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The map label for this gene is phoQ [H]

Identifier: 77465513

GI number: 77465513

Start: 590368

End: 591711

Strand: Direct

Name: phoQ [H]

Synonym: RSP_3512

Alternate gene names: 77465513

Gene position: 590368-591711 (Clockwise)

Preceding gene: 77465512

Following gene: 77465514

Centisome position: 62.6

GC content: 74.85

Gene sequence:

>1344_bases
GTGAAGCTCCGGTCGATCCGGCTCCGGCTCGTCGTCGTCAATGCTCTGGCGCTTGCCCTTGCACTTGCGGCGGCCGCCTG
GGGGCTGGCCCTGCTGTTCGACCGCCACGCCGAGCGCGTGGCCCTGTCGGCCCTTGCGGCCCGCGCCGATGCCCTGACAA
GCGCGCTCGAGCGCGATCCCGGCGGCACCCTGCGGTTTCTCGCGCCTTCGGGCGACCCGGCCTACCAGCAGCCGCTCTCG
GGTCATTACTGGCAGGTCTCGTTCGACGGCAGGCTGCTGCGCTCGCGGTCGCTGTGGGATTACGTCCTTCCCCTGCCCGA
GGACGCGCCCTCGCCCGCGCGCACGGGGCGACCGCTCACCCTGCCGGGGCCGCAGGGCGAGGCGTTGCTGGTCCTTGACC
GGACGGTGCAGATCGGACCGGGCGCGGACGCGGCCCGGGTGCGGATCTCCGTGGCGCAGGATCGCGCCGAACTTTCCCGC
GCGCAGCAGTCCTTCCTGCGCGAACTGGCCCCGTTCCTTGCGATGCTGGCGCTGGCGCTGGTCGCGGCCGGGGCGGTGCA
GGTGACGCTGGGGCTCCGGCCGCTCGCGGCCATCGGCCAGCGGGTCGGCGCGCTCGCCGCGGGCCGGGAGCGGCGGATCG
GGACCGACCTGCCGACGGAGGTCCTGCCGCTCGCGCGCGAGATCGACACCCTCCTCGAGGCCCGCGAGCAGGAGCTGGAA
CGGGCGCGGAGCCGCGCGGGAGACCTCGCGCATGGGCTGAAGACGCCGCTTCAGGCGCTTCTCGGCGAGGCGATGCGGCT
GCGCGCGCGGGGCGAAGAGGCGGCGGCGCGCGGCATCGAGGAGGTGGCCTCCGGCATCCAGCGCCATGTCGACCGCGAGC
TCATGCGCGCGCGGATCATGCGCGACCGCGCCGGAACCGCGTCCGATCCGGCGGAAGCCGCCCAGAGGCTGATCCGCGTC
CTGCGCCGGACGGAGCGGGGGTCGGCCCTCACCTGGCAGCTCGAGGCCGAGGAACGGCTCCTCGTCCGGCTCGAGAGCGC
GGATCTGACCGAGGCGCTGGGGCCGCTGATGGAGAATGCCGCCACCCATGCCGCAGAGGCGGTGCGCGTGCGGATCGCCG
CCGCGGGCACGTCGGTCGCGATCCATGTCTCCGACGACGGCCCCGGAACGCCGGACATCGAGGCGATCCGCGGGCGCGGC
GTGCGCTTCGACACCCGCAGCGGCGGCCACGGCCTCGGGCTCGCCATTGCGGGCGACATCGTCGAGACGGCGGGCGGCGA
GCTTCGCCTGCGCAACCTTTCGCCGGGGTTCGAGGCGACCCTGATCCTGCCGGCCGCCGCCTGA

Upstream 100 bases:

>100_bases
CGAATGCCCTCGAAGCGGTGGTGGCGCGACTGCGCCGCAAGGTCGGGCGCGGCGTCATAGGCACGCGGCGCGGCTTCGGC
TACCAGCTCGAAGCGGGCCC

Downstream 100 bases:

>100_bases
CCCGCCGGTCGGCGCGCTTCGGCAGGGAGGGCAACGATCCGGCGGAGGCCGGAGGCCGGGAGATCGCCTGCCGCATCCTG
CAGGACGAGGAGCGACCTCG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKLRSIRLRLVVVNALALALALAAAAWGLALLFDRHAERVALSALAARADALTSALERDPGGTLRFLAPSGDPAYQQPLS
GHYWQVSFDGRLLRSRSLWDYVLPLPEDAPSPARTGRPLTLPGPQGEALLVLDRTVQIGPGADAARVRISVAQDRAELSR
AQQSFLRELAPFLAMLALALVAAGAVQVTLGLRPLAAIGQRVGALAAGRERRIGTDLPTEVLPLAREIDTLLEAREQELE
RARSRAGDLAHGLKTPLQALLGEAMRLRARGEEAAARGIEEVASGIQRHVDRELMRARIMRDRAGTASDPAEAAQRLIRV
LRRTERGSALTWQLEAEERLLVRLESADLTEALGPLMENAATHAAEAVRVRIAAAGTSVAIHVSDDGPGTPDIEAIRGRG
VRFDTRSGGHGLGLAIAGDIVETAGGELRLRNLSPGFEATLILPAAA

Sequences:

>Translated_447_residues
MKLRSIRLRLVVVNALALALALAAAAWGLALLFDRHAERVALSALAARADALTSALERDPGGTLRFLAPSGDPAYQQPLS
GHYWQVSFDGRLLRSRSLWDYVLPLPEDAPSPARTGRPLTLPGPQGEALLVLDRTVQIGPGADAARVRISVAQDRAELSR
AQQSFLRELAPFLAMLALALVAAGAVQVTLGLRPLAAIGQRVGALAAGRERRIGTDLPTEVLPLAREIDTLLEAREQELE
RARSRAGDLAHGLKTPLQALLGEAMRLRARGEEAAARGIEEVASGIQRHVDRELMRARIMRDRAGTASDPAEAAQRLIRV
LRRTERGSALTWQLEAEERLLVRLESADLTEALGPLMENAATHAAEAVRVRIAAAGTSVAIHVSDDGPGTPDIEAIRGRG
VRFDTRSGGHGLGLAIAGDIVETAGGELRLRNLSPGFEATLILPAAA
>Mature_447_residues
MKLRSIRLRLVVVNALALALALAAAAWGLALLFDRHAERVALSALAARADALTSALERDPGGTLRFLAPSGDPAYQQPLS
GHYWQVSFDGRLLRSRSLWDYVLPLPEDAPSPARTGRPLTLPGPQGEALLVLDRTVQIGPGADAARVRISVAQDRAELSR
AQQSFLRELAPFLAMLALALVAAGAVQVTLGLRPLAAIGQRVGALAAGRERRIGTDLPTEVLPLAREIDTLLEAREQELE
RARSRAGDLAHGLKTPLQALLGEAMRLRARGEEAAARGIEEVASGIQRHVDRELMRARIMRDRAGTASDPAEAAQRLIRV
LRRTERGSALTWQLEAEERLLVRLESADLTEALGPLMENAATHAAEAVRVRIAAAGTSVAIHVSDDGPGTPDIEAIRGRG
VRFDTRSGGHGLGLAIAGDIVETAGGELRLRNLSPGFEATLILPAAA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=267, Percent_Identity=26.9662921348315, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788279, Length=327, Percent_Identity=25.0764525993884, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47670; Mature: 47670

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRSIRLRLVVVNALALALALAAAAWGLALLFDRHAERVALSALAARADALTSALERDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGTLRFLAPSGDPAYQQPLSGHYWQVSFDGRLLRSRSLWDYVLPLPEDAPSPARTGRPLT
CCEEEEECCCCCCHHHCCCCCCEEEEEECCHHHHCCCHHHHCCCCCCCCCCCCCCCCEEE
LPGPQGEALLVLDRTVQIGPGADAARVRISVAQDRAELSRAQQSFLRELAPFLAMLALAL
CCCCCCCEEEEEECEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAGAVQVTLGLRPLAAIGQRVGALAAGRERRIGTDLPTEVLPLAREIDTLLEAREQELE
HHCCHHEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RARSRAGDLAHGLKTPLQALLGEAMRLRARGEEAAARGIEEVASGIQRHVDRELMRARIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRAGTASDPAEAAQRLIRVLRRTERGSALTWQLEAEERLLVRLESADLTEALGPLMENA
HHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHH
ATHAAEAVRVRIAAAGTSVAIHVSDDGPGTPDIEAIRGRGVRFDTRSGGHGLGLAIAGDI
HHHHHHHHEEEEEECCCEEEEEECCCCCCCCCHHHHCCCCCEEECCCCCCCEEEEEEHHH
VETAGGELRLRNLSPGFEATLILPAAA
HHHCCCCEEEECCCCCCCEEEEEECCC
>Mature Secondary Structure
MKLRSIRLRLVVVNALALALALAAAAWGLALLFDRHAERVALSALAARADALTSALERDP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGTLRFLAPSGDPAYQQPLSGHYWQVSFDGRLLRSRSLWDYVLPLPEDAPSPARTGRPLT
CCEEEEECCCCCCHHHCCCCCCEEEEEECCHHHHCCCHHHHCCCCCCCCCCCCCCCCEEE
LPGPQGEALLVLDRTVQIGPGADAARVRISVAQDRAELSRAQQSFLRELAPFLAMLALAL
CCCCCCCEEEEEECEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAGAVQVTLGLRPLAAIGQRVGALAAGRERRIGTDLPTEVLPLAREIDTLLEAREQELE
HHCCHHEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RARSRAGDLAHGLKTPLQALLGEAMRLRARGEEAAARGIEEVASGIQRHVDRELMRARIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRAGTASDPAEAAQRLIRVLRRTERGSALTWQLEAEERLLVRLESADLTEALGPLMENA
HHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHH
ATHAAEAVRVRIAAAGTSVAIHVSDDGPGTPDIEAIRGRGVRFDTRSGGHGLGLAIAGDI
HHHHHHHHEEEEEECCCEEEEEECCCCCCCCCHHHHCCCCCEEECCCCCCCEEEEEEHHH
VETAGGELRLRNLSPGFEATLILPAAA
HHHCCCCEEEECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA