Click here to switch to the map view.

The map label for this gene is patB [H]

Identifier: 77458921

GI number: 77458921

Start: 3105440

End: 3106627

Strand: Reverse

Name: patB [H]

Synonym: Pfl01_2696

Alternate gene names: 77458921

Gene position: 3106627-3105440 (Counterclockwise)

Preceding gene: 77458927

Following gene: 77458920

Centisome position: 48.25

GC content: 64.48

Gene sequence:

>1188_bases
ATGGCGGGCACGACCCATCTCCGCCTTCAGAGACCGCGCATGACTTTCGATTTTGATCAGGTATTCGACCGCCACGACAC
CGGCAGCACCAAGTGGAGCCGCTACCCGGCCGACGTGTTGCCGATGTGGGTCGCTGACATGGATTTCGCCGCCCCGCCGG
TGGTCATCGAGGCGCTGCAACAACGTCTGCTGCACCCGTTGGTGGGCTACAGCGTGGCCCAGGACAACCTGCGCGAGGCC
ATCGTCGCCGACCTCTGGAACAAGTTCGCCTGGCGCGTGAAACCGCAAGAGCTGATCTTCCTGCCGGGCGTGGAGTCGGG
TTTCAACATGGCGCTCAAGGCGCTGGTGCAACCGCAGCAGAACGTCGTGGTGCAAACCCCGAACTACCCGCCGCTGCGCC
ATGCACCGGGCCATTGGGGCCTGAACAAGGTCGAGCTGGAATTCAACGCCCAGGCCGACGGCACCTACGCTACCCCGCTG
GACGCCTTGCGTGAATCCCTGCACGGCGGCGGCGCCCTGCTCCTGAGCAACCCGCACAACCCGATCGGCAAGGTCTTCGG
CCGCGAAGAACTGCAAGCGGTGGCGGACATCTGCGTGGCCCAGGACGCCTGGATCATCTCCGACGAAATCCACGCCGAGC
TGTGCTACGACGGTCGCGTACACATTCCGACCGCCTCCCTGAGCCCGGAAATCGCCCGCCGCACCATCACCCTGATGTCG
GCGAGCAAGGCCTACAACATCGCCGGTCTCAAGACTTCGTTCATGATCATCCAGGACGCCGCCCTGCGCGAACGCGTCAA
CCACGCCCGTTGCGGCATGGTCGACAGCGTCAACCCGCTGGGCATGGAAGCCACGCGCGTGGCCTACAGCGAAGCCGGTC
CGTGGCTTGAGGCGCTGAAGCAGTATCTGCAAGCCAACCGTGACTGGCTGGTGGACGCGGTGCGCAACCGCTTGCCCGGC
GTAACCCTCAATGTGCCGCAAGGCACGTATCTGGCCTGGCTCGATTGCTCGGCGCTGGATCTGGACGATCCGCAGAAGTT
CTTCCTGGACCACGCTCGCGTCGGCCTCAGCCCGGGTCTGGACTTTGGTGACCACAGCCAGCAATTCGTGCGCCTGAACT
TCGGTTGCCCGCGCTCGATGCTCGAAGAAGGCATTGCGCGGATGGAGCGAGCCCTCAAGTCCCGGTAA

Upstream 100 bases:

>100_bases
GCGGTGTGTCATTCAACATTGATGCTGCCTGACCAGACGCATTCGCGAGCAAGCTCGCTCCCACAGGTTTTGTGTGCTCC
TTCAAGGGCATGGGCTTATC

Downstream 100 bases:

>100_bases
TCACGTCAGGGCAAACCCAAGCGTCAATCCGATCGAACTCAGCGCAAACGGGCCGGGTCAACCGGCCTACCTGCCCTGAG
ACCCGGAGATTGACGATGAC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAGTTHLRLQRPRMTFDFDQVFDRHDTGSTKWSRYPADVLPMWVADMDFAAPPVVIEALQQRLLHPLVGYSVAQDNLREA
IVADLWNKFAWRVKPQELIFLPGVESGFNMALKALVQPQQNVVVQTPNYPPLRHAPGHWGLNKVELEFNAQADGTYATPL
DALRESLHGGGALLLSNPHNPIGKVFGREELQAVADICVAQDAWIISDEIHAELCYDGRVHIPTASLSPEIARRTITLMS
ASKAYNIAGLKTSFMIIQDAALRERVNHARCGMVDSVNPLGMEATRVAYSEAGPWLEALKQYLQANRDWLVDAVRNRLPG
VTLNVPQGTYLAWLDCSALDLDDPQKFFLDHARVGLSPGLDFGDHSQQFVRLNFGCPRSMLEEGIARMERALKSR

Sequences:

>Translated_395_residues
MAGTTHLRLQRPRMTFDFDQVFDRHDTGSTKWSRYPADVLPMWVADMDFAAPPVVIEALQQRLLHPLVGYSVAQDNLREA
IVADLWNKFAWRVKPQELIFLPGVESGFNMALKALVQPQQNVVVQTPNYPPLRHAPGHWGLNKVELEFNAQADGTYATPL
DALRESLHGGGALLLSNPHNPIGKVFGREELQAVADICVAQDAWIISDEIHAELCYDGRVHIPTASLSPEIARRTITLMS
ASKAYNIAGLKTSFMIIQDAALRERVNHARCGMVDSVNPLGMEATRVAYSEAGPWLEALKQYLQANRDWLVDAVRNRLPG
VTLNVPQGTYLAWLDCSALDLDDPQKFFLDHARVGLSPGLDFGDHSQQFVRLNFGCPRSMLEEGIARMERALKSR
>Mature_394_residues
AGTTHLRLQRPRMTFDFDQVFDRHDTGSTKWSRYPADVLPMWVADMDFAAPPVVIEALQQRLLHPLVGYSVAQDNLREAI
VADLWNKFAWRVKPQELIFLPGVESGFNMALKALVQPQQNVVVQTPNYPPLRHAPGHWGLNKVELEFNAQADGTYATPLD
ALRESLHGGGALLLSNPHNPIGKVFGREELQAVADICVAQDAWIISDEIHAELCYDGRVHIPTASLSPEIARRTITLMSA
SKAYNIAGLKTSFMIIQDAALRERVNHARCGMVDSVNPLGMEATRVAYSEAGPWLEALKQYLQANRDWLVDAVRNRLPGV
TLNVPQGTYLAWLDCSALDLDDPQKFFLDHARVGLSPGLDFGDHSQQFVRLNFGCPRSMLEEGIARMERALKSR

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=300, Percent_Identity=27.6666666666667, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI56713256, Length=300, Percent_Identity=27.6666666666667, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI169881281, Length=176, Percent_Identity=31.25, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI95147551, Length=176, Percent_Identity=31.25, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI169881279, Length=176, Percent_Identity=31.25, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=33.9285714285714, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788722, Length=366, Percent_Identity=23.4972677595628, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788627, Length=284, Percent_Identity=23.5915492957746, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=177, Percent_Identity=32.2033898305085, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573069, Length=192, Percent_Identity=30.2083333333333, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646114, Length=192, Percent_Identity=30.2083333333333, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573067, Length=192, Percent_Identity=30.2083333333333, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573065, Length=192, Percent_Identity=30.2083333333333, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44111; Mature: 43980

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTTHLRLQRPRMTFDFDQVFDRHDTGSTKWSRYPADVLPMWVADMDFAAPPVVIEALQ
CCCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
QRLLHPLVGYSVAQDNLREAIVADLWNKFAWRVKPQELIFLPGVESGFNMALKALVQPQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCCCCCHHHHHHHHHCCCC
NVVVQTPNYPPLRHAPGHWGLNKVELEFNAQADGTYATPLDALRESLHGGGALLLSNPHN
CEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCC
PIGKVFGREELQAVADICVAQDAWIISDEIHAELCYDGRVHIPTASLSPEIARRTITLMS
HHHHHCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCEEEECCCCCCHHHHHHHHHEEE
ASKAYNIAGLKTSFMIIQDAALRERVNHARCGMVDSVNPLGMEATRVAYSEAGPWLEALK
CCCCCEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
QYLQANRDWLVDAVRNRLPGVTLNVPQGTYLAWLDCSALDLDDPQKFFLDHARVGLSPGL
HHHHCCHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
DFGDHSQQFVRLNFGCPRSMLEEGIARMERALKSR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGTTHLRLQRPRMTFDFDQVFDRHDTGSTKWSRYPADVLPMWVADMDFAAPPVVIEALQ
CCCCCEEEECCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
QRLLHPLVGYSVAQDNLREAIVADLWNKFAWRVKPQELIFLPGVESGFNMALKALVQPQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCCCCCHHHHHHHHHCCCC
NVVVQTPNYPPLRHAPGHWGLNKVELEFNAQADGTYATPLDALRESLHGGGALLLSNPHN
CEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEECCCCC
PIGKVFGREELQAVADICVAQDAWIISDEIHAELCYDGRVHIPTASLSPEIARRTITLMS
HHHHHCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCEEEECCCCCCHHHHHHHHHEEE
ASKAYNIAGLKTSFMIIQDAALRERVNHARCGMVDSVNPLGMEATRVAYSEAGPWLEALK
CCCCCEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
QYLQANRDWLVDAVRNRLPGVTLNVPQGTYLAWLDCSALDLDDPQKFFLDHARVGLSPGL
HHHHCCHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
DFGDHSQQFVRLNFGCPRSMLEEGIARMERALKSR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]