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The map label for this gene is pepQ [H]

Identifier: 77460132

GI number: 77460132

Start: 4427762

End: 4429570

Strand: Reverse

Name: pepQ [H]

Synonym: Pfl01_3911

Alternate gene names: 77460132

Gene position: 4429570-4427762 (Counterclockwise)

Preceding gene: 77460133

Following gene: 77460130

Centisome position: 68.8

GC content: 62.3

Gene sequence:

>1809_bases
ATGAGTACCCAGACCTTTACCGAAGGAACGGTTCCCCAGCGCCTCGCGCACACCCGTGAACTGATGCGTCGCGAAGGTAT
CCACGCGTTGCTGGTGCCGTCCGCCGACCCGCACCTGTCGGAATACCTGCCGGGTTACTGGCAGGGTCGGCAATGGCTGT
CGGGTTTCCATGGCTCGGTCGGCACGTTGATTGTCACCACAGACTTCGCCGGGGTCTGGGCCGACAGCCGTTACTGGGAA
CAGGCGACCAAGGAACTCAAGGGCAGCGGCATCGAGCTGGTGAAACTGCAACCGGGTCAGCCGAGCCCGCTGGACTGGCT
GGCCGAGCAGACGCCGGAAGGTGGCGTGGTTGCGGTTGACGGTGCGGTGATGGCCGTTGCGTCGGCGCGCACGCTGGGCA
GCAAGCTCGAAGCCCGGGGCGCCAGTCTGCGTACCGACATCGACTTGTTGAAAGAAGTCTGGAGCGATCGCCCGGCGCTG
CCGAATGCGCCGATCTACCAGCACCTGCCACCGCAGGCGACTGTCAGCCGTGGCGAGAAAATCGCGAAACTGCGCGAAAC
CCTGCAGGAACGCGGTGCCGACTGGCACTTCATCGCCACCCTCGACGACATCGCCTGGCTGTTCAACCTGCGCGGCGGCG
ATGTGTCGTTCAACCCGGTGTTCGTTTCCTTCGCGCTGATCAGCCAGCACCAAGCCACGCTGTTTGTGGCCTTGAGCAAG
GTTGATGCTGAGCTGCGTGCCGTGCTGGAAAAAGACGGCGTAACCCTGCGCGACTACAGCGAAGTCGCTGATGCCTTGCG
TGCGATTCCGAACGGCGCGAGCCTGCTGGTGGATCCGGCGCGGGTTACCAGCGGTCTGTTGGATAACCTCGACACTGGCG
TGAAACTGGTCGAAGGCCTGAACCCGACCACACTGGCCAAGTCGCAGAAGAGTCTTGCAGACGCCGGCCACATCCGTCAG
GCGATGGAGCAGGATGGCGCGGCGCTTTGCGAGTTTTTCACCTGGCTGGAATCGGCCTGGGGGCGCGAGCGCATCACCGA
ACTGACCATCGACGAAAAGCTCACGGCGGCCCGTGAGCGTCGTCCGGATTATGTGTCGCTGAGTTTCAACACCATCGCTG
CGTTCAACGCCAACGGCGCGATGCCGCATTACCACGCCACCCCGGAAGAACACGCGGTGATCGAGGGTGATGGCCTGCTG
CTGATCGATTCGGGCGGCCAATACTTGGGCGGCACCACTGACATCACGCGCATGGTGGCAGTTGGTACGCCAACGGATGA
GCAGAAGCGCGATTGCACTCGTGTGTTGAAAGGCGTTATTGCTTTGTCCCGCGCGCATTTCCCGAAAGGCATTCTGTCGC
CGCTGCTGGACGCCATCGCTCGTGCGCCGATCTGGGCTGAGAACGTGGATTACGGCCATGGCACCGGACACGGCGTGGGT
TACTTCCTCAATGTTCACGAAGGTCCGCAGGTGATCGCTTATCAGGCAGCGCCGGCGCCACAAACCGCCATGCAACCGGG
AATGATCACCTCCATCGAACCGGGCACTTATCGTCCGGGCCGCTGGGGTGTGCGGATCGAGAACCTGGCGATGAACGTAT
TGGCTGGAAGCAGCGAATTCGGCGAGTTCCTCAAGTTCGAAACCCTGACCCTGTGCCCGATCGACACCCGTTGCCTGGAA
CCGTCGTTGCTGACGCAGGAAGAGAAACAATGGTTCAACGCCTATCACGCCGAAGTGCGCGAGCGCCTGAGTCCGCTGCT
CGATGGCGCGGCACTGGAATGGCTGAACACGCGTACTGCCGCTATCTGA

Upstream 100 bases:

>100_bases
CGCCTGCGCCAGTGCTACGGCATTCTGGGCGACAGGGCTTTAACGAGCCGAATTCGAACGGCACCAAACAATAACGATGA
AGTGATTCGCAGGAGACATG

Downstream 100 bases:

>100_bases
TCGGTTGAAGCTCGGGCGCTGCAGCCAGCGCCTGGGTCATGAAGTCGACAAACGCGTTGACCCTGGCGGACTGGCGACGG
TTCGCCGGGGACACGGCGTG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MSTQTFTEGTVPQRLAHTRELMRREGIHALLVPSADPHLSEYLPGYWQGRQWLSGFHGSVGTLIVTTDFAGVWADSRYWE
QATKELKGSGIELVKLQPGQPSPLDWLAEQTPEGGVVAVDGAVMAVASARTLGSKLEARGASLRTDIDLLKEVWSDRPAL
PNAPIYQHLPPQATVSRGEKIAKLRETLQERGADWHFIATLDDIAWLFNLRGGDVSFNPVFVSFALISQHQATLFVALSK
VDAELRAVLEKDGVTLRDYSEVADALRAIPNGASLLVDPARVTSGLLDNLDTGVKLVEGLNPTTLAKSQKSLADAGHIRQ
AMEQDGAALCEFFTWLESAWGRERITELTIDEKLTAARERRPDYVSLSFNTIAAFNANGAMPHYHATPEEHAVIEGDGLL
LIDSGGQYLGGTTDITRMVAVGTPTDEQKRDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWAENVDYGHGTGHGVG
YFLNVHEGPQVIAYQAAPAPQTAMQPGMITSIEPGTYRPGRWGVRIENLAMNVLAGSSEFGEFLKFETLTLCPIDTRCLE
PSLLTQEEKQWFNAYHAEVRERLSPLLDGAALEWLNTRTAAI

Sequences:

>Translated_602_residues
MSTQTFTEGTVPQRLAHTRELMRREGIHALLVPSADPHLSEYLPGYWQGRQWLSGFHGSVGTLIVTTDFAGVWADSRYWE
QATKELKGSGIELVKLQPGQPSPLDWLAEQTPEGGVVAVDGAVMAVASARTLGSKLEARGASLRTDIDLLKEVWSDRPAL
PNAPIYQHLPPQATVSRGEKIAKLRETLQERGADWHFIATLDDIAWLFNLRGGDVSFNPVFVSFALISQHQATLFVALSK
VDAELRAVLEKDGVTLRDYSEVADALRAIPNGASLLVDPARVTSGLLDNLDTGVKLVEGLNPTTLAKSQKSLADAGHIRQ
AMEQDGAALCEFFTWLESAWGRERITELTIDEKLTAARERRPDYVSLSFNTIAAFNANGAMPHYHATPEEHAVIEGDGLL
LIDSGGQYLGGTTDITRMVAVGTPTDEQKRDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWAENVDYGHGTGHGVG
YFLNVHEGPQVIAYQAAPAPQTAMQPGMITSIEPGTYRPGRWGVRIENLAMNVLAGSSEFGEFLKFETLTLCPIDTRCLE
PSLLTQEEKQWFNAYHAEVRERLSPLLDGAALEWLNTRTAAI
>Mature_601_residues
STQTFTEGTVPQRLAHTRELMRREGIHALLVPSADPHLSEYLPGYWQGRQWLSGFHGSVGTLIVTTDFAGVWADSRYWEQ
ATKELKGSGIELVKLQPGQPSPLDWLAEQTPEGGVVAVDGAVMAVASARTLGSKLEARGASLRTDIDLLKEVWSDRPALP
NAPIYQHLPPQATVSRGEKIAKLRETLQERGADWHFIATLDDIAWLFNLRGGDVSFNPVFVSFALISQHQATLFVALSKV
DAELRAVLEKDGVTLRDYSEVADALRAIPNGASLLVDPARVTSGLLDNLDTGVKLVEGLNPTTLAKSQKSLADAGHIRQA
MEQDGAALCEFFTWLESAWGRERITELTIDEKLTAARERRPDYVSLSFNTIAAFNANGAMPHYHATPEEHAVIEGDGLLL
IDSGGQYLGGTTDITRMVAVGTPTDEQKRDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWAENVDYGHGTGHGVGY
FLNVHEGPQVIAYQAAPAPQTAMQPGMITSIEPGTYRPGRWGVRIENLAMNVLAGSSEFGEFLKFETLTLCPIDTRCLEP
SLLTQEEKQWFNAYHAEVRERLSPLLDGAALEWLNTRTAAI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=627, Percent_Identity=36.2041467304625, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI93141226, Length=599, Percent_Identity=33.2220367278798, Blast_Score=333, Evalue=4e-91,
Organism=Homo sapiens, GI264681565, Length=627, Percent_Identity=34.6092503987241, Blast_Score=332, Evalue=6e-91,
Organism=Escherichia coli, GI1788728, Length=170, Percent_Identity=32.9411764705882, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=609, Percent_Identity=34.3185550082102, Blast_Score=323, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25149105, Length=594, Percent_Identity=26.7676767676768, Blast_Score=212, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6322999, Length=654, Percent_Identity=30.1223241590214, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17137632, Length=608, Percent_Identity=34.046052631579, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI161078230, Length=621, Percent_Identity=28.9855072463768, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21357287, Length=621, Percent_Identity=28.9855072463768, Blast_Score=259, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65810; Mature: 65679

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQTFTEGTVPQRLAHTRELMRREGIHALLVPSADPHLSEYLPGYWQGRQWLSGFHGSV
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCHHCCHHHHHHCCCCC
GTLIVTTDFAGVWADSRYWEQATKELKGSGIELVKLQPGQPSPLDWLAEQTPEGGVVAVD
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCCCEEEEC
GAVMAVASARTLGSKLEARGASLRTDIDLLKEVWSDRPALPNAPIYQHLPPQATVSRGEK
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
IAKLRETLQERGADWHFIATLDDIAWLFNLRGGDVSFNPVFVSFALISQHQATLFVALSK
HHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCEECCHHHHHHHHHHCCCCEEEEEHHH
VDAELRAVLEKDGVTLRDYSEVADALRAIPNGASLLVDPARVTSGLLDNLDTGVKLVEGL
HHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCC
NPTTLAKSQKSLADAGHIRQAMEQDGAALCEFFTWLESAWGRERITELTIDEKLTAARER
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
RPDYVSLSFNTIAAFNANGAMPHYHATPEEHAVIEGDGLLLIDSGGQYLGGTTDITRMVA
CCCEEEEEECEEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCHHHHEEEE
VGTPTDEQKRDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWAENVDYGHGTGHGVG
ECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
YFLNVHEGPQVIAYQAAPAPQTAMQPGMITSIEPGTYRPGRWGVRIENLAMNVLAGSSEF
EEEEECCCCCEEEEECCCCCHHHCCCCCEEECCCCCCCCCCCCEEEHHHHHHHHCCCHHH
GEFLKFETLTLCPIDTRCLEPSLLTQEEKQWFNAYHAEVRERLSPLLDGAALEWLNTRTA
HHHHHHCEEEECCCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHC
AI
CC
>Mature Secondary Structure 
STQTFTEGTVPQRLAHTRELMRREGIHALLVPSADPHLSEYLPGYWQGRQWLSGFHGSV
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCHHCCHHHHHHCCCCC
GTLIVTTDFAGVWADSRYWEQATKELKGSGIELVKLQPGQPSPLDWLAEQTPEGGVVAVD
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCCCEEEEC
GAVMAVASARTLGSKLEARGASLRTDIDLLKEVWSDRPALPNAPIYQHLPPQATVSRGEK
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
IAKLRETLQERGADWHFIATLDDIAWLFNLRGGDVSFNPVFVSFALISQHQATLFVALSK
HHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCEECCHHHHHHHHHHCCCCEEEEEHHH
VDAELRAVLEKDGVTLRDYSEVADALRAIPNGASLLVDPARVTSGLLDNLDTGVKLVEGL
HHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCC
NPTTLAKSQKSLADAGHIRQAMEQDGAALCEFFTWLESAWGRERITELTIDEKLTAARER
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
RPDYVSLSFNTIAAFNANGAMPHYHATPEEHAVIEGDGLLLIDSGGQYLGGTTDITRMVA
CCCEEEEEECEEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCHHHHEEEE
VGTPTDEQKRDCTRVLKGVIALSRAHFPKGILSPLLDAIARAPIWAENVDYGHGTGHGVG
ECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
YFLNVHEGPQVIAYQAAPAPQTAMQPGMITSIEPGTYRPGRWGVRIENLAMNVLAGSSEF
EEEEECCCCCEEEEECCCCCHHHCCCCCEEECCCCCCCCCCCCEEEHHHHHHHHCCCHHH
GEFLKFETLTLCPIDTRCLEPSLLTQEEKQWFNAYHAEVRERLSPLLDGAALEWLNTRTA
HHHHHHCEEEECCCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHC
AI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]