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The map label for this gene is bioC [H]

Identifier: 77461394

GI number: 77461394

Start: 5818500

End: 5819306

Strand: Reverse

Name: bioC [H]

Synonym: Pfl01_5173

Alternate gene names: 77461394

Gene position: 5819306-5818500 (Counterclockwise)

Preceding gene: 77461395

Following gene: 77461393

Centisome position: 90.38

GC content: 61.83

Gene sequence:

>807_bases
ATGACTGATTTGTCTGTCGCGGCGTTGCCCGGCGGCTTGCCTGACAAGCGCCAGGTCGCGGCTTCTTTTTCTCGCGCAGC
GGCCAGCTACGACAGCGTCGCCGAGTTGCAGCGCGATGTCGGTACGCAGTTGATGAATCGCTTGCCGGTGGATTTTCGGC
CGGCACGCTGGTTGGATCTGGGCTGTGGCACCGGGTATTTCACTCGGGCGCTGGCTGAGCGATTTGGTGAGGGGCTGGCA
CTGGATATCGCTGAGGGCATGCTCCATCACGCGCGGCCGTTGGGTGGGGCCATGCACTTTATTGCTGGCGATGCCGAACG
TTTGCCATTACAGGATTCGACCTGCGATCTGATCTTCTCCAGCCTCGCCGTGCAGTGGTGCGCGGACTTCGAAGCGGTGC
TCGGCGAAGCGTTTCGGGTGCTGAAACCTGGGGGGATTTTCGCGTTTGCTAGTCTTTGTGCAGGGACGCTGTACGAATTG
CGCGATAGCTGGCGTCAGGTCGATGGTCTGGTGCACGTCAACCGCTTCCGCGAATTCGCCCGCTACGAGCAATTGTGCGC
GGCCAGTGGTTTGCGCAGTGTTTGTCTGGAGAACCGGCCGCATGTGCTGCATTACCCGGATGTGCGCAGCCTGACCCATG
AACTCAAGGCCTTGGGCGCGCATAACCTGAACCCTGGCCGGCCGGGTGGATTGACCGGGCGGGCGCGGATTCTGGGGCTG
GTCGAGGCCTACGAGCAGTTCCGTCAGCCTGCGGGATTGCCGGCGACCTACCAGGTGGTCTACGCCGTGTTGGAGAAACC
CTTATGA

Upstream 100 bases:

>100_bases
GTCGAGGTCGGCCTGATCGAGCAGGCCAGCCATGCGTTTCTTCTGGAGGATCCCCACGGTGTGGCGGGTGCAATCCAGGC
GTTTTTAAGTGAGTGCGGTG

Downstream 100 bases:

>100_bases
GCGCAGCCTATTTCATCACCGGAACCGACACTGACGTTGGCAAGACCACCGTCGCCGCCGGGTTGCTGCACGCTGCGCGG
TCGGCGGGGCTGAGTACGGC

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTDLSVAALPGGLPDKRQVAASFSRAAASYDSVAELQRDVGTQLMNRLPVDFRPARWLDLGCGTGYFTRALAERFGEGLA
LDIAEGMLHHARPLGGAMHFIAGDAERLPLQDSTCDLIFSSLAVQWCADFEAVLGEAFRVLKPGGIFAFASLCAGTLYEL
RDSWRQVDGLVHVNRFREFARYEQLCAASGLRSVCLENRPHVLHYPDVRSLTHELKALGAHNLNPGRPGGLTGRARILGL
VEAYEQFRQPAGLPATYQVVYAVLEKPL

Sequences:

>Translated_268_residues
MTDLSVAALPGGLPDKRQVAASFSRAAASYDSVAELQRDVGTQLMNRLPVDFRPARWLDLGCGTGYFTRALAERFGEGLA
LDIAEGMLHHARPLGGAMHFIAGDAERLPLQDSTCDLIFSSLAVQWCADFEAVLGEAFRVLKPGGIFAFASLCAGTLYEL
RDSWRQVDGLVHVNRFREFARYEQLCAASGLRSVCLENRPHVLHYPDVRSLTHELKALGAHNLNPGRPGGLTGRARILGL
VEAYEQFRQPAGLPATYQVVYAVLEKPL
>Mature_267_residues
TDLSVAALPGGLPDKRQVAASFSRAAASYDSVAELQRDVGTQLMNRLPVDFRPARWLDLGCGTGYFTRALAERFGEGLAL
DIAEGMLHHARPLGGAMHFIAGDAERLPLQDSTCDLIFSSLAVQWCADFEAVLGEAFRVLKPGGIFAFASLCAGTLYELR
DSWRQVDGLVHVNRFREFARYEQLCAASGLRSVCLENRPHVLHYPDVRSLTHELKALGAHNLNPGRPGGLTGRARILGLV
EAYEQFRQPAGLPATYQVVYAVLEKPL

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=240, Percent_Identity=30.4166666666667, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI86792933, Length=239, Percent_Identity=26.7782426778243, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786994, Length=239, Percent_Identity=36.4016736401674, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922210, Length=261, Percent_Identity=29.1187739463602, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 29323; Mature: 29192

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDLSVAALPGGLPDKRQVAASFSRAAASYDSVAELQRDVGTQLMNRLPVDFRPARWLDL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GCGTGYFTRALAERFGEGLALDIAEGMLHHARPLGGAMHFIAGDAERLPLQDSTCDLIFS
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHHH
SLAVQWCADFEAVLGEAFRVLKPGGIFAFASLCAGTLYELRDSWRQVDGLVHVNRFREFA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RYEQLCAASGLRSVCLENRPHVLHYPDVRSLTHELKALGAHNLNPGRPGGLTGRARILGL
HHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
VEAYEQFRQPAGLPATYQVVYAVLEKPL
HHHHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]