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The map label for this gene is hisQ [H]

Identifier: 77460512

GI number: 77460512

Start: 4847268

End: 4847957

Strand: Reverse

Name: hisQ [H]

Synonym: Pfl01_4291

Alternate gene names: 77460512

Gene position: 4847957-4847268 (Counterclockwise)

Preceding gene: 77460513

Following gene: 77460511

Centisome position: 75.3

GC content: 62.17

Gene sequence:

>690_bases
ATGTTGAAAGGCTACGGGGCTGTCATCCTCGATGGCGCTTGGCTGACGCTTCAGCTCGCCTTGTCGTCCATGGCCCTGGC
CATCGTTCTCGGGCTGATCGGCGTCGCGTTGCGCCTGTCGCCGGTGCGCTGGCTGGCGTGGCTGGGCGATCTGTATTCCA
CGGTGATTCGCGGGATTCCCGACCTGGTGCTGATCCTGCTGATCTTCTACGGCGGTCAGGACCTGCTCAACCGCGTTGCG
CCTATGCTCGGCTATGACGACTACATCGACCTGAACCCGCTGGCCGCCGGTATCGGCACCCTCGGCTTCATCTTCGGTGC
GTACCTGTCGGAAACCTTCCGCGGCGCGTTCATGGCGATCCCCAAAGGTCAGGCCGAAGCGGGCATGGCGTACGGCATGA
GCAGCTTCCAGGTGTTCTTCCGGGTGCTGGTGCCGCAGATGATTCGTCTGGCGATTCCGGGCTTCACCAACAACTGGCTG
GTGTTGACCAAGGCCACCGCGCTGATTTCCGTGGTCGGTCTGCAAGACATGATGTTCAAGGCCAAGCAGGCGGCCGACGC
CACCCGCGAGCCTTTCACCTTCTTCCTCGCAGTGGCGGCGATGTACCTGGTGATCACCAGTGTCTCGTTGCTGGCGCTGC
GTCACCTTGAGAAGCGCTACTCGGTAGGCGTAAGGGCGGCTGATCTATGA

Upstream 100 bases:

>100_bases
GGCAAGTAAAGACGTCGCTCGACCCGTCCGAAATGGCGCAAGCAACAGGATCTCTGCGGTTTGCGCCATTTTTTCATCCC
AACTTTCGAGGACCTGAATC

Downstream 100 bases:

>100_bases
TCTTCGACTACAACGTCATTTGGGAGGCCCTGCCGCTGTACTTCGGCGGTCTGGTCACGACCCTCAAGTTGCTCGCGCTG
TCGCTGTTCTTCGGTCTGCT

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLKGYGAVILDGAWLTLQLALSSMALAIVLGLIGVALRLSPVRWLAWLGDLYSTVIRGIPDLVLILLIFYGGQDLLNRVA
PMLGYDDYIDLNPLAAGIGTLGFIFGAYLSETFRGAFMAIPKGQAEAGMAYGMSSFQVFFRVLVPQMIRLAIPGFTNNWL
VLTKATALISVVGLQDMMFKAKQAADATREPFTFFLAVAAMYLVITSVSLLALRHLEKRYSVGVRAADL

Sequences:

>Translated_229_residues
MLKGYGAVILDGAWLTLQLALSSMALAIVLGLIGVALRLSPVRWLAWLGDLYSTVIRGIPDLVLILLIFYGGQDLLNRVA
PMLGYDDYIDLNPLAAGIGTLGFIFGAYLSETFRGAFMAIPKGQAEAGMAYGMSSFQVFFRVLVPQMIRLAIPGFTNNWL
VLTKATALISVVGLQDMMFKAKQAADATREPFTFFLAVAAMYLVITSVSLLALRHLEKRYSVGVRAADL
>Mature_229_residues
MLKGYGAVILDGAWLTLQLALSSMALAIVLGLIGVALRLSPVRWLAWLGDLYSTVIRGIPDLVLILLIFYGGQDLLNRVA
PMLGYDDYIDLNPLAAGIGTLGFIFGAYLSETFRGAFMAIPKGQAEAGMAYGMSSFQVFFRVLVPQMIRLAIPGFTNNWL
VLTKATALISVVGLQDMMFKAKQAADATREPFTFFLAVAAMYLVITSVSLLALRHLEKRYSVGVRAADL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=229, Percent_Identity=52.4017467248908, Blast_Score=229, Evalue=8e-62,
Organism=Escherichia coli, GI1787087, Length=217, Percent_Identity=35.4838709677419, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788226, Length=217, Percent_Identity=31.3364055299539, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788645, Length=223, Percent_Identity=29.5964125560538, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787030, Length=220, Percent_Identity=30, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1786874, Length=215, Percent_Identity=26.9767441860465, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786873, Length=216, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=29.4392523364486, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082239, Length=123, Percent_Identity=31.7073170731707, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24889; Mature: 24889

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGYGAVILDGAWLTLQLALSSMALAIVLGLIGVALRLSPVRWLAWLGDLYSTVIRGIP
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DLVLILLIFYGGQDLLNRVAPMLGYDDYIDLNPLAAGIGTLGFIFGAYLSETFRGAFMAI
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEC
PKGQAEAGMAYGMSSFQVFFRVLVPQMIRLAIPGFTNNWLVLTKATALISVVGLQDMMFK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
AKQAADATREPFTFFLAVAAMYLVITSVSLLALRHLEKRYSVGVRAADL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKGYGAVILDGAWLTLQLALSSMALAIVLGLIGVALRLSPVRWLAWLGDLYSTVIRGIP
CCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DLVLILLIFYGGQDLLNRVAPMLGYDDYIDLNPLAAGIGTLGFIFGAYLSETFRGAFMAI
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEC
PKGQAEAGMAYGMSSFQVFFRVLVPQMIRLAIPGFTNNWLVLTKATALISVVGLQDMMFK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
AKQAADATREPFTFFLAVAAMYLVITSVSLLALRHLEKRYSVGVRAADL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]