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The map label for this gene is hexR [H]

Identifier: 77460585

GI number: 77460585

Start: 4916654

End: 4917523

Strand: Direct

Name: hexR [H]

Synonym: Pfl01_4364

Alternate gene names: 77460585

Gene position: 4916654-4917523 (Clockwise)

Preceding gene: 77460580

Following gene: 77460597

Centisome position: 76.36

GC content: 61.38

Gene sequence:

>870_bases
ATGGACCGCGTGCGAAATTTACTGGAACAGATCCAGAGTCGCCTTGAAGAGCTGAACAAGGCCGAACGCAAAGTCGCCGA
AGTGATCCTGCTCAACCCACAGCAGGCCACACGCTTCAGCATCGCCGCCCTCGCCCAGGCGGCGTCGGTCAGTGAACCGA
CGGTCAACCGTTTCTGCCGTTCGTTCGGTGTCAGCGGCTACCCCGAACTCAAGCTGCAACTGGCCCAGAGTCTGGCCAGC
GGCGCGGCGTATGTCAGCCGTGCAGTAGAAGCCGACGACAATCCCGAGGCTTACACGCAGAAGATTTTCGGCAGTGCGAT
CGCGTCTTTGGACAGCGCCTGCCAGGCGCTGGACCCGAACCTGATCAGCCGCGCCGTCGACCTGTTGATCCAGGCCCGGC
AGATCCACTTCTTCGGCCTCGGTGCTTCGGCTCCGGTGGCTTTGGATGCACAGCACAAGTTCTTCCGCTTCAACCTGGCG
GTCACCGCCCACGCCGATGTGCTGATGCAACGGATGATTGCCTCGGTGGCGCACACCGGCGAGCTGTTCGTGATCATTTC
CTACACCGGGCGCACCCGCGAGCTGGTGGAAGTGGCGCGCATCGCCCGGGAGAACGGCGCTTCGGTGCTGGGCCTGACGG
CAGAGAATTCGCCGCTGGCCAAGGCCAGTACGCTGAGCCTGAATATTCCGCTGCCGGAAGACACTGACATCTATATGCCG
ATGACTTCGCGGATCATTCAGTTGACCGTGCTGGATGTGCTGGCGACGGGGATGACGTTGCGTCGCGGGGTGGATTTCCA
GCCGCATCTGCGCAAGATCAAAGAGAGCTTGAATGCGAGCCGGTATCCGGTGGGTGACGAGTTCAACTAA

Upstream 100 bases:

>100_bases
GTCGGAGCCATCAGTAGGATAGGCCACCGTCACGGGCCACATCAAAGGCCCAATTTGCATAGCCGCGCGCTTATCGGCGC
CGGTGAATCTAGGAATTCTT

Downstream 100 bases:

>100_bases
CTAGAGATCAAAAGCCCCTCACCCCAGCCCTCTCCCGGAGGGAGAGGGGGCCGACCGAGGTGTCTTGCGCTAGACATCGA
CCTGAACGACCGAGTTGATT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MDRVRNLLEQIQSRLEELNKAERKVAEVILLNPQQATRFSIAALAQAASVSEPTVNRFCRSFGVSGYPELKLQLAQSLAS
GAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQALDPNLISRAVDLLIQARQIHFFGLGASAPVALDAQHKFFRFNLA
VTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARIARENGASVLGLTAENSPLAKASTLSLNIPLPEDTDIYMP
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNASRYPVGDEFN

Sequences:

>Translated_289_residues
MDRVRNLLEQIQSRLEELNKAERKVAEVILLNPQQATRFSIAALAQAASVSEPTVNRFCRSFGVSGYPELKLQLAQSLAS
GAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQALDPNLISRAVDLLIQARQIHFFGLGASAPVALDAQHKFFRFNLA
VTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARIARENGASVLGLTAENSPLAKASTLSLNIPLPEDTDIYMP
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNASRYPVGDEFN
>Mature_289_residues
MDRVRNLLEQIQSRLEELNKAERKVAEVILLNPQQATRFSIAALAQAASVSEPTVNRFCRSFGVSGYPELKLQLAQSLAS
GAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQALDPNLISRAVDLLIQARQIHFFGLGASAPVALDAQHKFFRFNLA
VTAHADVLMQRMIASVAHTGELFVIISYTGRTRELVEVARIARENGASVLGLTAENSPLAKASTLSLNIPLPEDTDIYMP
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNASRYPVGDEFN

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=277, Percent_Identity=57.7617328519856, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI87082369, Length=243, Percent_Identity=25.9259259259259, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788767, Length=259, Percent_Identity=25.0965250965251, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082130, Length=215, Percent_Identity=29.7674418604651, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31610; Mature: 31610

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVRNLLEQIQSRLEELNKAERKVAEVILLNPQQATRFSIAALAQAASVSEPTVNRFCR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCHHHHHHHH
SFGVSGYPELKLQLAQSLASGAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQALDPN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
LISRAVDLLIQARQIHFFGLGASAPVALDAQHKFFRFNLAVTAHADVLMQRMIASVAHTG
HHHHHHHHHHHHHHEEEEECCCCCCEEECCCCEEEEEEEEEEHHHHHHHHHHHHHHHCCC
ELFVIISYTGRTRELVEVARIARENGASVLGLTAENSPLAKASTLSLNIPLPEDTDIYMP
CEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCEECC
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNASRYPVGDEFN
HHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDRVRNLLEQIQSRLEELNKAERKVAEVILLNPQQATRFSIAALAQAASVSEPTVNRFCR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCHHHHHHHH
SFGVSGYPELKLQLAQSLASGAAYVSRAVEADDNPEAYTQKIFGSAIASLDSACQALDPN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
LISRAVDLLIQARQIHFFGLGASAPVALDAQHKFFRFNLAVTAHADVLMQRMIASVAHTG
HHHHHHHHHHHHHHEEEEECCCCCCEEECCCCEEEEEEEEEEHHHHHHHHHHHHHHHCCC
ELFVIISYTGRTRELVEVARIARENGASVLGLTAENSPLAKASTLSLNIPLPEDTDIYMP
CEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCEECC
MTSRIIQLTVLDVLATGMTLRRGVDFQPHLRKIKESLNASRYPVGDEFN
HHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]