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The map label for this gene is wzb [H]

Identifier: 77460066

GI number: 77460066

Start: 4347872

End: 4348312

Strand: Reverse

Name: wzb [H]

Synonym: Pfl01_3845

Alternate gene names: 77460066

Gene position: 4348312-4347872 (Counterclockwise)

Preceding gene: 77460069

Following gene: 77460065

Centisome position: 67.54

GC content: 54.88

Gene sequence:

>441_bases
TTGTTCAAAAAGATTCTTGTCGTTTGCGTAGGCAATATCTGCCGAAGTCCGACAGCGGAACTTCTGTTGCGCAACGCGCT
GACCCCCTCGGCGATCAGCGTGACCTCCGCAGGCTTGTCTGCACGGGTTGGCGAAGGCATGGAGTCGACCGCGCGCCAGG
TGCTGGAAGAACGCGGTCACAGTGCCGAAGGGTTCAAGGCGCGGCAACTGACAGCGGACATCGTCAATGAATCAGACCTG
ATTCTGGTGATGGAAAAACAACATGTTAATCAAGTACTGAAGATTGCCTCTCACGCCAGGGGCAAAGTGTTTCTGCTGGG
CAAGTGGCAGAGCGAACGAGAAATACAGGACCCGTATCGTCAGGGGCAAGCCGCTTTTATTCATGCCCATGCATTGATTG
AAGATGCTGTTAGCTCATGGGCGCAACGCCTGGCGCGTTGA

Upstream 100 bases:

>100_bases
TATTAAGGGTGAATCTATTTCCGAGTGAAGGAAGGTCTTGCGGGTTCACTCGAATTTGCAAGACATGTTGGCCGATTGAC
ATTACACGGGAAAGTAAACC

Downstream 100 bases:

>100_bases
TGAATATTCTTCAGTTCAGTGAATGGTAAGAAAGACTTATGCAGTTACCGTCAGTAATCGGCACCCGTGAAAATGATCAA
GACAGTATTGATCTTCTCGG

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MFKKILVVCVGNICRSPTAELLLRNALTPSAISVTSAGLSARVGEGMESTARQVLEERGHSAEGFKARQLTADIVNESDL
ILVMEKQHVNQVLKIASHARGKVFLLGKWQSEREIQDPYRQGQAAFIHAHALIEDAVSSWAQRLAR

Sequences:

>Translated_146_residues
MFKKILVVCVGNICRSPTAELLLRNALTPSAISVTSAGLSARVGEGMESTARQVLEERGHSAEGFKARQLTADIVNESDL
ILVMEKQHVNQVLKIASHARGKVFLLGKWQSEREIQDPYRQGQAAFIHAHALIEDAVSSWAQRLAR
>Mature_146_residues
MFKKILVVCVGNICRSPTAELLLRNALTPSAISVTSAGLSARVGEGMESTARQVLEERGHSAEGFKARQLTADIVNESDL
ILVMEKQHVNQVLKIASHARGKVFLLGKWQSEREIQDPYRQGQAAFIHAHALIEDAVSSWAQRLAR

Specific function: Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788375, Length=144, Percent_Identity=47.9166666666667, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI87081812, Length=145, Percent_Identity=46.8965517241379, Blast_Score=128, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16074; Mature: 16074

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILVVCVGNICRSPTAELLLRNALTPSAISVTSAGLSARVGEGMESTARQVLEERGH
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHCCCHHHHCCCHHHHHHHHHHHCCC
SAEGFKARQLTADIVNESDLILVMEKQHVNQVLKIASHARGKVFLLGKWQSEREIQDPYR
CCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
QGQAAFIHAHALIEDAVSSWAQRLAR
CCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKKILVVCVGNICRSPTAELLLRNALTPSAISVTSAGLSARVGEGMESTARQVLEERGH
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHCCCHHHHCCCHHHHHHHHHHHCCC
SAEGFKARQLTADIVNESDLILVMEKQHVNQVLKIASHARGKVFLLGKWQSEREIQDPYR
CCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
QGQAAFIHAHALIEDAVSSWAQRLAR
CCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]