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The map label for this gene is uraA [H]

Identifier: 77460950

GI number: 77460950

Start: 5334555

End: 5335829

Strand: Direct

Name: uraA [H]

Synonym: Pfl01_4729

Alternate gene names: 77460950

Gene position: 5334555-5335829 (Clockwise)

Preceding gene: 77460949

Following gene: 77460953

Centisome position: 82.86

GC content: 62.2

Gene sequence:

>1275_bases
ATGCAGCAAGAGTTCAACGATCCGCTCTGGCGTACGGTGCTGTCCGGCGCACAGATGCTGTTCGTGGCTTTCGGCGCCCT
GGTGCTGATGCCACTGATCACGGGCCTGGACCCGAACGTGGCACTGTTTACCGCAGGTTTAGGCACGATTCTGTTCCAGA
TCGTCACCGGGCGTCAGGTGCCGGTGTTCCTGGCATCGAGCTTCGCCTTCATCACCCCGATCATTCTCGCCAAGGGCCAG
TTCGGCCTCGCCGCGACCATGGGCGGCGTGATGGCGGCCGGTTTCGTCTACACCTTCCTCGGCCTGGCCGTGAAGATCAA
AGGCACCGGGTTCATTGACCGTCTGCTGCCGCCAGTCGTAATTGGCCCGGTGATCATCTCCATTGGCCTGGCCATGGCGC
CGATTGCCGCGAACATGGCGATGGGCAAGGCCGGTGACGGTTCCGAGCTGATCCATTACCAGACCGCAATGATGATCTCG
ATGCCGGCACTGCTGACCACGTTGATCGTGGCGGTGTTCGGCAAAGGCATTTTCCGTCTGGTGCCGATTATTTCCGGGGT
GCTGGTGGGCTTTGCCATGTCCTTCTATTTCGGTGTCGTCGACACCGCGAAGATTGCGGCGGCCCCATGGTTTGCACTTC
CTCATTTCACCGCGCCGGAGTTCAACTGGCAGGCGATCCTGTTCATCGTCCCGGTGGCGCTGGCCCCGGCCATCGAACAC
ATCGGCGGCGTGATTGCGGTCGGCAGCGTGACCGGTCGCGACTACCTGAAGAAGCCGGGCCTGCATCGCACCCTGCTCGG
TGACGGTATCGCCACCACGGCTGCCGGCCTGTTCGGCGGTCCGCCCAACACGACCTACGCGGAAGTGACTGGCGCGGTGA
TGCTGACCAAGAACTACAACCCTAAAATCATGACCTGGGCGGCGATCTTCGCCATCAGCCTGGCGTTCATCGGCAAGTTC
GGCGCCCTGCTGCAAAGCATTCCGGTGCCGGTGATGGGCGGGATTCTGTGCCTGCTGTTCGGTTCGATCGCGGCGGTGGG
GATGAACACCCTGATCCGTCACAAGATCGACCTGGGCGAAGCGCGCAATCTGGTAATCGTTTCGGTGACCCTGGTGTTCG
GTATCGGCGGTGTGCTGGTCGGCACCGGGACCGGCCCGGACGACTTCGGCCTCAAAGGCATCGCGCTGTGCGCGGTGGTG
GCGATTGCGCTGAACCTGCTGCTGCCGGGTAACGACAGCTGGAAACAGAAGAAGGCGGATGAGCCGCTGATCTAA

Upstream 100 bases:

>100_bases
CGTCCATCGATCAGAAACTCAACGAGCACGGTTACATCATTCCTGGGCTTGGCGACGCCGGTGACAAGATCTTCGGCACC
AAGCAGAAGGACGCGTAAGC

Downstream 100 bases:

>100_bases
GCCCTTAGCTTCATCGCCTGAAAGACCGCTATCGCCAGCAGGCTGGCTCCCACATTGAAATGCGCTTTCCTGTGGGAGCA
AGCCTGCTGGCGATGCTTTT

Product: xanthine/uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MQQEFNDPLWRTVLSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTILFQIVTGRQVPVFLASSFAFITPIILAKGQ
FGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPVVIGPVIISIGLAMAPIAANMAMGKAGDGSELIHYQTAMMIS
MPALLTTLIVAVFGKGIFRLVPIISGVLVGFAMSFYFGVVDTAKIAAAPWFALPHFTAPEFNWQAILFIVPVALAPAIEH
IGGVIAVGSVTGRDYLKKPGLHRTLLGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNYNPKIMTWAAIFAISLAFIGKF
GALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLGEARNLVIVSVTLVFGIGGVLVGTGTGPDDFGLKGIALCAVV
AIALNLLLPGNDSWKQKKADEPLI

Sequences:

>Translated_424_residues
MQQEFNDPLWRTVLSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTILFQIVTGRQVPVFLASSFAFITPIILAKGQ
FGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPVVIGPVIISIGLAMAPIAANMAMGKAGDGSELIHYQTAMMIS
MPALLTTLIVAVFGKGIFRLVPIISGVLVGFAMSFYFGVVDTAKIAAAPWFALPHFTAPEFNWQAILFIVPVALAPAIEH
IGGVIAVGSVTGRDYLKKPGLHRTLLGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNYNPKIMTWAAIFAISLAFIGKF
GALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLGEARNLVIVSVTLVFGIGGVLVGTGTGPDDFGLKGIALCAVV
AIALNLLLPGNDSWKQKKADEPLI
>Mature_424_residues
MQQEFNDPLWRTVLSGAQMLFVAFGALVLMPLITGLDPNVALFTAGLGTILFQIVTGRQVPVFLASSFAFITPIILAKGQ
FGLAATMGGVMAAGFVYTFLGLAVKIKGTGFIDRLLPPVVIGPVIISIGLAMAPIAANMAMGKAGDGSELIHYQTAMMIS
MPALLTTLIVAVFGKGIFRLVPIISGVLVGFAMSFYFGVVDTAKIAAAPWFALPHFTAPEFNWQAILFIVPVALAPAIEH
IGGVIAVGSVTGRDYLKKPGLHRTLLGDGIATTAAGLFGGPPNTTYAEVTGAVMLTKNYNPKIMTWAAIFAISLAFIGKF
GALLQSIPVPVMGGILCLLFGSIAAVGMNTLIRHKIDLGEARNLVIVSVTLVFGIGGVLVGTGTGPDDFGLKGIALCAVV
AIALNLLLPGNDSWKQKKADEPLI

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=439, Percent_Identity=25.5125284738041, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI40316845, Length=439, Percent_Identity=25.5125284738041, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI44680145, Length=435, Percent_Identity=24.5977011494253, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI44680143, Length=436, Percent_Identity=24.3119266055046, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788843, Length=405, Percent_Identity=39.7530864197531, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87081818, Length=431, Percent_Identity=38.7470997679814, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87082181, Length=448, Percent_Identity=28.3482142857143, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082178, Length=411, Percent_Identity=23.8442822384428, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790087, Length=443, Percent_Identity=22.3476297968397, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=203, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=172, Percent_Identity=29.6511627906977, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356175, Length=430, Percent_Identity=24.6511627906977, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44210; Mature: 44210

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure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CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]