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The map label for this gene is hpcH [H]

Identifier: 77465666

GI number: 77465666

Start: 767008

End: 767808

Strand: Reverse

Name: hpcH [H]

Synonym: RSP_3658

Alternate gene names: 77465666

Gene position: 767808-767008 (Counterclockwise)

Preceding gene: 77465667

Following gene: 77465665

Centisome position: 81.42

GC content: 69.91

Gene sequence:

>801_bases
ATGAGCCCCGAGTGGCGCGACAGGCTCGCCGCGGGCGGGCCGGTCTTCGGCATGAACGTCTATTCGGGCAGCCCCTCCGC
GGTCGAGATCGCGGGCGCCTGGGGGCTCGACTTCGTGTTCATCGACGCCGAGCACAGCGTGCTGGGCCTCGATCTGCCGA
TGGAGCGCATGATCCTCGCCGCGCGGCTGGCCGGGGTGGCGCCGCTCGTCCGGGTACCCGACAGCGCGCCCACCGGGTTG
CGCAAGGCGCTCGAACTCGGCGCGGCGGGGGTGATCGTGCCGCAGGTCCACGATGCGGACCAGATGCGCGCGATCATCGC
GGCCACGAAGTTCCCGCCCCTGGGTCGGCGCGGCGGGGACAGCTCCGTCCGTTCGGCCGGATGGGCGGGACCGGGGTTCG
ACTGGGCGGACTATGCCCGGCGCAGCAACCGCGACACGTTCATCGTCCCGATGGCCGAAAGCCCGGAGTTCTTCGAGAAC
ATCGACGAGATCCTCGACGTGCCCGGCATCGATGCCGTGCATTTCGGCCCGGCGGACTTTGCCCTCTCGAGCGGCCTCGA
GGTGGATTATTCCATGCGCGAGCCGACGGTCCGCGAGGCCATGCGCCTGCTTATCGCGAAATGCCGCGAGAAGGGCATTC
ATGTGATGCTGCCCTGCGCGCCCGCCACGGACGAACAGGCCGCGGACCTTCTTGCCGAGGGCGGCGACATGCTGCTGGTC
GGCAATGACATCGGCTTCCTGAATCAGGGCTGCCGCACGGCGGCAGGGATCGCCACGGCGCTGCGGGAGACCCGGGCATG
A

Upstream 100 bases:

>100_bases
TCATCCGCGATCCCGGCGTCTACGAGGTGCATCCCTTCCGCGACCGCCGCCCGCAGGATTACCGCATCTGCGCCGCCCCC
GCAGCACTCTGGCTCGAGGC

Downstream 100 bases:

>100_bases
TCCGGCACCCCCGACGCCCCACGGCCGCGCTGGACCCTGACCTGATCGAGCGGTTGCGCGCCCTGCAGCCCGCCTCGCTC
GGGCACCATCTGACGGCGGG

Product: putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Products: NA

Alternate protein names: KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSPEWRDRLAAGGPVFGMNVYSGSPSAVEIAGAWGLDFVFIDAEHSVLGLDLPMERMILAARLAGVAPLVRVPDSAPTGL
RKALELGAAGVIVPQVHDADQMRAIIAATKFPPLGRRGGDSSVRSAGWAGPGFDWADYARRSNRDTFIVPMAESPEFFEN
IDEILDVPGIDAVHFGPADFALSSGLEVDYSMREPTVREAMRLLIAKCREKGIHVMLPCAPATDEQAADLLAEGGDMLLV
GNDIGFLNQGCRTAAGIATALRETRA

Sequences:

>Translated_266_residues
MSPEWRDRLAAGGPVFGMNVYSGSPSAVEIAGAWGLDFVFIDAEHSVLGLDLPMERMILAARLAGVAPLVRVPDSAPTGL
RKALELGAAGVIVPQVHDADQMRAIIAATKFPPLGRRGGDSSVRSAGWAGPGFDWADYARRSNRDTFIVPMAESPEFFEN
IDEILDVPGIDAVHFGPADFALSSGLEVDYSMREPTVREAMRLLIAKCREKGIHVMLPCAPATDEQAADLLAEGGDMLLV
GNDIGFLNQGCRTAAGIATALRETRA
>Mature_265_residues
SPEWRDRLAAGGPVFGMNVYSGSPSAVEIAGAWGLDFVFIDAEHSVLGLDLPMERMILAARLAGVAPLVRVPDSAPTGLR
KALELGAAGVIVPQVHDADQMRAIIAATKFPPLGRRGGDSSVRSAGWAGPGFDWADYARRSNRDTFIVPMAESPEFFENI
DEILDVPGIDAVHFGPADFALSSGLEVDYSMREPTVREAMRLLIAKCREKGIHVMLPCAPATDEQAADLLAEGGDMLLVG
NDIGFLNQGCRTAAGIATALRETRA

Specific function: Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde [H]

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788578, Length=250, Percent_Identity=32, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789514, Length=232, Percent_Identity=26.7241379310345, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: NA

Molecular weight: Translated: 28330; Mature: 28198

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPEWRDRLAAGGPVFGMNVYSGSPSAVEIAGAWGLDFVFIDAEHSVLGLDLPMERMILA
CCCCHHHHHCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHHH
ARLAGVAPLVRVPDSAPTGLRKALELGAAGVIVPQVHDADQMRAIIAATKFPPLGRRGGD
HHHHCCCCEEECCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
SSVRSAGWAGPGFDWADYARRSNRDTFIVPMAESPEFFENIDEILDVPGIDAVHFGPADF
CHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCHHH
ALSSGLEVDYSMREPTVREAMRLLIAKCREKGIHVMLPCAPATDEQAADLLAEGGDMLLV
HHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEE
GNDIGFLNQGCRTAAGIATALRETRA
ECCCCHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPEWRDRLAAGGPVFGMNVYSGSPSAVEIAGAWGLDFVFIDAEHSVLGLDLPMERMILA
CCCHHHHHCCCCCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHHH
ARLAGVAPLVRVPDSAPTGLRKALELGAAGVIVPQVHDADQMRAIIAATKFPPLGRRGGD
HHHHCCCCEEECCCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
SSVRSAGWAGPGFDWADYARRSNRDTFIVPMAESPEFFENIDEILDVPGIDAVHFGPADF
CHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCHHH
ALSSGLEVDYSMREPTVREAMRLLIAKCREKGIHVMLPCAPATDEQAADLLAEGGDMLLV
HHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEE
GNDIGFLNQGCRTAAGIATALRETRA
ECCCCHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA