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The map label for this gene is hisG

Identifier: 77465548

GI number: 77465548

Start: 639292

End: 640002

Strand: Reverse

Name: hisG

Synonym: RSP_3549

Alternate gene names: 77465548

Gene position: 640002-639292 (Counterclockwise)

Preceding gene: 77465549

Following gene: 77465546

Centisome position: 67.87

GC content: 69.48

Gene sequence:

>711_bases
ATGACGCTGAAGATCGGGGTGCCCTCGAAGGGCCGGCTGATGGAAAAGACCTTCGACTGGTTCGGCGCGCGCGGCGTGAC
CATGCGCCAGACCGGGGCCGAGCGGGAATATTCCGGCGCCGTCGACGGGGTGGACGGGGTCGAGCTCGTGCTGCTCTCGG
CGGGAGAGATCCCGCGCGAGCTCGGCGCCGGGCGGATCCATCTGGGGGTGACGGGGTCCGATCTGGTGCGCGAGAAGCTT
GCGGACTGGTCGCTGCAGGTGGCCGAGATGGCGCCGCTCGGCTTCGGTCATGCCGATCTCATCATCGCGGTGCCGGCCTT
CTGGATCGATGTGGATACGCTCGACGATCTCGACGCCGCCGCCGCGGCCTTCCGCGCGGCCCACGGCTTCCGGCTTCGGA
TCGCCACCAAATACCACCGGCTCGTGCGCGAGTTCCTGATGGCCAACGGGGTTGCGGATTATCAGCTGGTGGACAGCCAG
GGCGCGACCGAGGGCACGGTGAAAAACGGAACCGCCGAGGCCATCGCCGACATCACCTCGTCGGGCGAGACGCTGCGGGC
GAACCACCTGAAAATCCTTTCCGACGCGCTGGTACACAGTTCGCAGGCCGTGCTCTTCGCCTCGCGCCGGGCCGACTGGT
CCGAGGCCGCGGGGCCCTTCGCGGCGCTCGGCGCGCGGCTGGGCCTGCCCCTGCCCGAGGCGCTTACCTGA

Upstream 100 bases:

>100_bases
GTTACGACGCGCTGACGGCGGTGCTGGGGCAGGGGCGGTCCATCCCGGCCATCGGGGGCGTGATCCGCCCGGGCCTCGTG
GCCAGGCTGAAGGGGCTCGC

Downstream 100 bases:

>100_bases
GGCCTATGTCGGCCAGAGCCCGCGCCAGTTCCGGCGGCAGCGGCTCCTCGCGGGCGCGGTCCCTGGGCAGGTCGGCCGGG
GCCTCTTCGGGCGAGAGATA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTLKIGVPSKGRLMEKTFDWFGARGVTMRQTGAEREYSGAVDGVDGVELVLLSAGEIPRELGAGRIHLGVTGSDLVREKL
ADWSLQVAEMAPLGFGHADLIIAVPAFWIDVDTLDDLDAAAAAFRAAHGFRLRIATKYHRLVREFLMANGVADYQLVDSQ
GATEGTVKNGTAEAIADITSSGETLRANHLKILSDALVHSSQAVLFASRRADWSEAAGPFAALGARLGLPLPEALT

Sequences:

>Translated_236_residues
MTLKIGVPSKGRLMEKTFDWFGARGVTMRQTGAEREYSGAVDGVDGVELVLLSAGEIPRELGAGRIHLGVTGSDLVREKL
ADWSLQVAEMAPLGFGHADLIIAVPAFWIDVDTLDDLDAAAAAFRAAHGFRLRIATKYHRLVREFLMANGVADYQLVDSQ
GATEGTVKNGTAEAIADITSSGETLRANHLKILSDALVHSSQAVLFASRRADWSEAAGPFAALGARLGLPLPEALT
>Mature_235_residues
TLKIGVPSKGRLMEKTFDWFGARGVTMRQTGAEREYSGAVDGVDGVELVLLSAGEIPRELGAGRIHLGVTGSDLVREKLA
DWSLQVAEMAPLGFGHADLIIAVPAFWIDVDTLDDLDAAAAAFRAAHGFRLRIATKYHRLVREFLMANGVADYQLVDSQG
ATEGTVKNGTAEAIADITSSGETLRANHLKILSDALVHSSQAVLFASRRADWSEAAGPFAALGARLGLPLPEALT

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_RHOS4 (O08385)

Other databases:

- EMBL:   Y10050
- EMBL:   CP000144
- RefSeq:   YP_355051.1
- ProteinModelPortal:   O08385
- SMR:   O08385
- STRING:   O08385
- GeneID:   3721963
- GenomeReviews:   CP000144_GR
- KEGG:   rsp:RSP_3549
- NMPDR:   fig|272943.3.peg.3295
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   RMRVATK
- ProtClustDB:   PRK13583
- BioCyc:   RSPH272943:RSP_3549-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 25124; Mature: 24993

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKIGVPSKGRLMEKTFDWFGARGVTMRQTGAEREYSGAVDGVDGVELVLLSAGEIPRE
CEEEECCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
LGAGRIHLGVTGSDLVREKLADWSLQVAEMAPLGFGHADLIIAVPAFWIDVDTLDDLDAA
HCCCEEEEECCCHHHHHHHHHHCCEEHHHHCCCCCCCCHHEEEEHHHEEECCCCCCHHHH
AAAFRAAHGFRLRIATKYHRLVREFLMANGVADYQLVDSQGATEGTVKNGTAEAIADITS
HHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHC
SGETLRANHLKILSDALVHSSQAVLFASRRADWSEAAGPFAALGARLGLPLPEALT
CCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TLKIGVPSKGRLMEKTFDWFGARGVTMRQTGAEREYSGAVDGVDGVELVLLSAGEIPRE
EEEECCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
LGAGRIHLGVTGSDLVREKLADWSLQVAEMAPLGFGHADLIIAVPAFWIDVDTLDDLDAA
HCCCEEEEECCCHHHHHHHHHHCCEEHHHHCCCCCCCCHHEEEEHHHEEECCCCCCHHHH
AAAFRAAHGFRLRIATKYHRLVREFLMANGVADYQLVDSQGATEGTVKNGTAEAIADITS
HHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHC
SGETLRANHLKILSDALVHSSQAVLFASRRADWSEAAGPFAALGARLGLPLPEALT
CCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA