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The map label for this gene is nrdZ [H]

Identifier: 77465546

GI number: 77465546

Start: 636449

End: 638716

Strand: Reverse

Name: nrdZ [H]

Synonym: RSP_3547

Alternate gene names: 77465546

Gene position: 638716-636449 (Counterclockwise)

Preceding gene: 77465548

Following gene: 77465545

Centisome position: 67.73

GC content: 66.23

Gene sequence:

>2268_bases
ATGTCCCGATTCCATGCCCCCATCGCCGAGCAGATCTGGGATATGAAGTATCGCCTGAAGGATGGCGCGGGCCATCCGGT
CGACGGATCGGTCGAAGATACCTGGCGGCGGATCGCGCGGGCGCTGGCCGAAGTCGAGGCCGAGCCTGCGCTTTGGGAGG
ATCGGTTCTACAGCGCGCTCGAGGATTTCCGCTTCCTGCCGGCCGGCCGGATCACCGCTGGGGCGGGCACCGGGCGCACG
GTCACGCTCTTCAACTGCTTCGTCATGGGCACCGTCCCGGACAGCATGGCGGGTATCTTCGACGCGCTGAAGGAAGCGGC
GCTGACGATGCAGCAGGGCGGCGGGATCGGCTATGACTTCTCGACCATCCGCCCGCGCGGCGCCGAGGTGAAGGGCGTCG
CCGCCGACGCCTCGGGGCCCCTTTCCTTCATGGATGTCTGGGATGCGATGTGCCGGACGATCATGTCGGCAGGCTCGCGG
CGCGGCGCCATGATGGCCACGATGCGCTGCGACCATCCCGACATCGAGAGTTTCATCGAAGCCAAGAAAGACCCGGCCCG
GCTGCGGATGTTCAACCTCTCGGTTCTCGTGACCGACGCCTTCATGGAGGCCGTGAAGGCGGACGGCCCGTGGGAGCTCA
CCTTCGGCGGCAAGGTCTACAGGACGCTGCAGGCGCGCGACCTCTGGAACCGCATCATGCGTTCCACCTACGATTTCGCC
GAGCCGGGCGTGATTTTCATCGACCGCATCAACCAGATGAACAATCTCGCCTACTGCGAGACGATCTCTGCCACCAACCC
CTGCGGCGAGCAGCCGCTGCCGCCCTATGGCGCCTGCCTTCTCGGCTCGGTGAACCTCGCCCGGCTGGTCGCGAAACCGT
TTTCCGACGGGGCGGAGCTCGATCTAGCCGAGCTGGACGAGCTGGTGCGCCTTGCCGTCCGGATGATGGACAATGTGGTG
GATGCCTCGCGCTTCCCGCTGCCCGAACAGGCGCGCGAGGCGCAGATGAAGCGCCGGATCGGCCTCGGCGTGACGGGCCT
TGCGGATGCCCTGCTGATGGTGGGGCTGCGCTACGGCTCGGAAGAAGCCGCCGCCCGGACCGAGGCCTGGATGAAGGCCA
TCGCGCGCTCGGCCTATCTCGCCTCTGCGGATCTCGCGCGCGAGAAGGGCGCCTTCCCGCTGTTCGAGGCCGACAAGTAT
CTCGGGTCGGGCTCGCTCACCCATATGGACGAGGATGTGCGCGCGGCGATCCGCACCCACGGCATCCGCAACGCGCTGCT
GACCTCGATCGCCCCCACCGGCACGATCAGCCTCTACGCCGGCAACGTCTCGTCGGGGATCGAGCCGGTCTTCGCCTATG
CCTACAAGCGCAAGGTGCTGCAGAAGGACGGAAGCCGCACCGAGGAGGAGGTCGTCGATTACGCCGTCCGCCTCTGGCGC
GAACAGATGGGCGACGCCCCGCTGCCGGACTATTTCGTGAATGCCCAGACGCTGGCGCCGCTCGAACATGTGCGGATGCA
GGCGGCGGCGCAGAAATGGATCGACAGTTCGATTTCCAAGACGATCAACTGCCCGGAAGATATCGGTTTCGAGGAATTCG
CCGACGTCTACCTCGCGGCCTGGGATCAGGGCTGCAAGGGCTGCACGACCTATCGGCCGAACGAGGTGACGGGCTCGGTG
CTCTCGGTCTCCGAGGCGGGGCAGGCGGCTCCGGCCGAGGCGCCCGAGCCCAAGGGCGGCGAGGTGGTCTATCTCACCGA
TCCGCTCGACCGCCCCGCAGCCCTTGAGGGCGCGACCTACAAGGTGAAATGGCCGGGCTCGGAACATGCGCTCTACATCA
CGGTGAACGACATCGTCATCTCCGGCCACCGCCGGCCGTTCGAAGTGTTCATCAACTCGAAGAACATGGAGCATTTCGCC
TGGACGGTGGCGCTCACGCGGATGATCTCGGCCGTCTTCCGGCGCGGCGGCGACATTTCCTTCGTGGTCGAGGAGCTGAA
GGCGGTCTTCGACCCCCGCGGCGGCGCCTGGATGGAGGGGCGCTACATTCCCTCGATCCTAGCAGCCATCGGCGGCGTGA
TCGAGCGCCACCTGATCGCGATCGGCTTCATCGAGGGCGAGGGCATGGGTCTGAAGACCGACCCTCATGCCGATGTGCAG
GTCTTGGGGGTGAAGGCCAAGGCCTGCTCCTCCTGCGGCAGCTACGACCTCCGCATGGTGGAAGGCTGCATGACCTGCGC
CAGCTGCGGCTTCTCCAAGTGCGGATGA

Upstream 100 bases:

>100_bases
CCAAGCGCCCCGGACATGGCTCTTTACGTTTGACCGCTCCCGCCCATGGGCATATCTTGGGCAACTCCTCCCTGAGAACC
ACAAGCCCAAGGATCTGCCC

Downstream 100 bases:

>100_bases
GGGCGGGGAGGCAAGAGTCTCGCGGTTCAGATAAATTGTCCATTATGCTGAAAAACGACGTCAAATGAGCAAAAAGCGAC
GGCTAGTCGTGGTGCGCAAT

Product: ribonucleotide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MSRFHAPIAEQIWDMKYRLKDGAGHPVDGSVEDTWRRIARALAEVEAEPALWEDRFYSALEDFRFLPAGRITAGAGTGRT
VTLFNCFVMGTVPDSMAGIFDALKEAALTMQQGGGIGYDFSTIRPRGAEVKGVAADASGPLSFMDVWDAMCRTIMSAGSR
RGAMMATMRCDHPDIESFIEAKKDPARLRMFNLSVLVTDAFMEAVKADGPWELTFGGKVYRTLQARDLWNRIMRSTYDFA
EPGVIFIDRINQMNNLAYCETISATNPCGEQPLPPYGACLLGSVNLARLVAKPFSDGAELDLAELDELVRLAVRMMDNVV
DASRFPLPEQAREAQMKRRIGLGVTGLADALLMVGLRYGSEEAAARTEAWMKAIARSAYLASADLAREKGAFPLFEADKY
LGSGSLTHMDEDVRAAIRTHGIRNALLTSIAPTGTISLYAGNVSSGIEPVFAYAYKRKVLQKDGSRTEEEVVDYAVRLWR
EQMGDAPLPDYFVNAQTLAPLEHVRMQAAAQKWIDSSISKTINCPEDIGFEEFADVYLAAWDQGCKGCTTYRPNEVTGSV
LSVSEAGQAAPAEAPEPKGGEVVYLTDPLDRPAALEGATYKVKWPGSEHALYITVNDIVISGHRRPFEVFINSKNMEHFA
WTVALTRMISAVFRRGGDISFVVEELKAVFDPRGGAWMEGRYIPSILAAIGGVIERHLIAIGFIEGEGMGLKTDPHADVQ
VLGVKAKACSSCGSYDLRMVEGCMTCASCGFSKCG

Sequences:

>Translated_755_residues
MSRFHAPIAEQIWDMKYRLKDGAGHPVDGSVEDTWRRIARALAEVEAEPALWEDRFYSALEDFRFLPAGRITAGAGTGRT
VTLFNCFVMGTVPDSMAGIFDALKEAALTMQQGGGIGYDFSTIRPRGAEVKGVAADASGPLSFMDVWDAMCRTIMSAGSR
RGAMMATMRCDHPDIESFIEAKKDPARLRMFNLSVLVTDAFMEAVKADGPWELTFGGKVYRTLQARDLWNRIMRSTYDFA
EPGVIFIDRINQMNNLAYCETISATNPCGEQPLPPYGACLLGSVNLARLVAKPFSDGAELDLAELDELVRLAVRMMDNVV
DASRFPLPEQAREAQMKRRIGLGVTGLADALLMVGLRYGSEEAAARTEAWMKAIARSAYLASADLAREKGAFPLFEADKY
LGSGSLTHMDEDVRAAIRTHGIRNALLTSIAPTGTISLYAGNVSSGIEPVFAYAYKRKVLQKDGSRTEEEVVDYAVRLWR
EQMGDAPLPDYFVNAQTLAPLEHVRMQAAAQKWIDSSISKTINCPEDIGFEEFADVYLAAWDQGCKGCTTYRPNEVTGSV
LSVSEAGQAAPAEAPEPKGGEVVYLTDPLDRPAALEGATYKVKWPGSEHALYITVNDIVISGHRRPFEVFINSKNMEHFA
WTVALTRMISAVFRRGGDISFVVEELKAVFDPRGGAWMEGRYIPSILAAIGGVIERHLIAIGFIEGEGMGLKTDPHADVQ
VLGVKAKACSSCGSYDLRMVEGCMTCASCGFSKCG
>Mature_754_residues
SRFHAPIAEQIWDMKYRLKDGAGHPVDGSVEDTWRRIARALAEVEAEPALWEDRFYSALEDFRFLPAGRITAGAGTGRTV
TLFNCFVMGTVPDSMAGIFDALKEAALTMQQGGGIGYDFSTIRPRGAEVKGVAADASGPLSFMDVWDAMCRTIMSAGSRR
GAMMATMRCDHPDIESFIEAKKDPARLRMFNLSVLVTDAFMEAVKADGPWELTFGGKVYRTLQARDLWNRIMRSTYDFAE
PGVIFIDRINQMNNLAYCETISATNPCGEQPLPPYGACLLGSVNLARLVAKPFSDGAELDLAELDELVRLAVRMMDNVVD
ASRFPLPEQAREAQMKRRIGLGVTGLADALLMVGLRYGSEEAAARTEAWMKAIARSAYLASADLAREKGAFPLFEADKYL
GSGSLTHMDEDVRAAIRTHGIRNALLTSIAPTGTISLYAGNVSSGIEPVFAYAYKRKVLQKDGSRTEEEVVDYAVRLWRE
QMGDAPLPDYFVNAQTLAPLEHVRMQAAAQKWIDSSISKTINCPEDIGFEEFADVYLAAWDQGCKGCTTYRPNEVTGSVL
SVSEAGQAAPAEAPEPKGGEVVYLTDPLDRPAALEGATYKVKWPGSEHALYITVNDIVISGHRRPFEVFINSKNMEHFAW
TVALTRMISAVFRRGGDISFVVEELKAVFDPRGGAWMEGRYIPSILAAIGGVIERHLIAIGFIEGEGMGLKTDPHADVQV
LGVKAKACSSCGSYDLRMVEGCMTCASCGFSKCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=557, Percent_Identity=26.2118491921005, Blast_Score=176, Evalue=8e-44,
Organism=Escherichia coli, GI1789030, Length=572, Percent_Identity=22.9020979020979, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI2367133, Length=524, Percent_Identity=25.763358778626, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555242, Length=569, Percent_Identity=25.6590509666081, Blast_Score=171, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6322123, Length=473, Percent_Identity=27.6955602536998, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320914, Length=473, Percent_Identity=27.2727272727273, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17352481, Length=600, Percent_Identity=25.5, Blast_Score=177, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 82520; Mature: 82389

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFHAPIAEQIWDMKYRLKDGAGHPVDGSVEDTWRRIARALAEVEAEPALWEDRFYSAL
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFRFLPAGRITAGAGTGRTVTLFNCFVMGTVPDSMAGIFDALKEAALTMQQGGGIGYDF
HHHHCCCCCCEEECCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
STIRPRGAEVKGVAADASGPLSFMDVWDAMCRTIMSAGSRRGAMMATMRCDHPDIESFIE
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
AKKDPARLRMFNLSVLVTDAFMEAVKADGPWELTFGGKVYRTLQARDLWNRIMRSTYDFA
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCC
EPGVIFIDRINQMNNLAYCETISATNPCGEQPLPPYGACLLGSVNLARLVAKPFSDGAEL
CCCEEEEECHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCCC
DLAELDELVRLAVRMMDNVVDASRFPLPEQAREAQMKRRIGLGVTGLADALLMVGLRYGS
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
EEAAARTEAWMKAIARSAYLASADLAREKGAFPLFEADKYLGSGSLTHMDEDVRAAIRTH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
GIRNALLTSIAPTGTISLYAGNVSSGIEPVFAYAYKRKVLQKDGSRTEEEVVDYAVRLWR
HHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EQMGDAPLPDYFVNAQTLAPLEHVRMQAAAQKWIDSSISKTINCPEDIGFEEFADVYLAA
HHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHH
WDQGCKGCTTYRPNEVTGSVLSVSEAGQAAPAEAPEPKGGEVVYLTDPLDRPAALEGATY
HHCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEE
KVKWPGSEHALYITVNDIVISGHRRPFEVFINSKNMEHFAWTVALTRMISAVFRRGGDIS
EEECCCCCCEEEEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHH
FVVEELKAVFDPRGGAWMEGRYIPSILAAIGGVIERHLIAIGFIEGEGMGLKTDPHADVQ
HHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEE
VLGVKAKACSSCGSYDLRMVEGCMTCASCGFSKCG
EEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SRFHAPIAEQIWDMKYRLKDGAGHPVDGSVEDTWRRIARALAEVEAEPALWEDRFYSAL
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFRFLPAGRITAGAGTGRTVTLFNCFVMGTVPDSMAGIFDALKEAALTMQQGGGIGYDF
HHHHCCCCCCEEECCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
STIRPRGAEVKGVAADASGPLSFMDVWDAMCRTIMSAGSRRGAMMATMRCDHPDIESFIE
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHH
AKKDPARLRMFNLSVLVTDAFMEAVKADGPWELTFGGKVYRTLQARDLWNRIMRSTYDFA
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCC
EPGVIFIDRINQMNNLAYCETISATNPCGEQPLPPYGACLLGSVNLARLVAKPFSDGAEL
CCCEEEEECHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCCC
DLAELDELVRLAVRMMDNVVDASRFPLPEQAREAQMKRRIGLGVTGLADALLMVGLRYGS
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
EEAAARTEAWMKAIARSAYLASADLAREKGAFPLFEADKYLGSGSLTHMDEDVRAAIRTH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
GIRNALLTSIAPTGTISLYAGNVSSGIEPVFAYAYKRKVLQKDGSRTEEEVVDYAVRLWR
HHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EQMGDAPLPDYFVNAQTLAPLEHVRMQAAAQKWIDSSISKTINCPEDIGFEEFADVYLAA
HHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHH
WDQGCKGCTTYRPNEVTGSVLSVSEAGQAAPAEAPEPKGGEVVYLTDPLDRPAALEGATY
HHCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEE
KVKWPGSEHALYITVNDIVISGHRRPFEVFINSKNMEHFAWTVALTRMISAVFRRGGDIS
EEECCCCCCEEEEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHH
FVVEELKAVFDPRGGAWMEGRYIPSILAAIGGVIERHLIAIGFIEGEGMGLKTDPHADVQ
HHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEE
VLGVKAKACSSCGSYDLRMVEGCMTCASCGFSKCG
EEEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]