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The map label for this gene is envZ [H]

Identifier: 77458927

GI number: 77458927

Start: 3112510

End: 3113841

Strand: Reverse

Name: envZ [H]

Synonym: Pfl01_2702

Alternate gene names: 77458927

Gene position: 3113841-3112510 (Counterclockwise)

Preceding gene: 77458928

Following gene: 77458921

Centisome position: 48.36

GC content: 64.71

Gene sequence:

>1332_bases
ATGATCGGCCGGATGCTGCGGCGCGACACCCTCAGCCGGCGGATTGCCCTGACAATCGTCGCGGCGATGCTCGCTTCGCT
GCTGCTCAATGCGCTGTTCGTTCAGGTCGCGGGGATCTGGGCCCGACCGCCGATCGAGCGCACCGGGCTGCTGGAACAGA
TCGCCGCCACCACCCGAGTGATCGAGGCAGCGCCGGCGACCTTGCGCCCGCAACTGGCCAGTGCCGCCAGCAGCCCGATG
CTTGAAGTGCTGTGGAAACCTCGTCGGGTCGACTTCGGCCTGCCGGGGGAAGGCGAACAGGTCGAGGCCGGAAAAGTGCC
GGCGCTGCGGCAATTGCTCGGCGATGACCGGCAGATCGACGTGTTCAACCCCGATGACTGGCCAGCCGGTAGCCCTCGCG
CGCACTACATGGCGCTGGTACGGCTGGCCGATGACAGCTGGCTGTCGTTCACGCCGCCGGAGCGCAGTTGGGGCTTGAGC
CTGAACGTGCGGATTGCCGTCATCGTTGCCCTGGGGCTGGTCGCCACCCTGTTGGTCGCCTGGCTCGCCACACGGCAACT
GGCTCAGCCGTTGCAGCGCTTTGCCCATGCGGCGCGGCGTTTCGGCGGGGATCTGAAAGCGCCGCCGATTCATCTCGAAG
GCCCGCACGAAATCCGTCAGGCCATCGTCGCGTTCAACACGATGCAGGCGCAGATCCAGCATTTCATCGGCGAGCGCACC
CACATGCTCGCCGCCATCTCCCACGACTTGCGCGCCCCGCTGACCCGGATGCGCCTGCGCAGCGAGTTCATGGAGGATCT
GGACCATCAGGGCAAACTGATCCGCGACATCGAGGAAATGCAATCGATGATCAACGCCGCCCTGGCGTTCTTCCGGGAAG
ACACCCACCTGGAGCAATCCACCGCGTTCGATCTGTCGGAGTTGCTGCAAACCATCGTCGATGACTACCGCGATCAGCAC
ATCGACATCGACTTCAGCGGTCCGGCACATGTGGTGTACGACGGCCGGCCGCTGGGCATCAAACGGGTCATCGTCAATCT
GTTGGATAACGCGGTGAAATACGCACAGCGCCCCAGCGTGGCGCTGAGCAGCGATGACACGTCGATCCGCATCGAGGTGA
TAGACGAGGGGCCGGGAATTCCTGAGGACGCACTGGAGCGGGTATTCGATCCGTTCTTCCGACTCGAGACCTCGCGCAAC
CGCGACACCGGCGGGGTCGGGCTCGGTCTTTCGGCGGCACGGGGAATCATTCGTGAACAGGGTGGCGAACTCAGTTTGCG
TAACCGCCGCAGCGGCGGCTTACGCGCCCGGGTTGAATTGCCGCATCGCTGA

Upstream 100 bases:

>100_bases
GCCGGCTGCGGCGCAAGATCGAACCGGACAGCAAACGCCCGGACCTGATCCGCACGGTGCGCAACGGCGGCTACATGTTC
ACCGCCAAGGTCAGCCGCTC

Downstream 100 bases:

>100_bases
GGCTTATTCGTCGCCGGGCGCCAGCAACAGATTCGGCGCCAGGCGCTGATAACCGTCCTGAGCCAGGCGCATGTCGAGCA
GCAGACTACCCAGATCCGCC

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MIGRMLRRDTLSRRIALTIVAAMLASLLLNALFVQVAGIWARPPIERTGLLEQIAATTRVIEAAPATLRPQLASAASSPM
LEVLWKPRRVDFGLPGEGEQVEAGKVPALRQLLGDDRQIDVFNPDDWPAGSPRAHYMALVRLADDSWLSFTPPERSWGLS
LNVRIAVIVALGLVATLLVAWLATRQLAQPLQRFAHAARRFGGDLKAPPIHLEGPHEIRQAIVAFNTMQAQIQHFIGERT
HMLAAISHDLRAPLTRMRLRSEFMEDLDHQGKLIRDIEEMQSMINAALAFFREDTHLEQSTAFDLSELLQTIVDDYRDQH
IDIDFSGPAHVVYDGRPLGIKRVIVNLLDNAVKYAQRPSVALSSDDTSIRIEVIDEGPGIPEDALERVFDPFFRLETSRN
RDTGGVGLGLSAARGIIREQGGELSLRNRRSGGLRARVELPHR

Sequences:

>Translated_443_residues
MIGRMLRRDTLSRRIALTIVAAMLASLLLNALFVQVAGIWARPPIERTGLLEQIAATTRVIEAAPATLRPQLASAASSPM
LEVLWKPRRVDFGLPGEGEQVEAGKVPALRQLLGDDRQIDVFNPDDWPAGSPRAHYMALVRLADDSWLSFTPPERSWGLS
LNVRIAVIVALGLVATLLVAWLATRQLAQPLQRFAHAARRFGGDLKAPPIHLEGPHEIRQAIVAFNTMQAQIQHFIGERT
HMLAAISHDLRAPLTRMRLRSEFMEDLDHQGKLIRDIEEMQSMINAALAFFREDTHLEQSTAFDLSELLQTIVDDYRDQH
IDIDFSGPAHVVYDGRPLGIKRVIVNLLDNAVKYAQRPSVALSSDDTSIRIEVIDEGPGIPEDALERVFDPFFRLETSRN
RDTGGVGLGLSAARGIIREQGGELSLRNRRSGGLRARVELPHR
>Mature_443_residues
MIGRMLRRDTLSRRIALTIVAAMLASLLLNALFVQVAGIWARPPIERTGLLEQIAATTRVIEAAPATLRPQLASAASSPM
LEVLWKPRRVDFGLPGEGEQVEAGKVPALRQLLGDDRQIDVFNPDDWPAGSPRAHYMALVRLADDSWLSFTPPERSWGLS
LNVRIAVIVALGLVATLLVAWLATRQLAQPLQRFAHAARRFGGDLKAPPIHLEGPHEIRQAIVAFNTMQAQIQHFIGERT
HMLAAISHDLRAPLTRMRLRSEFMEDLDHQGKLIRDIEEMQSMINAALAFFREDTHLEQSTAFDLSELLQTIVDDYRDQH
IDIDFSGPAHVVYDGRPLGIKRVIVNLLDNAVKYAQRPSVALSSDDTSIRIEVIDEGPGIPEDALERVFDPFFRLETSRN
RDTGGVGLGLSAARGIIREQGGELSLRNRRSGGLRARVELPHR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=266, Percent_Identity=31.9548872180451, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1787894, Length=324, Percent_Identity=29.9382716049383, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=27.8195488721804, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082128, Length=291, Percent_Identity=27.4914089347079, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=24.6428571428571, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=28.6343612334802, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=28.7671232876712, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=304, Percent_Identity=25, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=301, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=244, Percent_Identity=25.8196721311475, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=28.1818181818182, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=24.9110320284698, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=25.7918552036199, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786600, Length=290, Percent_Identity=23.7931034482759, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=24.8847926267281, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787374, Length=286, Percent_Identity=24.8251748251748, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49297; Mature: 49297

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGRMLRRDTLSRRIALTIVAAMLASLLLNALFVQVAGIWARPPIERTGLLEQIAATTRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IEAAPATLRPQLASAASSPMLEVLWKPRRVDFGLPGEGEQVEAGKVPALRQLLGDDRQID
HHCCCCHHCHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEE
VFNPDDWPAGSPRAHYMALVRLADDSWLSFTPPERSWGLSLNVRIAVIVALGLVATLLVA
CCCCCCCCCCCCHHHHHHHEEECCCCCEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
WLATRQLAQPLQRFAHAARRFGGDLKAPPIHLEGPHEIRQAIVAFNTMQAQIQHFIGERT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HMLAAISHDLRAPLTRMRLRSEFMEDLDHQGKLIRDIEEMQSMINAALAFFREDTHLEQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
TAFDLSELLQTIVDDYRDQHIDIDFSGPAHVVYDGRPLGIKRVIVNLLDNAVKYAQRPSV
HHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCE
ALSSDDTSIRIEVIDEGPGIPEDALERVFDPFFRLETSRNRDTGGVGLGLSAARGIIREQ
EEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHC
GGELSLRNRRSGGLRARVELPHR
CCCEEECCCCCCCCEEEEECCCC
>Mature Secondary Structure
MIGRMLRRDTLSRRIALTIVAAMLASLLLNALFVQVAGIWARPPIERTGLLEQIAATTRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IEAAPATLRPQLASAASSPMLEVLWKPRRVDFGLPGEGEQVEAGKVPALRQLLGDDRQID
HHCCCCHHCHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEE
VFNPDDWPAGSPRAHYMALVRLADDSWLSFTPPERSWGLSLNVRIAVIVALGLVATLLVA
CCCCCCCCCCCCHHHHHHHEEECCCCCEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
WLATRQLAQPLQRFAHAARRFGGDLKAPPIHLEGPHEIRQAIVAFNTMQAQIQHFIGERT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HMLAAISHDLRAPLTRMRLRSEFMEDLDHQGKLIRDIEEMQSMINAALAFFREDTHLEQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
TAFDLSELLQTIVDDYRDQHIDIDFSGPAHVVYDGRPLGIKRVIVNLLDNAVKYAQRPSV
HHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCE
ALSSDDTSIRIEVIDEGPGIPEDALERVFDPFFRLETSRNRDTGGVGLGLSAARGIIREQ
EEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHC
GGELSLRNRRSGGLRARVELPHR
CCCEEECCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]