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The map label for this gene is pmrA [H]

Identifier: 77465512

GI number: 77465512

Start: 589709

End: 590371

Strand: Direct

Name: pmrA [H]

Synonym: RSP_3511

Alternate gene names: 77465512

Gene position: 589709-590371 (Clockwise)

Preceding gene: 77465511

Following gene: 77465513

Centisome position: 62.53

GC content: 71.04

Gene sequence:

>663_bases
ATGCGCGCGCTGGTGGTCGAGGATGATGCGCGGATCGCGCAGGATCTGAGCGTCGCGCTCGGCTCGGCCGGCTTCAGGGT
CGAGACGGCCGCAGACGGCGAGACCGCGTGGTTTCTGGGCGGGACAGAGGGCTACGATCTGATCGTGCTCGACCTCGGCC
TGCCGAAGCTCGATGGCCTCGCCGTGCTGAAGCGATGGCGGGCGGAAGGCGTGGAGATCCCGGTGCTGGTGCTGACGGCG
CGGGGCACCTGGACCGAGCGCGTGGAAGGCATCGATGCGGGGGCCGACGACTATCTGCCCAAGCCCTTCCGGATCGAGGA
ACTGGTCGCCCGCGCCCGGGCGCTCGTGCGCCGCTCGACCGGCCGGGCCGCGCCCCTGCAGAGCGTGGGGCGGCTCGCGC
TCGACATGAACCGCATGACCGCGACCCTCGACGGCCTGCCGCTCGGCCTCGCACCGCTGGAGTTCCGCCTGCTGGCCTAT
CTGATGCTGCACCGAGACAGGGTCGTGCCGCCGACCGAGCTTCTCGAACATCTTTACGGCGACAACGATGCCCGCGAGGC
GAATGCCCTCGAAGCGGTGGTGGCGCGACTGCGCCGCAAGGTCGGGCGCGGCGTCATAGGCACGCGGCGCGGCTTCGGCT
ACCAGCTCGAAGCGGGCCCGTGA

Upstream 100 bases:

>100_bases
AGGTGGATGTCGATGTCGTCACGGGTCTTGTCGTCGAAGTGGAAGACGAGGAGGATGACGACGATGATGACGATGACGAT
GATGACGACGGGATGGAGTG

Downstream 100 bases:

>100_bases
AGCTCCGGTCGATCCGGCTCCGGCTCGTCGTCGTCAATGCTCTGGCGCTTGCCCTTGCACTTGCGGCGGCCGCCTGGGGG
CTGGCCCTGCTGTTCGACCG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRALVVEDDARIAQDLSVALGSAGFRVETAADGETAWFLGGTEGYDLIVLDLGLPKLDGLAVLKRWRAEGVEIPVLVLTA
RGTWTERVEGIDAGADDYLPKPFRIEELVARARALVRRSTGRAAPLQSVGRLALDMNRMTATLDGLPLGLAPLEFRLLAY
LMLHRDRVVPPTELLEHLYGDNDAREANALEAVVARLRRKVGRGVIGTRRGFGYQLEAGP

Sequences:

>Translated_220_residues
MRALVVEDDARIAQDLSVALGSAGFRVETAADGETAWFLGGTEGYDLIVLDLGLPKLDGLAVLKRWRAEGVEIPVLVLTA
RGTWTERVEGIDAGADDYLPKPFRIEELVARARALVRRSTGRAAPLQSVGRLALDMNRMTATLDGLPLGLAPLEFRLLAY
LMLHRDRVVPPTELLEHLYGDNDAREANALEAVVARLRRKVGRGVIGTRRGFGYQLEAGP
>Mature_220_residues
MRALVVEDDARIAQDLSVALGSAGFRVETAADGETAWFLGGTEGYDLIVLDLGLPKLDGLAVLKRWRAEGVEIPVLVLTA
RGTWTERVEGIDAGADDYLPKPFRIEELVARARALVRRSTGRAAPLQSVGRLALDMNRMTATLDGLPLGLAPLEFRLLAY
LMLHRDRVVPPTELLEHLYGDNDAREANALEAVVARLRRKVGRGVIGTRRGFGYQLEAGP

Specific function: Member of the two-component regulatory system pmrB/pmrA involved in regulation of virulence. Unphosphorylated pmrA represses extracellular enzyme genes. Phosphorylation of pmrA by pmrB relieves such repression, which leads to activation of extracellular e

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=42.4107142857143, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=42.0091324200913, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=37.3333333333333, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=33.7837837837838, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.4864864864865, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=35.7142857142857, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.8888888888889, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=37.6106194690265, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=32.5892857142857, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=31.8181818181818, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=25.9911894273128, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790299, Length=106, Percent_Identity=36.7924528301887, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790437, Length=179, Percent_Identity=29.608938547486, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24008; Mature: 24008

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVVEDDARIAQDLSVALGSAGFRVETAADGETAWFLGGTEGYDLIVLDLGLPKLDGL
CCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCCCHHH
AVLKRWRAEGVEIPVLVLTARGTWTERVEGIDAGADDYLPKPFRIEELVARARALVRRST
HHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GRAAPLQSVGRLALDMNRMTATLDGLPLGLAPLEFRLLAYLMLHRDRVVPPTELLEHLYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DNDAREANALEAVVARLRRKVGRGVIGTRRGFGYQLEAGP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCC
>Mature Secondary Structure
MRALVVEDDARIAQDLSVALGSAGFRVETAADGETAWFLGGTEGYDLIVLDLGLPKLDGL
CCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEEEEEECCCCCCHHH
AVLKRWRAEGVEIPVLVLTARGTWTERVEGIDAGADDYLPKPFRIEELVARARALVRRST
HHHHHHHHCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GRAAPLQSVGRLALDMNRMTATLDGLPLGLAPLEFRLLAYLMLHRDRVVPPTELLEHLYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DNDAREANALEAVVARLRRKVGRGVIGTRRGFGYQLEAGP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14617142 [H]