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The map label for this gene is guaA [H]

Identifier: 77460808

GI number: 77460808

Start: 5185841

End: 5187418

Strand: Reverse

Name: guaA [H]

Synonym: Pfl01_4587

Alternate gene names: 77460808

Gene position: 5187418-5185841 (Counterclockwise)

Preceding gene: 77460809

Following gene: 77460806

Centisome position: 80.57

GC content: 61.6

Gene sequence:

>1578_bases
ATGGCCCTCGACATTCACGCTCACCGCATCCTGATCCTCGACTTCGGTTCGCAATACACCCAACTGATCGCCCGCCGCGT
GCGCGAGATCGGTGTGTACTGCGAACTGCACCCGTTCGACATGGACGAAGATGCGATCCGCGAATTTGCGCCAAAAGGCG
TGATCCTCGCCGGCGGTCCCGAGTCCGTGCACGAAGCCAACAGCCCGCGCTGCCCGCAAGCGGTTTTCGACCTGGGCGTA
CCGGTCTTCGGTATCTGCTACGGCATGCAGACCATGGCCGAGCAACTGGGCGGCAAGGTTGAAGGCTCCGAACTGCGTGA
GTTCGGTTATGCCCGCGTTGACGTGGTCGGCAAGAGCCGTCTGCTCGACGGCATCGAAGACCACATCGACGCCGACGGCC
TGTTCGGCCTCGACGTGTGGATGAGCCACGGTGACAAGGTCACCAAGATGCCAAGCGATTTCCACATTCTGGCCAGCACC
CCGAGCTGCCCGATCGCCGGCATGTTCAACGACGAACGCGCTTACTACGGCGTACAGTTCCACCCGGAAGTGACCCACAC
CAAGCAGGGCGGTCGCATCCTGTCGCGTTTCGTTCTCGACATCTGCGGCTGTGAAGCCCTGTGGACCCCGTCGAAGATCG
CCGAAGACGCCATCGCCAACATTCGCGCGCAGGTCGGCACTGACAACGTGCTGCTGGGTCTGTCCGGCGGTGTGGATTCC
TCGGTGGTTGCGGCGCTGCTGCACAAGGCCATCGGTGATCAACTGACCTGCGTCTTCGTCGACAACGGCCTGCTGCGCCT
GCACGAAGGCGAGCAGGTTATGGCCATGTTCGCCGAAAACATGGGCGTCAAGGTGATCCGCGCCAACGCTGAAGACCAGT
TCCTCAACAACCTGGCCGGCGAAGCCGATCCGGAGAAGAAGCGCAAGATCATCGGCCGCACCTTCATCGACGTGTTCGAT
GCCGAATCCTGCAAGCTGGACAACATCAAGTACCTGGCTCAGGGCACCATCTACCCGGACGTGATCGAGTCGGCTGGCGC
GAAAAGCGGCAAGGCCCACGTGATCAAGTCGCACCACAACGTGGGCGGCCTGCCGGAAGAAATGAACCTGAAACTGGTCG
AGCCACTGCGCGAACTGTTCAAGGACGAAGTCCGTCGTCTGGGTCTGGAACTGGGCCTGCCGTACGACATGGTCTACCGT
CACCCGTTCCCGGGCCCGGGCCTGGGCGTACGGATCCTCGGTGAAGTGAAGAAGGAATACGCCGACCTGCTGCGTCGCGC
CGACCACATCTTCATCGAAGAACTGCGCAAGGCCGACTGGTACCACAAGGTCAGCCAGGCGTTTGTCGTGTTCCAGCCGG
TGAAATCGGTGGGCGTGGTCGGCGATGGCCGCCGTTACGCCTGGGTCGTGGCCCTGCGTGCCGTGGAAACCATCGACTTC
ATGACCGCACGTTGGGCACACCTGCCTTACGAACTGCTGGAAACCGTTTCCGGCCGAATCATCAATGAAATCGAAGGCAT
CTCCCGCGTGACTTACGACGTGTCGAGCAAGCCGCCGGCGACGATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
AACTACCGCGTAGGTTGAGGCTTCAAGCAAAACGTTAAATGACCGGGGCTGTTTTATTCAGCCCCGAGTCGTTTCTGAAT
TACTTAGACGAGACTGAATC

Downstream 100 bases:

>100_bases
TCCCGCGACACCGGTTGTATTGATGCAATGAAAAACCCTGGCTTCGGCCAGGGTTTTTTTGTTTGTGGCAATGGGCAGGT
CAGTGGGGAAGGCGGCTTTG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDEDAIREFAPKGVILAGGPESVHEANSPRCPQAVFDLGV
PVFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKMPSDFHILAST
PSCPIAGMFNDERAYYGVQFHPEVTHTKQGGRILSRFVLDICGCEALWTPSKIAEDAIANIRAQVGTDNVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAGEADPEKKRKIIGRTFIDVFD
AESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE

Sequences:

>Translated_525_residues
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDEDAIREFAPKGVILAGGPESVHEANSPRCPQAVFDLGV
PVFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKMPSDFHILAST
PSCPIAGMFNDERAYYGVQFHPEVTHTKQGGRILSRFVLDICGCEALWTPSKIAEDAIANIRAQVGTDNVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAGEADPEKKRKIIGRTFIDVFD
AESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
>Mature_524_residues
ALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDEDAIREFAPKGVILAGGPESVHEANSPRCPQAVFDLGVP
VFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSRLLDGIEDHIDADGLFGLDVWMSHGDKVTKMPSDFHILASTP
SCPIAGMFNDERAYYGVQFHPEVTHTKQGGRILSRFVLDICGCEALWTPSKIAEDAIANIRAQVGTDNVLLGLSGGVDSS
VVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAGEADPEKKRKIIGRTFIDVFDA
ESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHNVGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRH
PFPGPGLGVRILGEVKKEYADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDFM
TARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=528, Percent_Identity=36.5530303030303, Blast_Score=299, Evalue=5e-81,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=72.952380952381, Blast_Score=801, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=36, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=36, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=36, Blast_Score=300, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=49.3307839388145, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI281365319, Length=554, Percent_Identity=34.115523465704, Blast_Score=274, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58223; Mature: 58092

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDEDAIREFAPKGVILAGGP
CEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHCCCCEEEECCC
ESVHEANSPRCPQAVFDLGVPVFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSR
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCHHH
LLDGIEDHIDADGLFGLDVWMSHGDKVTKMPSDFHILASTPSCPIAGMFNDERAYYGVQF
HHHHHHHHCCCCCEEEHHHHHCCCCEEECCCCCCEEEECCCCCCEECCCCCCCEEEEEEE
HPEVTHTKQGGRILSRFVLDICGCEALWTPSKIAEDAIANIRAQVGTDNVLLGLSGGVDS
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAG
HHHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHCC
EADPEKKRKIIGRTFIDVFDAESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEY
CCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
ADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHCCCCCCCCCEEEHHHHHHHHHHHH
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC
>Mature Secondary Structure 
ALDIHAHRILILDFGSQYTQLIARRVREIGVYCELHPFDMDEDAIREFAPKGVILAGGP
EEEEEEEEEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHCCCCEEEECCC
ESVHEANSPRCPQAVFDLGVPVFGICYGMQTMAEQLGGKVEGSELREFGYARVDVVGKSR
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCHHH
LLDGIEDHIDADGLFGLDVWMSHGDKVTKMPSDFHILASTPSCPIAGMFNDERAYYGVQF
HHHHHHHHCCCCCEEEHHHHHCCCCEEECCCCCCEEEECCCCCCEECCCCCCCEEEEEEE
HPEVTHTKQGGRILSRFVLDICGCEALWTPSKIAEDAIANIRAQVGTDNVLLGLSGGVDS
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDNGLLRLHEGEQVMAMFAENMGVKVIRANAEDQFLNNLAG
HHHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHCC
EADPEKKRKIIGRTFIDVFDAESCKLDNIKYLAQGTIYPDVIESAGAKSGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPEEMNLKLVEPLRELFKDEVRRLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEY
CCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
ADLLRRADHIFIEELRKADWYHKVSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHCCCCCCCCCEEEHHHHHHHHHHHH
MTARWAHLPYELLETVSGRIINEIEGISRVTYDVSSKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA