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The map label for this gene is cysM [H]

Identifier: 77460440

GI number: 77460440

Start: 4762123

End: 4763064

Strand: Reverse

Name: cysM [H]

Synonym: Pfl01_4219

Alternate gene names: 77460440

Gene position: 4763064-4762123 (Counterclockwise)

Preceding gene: 77460441

Following gene: 77460439

Centisome position: 73.98

GC content: 62.21

Gene sequence:

>942_bases
ATGATAGGCGCCCCCGCTGTCCGGATTGCGAAAAACGCCATGACCTTGCAGTACCCAACCATCGCCGATTGCGTCGGCAA
CACGCCGCTGGTGCGTTTGCAGCGCCTGCCCGGTGTCACCAGCAACACCCTTTTGCTCAAGCTTGAAGGGAACAACCCGG
CGGGTTCGGTCAAGGATCGTCCGGCGCTGTCGATGATCACCCGTGCCGAGTTGCGCGGGCAGATCCACGAAGGCGATACG
CTGATCGAAGCGACCTCGGGCAACACCGGGATCGCCTTGGCGATGGCCGCCGCGATCAAGGGTTACAAGATGATCCTGAT
CATGCCGGACAACTCCAGCGCCGAACGTAAAGCGGCGATGACCGCTTACGGCGCAGAGCTGATTCTGGTCAGCCAGGAAG
AGGGCATGGAAGGCGCTCGCGATCTCGCCCAGCGGATGGAAGCCGAAGGCCGTGGCAAGGTGCTGGATCAGTTCGCCAAC
GGCGACAATCCTGAAGCGCACTACACCACCACCGGCCCGGAAATCTGGCGTCAGACCCAGGGCTCCATCACCCATTTCGT
CAGCTCCATGGGTACCACCGGCACCATCATGGGCGTGTCGCGCTACCTCAAGGAGCAGAACGACAACGTACAGATCGTCG
GCCTGCAACCGATGGAAGGCTCGGCCATTCCCGGCATCCGCCGCTGGCCGCAGGAATACCTGCCGAAGATCTATCAGGCC
GACCGCGTCGACCGCATCGTCGACATGGCGCAAAGCGAGGCCGAAAACGTTACCCGGCGTCTGGCCCGCGAAGAAGGCAT
CTTCTGCGGCGTGTCCTCGGGCGGTGCAGTGGCAGCGATGCTGCGCCTGTCCAAAGAAGTTGAAAACGCGGTGATCGTTG
CGATCATCTGCGACCGTGGCGACCGTTACCTGTCGACCGGCATTTTCGACGCGCCCAACTGA

Upstream 100 bases:

>100_bases
CTCTTTAAAAAGTCTCACCACTGGTGAGACTTTTACTGCTTATTCCAAGAAACCATAAGCACCACACTTTGCGTGATATG
GCCTGCGCAGGTTTGCCGGT

Downstream 100 bases:

>100_bases
TGGCCAAGCACGAGAGAGGCCTGCGCTTCCAGCCCACCGGCGGCAGCAAGGCCCCGCAAATCCCGACCGGCAAAAAGCAG
CGCCTGAGCATCGAGCGCCT

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MIGAPAVRIAKNAMTLQYPTIADCVGNTPLVRLQRLPGVTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHEGDT
LIEATSGNTGIALAMAAAIKGYKMILIMPDNSSAERKAAMTAYGAELILVSQEEGMEGARDLAQRMEAEGRGKVLDQFAN
GDNPEAHYTTTGPEIWRQTQGSITHFVSSMGTTGTIMGVSRYLKEQNDNVQIVGLQPMEGSAIPGIRRWPQEYLPKIYQA
DRVDRIVDMAQSEAENVTRRLAREEGIFCGVSSGGAVAAMLRLSKEVENAVIVAIICDRGDRYLSTGIFDAPN

Sequences:

>Translated_313_residues
MIGAPAVRIAKNAMTLQYPTIADCVGNTPLVRLQRLPGVTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHEGDT
LIEATSGNTGIALAMAAAIKGYKMILIMPDNSSAERKAAMTAYGAELILVSQEEGMEGARDLAQRMEAEGRGKVLDQFAN
GDNPEAHYTTTGPEIWRQTQGSITHFVSSMGTTGTIMGVSRYLKEQNDNVQIVGLQPMEGSAIPGIRRWPQEYLPKIYQA
DRVDRIVDMAQSEAENVTRRLAREEGIFCGVSSGGAVAAMLRLSKEVENAVIVAIICDRGDRYLSTGIFDAPN
>Mature_313_residues
MIGAPAVRIAKNAMTLQYPTIADCVGNTPLVRLQRLPGVTSNTLLLKLEGNNPAGSVKDRPALSMITRAELRGQIHEGDT
LIEATSGNTGIALAMAAAIKGYKMILIMPDNSSAERKAAMTAYGAELILVSQEEGMEGARDLAQRMEAEGRGKVLDQFAN
GDNPEAHYTTTGPEIWRQTQGSITHFVSSMGTTGTIMGVSRYLKEQNDNVQIVGLQPMEGSAIPGIRRWPQEYLPKIYQA
DRVDRIVDMAQSEAENVTRRLAREEGIFCGVSSGGAVAAMLRLSKEVENAVIVAIICDRGDRYLSTGIFDAPN

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=36.1022364217252, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=36.1022364217252, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=36.1022364217252, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI2367138, Length=290, Percent_Identity=70, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=40.9836065573771, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=40.9836065573771, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=41.2751677852349, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=41.9795221843003, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=41.1371237458194, Blast_Score=203, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=39.9328859060403, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.7358490566038, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=35.6687898089172, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=34.384858044164, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321594, Length=319, Percent_Identity=38.5579937304075, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=31.1728395061728, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24643623, Length=314, Percent_Identity=36.624203821656, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI20129101, Length=314, Percent_Identity=36.624203821656, Blast_Score=157, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33780; Mature: 33780

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGAPAVRIAKNAMTLQYPTIADCVGNTPLVRLQRLPGVTSNTLLLKLEGNNPAGSVKDR
CCCCCHHHHHCCCEEEECCCHHHHHCCCCEEHHHHCCCCCCCEEEEEEECCCCCCCCCCC
PALSMITRAELRGQIHEGDTLIEATSGNTGIALAMAAAIKGYKMILIMPDNSSAERKAAM
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEEECCCCHHHHHHH
TAYGAELILVSQEEGMEGARDLAQRMEAEGRGKVLDQFANGDNPEAHYTTTGPEIWRQTQ
HHCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEECCCHHHHHHHC
GSITHFVSSMGTTGTIMGVSRYLKEQNDNVQIVGLQPMEGSAIPGIRRWPQEYLPKIYQA
CHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHH
DRVDRIVDMAQSEAENVTRRLAREEGIFCGVSSGGAVAAMLRLSKEVENAVIVAIICDRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCC
DRYLSTGIFDAPN
CCEEECCCCCCCC
>Mature Secondary Structure
MIGAPAVRIAKNAMTLQYPTIADCVGNTPLVRLQRLPGVTSNTLLLKLEGNNPAGSVKDR
CCCCCHHHHHCCCEEEECCCHHHHHCCCCEEHHHHCCCCCCCEEEEEEECCCCCCCCCCC
PALSMITRAELRGQIHEGDTLIEATSGNTGIALAMAAAIKGYKMILIMPDNSSAERKAAM
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEEECCCCHHHHHHH
TAYGAELILVSQEEGMEGARDLAQRMEAEGRGKVLDQFANGDNPEAHYTTTGPEIWRQTQ
HHCCCEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCEEECCCHHHHHHHC
GSITHFVSSMGTTGTIMGVSRYLKEQNDNVQIVGLQPMEGSAIPGIRRWPQEYLPKIYQA
CHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHH
DRVDRIVDMAQSEAENVTRRLAREEGIFCGVSSGGAVAAMLRLSKEVENAVIVAIICDRG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCC
DRYLSTGIFDAPN
CCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]