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The map label for this gene is hemA [H]

Identifier: 77460970

GI number: 77460970

Start: 5352211

End: 5353497

Strand: Reverse

Name: hemA [H]

Synonym: Pfl01_4749

Alternate gene names: 77460970

Gene position: 5353497-5352211 (Counterclockwise)

Preceding gene: 77460978

Following gene: 77460969

Centisome position: 83.15

GC content: 62.08

Gene sequence:

>1287_bases
ATGGCCTTCCTTGCACTCGGTATCAACCACAAGACTGCTTCAGTAGACGTCCGCGAGCGCGTGGCCTTTACCCCTGAGCA
GCTGGTGGAGGCCTTGCAGCAGCTCTGCCGACTCACCGACAGCCGCGAAGCTGCGATCCTCTCCACCTGCAATCGCAGTG
AGCTGTATATAGAACAGGATCAGCTTTCGGCCGATATCGTGCTGCGCTGGCTGGCCGACTATCACCATTTAAGCCTCGAT
GAGCTGCGCGCGAGTGCTTATGTGCATGAAGATGATGCGGCAGTTCGTCACATGATGCGTGTCGCCTCCGGGCTCGACTC
GCTGGTGCTGGGCGAACCGCAGATTCTCGGCCAGATGAAATCGGCCTACGCCGTGGCCCGCGAGGCCGGCACCATCGGGC
CGCTGCTGGGGCGACTGTTCCAGGCGACCTTCAACGCCGCCAAGCAAGTACGTACCGACACCGCCATCGGCGAAAACCCG
GTGTCCGTGGCGTTTGCCGCCGTCAGTCTGGCCAAACAGATTTTCAGCGACCTGCAACGCAGCCAGGCCCTGCTGATCGG
CGCCGGCGAGACCATCACCCTGGTCGCCCGCCACCTGCATGAACTGGGGGTCAAGCGCATCGTGGTCGCCAACCGGACGC
TGGAGCGCGCCAGCCTGCTGGCCGAGCAGTTCGGTGCCCACGCAGTGTTGCTCTCGGACATCCCGGCCGAACTGGTGCGC
AGCGACATCGTCATCAGTTCTACCGCCAGTCAGTTGCCGATTCTCGGTAAAGGCGCGGTGGAAAGCGCGCTGAAGCTGCG
CAAGCACAAGCCGATCTTCATGGTCGACATCGCCGTTCCCCGTGACATCGAGCCAGAAGTCGGCGAACTCGACGACGTTT
ACCTCTATAGCGTCGACGATCTGCACGAAGTGGTCGCTGAAAACCTCAAGAGCCGTCAGGGCGCAGCGCAGGCGGCCGAA
GAGATGGTTTCGGTCGGCGCCGACGATTTCATGGTGCGCCTGCGCGAGCTGGCGGCAGTCGATGTGCTCAAGGCCTATCG
TCAACAGAGCGAACGCCTGCGCGACGAAGAACTGCAAAAGGCCCTGCGCCTGCTGGCCAATGGCGGCAACGCCGAAGACG
TGCTCGGGCAACTGGCCCGTGGCCTGACCAACAAACTCCTGCACGCCCCGAGCGTGCAGTTGAAAAAGCTTTCTGCCGAA
GGCCGCCTCGATGCGCTGGCCATGGCTCAGGAACTCTTTGCCCTCGAGGGCTCACCGGATAGCTTTTCGGATAAAAAACC
GCAATGA

Upstream 100 bases:

>100_bases
ATTATAGGGGCCGGCAATTGGGACAATAGTCAGCGGTAGTTGTTCTGAATCTGACGAAGTAGGACAATTGCCGGCTTCAC
GTCACCATCAGCGACCTTGA

Downstream 100 bases:

>100_bases
AAGCGTCACTGCTCAATAAGCTGGACATTCTCCAGGACCGTTTCGAGGAACTGACCGCGCTGCTCGGCGACGGCGAAGTC
ATTTCCGACCAGACCAAATT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MAFLALGINHKTASVDVRERVAFTPEQLVEALQQLCRLTDSREAAILSTCNRSELYIEQDQLSADIVLRWLADYHHLSLD
ELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTIGPLLGRLFQATFNAAKQVRTDTAIGENP
VSVAFAAVSLAKQIFSDLQRSQALLIGAGETITLVARHLHELGVKRIVVANRTLERASLLAEQFGAHAVLLSDIPAELVR
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAAQAAE
EMVSVGADDFMVRLRELAAVDVLKAYRQQSERLRDEELQKALRLLANGGNAEDVLGQLARGLTNKLLHAPSVQLKKLSAE
GRLDALAMAQELFALEGSPDSFSDKKPQ

Sequences:

>Translated_428_residues
MAFLALGINHKTASVDVRERVAFTPEQLVEALQQLCRLTDSREAAILSTCNRSELYIEQDQLSADIVLRWLADYHHLSLD
ELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTIGPLLGRLFQATFNAAKQVRTDTAIGENP
VSVAFAAVSLAKQIFSDLQRSQALLIGAGETITLVARHLHELGVKRIVVANRTLERASLLAEQFGAHAVLLSDIPAELVR
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAAQAAE
EMVSVGADDFMVRLRELAAVDVLKAYRQQSERLRDEELQKALRLLANGGNAEDVLGQLARGLTNKLLHAPSVQLKKLSAE
GRLDALAMAQELFALEGSPDSFSDKKPQ
>Mature_427_residues
AFLALGINHKTASVDVRERVAFTPEQLVEALQQLCRLTDSREAAILSTCNRSELYIEQDQLSADIVLRWLADYHHLSLDE
LRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMKSAYAVAREAGTIGPLLGRLFQATFNAAKQVRTDTAIGENPV
SVAFAAVSLAKQIFSDLQRSQALLIGAGETITLVARHLHELGVKRIVVANRTLERASLLAEQFGAHAVLLSDIPAELVRS
DIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAAQAAEE
MVSVGADDFMVRLRELAAVDVLKAYRQQSERLRDEELQKALRLLANGGNAEDVLGQLARGLTNKLLHAPSVQLKKLSAEG
RLDALAMAQELFALEGSPDSFSDKKPQ

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=419, Percent_Identity=51.5513126491647, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 46687; Mature: 46556

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLALGINHKTASVDVRERVAFTPEQLVEALQQLCRLTDSREAAILSTCNRSELYIEQD
CEEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEHH
QLSADIVLRWLADYHHLSLDELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMK
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
SAYAVAREAGTIGPLLGRLFQATFNAAKQVRTDTAIGENPVSVAFAAVSLAKQIFSDLQR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SQALLIGAGETITLVARHLHELGVKRIVVANRTLERASLLAEQFGAHAVLLSDIPAELVR
CCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCHHHHH
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDD
HHHEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHH
LHEVVAENLKSRQGAAQAAEEMVSVGADDFMVRLRELAAVDVLKAYRQQSERLRDEELQK
HHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRLLANGGNAEDVLGQLARGLTNKLLHAPSVQLKKLSAEGRLDALAMAQELFALEGSPD
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
SFSDKKPQ
CCCCCCCC
>Mature Secondary Structure 
AFLALGINHKTASVDVRERVAFTPEQLVEALQQLCRLTDSREAAILSTCNRSELYIEQD
EEEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEHH
QLSADIVLRWLADYHHLSLDELRASAYVHEDDAAVRHMMRVASGLDSLVLGEPQILGQMK
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHH
SAYAVAREAGTIGPLLGRLFQATFNAAKQVRTDTAIGENPVSVAFAAVSLAKQIFSDLQR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SQALLIGAGETITLVARHLHELGVKRIVVANRTLERASLLAEQFGAHAVLLSDIPAELVR
CCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCHHHHH
SDIVISSTASQLPILGKGAVESALKLRKHKPIFMVDIAVPRDIEPEVGELDDVYLYSVDD
HHHEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHH
LHEVVAENLKSRQGAAQAAEEMVSVGADDFMVRLRELAAVDVLKAYRQQSERLRDEELQK
HHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRLLANGGNAEDVLGQLARGLTNKLLHAPSVQLKKLSAEGRLDALAMAQELFALEGSPD
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
SFSDKKPQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA