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The map label for this gene is wzc [H]

Identifier: 77460065

GI number: 77460065

Start: 4345611

End: 4347833

Strand: Reverse

Name: wzc [H]

Synonym: Pfl01_3844

Alternate gene names: 77460065

Gene position: 4347833-4345611 (Counterclockwise)

Preceding gene: 77460066

Following gene: 77460064

Centisome position: 67.53

GC content: 61.31

Gene sequence:

>2223_bases
ATGCAGTTACCGTCAGTAATCGGCACCCGTGAAAATGATCAAGACAGTATTGATCTTCTCGGCATCTTCGGCAGCCTGAT
CGATCAGAAGTGGTTGATCGGTGCGTTCACCGGCGCATTCATGATGACCGGTGTGGCCTATGCGATTTTGGCCACGCCGG
TGTATCTGGCCAATGCGTTGGTGCAGGTCGAACCGAAAAAGAACGACATGCTCGGTTTTTCCGACCTCAACAGCATGCTC
GGCGGGCAATCGCCGTCGGTGACCGAAATCGGCATCATCAAATCCCGCGCGGTGATCGGCAAGACAGTCGACGACCTGCG
CCTGGACATCGACGTCACCCCCAACACCTTTCCGCTGATTGGCGGCTTTCTTTCCCGGCGTTATCGCGGCGAGACCGAAC
TCAGCGTCGCGCCGCCGCGCTTCGGCCTGAGCAGCTACGCCTGGGGCGGTGAACGCCTGGAGTTTGCCAAGCTCAATCTG
CCCAAGGAGCTGCTGGGCAAGAAACTCACCCTGATCGCCGGCGAACAACATCGCTTCCAACTGCTCGACGACAACGACAA
CCTGCTGGTCGACGGTGTGGCGGGCGAAGCCTTCGCCCAGGACGGCGTAGAAGGGCAGATCGCGCAGCTGTTGGCCAACC
CCGGGACCCGTTTCGAAGTGGTGCGCTACCCACGAATCGTGACCATTCAGGGTTATCAGGACGCGCTGGACATCTCCGAG
CAAGGCAAGGAATCGGGGATCATCCGTCTGGCCCTGGCCAGCAGCGACGCCGCCGAAGCGGTGAAGATCCTCAACAAGAT
CGCTTCGCTGTACGTCGATCAGAACGTGCGCCGCACCTCGGCCGAAGCGGCGCAGAGCCTGGCCTTCCTGCAAAGCCAGT
TGCCGCAGGTCAAACGCGATCTGGCCAAGGCCAGCGATGCGCTCAACGCCTATCAGACCCACGGCAAGACCGTGAACATC
TCGCTGGAAACCCAATCGGTGCTCGGCCAGTCCGTGGCGCTCGAAACGCGGATTTCCGAGCTGAAACTGCAACAGGCGGA
GATGGATCGCAAGTTCACCAAACAGCACCCGGCCTACCGCGCGCTGATGACCCAGATTGGCGAATTGACCCAGCAACAGC
GCTCGCTGGAAGGCAAGGTTCAGGACCTGCCGGCCACGCAGCAGGAACTGCTCAACCTGACCCGCGATGTCGAAGTCGCC
TCGCAGATCTACACCCAGTTGCTGAACAAATCCCAGGAGCTGGACATTATCCGCGCCGGTGCCGTGGGTAACGTGCGTCT
GGTGGATACGGCGGACGTCGACCTGACCAGCCCGGTCAAACCGAAAAAAGCCCTGATCGTGTTGATCGCCACCTTCCTCG
GCGCCTTCGTCGGCGTGGCGCTGGTGCTGTTGCGCAAATCCCTGAGCAAGGGCCTGGAAGGGCCGGAAGCCATCGAGCAG
CTCGGCTTGCCGGTCTACGCGTCGATTCCCTACAGCGCCCTGCAGCAGGAAGAGGACAGCAAAAAAGTCCGGGCCAAAGT
CGCGGCGGACACGCCGGCGTATCTGCTGGCCCTGCGCAACCCGACGGACCTGTCCATCGAATCGATCCGCAGCCTGCGCA
CCTGCCTGCACTTCGCGGCGCTGGATTCGACCAACAACCGCATCATGATTTCCGGCCCGAGCCCGCAGGTCGGCAAGACC
TTCGTCTCTTCCAACCTGGCGGCGGTCATGGCCCAGAGCGGGCAGCGCGTGGTGCTGATCGACGCCGACATGCGCAAGGG
TCATCTGCACAAGACGCTGAACACGCCGATCACCAACGGCTTGTCGGATCTGCTGGTCAAGCGCTGCACCCTCGAGCAGG
CGATCAACAAGGTCGAAGTCGACAACCTGCACTTCATCAGCCGTGGCCAGGTTCCGCCTAACCCTTCCGAACTGTTGATG
CACGCGAATTTCCGCGAACTGCTGGCGCAACTCAGCGAGCGCTATGACGTGGTGATCATCGACACGCCACCGCTGCTGGC
GGTGACCGATGCGGCGATTGTCGGTCGCGAAGCCGGCATCAGCCTGATTGTCGCGCGGTTCGGGGTGAACCCGGCCAAGG
AAATCGAAATGACGATCCGGCGTTTCGCCCAGAACGGTATCGAGTTGAAGGGCGCGGTGTTCAACGGCGTCGAGAAGCGC
GCGGCCAGCTATTACGGCAACGGCAGCTATTACAACTACGAATACGCGTCCGACCAGTCCTGA

Upstream 100 bases:

>100_bases
TTCATGCCCATGCATTGATTGAAGATGCTGTTAGCTCATGGGCGCAACGCCTGGCGCGTTGATGAATATTCTTCAGTTCA
GTGAATGGTAAGAAAGACTT

Downstream 100 bases:

>100_bases
ATCTCAGCGACGGTCCTTACAGGCATGAAAGTGGGTGGGTTGTGAAAAAAATACTGCACGTGGCGGAAACGATCAAAGGT
GGGGTGGCGACGGTCATCCG

Product: lipopolysaccharide biosynthesis protein

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 740

Protein sequence:

>740_residues
MQLPSVIGTRENDQDSIDLLGIFGSLIDQKWLIGAFTGAFMMTGVAYAILATPVYLANALVQVEPKKNDMLGFSDLNSML
GGQSPSVTEIGIIKSRAVIGKTVDDLRLDIDVTPNTFPLIGGFLSRRYRGETELSVAPPRFGLSSYAWGGERLEFAKLNL
PKELLGKKLTLIAGEQHRFQLLDDNDNLLVDGVAGEAFAQDGVEGQIAQLLANPGTRFEVVRYPRIVTIQGYQDALDISE
QGKESGIIRLALASSDAAEAVKILNKIASLYVDQNVRRTSAEAAQSLAFLQSQLPQVKRDLAKASDALNAYQTHGKTVNI
SLETQSVLGQSVALETRISELKLQQAEMDRKFTKQHPAYRALMTQIGELTQQQRSLEGKVQDLPATQQELLNLTRDVEVA
SQIYTQLLNKSQELDIIRAGAVGNVRLVDTADVDLTSPVKPKKALIVLIATFLGAFVGVALVLLRKSLSKGLEGPEAIEQ
LGLPVYASIPYSALQQEEDSKKVRAKVAADTPAYLLALRNPTDLSIESIRSLRTCLHFAALDSTNNRIMISGPSPQVGKT
FVSSNLAAVMAQSGQRVVLIDADMRKGHLHKTLNTPITNGLSDLLVKRCTLEQAINKVEVDNLHFISRGQVPPNPSELLM
HANFRELLAQLSERYDVVIIDTPPLLAVTDAAIVGREAGISLIVARFGVNPAKEIEMTIRRFAQNGIELKGAVFNGVEKR
AASYYGNGSYYNYEYASDQS

Sequences:

>Translated_740_residues
MQLPSVIGTRENDQDSIDLLGIFGSLIDQKWLIGAFTGAFMMTGVAYAILATPVYLANALVQVEPKKNDMLGFSDLNSML
GGQSPSVTEIGIIKSRAVIGKTVDDLRLDIDVTPNTFPLIGGFLSRRYRGETELSVAPPRFGLSSYAWGGERLEFAKLNL
PKELLGKKLTLIAGEQHRFQLLDDNDNLLVDGVAGEAFAQDGVEGQIAQLLANPGTRFEVVRYPRIVTIQGYQDALDISE
QGKESGIIRLALASSDAAEAVKILNKIASLYVDQNVRRTSAEAAQSLAFLQSQLPQVKRDLAKASDALNAYQTHGKTVNI
SLETQSVLGQSVALETRISELKLQQAEMDRKFTKQHPAYRALMTQIGELTQQQRSLEGKVQDLPATQQELLNLTRDVEVA
SQIYTQLLNKSQELDIIRAGAVGNVRLVDTADVDLTSPVKPKKALIVLIATFLGAFVGVALVLLRKSLSKGLEGPEAIEQ
LGLPVYASIPYSALQQEEDSKKVRAKVAADTPAYLLALRNPTDLSIESIRSLRTCLHFAALDSTNNRIMISGPSPQVGKT
FVSSNLAAVMAQSGQRVVLIDADMRKGHLHKTLNTPITNGLSDLLVKRCTLEQAINKVEVDNLHFISRGQVPPNPSELLM
HANFRELLAQLSERYDVVIIDTPPLLAVTDAAIVGREAGISLIVARFGVNPAKEIEMTIRRFAQNGIELKGAVFNGVEKR
AASYYGNGSYYNYEYASDQS
>Mature_740_residues
MQLPSVIGTRENDQDSIDLLGIFGSLIDQKWLIGAFTGAFMMTGVAYAILATPVYLANALVQVEPKKNDMLGFSDLNSML
GGQSPSVTEIGIIKSRAVIGKTVDDLRLDIDVTPNTFPLIGGFLSRRYRGETELSVAPPRFGLSSYAWGGERLEFAKLNL
PKELLGKKLTLIAGEQHRFQLLDDNDNLLVDGVAGEAFAQDGVEGQIAQLLANPGTRFEVVRYPRIVTIQGYQDALDISE
QGKESGIIRLALASSDAAEAVKILNKIASLYVDQNVRRTSAEAAQSLAFLQSQLPQVKRDLAKASDALNAYQTHGKTVNI
SLETQSVLGQSVALETRISELKLQQAEMDRKFTKQHPAYRALMTQIGELTQQQRSLEGKVQDLPATQQELLNLTRDVEVA
SQIYTQLLNKSQELDIIRAGAVGNVRLVDTADVDLTSPVKPKKALIVLIATFLGAFVGVALVLLRKSLSKGLEGPEAIEQ
LGLPVYASIPYSALQQEEDSKKVRAKVAADTPAYLLALRNPTDLSIESIRSLRTCLHFAALDSTNNRIMISGPSPQVGKT
FVSSNLAAVMAQSGQRVVLIDADMRKGHLHKTLNTPITNGLSDLLVKRCTLEQAINKVEVDNLHFISRGQVPPNPSELLM
HANFRELLAQLSERYDVVIIDTPPLLAVTDAAIVGREAGISLIVARFGVNPAKEIEMTIRRFAQNGIELKGAVFNGVEKR
AASYYGNGSYYNYEYASDQS

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=727, Percent_Identity=42.9160935350757, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1787216, Length=726, Percent_Identity=40.9090909090909, Blast_Score=538, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 80696; Mature: 80696

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPSVIGTRENDQDSIDLLGIFGSLIDQKWLIGAFTGAFMMTGVAYAILATPVYLANAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQVEPKKNDMLGFSDLNSMLGGQSPSVTEIGIIKSRAVIGKTVDDLRLDIDVTPNTFPLI
EEECCCCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCCCEEEEEEECCCCHHHH
GGFLSRRYRGETELSVAPPRFGLSSYAWGGERLEFAKLNLPKELLGKKLTLIAGEQHRFQ
HHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHCCEEEEEECCCCEEE
LLDDNDNLLVDGVAGEAFAQDGVEGQIAQLLANPGTRFEVVRYPRIVTIQGYQDALDISE
EECCCCCEEEECCCCHHHHHCCCCHHHHHHHCCCCCCEEEEECCEEEEECCCHHHHCHHH
QGKESGIIRLALASSDAAEAVKILNKIASLYVDQNVRRTSAEAAQSLAFLQSQLPQVKRD
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LAKASDALNAYQTHGKTVNISLETQSVLGQSVALETRISELKLQQAEMDRKFTKQHPAYR
HHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ALMTQIGELTQQQRSLEGKVQDLPATQQELLNLTRDVEVASQIYTQLLNKSQELDIIRAG
HHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
AVGNVRLVDTADVDLTSPVKPKKALIVLIATFLGAFVGVALVLLRKSLSKGLEGPEAIEQ
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LGLPVYASIPYSALQQEEDSKKVRAKVAADTPAYLLALRNPTDLSIESIRSLRTCLHFAA
CCCCEEECCCHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
LDSTNNRIMISGPSPQVGKTFVSSNLAAVMAQSGQRVVLIDADMRKGHLHKTLNTPITNG
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCC
LSDLLVKRCTLEQAINKVEVDNLHFISRGQVPPNPSELLMHANFRELLAQLSERYDVVII
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHEECCCHHHHHHHHHCCCCEEEE
DTPPLLAVTDAAIVGREAGISLIVARFGVNPAKEIEMTIRRFAQNGIELKGAVFNGVEKR
CCCCCEEECCHHHHCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
AASYYGNGSYYNYEYASDQS
HHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure
MQLPSVIGTRENDQDSIDLLGIFGSLIDQKWLIGAFTGAFMMTGVAYAILATPVYLANAL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQVEPKKNDMLGFSDLNSMLGGQSPSVTEIGIIKSRAVIGKTVDDLRLDIDVTPNTFPLI
EEECCCCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCCCEEEEEEECCCCHHHH
GGFLSRRYRGETELSVAPPRFGLSSYAWGGERLEFAKLNLPKELLGKKLTLIAGEQHRFQ
HHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHCCEEEEEECCCCEEE
LLDDNDNLLVDGVAGEAFAQDGVEGQIAQLLANPGTRFEVVRYPRIVTIQGYQDALDISE
EECCCCCEEEECCCCHHHHHCCCCHHHHHHHCCCCCCEEEEECCEEEEECCCHHHHCHHH
QGKESGIIRLALASSDAAEAVKILNKIASLYVDQNVRRTSAEAAQSLAFLQSQLPQVKRD
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LAKASDALNAYQTHGKTVNISLETQSVLGQSVALETRISELKLQQAEMDRKFTKQHPAYR
HHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
ALMTQIGELTQQQRSLEGKVQDLPATQQELLNLTRDVEVASQIYTQLLNKSQELDIIRAG
HHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
AVGNVRLVDTADVDLTSPVKPKKALIVLIATFLGAFVGVALVLLRKSLSKGLEGPEAIEQ
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LGLPVYASIPYSALQQEEDSKKVRAKVAADTPAYLLALRNPTDLSIESIRSLRTCLHFAA
CCCCEEECCCHHHHHCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
LDSTNNRIMISGPSPQVGKTFVSSNLAAVMAQSGQRVVLIDADMRKGHLHKTLNTPITNG
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCC
LSDLLVKRCTLEQAINKVEVDNLHFISRGQVPPNPSELLMHANFRELLAQLSERYDVVII
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHEECCCHHHHHHHHHCCCCEEEE
DTPPLLAVTDAAIVGREAGISLIVARFGVNPAKEIEMTIRRFAQNGIELKGAVFNGVEKR
CCCCCEEECCHHHHCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
AASYYGNGSYYNYEYASDQS
HHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]