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The map label for this gene is upp [H]

Identifier: 77460949

GI number: 77460949

Start: 5333914

End: 5334552

Strand: Direct

Name: upp [H]

Synonym: Pfl01_4728

Alternate gene names: 77460949

Gene position: 5333914-5334552 (Clockwise)

Preceding gene: 77460945

Following gene: 77460950

Centisome position: 82.85

GC content: 59.15

Gene sequence:

>639_bases
ATGTCCATCCAAGAGATCCGCCATCCGCTGATCCGTCACAAACTTGGCCTTATGCGCCGTGCAGACATCAGCACCAAGAA
TTTCCGTGAGCTCGCTCAGGAAGTCGGTGCCCTGTTGACCTATGAAGCTACCAAAGACCTGCCGCTGGAAACCTACGATA
TCGAAGGTTGGTGCGGCACCGTGTCGGTCGAGAAAATCGCCGGCAAGAAGATCACCGTCGTGCCGATCCTGCGTGCCGGC
ATCGGCATGCTCGAAGGCGTGCTGAGCCTGATCCCGGGTGCGAAAGTCAGCGCCGTCGGCGTTGCCCGTAACGAAGAAAC
CCTGCAGGCCCACACCTATCTGGAAAAACTGGTTCCGGAAATCGACGAACGCCTGGCGATGATCATCGACCCGATGCTCG
CCACCGGCAGCTCCATGGTCGCGACCATCGACCTGCTGAAGAAGGCCGGTTGCAAGGACATCCGTGCGATGGTGCTGGTT
GCCGCGCCGGAAGGCATTGCCGCTGTCGAGCAAGCCCACCCGGACGTGATCATCTACACCGCGTCCATCGATCAGAAACT
CAACGAGCACGGTTACATCATTCCTGGGCTTGGCGACGCCGGTGACAAGATCTTCGGCACCAAGCAGAAGGACGCGTAA

Upstream 100 bases:

>100_bases
CAAGCATTTGTGGACTAACGTACTGTATGTCCTATAGGACATCACCCTCGGATAGATTAATCTAGGCCGGTTTTTTTGCC
CGCCGCCGGAGCCTTTCCCC

Downstream 100 bases:

>100_bases
GCATGCAGCAAGAGTTCAACGATCCGCTCTGGCGTACGGTGCTGTCCGGCGCACAGATGCTGTTCGTGGCTTTCGGCGCC
CTGGTGCTGATGCCACTGAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSIQEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWCGTVSVEKIAGKKITVVPILRAG
IGMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLV
AAPEGIAAVEQAHPDVIIYTASIDQKLNEHGYIIPGLGDAGDKIFGTKQKDA

Sequences:

>Translated_212_residues
MSIQEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWCGTVSVEKIAGKKITVVPILRAG
IGMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLV
AAPEGIAAVEQAHPDVIIYTASIDQKLNEHGYIIPGLGDAGDKIFGTKQKDA
>Mature_211_residues
SIQEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWCGTVSVEKIAGKKITVVPILRAGI
GMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLVA
APEGIAAVEQAHPDVIIYTASIDQKLNEHGYIIPGLGDAGDKIFGTKQKDA

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=71.1538461538462, Blast_Score=310, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=26.3681592039801, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=26.3681592039801, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=207, Percent_Identity=32.8502415458937, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22923; Mature: 22792

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWCGT
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCC
VSVEKIAGKKITVVPILRAGIGMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPE
EEHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
IDERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLVAAPEGIAAVEQAHPDVIIYT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEEEEEECCCCHHHHHHCCCCEEEEE
ASIDQKLNEHGYIIPGLGDAGDKIFGTKQKDA
CCHHHHHCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIQEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWCGT
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCC
VSVEKIAGKKITVVPILRAGIGMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPE
EEHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
IDERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLVAAPEGIAAVEQAHPDVIIYT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEEEEEECCCCHHHHHHCCCCEEEEE
ASIDQKLNEHGYIIPGLGDAGDKIFGTKQKDA
CCHHHHHCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA