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The map label for this gene is qor [C]

Identifier: 77460130

GI number: 77460130

Start: 4425750

End: 4426748

Strand: Reverse

Name: qor [C]

Synonym: Pfl01_3909

Alternate gene names: 77460130

Gene position: 4426748-4425750 (Counterclockwise)

Preceding gene: 77460132

Following gene: 77460127

Centisome position: 68.76

GC content: 60.06

Gene sequence:

>999_bases
ATGACTGACTCACTGCACATGAAAGCCCTGATAGTGGACACCGCTAACGGGCCGTTACGCTTGGTTTCCCTTGAGCGCCC
AGTGGCTGGGGCTGGACAGGTACTGGTGCGGATCAAGGCCAGTGGTGTTAATCCGCTGGATCTGAAAATCCGTGCAGGGC
AGGCCGCCCATGCCCGGCAACCGTTGCCAGCGGTGTTGGGGCTTGATCTGGCGGGTGTGATCGAAGCGGTGGGTGAGGGC
GTGCAGGATTGGGTGCCGGGCGATGAGGTGTATGCGTTGGCCACGGGCATTGGTGGCGCGCAAGGTTCGTTGGCCGAGTT
TGCAGTGGTGGACGCACGACTGCTGGCGCGTAAGCCTTTGAACCTGAACCAGCGTGAGGCTGCGAGTCTGCCATTGATAT
TGATCACGGCGTGGGAAGGCCTGGTGGATCGGGCTCGGGTGAGTGCGGGGCAGAAGGTGTTGATTCACGGTGGTGCGGGT
GGTGTCGGGCATGTGGCCGTTCAACTGGCCCGAGCATTCGGTGCAGATGTTTATGCAACAGGTTCTGTGAGGCAGCGCTC
GATCATCGAGGGTTACGGTGCGACGTTCATCGATTATCTAGAGAGCTCGGTGGAGGAGTATGTCGCCGAGTTCACGGCGG
GGGAGGGGTTCGACATTGTCTATGATACGGTCGGCGGCGAGACGCTGGACGTTTCCTTCAAAGCTGCACGGATCTACAGC
GGACATGTACTGAGTTGTCTGGGCTGGGGGCAGCACAGTCTTGCGCCGTTGTCGTTTCGTGGGGCGACGTATTCGGGCGT
GTTCACCTTGCTGCCGTTACTGACCGGCAGTGGGTGTGAGCATCATGGCGAGATTTTGCGCCAGGCTGCCGCGTTGATTG
AGTCCGGGCAGCTGCGACCGCTGCTCGATCCGCATCGGTTCACGCTGGAAACCGCAGCAAAAGCCCATGAGCTGCTTGCA
ACGAAAGCAGCTCAGGGGCGTTTGGTTGTGGAGATTTAG

Upstream 100 bases:

>100_bases
TCATGCCGATTTGGCATGCTTACTATAGTCATTTGACGTCTTATCGGCATGGAGCTGCTGCGGGAACATGGCTTCACTTT
CTCCCACAGGAATGACCGAA

Downstream 100 bases:

>100_bases
CGAAGGGCTTCCAGCACGAAGTCGAGCCGGTCCTGACCGAAGAACAACTGGTTGTCGATGAACATGCTCGGCGCGCCGAA
GACGCCGCGCTTCACTGCGG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTDSLHMKALIVDTANGPLRLVSLERPVAGAGQVLVRIKASGVNPLDLKIRAGQAAHARQPLPAVLGLDLAGVIEAVGEG
VQDWVPGDEVYALATGIGGAQGSLAEFAVVDARLLARKPLNLNQREAASLPLILITAWEGLVDRARVSAGQKVLIHGGAG
GVGHVAVQLARAFGADVYATGSVRQRSIIEGYGATFIDYLESSVEEYVAEFTAGEGFDIVYDTVGGETLDVSFKAARIYS
GHVLSCLGWGQHSLAPLSFRGATYSGVFTLLPLLTGSGCEHHGEILRQAAALIESGQLRPLLDPHRFTLETAAKAHELLA
TKAAQGRLVVEI

Sequences:

>Translated_332_residues
MTDSLHMKALIVDTANGPLRLVSLERPVAGAGQVLVRIKASGVNPLDLKIRAGQAAHARQPLPAVLGLDLAGVIEAVGEG
VQDWVPGDEVYALATGIGGAQGSLAEFAVVDARLLARKPLNLNQREAASLPLILITAWEGLVDRARVSAGQKVLIHGGAG
GVGHVAVQLARAFGADVYATGSVRQRSIIEGYGATFIDYLESSVEEYVAEFTAGEGFDIVYDTVGGETLDVSFKAARIYS
GHVLSCLGWGQHSLAPLSFRGATYSGVFTLLPLLTGSGCEHHGEILRQAAALIESGQLRPLLDPHRFTLETAAKAHELLA
TKAAQGRLVVEI
>Mature_331_residues
TDSLHMKALIVDTANGPLRLVSLERPVAGAGQVLVRIKASGVNPLDLKIRAGQAAHARQPLPAVLGLDLAGVIEAVGEGV
QDWVPGDEVYALATGIGGAQGSLAEFAVVDARLLARKPLNLNQREAASLPLILITAWEGLVDRARVSAGQKVLIHGGAGG
VGHVAVQLARAFGADVYATGSVRQRSIIEGYGATFIDYLESSVEEYVAEFTAGEGFDIVYDTVGGETLDVSFKAARIYSG
HVLSCLGWGQHSLAPLSFRGATYSGVFTLLPLLTGSGCEHHGEILRQAAALIESGQLRPLLDPHRFTLETAAKAHELLAT
KAAQGRLVVEI

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=372, Percent_Identity=29.0322580645161, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI194239674, Length=336, Percent_Identity=29.7619047619048, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI13236495, Length=336, Percent_Identity=29.7619047619048, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI194239676, Length=183, Percent_Identity=37.1584699453552, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI22538446, Length=228, Percent_Identity=35.5263157894737, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI22538444, Length=228, Percent_Identity=35.5263157894737, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI24308257, Length=354, Percent_Identity=24.0112994350282, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI18379349, Length=320, Percent_Identity=29.6875, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI41872631, Length=248, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI28557745, Length=237, Percent_Identity=29.957805907173, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790485, Length=312, Percent_Identity=28.525641025641, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=262, Percent_Identity=33.206106870229, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17507255, Length=341, Percent_Identity=29.3255131964809, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=338, Percent_Identity=24.5562130177515, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=262, Percent_Identity=28.6259541984733, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319401, Length=283, Percent_Identity=27.208480565371, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=224, Percent_Identity=31.25, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320948, Length=179, Percent_Identity=29.0502793296089, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=262, Percent_Identity=27.4809160305344, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=25.4480286738351, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=25.4480286738351, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581345, Length=279, Percent_Identity=24.7311827956989, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34849; Mature: 34718

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSLHMKALIVDTANGPLRLVSLERPVAGAGQVLVRIKASGVNPLDLKIRAGQAAHARQ
CCCCEEEEEEEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHCCC
PLPAVLGLDLAGVIEAVGEGVQDWVPGDEVYALATGIGGAQGSLAEFAVVDARLLARKPL
CCHHHHCCCHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
NLNQREAASLPLILITAWEGLVDRARVSAGQKVLIHGGAGGVGHVAVQLARAFGADVYAT
CCCCHHHCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEE
GSVRQRSIIEGYGATFIDYLESSVEEYVAEFTAGEGFDIVYDTVGGETLDVSFKAARIYS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEEEEC
GHVLSCLGWGQHSLAPLSFRGATYSGVFTLLPLLTGSGCEHHGEILRQAAALIESGQLRP
CCEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
LLDPHRFTLETAAKAHELLATKAAQGRLVVEI
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
TDSLHMKALIVDTANGPLRLVSLERPVAGAGQVLVRIKASGVNPLDLKIRAGQAAHARQ
CCCEEEEEEEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCEEEEEEECCCCHHCCC
PLPAVLGLDLAGVIEAVGEGVQDWVPGDEVYALATGIGGAQGSLAEFAVVDARLLARKPL
CCHHHHCCCHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCC
NLNQREAASLPLILITAWEGLVDRARVSAGQKVLIHGGAGGVGHVAVQLARAFGADVYAT
CCCCHHHCCCCEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEE
GSVRQRSIIEGYGATFIDYLESSVEEYVAEFTAGEGFDIVYDTVGGETLDVSFKAARIYS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEEEEC
GHVLSCLGWGQHSLAPLSFRGATYSGVFTLLPLLTGSGCEHHGEILRQAAALIESGQLRP
CCEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
LLDPHRFTLETAAKAHELLATKAAQGRLVVEI
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]