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The map label for this gene is bioA [H]

Identifier: 77461508

GI number: 77461508

Start: 5949854

End: 5951260

Strand: Direct

Name: bioA [H]

Synonym: Pfl01_5287

Alternate gene names: 77461508

Gene position: 5949854-5951260 (Clockwise)

Preceding gene: 77461504

Following gene: 77461509

Centisome position: 92.41

GC content: 61.69

Gene sequence:

>1407_bases
ATGGGCCTGAACAACCAGTGGATGCAACGCGATCTCGCGGTGCTGTGGCATCCCTGCACCCAGATGAAAGACCACGAACA
GCTGCCGCTGATCCCGATCAAGCGCGGTGAAGGCGTCTGGCTGGAAGACTTCGAAGGCAAGCGTTATCTGGATGCGGTCA
GCTCCTGGTGGGTCAACGTGTTCGGCCACGCCAACCCGCGCATCAACCAACGCATCAAGGATCAGGTCGATCAGCTGGAA
CACGTGATTCTGGCCGGTTTCAGCCATCAGCCGGTGATCGAACTGTCCGAGCGTCTGGTGAAGATGACGCCGGAAGGCCT
GAACCGGGTGTTCTACGCCGATAACGGTTCGTCCTGCATCGAAGTCGCGCTGAAAATGAGCTTTCACTACTGGCTCAACC
GCGGCCAGCCGAACAAGAAGCGCTTCGTCACCCTGACCAACAGCTACCACGGCGAAACCATGGCGGCGATGGCGGTCGGT
GACGTGCCATTGTTCACCGAAACCTACAAAGCCCTGCTGATGGACACCATCAAGGTGCCGAGCCCGGATTGCTACCTGCG
CCCGCAGGGCATGAGCTGGGAAGAGCATTCGCGCAACATGTTCGCGGCCATGGAACAGACGCTGGCGGAAAATCATGACA
GCGTCGCGGCCGTGATCGTCGAGCCACTGATCCAGGGCGCCGGCGGCATGCGCATGTACCACCCGGTCTATCTCAAGCTG
CTGCGCGAAGCCTGCGACCGTTACGGTGTGCACCTGATCCACGACGAAATCGCCGTCGGCTTCGGCCGCACCGGAACGAT
GTTCGCCTGCGAACAGGCCGGCATCCGCCCGGACTTCCTGTGCCTGTCGAAAGCCCTGACCGGCGGTTATCTGCCGTTGG
CCGCGTGCCTGACCACCGACGAGGTGTACAGCGCGTTCTACGACGATTACCCGACCCTGCGTGCGTTCCTGCATTCGCAC
AGCTACACCGGCAACCCGCTGGCGTGTGCGGCGGCGTTGGCGACCCTGGATATTTTCGAACAGGACAACGTGATCGAGAA
CAACCGGGCGCTGGCTCAACGCATGGCCTCGGCGACGGCGCATCTGGTGGATCATGCGAATGTTTCGGAAGTCCGTCAGA
CCGGCATGGTGCTGGCGATCGAGATGGTCAAGGACAAAGCCACGAAAGAGGCCTATCCGTGGCAGGAACGTCGCGGGTTG
AAGGTGTTCCAGCATGCGCTGGAGCGCGGCGCGTTGCTGCGCCCGTTGGGCAGCGTGGTGTATTTCCTGCCGCCGTACGT
GATCACCCCGGAGCAGATCGACTTCCTCGCCGAAGTCGCCAGCGAAGGCATCGACATTGCTACCCGCGACAGCGTCAGCG
TGGCGGTGCCGAAAGATTTCCATCCCGGGTTCCGCGATCCGGGCTAA

Upstream 100 bases:

>100_bases
AGCTCAATCGACACAATGGGTTGTTCCGGCGCGACGCATTGCATAGGCTTGCGCGATTGTTTGCCCGCGCCTGACGCGAG
CCGCCTCGAGGAGACTGAAC

Downstream 100 bases:

>100_bases
GCATCACTCGCCACAACAGCGATCCTGATCCAATTTTCTAGAGAACCACCATGAGACTGTCCCGCTTCTTTATCGACGCC
CCGCTCAGCACCGGCGAACA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MGLNNQWMQRDLAVLWHPCTQMKDHEQLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNVFGHANPRINQRIKDQVDQLE
HVILAGFSHQPVIELSERLVKMTPEGLNRVFYADNGSSCIEVALKMSFHYWLNRGQPNKKRFVTLTNSYHGETMAAMAVG
DVPLFTETYKALLMDTIKVPSPDCYLRPQGMSWEEHSRNMFAAMEQTLAENHDSVAAVIVEPLIQGAGGMRMYHPVYLKL
LREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTDEVYSAFYDDYPTLRAFLHSH
SYTGNPLACAAALATLDIFEQDNVIENNRALAQRMASATAHLVDHANVSEVRQTGMVLAIEMVKDKATKEAYPWQERRGL
KVFQHALERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDSVSVAVPKDFHPGFRDPG

Sequences:

>Translated_468_residues
MGLNNQWMQRDLAVLWHPCTQMKDHEQLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNVFGHANPRINQRIKDQVDQLE
HVILAGFSHQPVIELSERLVKMTPEGLNRVFYADNGSSCIEVALKMSFHYWLNRGQPNKKRFVTLTNSYHGETMAAMAVG
DVPLFTETYKALLMDTIKVPSPDCYLRPQGMSWEEHSRNMFAAMEQTLAENHDSVAAVIVEPLIQGAGGMRMYHPVYLKL
LREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTDEVYSAFYDDYPTLRAFLHSH
SYTGNPLACAAALATLDIFEQDNVIENNRALAQRMASATAHLVDHANVSEVRQTGMVLAIEMVKDKATKEAYPWQERRGL
KVFQHALERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDSVSVAVPKDFHPGFRDPG
>Mature_467_residues
GLNNQWMQRDLAVLWHPCTQMKDHEQLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNVFGHANPRINQRIKDQVDQLEH
VILAGFSHQPVIELSERLVKMTPEGLNRVFYADNGSSCIEVALKMSFHYWLNRGQPNKKRFVTLTNSYHGETMAAMAVGD
VPLFTETYKALLMDTIKVPSPDCYLRPQGMSWEEHSRNMFAAMEQTLAENHDSVAAVIVEPLIQGAGGMRMYHPVYLKLL
REACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTDEVYSAFYDDYPTLRAFLHSHS
YTGNPLACAAALATLDIFEQDNVIENNRALAQRMASATAHLVDHANVSEVRQTGMVLAIEMVKDKATKEAYPWQERRGLK
VFQHALERGALLRPLGSVVYFLPPYVITPEQIDFLAEVASEGIDIATRDSVSVAVPKDFHPGFRDPG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=29.7169811320755, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=28.604118993135, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI37574042, Length=455, Percent_Identity=26.3736263736264, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI284507298, Length=334, Percent_Identity=29.0419161676647, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226442705, Length=455, Percent_Identity=25.7142857142857, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI226442709, Length=425, Percent_Identity=26.1176470588235, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24119277, Length=379, Percent_Identity=24.802110817942, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1786991, Length=439, Percent_Identity=40.0911161731207, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI145693181, Length=422, Percent_Identity=30.8056872037915, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789759, Length=407, Percent_Identity=30.958230958231, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1788044, Length=410, Percent_Identity=30.4878048780488, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789016, Length=455, Percent_Identity=27.2527472527473, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1787560, Length=442, Percent_Identity=26.6968325791855, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1786349, Length=389, Percent_Identity=24.4215938303342, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=439, Percent_Identity=26.4236902050114, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144271, Length=421, Percent_Identity=28.0285035629454, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=261, Percent_Identity=32.183908045977, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=421, Percent_Identity=23.2779097387173, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=318, Percent_Identity=22.0125786163522, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324386, Length=462, Percent_Identity=32.034632034632, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6324432, Length=445, Percent_Identity=28.5393258426966, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=451, Percent_Identity=26.6075388026608, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6321456, Length=285, Percent_Identity=23.5087719298246, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=28.5714285714286, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI161085790, Length=458, Percent_Identity=27.5109170305677, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574759, Length=459, Percent_Identity=27.6688453159041, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=25.5369928400955, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 52598; Mature: 52467

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNNQWMQRDLAVLWHPCTQMKDHEQLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNV
CCCCHHHHHHHHHHHHCCHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHH
FGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKMTPEGLNRVFYADNGSSCI
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCEEEEECCCCHHH
EVALKMSFHYWLNRGQPNKKRFVTLTNSYHGETMAAMAVGDVPLFTETYKALLMDTIKVP
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEHEECCCCHHHHHHHHHHHHHHCCC
SPDCYLRPQGMSWEEHSRNMFAAMEQTLAENHDSVAAVIVEPLIQGAGGMRMYHPVYLKL
CCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
LREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTD
HHHHHHHCCEEEEEHHHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHCCCCHHHHHHHHHH
EVYSAFYDDYPTLRAFLHSHSYTGNPLACAAALATLDIFEQDNVIENNRALAQRMASATA
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
HLVDHANVSEVRQTGMVLAIEMVKDKATKEAYPWQERRGLKVFQHALERGALLRPLGSVV
HHHHCCCHHHHHHCCCEEEEEHHHHHHHHCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHH
YFLPPYVITPEQIDFLAEVASEGIDIATRDSVSVAVPKDFHPGFRDPG
HHCCCEEECHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
GLNNQWMQRDLAVLWHPCTQMKDHEQLPLIPIKRGEGVWLEDFEGKRYLDAVSSWWVNV
CCCHHHHHHHHHHHHCCHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHH
FGHANPRINQRIKDQVDQLEHVILAGFSHQPVIELSERLVKMTPEGLNRVFYADNGSSCI
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCEEEEECCCCHHH
EVALKMSFHYWLNRGQPNKKRFVTLTNSYHGETMAAMAVGDVPLFTETYKALLMDTIKVP
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEHEECCCCHHHHHHHHHHHHHHCCC
SPDCYLRPQGMSWEEHSRNMFAAMEQTLAENHDSVAAVIVEPLIQGAGGMRMYHPVYLKL
CCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
LREACDRYGVHLIHDEIAVGFGRTGTMFACEQAGIRPDFLCLSKALTGGYLPLAACLTTD
HHHHHHHCCEEEEEHHHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHCCCCHHHHHHHHHH
EVYSAFYDDYPTLRAFLHSHSYTGNPLACAAALATLDIFEQDNVIENNRALAQRMASATA
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
HLVDHANVSEVRQTGMVLAIEMVKDKATKEAYPWQERRGLKVFQHALERGALLRPLGSVV
HHHHCCCHHHHHHCCCEEEEEHHHHHHHHCCCCCHHHCCHHHHHHHHHCCHHHHHHHHHH
YFLPPYVITPEQIDFLAEVASEGIDIATRDSVSVAVPKDFHPGFRDPG
HHCCCEEECHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]