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The map label for this gene is guaB [H]

Identifier: 77460809

GI number: 77460809

Start: 5187501

End: 5188970

Strand: Reverse

Name: guaB [H]

Synonym: Pfl01_4588

Alternate gene names: 77460809

Gene position: 5188970-5187501 (Counterclockwise)

Preceding gene: 77460810

Following gene: 77460808

Centisome position: 80.59

GC content: 60.54

Gene sequence:

>1470_bases
ATGCTGCGTATCAGCCAAGAAGCTCTGACCTTCGACGACATTCTTTTAGTGCCTGGTTATTCCGAGGTGCTTCCTAACGA
AGTCAGTCTGAAGACCCGCCTTACCCGTGGCATCGAGCTGAACATTCCTCTGGTTTCTGCCGCCATGGACACCGTCACCG
AAGCCCGTCTGGCAATCGCCATGGCTCAGGAAGGTGGCATCGGCATTATCCACAAGAACATGACCATCGAGCAGCAAGCT
GCCGAAGTTCGCAAGGTCAAGAAGTTCGAAGCCGGTGTGGTCAAGGACCCAATCACGATCGAGGCTGACGCCACGGTTCG
TGATCTGTTCGAACTGACCCGCATGCACAACATTTCCGGCGTTCCGGTCCTGCACGATGGCGACCTGGTCGGCATCGTCA
CTTCCCGTGACGTGCGTTTCGAAACCCGTCTGGACGCCACCGTTCGTGAAGTGATGACGCCGAAAGAGCGTCTGGTCACT
GTTCGCGAAGGCGCCGACAAGAACGAAGTCCGCGAGCTGCTGCACAAGCACCGCCTGGAAAAAGTCCTGATCGTCGACGA
CAAGTTTGCCCTCAAAGGCATGATGACCGTCAAAGACATCGAAAAAGCCAAGGCCTACCCGCTGGCCAGCAAGGACGACC
AAGGTCGTCTGCGCGTCGGCGCTGCGGTCGGTACCGGTAAAGACACCGGTGACCGCGTTGCAGCCCTGGTCAATGCCGGT
GTGGACGTGGTGGTGGTCGACACCGCTCACGGTCACTCCAAAGGCGTGATCGACCGCGTTCGCTGGGTCAAAGAGAACTT
CCCTGAAGTGCAGGTGATCGGCGGCAACATCGCCACCGGCGCTGCCGCCAAGGCCCTGGCCGAAGCTGGCGCCGACGCGG
TCAAGGTCGGTATCGGCCCTGGCTCGATCTGCACCACCCGTATCGTCGCCGGTGTCGGCGTTCCGCAAATCAGTGCCATC
GCCAACGTTGCCGCTGCCCTCGAAGGCACCGGCGTTCCGTTGATCGCCGACGGCGGCATCCGTTTCTCCGGTGACCTGTC
CAAGGCCATCGTGGCCGGTGCGTCCTGCGTGATGATGGGCTCGATGTTCGCCGGTACCGAAGAAGCACCGGGCGAGATCG
AACTGTTCCAGGGCCGTTCGTACAAGGCTTATCGCGGCATGGGTTCGCTGGGCGCCATGTCCCAGGCTCAAGGTTCCTCC
GACCGTTACTTCCAGGACTCCTCGGCAGGCGCCGAGAAACTCGTTCCGGAAGGCATCGAAGGCCGTGTGCCTTACAAGGG
CACCCTGAGCGCGATCATTCACCAGTTGATGGGCGGTCTGCGTTCCTCGATGGGTTACACCGGCAGCGCCAACATCGAAG
AAATGCGCACCAAGCCTGAGTTCGTGCGGATCACCGGTGCCGGCATGGCCGAATCCCACGTTCACGACGTGCAGATCACC
AAGGAAGCGCCAAACTACCGCGTAGGTTGA

Upstream 100 bases:

>100_bases
TACATCAGCAACATTGATATAAGACAAGTTTTACATTGAGCCCGGTAGGGTGTCTGAGTATAATGGCGCGCTTCCATTTT
CCCGCTCGGGAGCCCCCGCG

Downstream 100 bases:

>100_bases
GGCTTCAAGCAAAACGTTAAATGACCGGGGCTGTTTTATTCAGCCCCGAGTCGTTTCTGAATTACTTAGACGAGACTGAA
TCATGGCCCTCGACATTCAC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMTIEQQA
AEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISGVPVLHDGDLVGIVTSRDVRFETRLDATVREVMTPKERLVT
VREGADKNEVRELLHKHRLEKVLIVDDKFALKGMMTVKDIEKAKAYPLASKDDQGRLRVGAAVGTGKDTGDRVAALVNAG
VDVVVVDTAHGHSKGVIDRVRWVKENFPEVQVIGGNIATGAAAKALAEAGADAVKVGIGPGSICTTRIVAGVGVPQISAI
ANVAAALEGTGVPLIADGGIRFSGDLSKAIVAGASCVMMGSMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSS
DRYFQDSSAGAEKLVPEGIEGRVPYKGTLSAIIHQLMGGLRSSMGYTGSANIEEMRTKPEFVRITGAGMAESHVHDVQIT
KEAPNYRVG

Sequences:

>Translated_489_residues
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMTIEQQA
AEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISGVPVLHDGDLVGIVTSRDVRFETRLDATVREVMTPKERLVT
VREGADKNEVRELLHKHRLEKVLIVDDKFALKGMMTVKDIEKAKAYPLASKDDQGRLRVGAAVGTGKDTGDRVAALVNAG
VDVVVVDTAHGHSKGVIDRVRWVKENFPEVQVIGGNIATGAAAKALAEAGADAVKVGIGPGSICTTRIVAGVGVPQISAI
ANVAAALEGTGVPLIADGGIRFSGDLSKAIVAGASCVMMGSMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSS
DRYFQDSSAGAEKLVPEGIEGRVPYKGTLSAIIHQLMGGLRSSMGYTGSANIEEMRTKPEFVRITGAGMAESHVHDVQIT
KEAPNYRVG
>Mature_489_residues
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMTIEQQA
AEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISGVPVLHDGDLVGIVTSRDVRFETRLDATVREVMTPKERLVT
VREGADKNEVRELLHKHRLEKVLIVDDKFALKGMMTVKDIEKAKAYPLASKDDQGRLRVGAAVGTGKDTGDRVAALVNAG
VDVVVVDTAHGHSKGVIDRVRWVKENFPEVQVIGGNIATGAAAKALAEAGADAVKVGIGPGSICTTRIVAGVGVPQISAI
ANVAAALEGTGVPLIADGGIRFSGDLSKAIVAGASCVMMGSMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSS
DRYFQDSSAGAEKLVPEGIEGRVPYKGTLSAIIHQLMGGLRSSMGYTGSANIEEMRTKPEFVRITGAGMAESHVHDVQIT
KEAPNYRVG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=485, Percent_Identity=43.298969072165, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=462, Percent_Identity=44.3722943722944, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=462, Percent_Identity=44.3722943722944, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=462, Percent_Identity=44.3722943722944, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=42.1487603305785, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=44.5676274944568, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI217035148, Length=485, Percent_Identity=42.2680412371134, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI217035150, Length=485, Percent_Identity=39.7938144329897, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=36.1538461538462, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=37.2, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=37.2, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=37.2, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=37.2, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=67.1428571428571, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1786293, Length=228, Percent_Identity=36.4035087719298, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=501, Percent_Identity=38.9221556886228, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=42.5178147268409, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=36.0995850622407, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=40.9090909090909, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=41.1157024793388, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=486, Percent_Identity=41.358024691358, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=41.7159763313609, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=102, Percent_Identity=43.1372549019608, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=41.8219461697723, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=41.8219461697723, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.7233560090703, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51949; Mature: 51949

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEECCCHHHHCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHEEE
MAQEGGIGIIHKNMTIEQQAAEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
VPVLHDGDLVGIVTSRDVRFETRLDATVREVMTPKERLVTVREGADKNEVRELLHKHRLE
CEEEECCCEEEEEECCCEEEEHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHHCCC
KVLIVDDKFALKGMMTVKDIEKAKAYPLASKDDQGRLRVGAAVGTGKDTGDRVAALVNAG
EEEEECCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
VDVVVVDTAHGHSKGVIDRVRWVKENFPEVQVIGGNIATGAAAKALAEAGADAVKVGIGP
CEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLSKAIVAGASCVMMG
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHHCCHHHHHH
SMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSSDRYFQDSSAGAEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCHHCCCCCCCEECCCCCCHHHHCCCCCC
GRVPYKGTLSAIIHQLMGGLRSSMGYTGSANIEEMRTKPEFVRITGAGMAESHVHDVQIT
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEEEEE
KEAPNYRVG
CCCCCCCCC
>Mature Secondary Structure
MLRISQEALTFDDILLVPGYSEVLPNEVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEECCCHHHHCCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHEEE
MAQEGGIGIIHKNMTIEQQAAEVRKVKKFEAGVVKDPITIEADATVRDLFELTRMHNISG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
VPVLHDGDLVGIVTSRDVRFETRLDATVREVMTPKERLVTVREGADKNEVRELLHKHRLE
CEEEECCCEEEEEECCCEEEEHHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHHCCC
KVLIVDDKFALKGMMTVKDIEKAKAYPLASKDDQGRLRVGAAVGTGKDTGDRVAALVNAG
EEEEECCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
VDVVVVDTAHGHSKGVIDRVRWVKENFPEVQVIGGNIATGAAAKALAEAGADAVKVGIGP
CEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLSKAIVAGASCVMMG
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHHHCCHHHHHH
SMFAGTEEAPGEIELFQGRSYKAYRGMGSLGAMSQAQGSSDRYFQDSSAGAEKLVPEGIE
HHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCHHCCCCCCCEECCCCCCHHHHCCCCCC
GRVPYKGTLSAIIHQLMGGLRSSMGYTGSANIEEMRTKPEFVRITGAGMAESHVHDVQIT
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEEEEE
KEAPNYRVG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA