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The map label for this gene is zitB [H]

Identifier: 77459695

GI number: 77459695

Start: 3958506

End: 3959453

Strand: Reverse

Name: zitB [H]

Synonym: Pfl01_3473

Alternate gene names: 77459695

Gene position: 3959453-3958506 (Counterclockwise)

Preceding gene: 77459696

Following gene: 77459693

Centisome position: 61.5

GC content: 62.45

Gene sequence:

>948_bases
GTGAGCGCCGACATCATGACCCTCAAGGTTGATGACTTTTCCCACAACCACCAGTTTCTCGGTGCTTCGCACGATGAAAA
CGCCCGCCGCACCCTGTGGGTGGTGGTGCTGACTTTCGTGATGATGATCGGCGAAATTGCCGCCGGTTATCTCACCGGTT
CCATGGCATTGCTGGCCGACGGTTTCCACATGGCGACCCACGCCGGCGCTTTGGGCATCGCGGCGGCGGCCTATGGTTTT
GCGCGGCGTAACGCCAACAACCGACGCTACAGTTTCGGCACCGGCAAGGTCGGTGATCTGGCGGGTTTTGCCTCGGCGAT
GGTGCTGGGGCTGGTGTCGCTGGGGATTGCCGGGGAATCGGTTTTCCGTCTGTTCCAGCCAACCAGTGTGGCGTTCGGAG
AAGCAACCTTGATCGCCGTGGTCGGCTTGGGCGTCAATCTGCTCAGCGCTTTTCTGCTGGCCGGTCACCACAGCCATCAC
GACCACGGCCATAGTCACGACCACAGCCACGATCATGGCCATCACCACCATCACGACAACAACCTGCGTTCAGCCTACGT
GCACGTATTGGCGGACGCGTTGACATCGGTGCTGGCGATTGCCGCGCTGCTGGCCGGTCGCTATCTGGGCTGGGTGTGGA
TGGATCCGGTGATGGGCATCGTCGGTTCCATCGTCATCGCCAAATGGGCCTGGAACCTGATGCGCGACAGCGCCGCCGTG
TTGCTCGACACCACCGATGAACCCGTGGCCGAGGAGATCCGCGAACTGCTGGAAACCTCCGATGATGTGCGCATCAGCGA
CCTGCACGTCTGGCAGGTCGGCCCGCAGGCGCGGGCGGCGATTGTCAGTGTGGTCGCGGTGGCGGGCGTGACTGCCGACG
CGATCCGTGAGCGCCTGGCGCCGGTGCATGAGCTTTCGCACCTGACCATCGAATTGCGCAACGCTTAA

Upstream 100 bases:

>100_bases
AGGCCCACGCCCGCGAGCATGTCGCCCGTCCCGACCTCAGCGACGAAGCCCGCGCCCAGGGCGTGGAAGAGTTGCTGCTG
GCCATCCGCCGATATTCCAA

Downstream 100 bases:

>100_bases
GGCTGCACCTCGCTGAACATCGGAACTCGTCCATTCAGCGAAGGCCGGTAGTGCCACGTGAATCTTCCCGGATCAATGTT
GCGGGCTAGAATTTCAGTGA

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSADIMTLKVDDFSHNHQFLGASHDENARRTLWVVVLTFVMMIGEIAAGYLTGSMALLADGFHMATHAGALGIAAAAYGF
ARRNANNRRYSFGTGKVGDLAGFASAMVLGLVSLGIAGESVFRLFQPTSVAFGEATLIAVVGLGVNLLSAFLLAGHHSHH
DHGHSHDHSHDHGHHHHHDNNLRSAYVHVLADALTSVLAIAALLAGRYLGWVWMDPVMGIVGSIVIAKWAWNLMRDSAAV
LLDTTDEPVAEEIRELLETSDDVRISDLHVWQVGPQARAAIVSVVAVAGVTADAIRERLAPVHELSHLTIELRNA

Sequences:

>Translated_315_residues
MSADIMTLKVDDFSHNHQFLGASHDENARRTLWVVVLTFVMMIGEIAAGYLTGSMALLADGFHMATHAGALGIAAAAYGF
ARRNANNRRYSFGTGKVGDLAGFASAMVLGLVSLGIAGESVFRLFQPTSVAFGEATLIAVVGLGVNLLSAFLLAGHHSHH
DHGHSHDHSHDHGHHHHHDNNLRSAYVHVLADALTSVLAIAALLAGRYLGWVWMDPVMGIVGSIVIAKWAWNLMRDSAAV
LLDTTDEPVAEEIRELLETSDDVRISDLHVWQVGPQARAAIVSVVAVAGVTADAIRERLAPVHELSHLTIELRNA
>Mature_314_residues
SADIMTLKVDDFSHNHQFLGASHDENARRTLWVVVLTFVMMIGEIAAGYLTGSMALLADGFHMATHAGALGIAAAAYGFA
RRNANNRRYSFGTGKVGDLAGFASAMVLGLVSLGIAGESVFRLFQPTSVAFGEATLIAVVGLGVNLLSAFLLAGHHSHHD
HGHSHDHSHDHGHHHHHDNNLRSAYVHVLADALTSVLAIAALLAGRYLGWVWMDPVMGIVGSIVIAKWAWNLMRDSAAVL
LDTTDEPVAEEIRELLETSDDVRISDLHVWQVGPQARAAIVSVVAVAGVTADAIRERLAPVHELSHLTIELRNA

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=333, Percent_Identity=25.8258258258258, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI222080086, Length=299, Percent_Identity=25.0836120401338, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI40255009, Length=299, Percent_Identity=25.0836120401338, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI21359890, Length=299, Percent_Identity=26.4214046822742, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI52352805, Length=250, Percent_Identity=25.6, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21361112, Length=255, Percent_Identity=27.843137254902, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=297, Percent_Identity=33.6700336700337, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI32564488, Length=288, Percent_Identity=32.2916666666667, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193210990, Length=322, Percent_Identity=27.9503105590062, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555794, Length=262, Percent_Identity=27.8625954198473, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17555796, Length=261, Percent_Identity=27.2030651340996, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=154, Percent_Identity=30.5194805194805, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=194, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656728, Length=301, Percent_Identity=27.2425249169435, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24656724, Length=301, Percent_Identity=27.2425249169435, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24656720, Length=301, Percent_Identity=27.2425249169435, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24656715, Length=301, Percent_Identity=27.2425249169435, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357035, Length=301, Percent_Identity=27.2425249169435, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24645863, Length=259, Percent_Identity=24.7104247104247, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33831; Mature: 33700

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADIMTLKVDDFSHNHQFLGASHDENARRTLWVVVLTFVMMIGEIAAGYLTGSMALLAD
CCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHC
GFHMATHAGALGIAAAAYGFARRNANNRRYSFGTGKVGDLAGFASAMVLGLVSLGIAGES
CHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHH
VFRLFQPTSVAFGEATLIAVVGLGVNLLSAFLLAGHHSHHDHGHSHDHSHDHGHHHHHDN
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
NLRSAYVHVLADALTSVLAIAALLAGRYLGWVWMDPVMGIVGSIVIAKWAWNLMRDSAAV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLDTTDEPVAEEIRELLETSDDVRISDLHVWQVGPQARAAIVSVVAVAGVTADAIRERLA
EEECCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHH
PVHELSHLTIELRNA
HHHHHHEEEEEEECC
>Mature Secondary Structure 
SADIMTLKVDDFSHNHQFLGASHDENARRTLWVVVLTFVMMIGEIAAGYLTGSMALLAD
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHC
GFHMATHAGALGIAAAAYGFARRNANNRRYSFGTGKVGDLAGFASAMVLGLVSLGIAGES
CHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHH
VFRLFQPTSVAFGEATLIAVVGLGVNLLSAFLLAGHHSHHDHGHSHDHSHDHGHHHHHDN
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
NLRSAYVHVLADALTSVLAIAALLAGRYLGWVWMDPVMGIVGSIVIAKWAWNLMRDSAAV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLDTTDEPVAEEIRELLETSDDVRISDLHVWQVGPQARAAIVSVVAVAGVTADAIRERLA
EEECCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHH
PVHELSHLTIELRNA
HHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]