTACGCCGGTAGGCAAGGCGCCGAAGGGCGTGTTCCG
CAACACCCGCCCCGACGACATGCTGGCGCACGTGCTGCGCGCCGTGGTCGCGCAGGCGCCGGGCATCGATACCTCGCGCA
TCGACGACGCCATCATCGGCTGCGCGATGCCCGAAGGCGAGCAAGGCATGAACGTGGCGCGCATTGGCGTGCTGCTGGCG
GGCCTGCCCAATTCGGTGGCCGGTCAGACCATCAACCGCTTCTGTTCGTCCGGCATCCAGGCCATCGCCATGGCGGCCGA
TCAGATTCGTCTGGGCAATGCCGACCTGATGCTGGCCGGCGGCACTGAGTCGATGTCGATGGTGCCGATGATGGGCAACA
AGGTGGCGATGTCGCCAAGCGTGTTCGCCGACGACCATGTGGCCATTGCGTACGGCATGGGCATCACTGCCGAGAAGGTC
GCAGAAGAGTGGAAGGTGTCGCGCGAAGACCAGGATGCGTTCGCGCTGGCCTCGCACCAGAAAGCGATCGCGGCGATTGC
GGCCGGCGAGTTCCGCGACGAAATCAGCCCGTACGAAATCCACTCGCACCAGCCCGACTTGGCCGGCAACGTCATCACCT
TGCGCAAGAAGCTGGTCGATACGGACGAAGGTCCGCGTCCGGACAGCTCGCTCGAGGGCCTGGCCAAGCTGCGCCCGGTG
TTCCGCAACGGCCAGTTCGGCGGCAGCGTCACCGCCGGCAATTCGTCGCAGATGAGCGATGGTGCCGGCGCGGTGCTGCT
GGCCTCCGAGCAGGCGATCAGGGATTACGGCCTGACTCCGCTGGCCCGCTTCGTCAGCTTCTCGGTCGCTGGCGTGCGCC
CGGAAGTCATGGGTATCGGACCGATCGCCGCCATTCCCAAGGCGCTCAAGCAGGCCGGCCTGACCAAGGACCAGCTGGAC
TGGATCGAGCTCAACGAAGCCTTCGCGGCACAGGCGTTGGCGGTCATCCGCGACAGCGAGCTGGATCCATCCAAGGTCAA
CCCACTGGGCGGCGCAATCGCCCTTGGCCACCCGCTGGGCGCCACCGGCGCGATCCGTGCGGCCACGCTGGTGCATGGCC
TGCGCCGTCGTCAGCAGAAGTACGGCATGGTCACCATGTGCATCGGGACCGGCATGGGCGCTGCGGGCATCATCGAAGCG
CTGTAA

Upstream 100 bases:

>100_bases
CCAATTATCTGCCGGGTGATGAAGATGGCGAACCCAGGCGAATCCGCACTTGCGATTCCCGATTCCCCTCTCCCCATTCC
CGGCTTTCGGAGATAGCCAA

Downstream 100 bases:

>100_bases
GGCGCGCTGGAGCGCCGGGTCGGCCTTCCGGGTCGATCTGGTGTCTCCATCGGTGTCATCGACCTGCGGATATCAGGTCA
GCGATCAAATTTCCATGCTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLA
GLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKV
AEEWKVSREDQDAFALASHQKAIAAIAAGEFRDEISPYEIHSHQPDLAGNVITLRKKLVDTDEGPRPDSSLEGLAKLRPV
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIRDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGLTKDQLD
WIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEA
L

Sequences:

>Translated_401_residues
MSKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLA
GLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKV
AEEWKVSREDQDAFALASHQKAIAAIAAGEFRDEISPYEIHSHQPDLAGNVITLRKKLVDTDEGPRPDSSLEGLAKLRPV
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIRDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGLTKDQLD
WIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEA
L
>Mature_400_residues
SKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIGCAMPEGEQGMNVARIGVLLAG
LPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAGGTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVA
EEWKVSREDQDAFALASHQKAIAAIAAGEFRDEISPYEIHSHQPDLAGNVITLRKKLVDTDEGPRPDSSLEGLAKLRPVF
RNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIRDYGLTPLARFVSFSVAGVRPEVMGIGPIAAIPKALKQAGLTKDQLDW
IELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLGATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEAL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=45.3164556962025, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI167614485, Length=405, Percent_Identity=41.2345679012346, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=38.5572139303483, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=35.7843137254902, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=31.1659192825112, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI194353979, Length=247, Percent_Identity=36.0323886639676, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=44.9029126213592, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=43.25, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=41.3793103448276, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1788554, Length=410, Percent_Identity=41.9512195121951, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788683, Length=452, Percent_Identity=31.858407079646, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=406, Percent_Identity=38.423645320197, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI25147385, Length=405, Percent_Identity=34.320987654321, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=32.7586206896552, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=443, Percent_Identity=28.8939051918736, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=30.3258145363409, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=41.0891089108911, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=36.4077669902913, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24655093, Length=407, Percent_Identity=39.5577395577396, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17648125, Length=418, Percent_Identity=38.755980861244, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=34.4743276283619, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.2217194570136, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41960; Mature: 41829

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIG
CCCCCCEEEEEEEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
CAMPEGEQGMNVARIGVLLAGLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
GTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVAEEWKVSREDQDAFALASHQ
CCCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KAIAAIAAGEFRDEISPYEIHSHQPDLAGNVITLRKKLVDTDEGPRPDSSLEGLAKLRPV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIRDYGLTPLARFVSFSVAGVRPEVMGIG
HHCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHCCCCCHHEECC
PIAAIPKALKQAGLTKDQLDWIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLG
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
ATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEAL
CCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCC
>Mature Secondary Structure 
SKQIQEAYIVAATRTPVGKAPKGVFRNTRPDDMLAHVLRAVVAQAPGIDTSRIDDAIIG
CCCCCEEEEEEEECCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
CAMPEGEQGMNVARIGVLLAGLPNSVAGQTINRFCSSGIQAIAMAADQIRLGNADLMLAG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEC
GTESMSMVPMMGNKVAMSPSVFADDHVAIAYGMGITAEKVAEEWKVSREDQDAFALASHQ
CCCCCEEEECCCCEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHH
KAIAAIAAGEFRDEISPYEIHSHQPDLAGNVITLRKKLVDTDEGPRPDSSLEGLAKLRPV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FRNGQFGGSVTAGNSSQMSDGAGAVLLASEQAIRDYGLTPLARFVSFSVAGVRPEVMGIG
HHCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHCCCCCHHEECC
PIAAIPKALKQAGLTKDQLDWIELNEAFAAQALAVIRDSELDPSKVNPLGGAIALGHPLG
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCC
ATGAIRAATLVHGLRRRQQKYGMVTMCIGTGMGAAGIIEAL
CCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]