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The map label for this gene is mco [H]

Identifier: 77460806

GI number: 77460806

Start: 5181107

End: 5182489

Strand: Reverse

Name: mco [H]

Synonym: Pfl01_4585

Alternate gene names: 77460806

Gene position: 5182489-5181107 (Counterclockwise)

Preceding gene: 77460808

Following gene: 77460805

Centisome position: 80.49

GC content: 63.2

Gene sequence:

>1383_bases
GTGTCCATCTCCTTTACCCGTCGACAAATTCTCGGTGGCCTGGCCGGTCTTGCAGTGGTTGGCGCGGGAGCCGGTGGTGC
GACGCGTTACTGGTTGGGCAAGGTGGCGGATGCCAACGCGGGACACGACTACGAACTGATCGCTGCGCCTCTGGACGTCG
AGCTGGTGCCGGGACACAAGACCGAGGCCTGGGCGTTCGGTCCGTCGGCGCCGGGCACCGAATTGCGTGTGCGTCAGGGC
GAGTGGCTGCGGGTGCGGTTCATCAACCATCTGCCGGTGGCGACGACCATTCACTGGCACGGCATCCGCCTGCCGCTGGA
GATGGACGGCGTGCCCTATGTGTCGCAGTTGCCGGTGCTGCCGGGCGAATACTTCGATTACAAATTCCGTGTGCCGGACG
CCGGCAGCTACTGGTATCACCCGCACGTCAGCAGCAGCGAAGAACTCGGTCGCGGGCTGGTCGGGCCGTTGATTGTCGAG
GAGCGCGAGCCGACCGGGTTCAAGTACGAAAAGACCCTGAGCCTGAAAAACTGGCACATCGACGACGAGGGCAACTTCGT
CGAGTTCAGCATTCCCCGTGAAGCGGCCCGAGGCGGTACGGCGGGGCGGCTGTCGACGATCAACGGCGTTCCGACCCCGG
TGATCGAGTTGCCGGCGGGGCAGATCACCCGCGTACGCCTGCTCAACCTCGACAATACCCTGACCTATCGCATCAACATT
CCCGGCGTCGAAGCGCAGATCTATGCGCTGGACGGCAACCCGGTCGAGCCGCGCCCATTGGGCAAGGAATACTGGCTCGG
CCCGGGCATGCGCATCTGCCTGGCGATCAAGGCACCGCCGGCCGGTGAAGAACTGTCGCTGCGCAACGGCCCGGTTCGCC
TGGGCACCCTGCGTTCAGTGGCCAACACTGACGCGCCGACCGACTGGCCGAAAGCACTGCCGGCCAACCCGGTGGCCGAG
CCGGACCTGGCCAATGCCGAGAAACTCAACTTCAATTTCGAATGGGTCGGTTCGGTGTCGGTCAACGTCGACAACGGCAA
GCCACCGAGCCTGTGGCAGATCAACGGCAAGGCTTGGGACATCACCGACAAGACCTGCGCCGACCGGCCAATCGCCAGCC
TGAAACTCGGCCAGAGCTATATTTTCGAACTGAAGAACATGACTCAGTACCAGCACCCGATCCACTTGCACGGCATGAGT
TTCAAGGTGATTGCGTCGAACCGGCACAAGATCGTGCCGTACTTCACCGACACCTACCTGCTGGGCAAGAACGAGCGCGC
GCAAGTGGCGCTGGTGGCGGATAACCCCGGGGTGTGGATGTTCCACTGCCATGTGATCGACCACATGGAAACCGGCCTGA
TGGCCGCCATCGAGGTGAAGTGA

Upstream 100 bases:

>100_bases
GCGGCCATCCGCCGCGCCGCCCTTACTGTTTCCCAGGCGCAGGTGTATCGTATTCGCCTTTTGCGGGCGCCCTGGCCCGC
GGCTGATACGTGAGGTAGTT

Downstream 100 bases:

>100_bases
TGCGCCAGATTCGCCCCGCGGCGATCATCGACCGCAGCCGTGACCGCGACTTCATGCGCGAGGCGCTGGAGTTGGCAGCC
CAAGGCGCGGCCCTCGGCGA

Product: twin-arginine translocation pathway signal protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSISFTRRQILGGLAGLAVVGAGAGGATRYWLGKVADANAGHDYELIAAPLDVELVPGHKTEAWAFGPSAPGTELRVRQG
EWLRVRFINHLPVATTIHWHGIRLPLEMDGVPYVSQLPVLPGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVE
EREPTGFKYEKTLSLKNWHIDDEGNFVEFSIPREAARGGTAGRLSTINGVPTPVIELPAGQITRVRLLNLDNTLTYRINI
PGVEAQIYALDGNPVEPRPLGKEYWLGPGMRICLAIKAPPAGEELSLRNGPVRLGTLRSVANTDAPTDWPKALPANPVAE
PDLANAEKLNFNFEWVGSVSVNVDNGKPPSLWQINGKAWDITDKTCADRPIASLKLGQSYIFELKNMTQYQHPIHLHGMS
FKVIASNRHKIVPYFTDTYLLGKNERAQVALVADNPGVWMFHCHVIDHMETGLMAAIEVK

Sequences:

>Translated_460_residues
MSISFTRRQILGGLAGLAVVGAGAGGATRYWLGKVADANAGHDYELIAAPLDVELVPGHKTEAWAFGPSAPGTELRVRQG
EWLRVRFINHLPVATTIHWHGIRLPLEMDGVPYVSQLPVLPGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVE
EREPTGFKYEKTLSLKNWHIDDEGNFVEFSIPREAARGGTAGRLSTINGVPTPVIELPAGQITRVRLLNLDNTLTYRINI
PGVEAQIYALDGNPVEPRPLGKEYWLGPGMRICLAIKAPPAGEELSLRNGPVRLGTLRSVANTDAPTDWPKALPANPVAE
PDLANAEKLNFNFEWVGSVSVNVDNGKPPSLWQINGKAWDITDKTCADRPIASLKLGQSYIFELKNMTQYQHPIHLHGMS
FKVIASNRHKIVPYFTDTYLLGKNERAQVALVADNPGVWMFHCHVIDHMETGLMAAIEVK
>Mature_459_residues
SISFTRRQILGGLAGLAVVGAGAGGATRYWLGKVADANAGHDYELIAAPLDVELVPGHKTEAWAFGPSAPGTELRVRQGE
WLRVRFINHLPVATTIHWHGIRLPLEMDGVPYVSQLPVLPGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEE
REPTGFKYEKTLSLKNWHIDDEGNFVEFSIPREAARGGTAGRLSTINGVPTPVIELPAGQITRVRLLNLDNTLTYRINIP
GVEAQIYALDGNPVEPRPLGKEYWLGPGMRICLAIKAPPAGEELSLRNGPVRLGTLRSVANTDAPTDWPKALPANPVAEP
DLANAEKLNFNFEWVGSVSVNVDNGKPPSLWQINGKAWDITDKTCADRPIASLKLGQSYIFELKNMTQYQHPIHLHGMSF
KVIASNRHKIVPYFTDTYLLGKNERAQVALVADNPGVWMFHCHVIDHMETGLMAAIEVK

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=186, Percent_Identity=27.9569892473118, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321067, Length=482, Percent_Identity=23.2365145228216, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323703, Length=116, Percent_Identity=32.7586206896552, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859919, Length=254, Percent_Identity=29.9212598425197, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24650186, Length=100, Percent_Identity=37, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 50719; Mature: 50587

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISFTRRQILGGLAGLAVVGAGAGGATRYWLGKVADANAGHDYELIAAPLDVELVPGHK
CCCCHHHHHHHHHHHCEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEECCEEEEECCCC
TEAWAFGPSAPGTELRVRQGEWLRVRFINHLPVATTIHWHGIRLPLEMDGVPYVSQLPVL
CCEEEECCCCCCCEEEEECCCEEEEEEECCCCEEEEEEEEEEEEEEEECCCCCHHHCCCC
PGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEEREPTGFKYEKTLSLKNWHI
CCCCCEEEEECCCCCCEEECCCCCCHHHHCCCCCCCEEEECCCCCCCEEEEEEEEECEEE
DDEGNFVEFSIPREAARGGTAGRLSTINGVPTPVIELPAGQITRVRLLNLDNTLTYRINI
CCCCCEEEEECCHHHHCCCCCCEEEECCCCCCCEEECCCCCEEEEEEEECCCEEEEEEEC
PGVEAQIYALDGNPVEPRPLGKEYWLGPGMRICLAIKAPPAGEELSLRNGPVRLGTLRSV
CCCEEEEEEECCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCEEECCCCEEEEEEHHH
ANTDAPTDWPKALPANPVAEPDLANAEKLNFNFEWVGSVSVNVDNGKPPSLWQINGKAWD
HCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEECCCCCCCEEEECCEEEE
ITDKTCADRPIASLKLGQSYIFELKNMTQYQHPIHLHGMSFKVIASNRHKIVPYFTDTYL
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEECEEE
LGKNERAQVALVADNPGVWMFHCHVIDHMETGLMAAIEVK
ECCCCCEEEEEEECCCCEEEEEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure 
SISFTRRQILGGLAGLAVVGAGAGGATRYWLGKVADANAGHDYELIAAPLDVELVPGHK
CCCHHHHHHHHHHHCEEEEECCCCCCCEEEEEEECCCCCCCCEEEEEECCEEEEECCCC
TEAWAFGPSAPGTELRVRQGEWLRVRFINHLPVATTIHWHGIRLPLEMDGVPYVSQLPVL
CCEEEECCCCCCCEEEEECCCEEEEEEECCCCEEEEEEEEEEEEEEEECCCCCHHHCCCC
PGEYFDYKFRVPDAGSYWYHPHVSSSEELGRGLVGPLIVEEREPTGFKYEKTLSLKNWHI
CCCCCEEEEECCCCCCEEECCCCCCHHHHCCCCCCCEEEECCCCCCCEEEEEEEEECEEE
DDEGNFVEFSIPREAARGGTAGRLSTINGVPTPVIELPAGQITRVRLLNLDNTLTYRINI
CCCCCEEEEECCHHHHCCCCCCEEEECCCCCCCEEECCCCCEEEEEEEECCCEEEEEEEC
PGVEAQIYALDGNPVEPRPLGKEYWLGPGMRICLAIKAPPAGEELSLRNGPVRLGTLRSV
CCCEEEEEEECCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCEEECCCCEEEEEEHHH
ANTDAPTDWPKALPANPVAEPDLANAEKLNFNFEWVGSVSVNVDNGKPPSLWQINGKAWD
HCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEECCCCCCCEEEECCEEEE
ITDKTCADRPIASLKLGQSYIFELKNMTQYQHPIHLHGMSFKVIASNRHKIVPYFTDTYL
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCEEEEEEECEEE
LGKNERAQVALVADNPGVWMFHCHVIDHMETGLMAAIEVK
ECCCCCEEEEEEECCCCEEEEEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]