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The map label for this gene is thrC [H]

Identifier: 77458540

GI number: 77458540

Start: 2667282

End: 2668550

Strand: Reverse

Name: thrC [H]

Synonym: Pfl01_2313

Alternate gene names: 77458540

Gene position: 2668550-2667282 (Counterclockwise)

Preceding gene: 77458541

Following gene: 77458539

Centisome position: 41.45

GC content: 62.73

Gene sequence:

>1269_bases
ATGAAGAATTCGTACAGAGAGTATGTGTTGCAGTGTCTGGTGTGCGACCGCAGCTACCAGCCGCACGAGGTCAGTTATTT
CTGCCCTCATTGCAAAGTCGATGGTGCCCTTGACGCGCTTTACGATTACCCGACGCTCAGACGTGAATGGCCCAAAGAAA
GCCTGGCCCACCACCAGGCCCGTGGCATGTGGCGCTATGACCGACTGATGCCGTTGAGCTCGACGCAGTTCATTCCGCCG
CTACTGGTGGGCAATACGCCGCTGTACGCACCGACCGATCTGCTCGGCAAAGGCTCGCGGATCAAGGTCTTGATCAAGGA
TGAATCGCGCCAGCCCACCGGGTCGCTGAAGGATCGCGCCAGCGCGTTGGCCGTGGCTCACGCCATGCAGTCCGGTGCGC
GCACCGTGGCGGTGGCCAGCACCGGCAACGCGGCTTCGGCACTGGCCGGAATGAGTGCCAGTCTGGGCCTGCACAACGTG
ATCTACCTGCCCCGAAGCGCACCCCGTGAAAAGCGCGCGCAGATGCAGGGCTACGGCGCCGAGATCGTGCTGGTCGACGG
TCAGTACGACGAAGCCTTCGAGCAATGCCTCAACGCCTGTGAACGATACGGCTGGTACAACCGCACCACCGGCATCAATT
CGTACATGAGCGAAGGCAAGAAAACCGTCGCCTTCGAGATCTGCGAACAACTGCACTGGCAGGTGCCGGATCTGGTGTTC
GTGCCCGTCGGCAATGGCTGCATTCTGGGCTCGGTCTACAAGGGTTTCTTCGACCTGCTGCAACTGGGCTGGATCGAGCG
CATCCCGCGCCTGATCGGCGTGCAGGCCGAGCACAGCAACTTCATGTACCGGGCCTGGCGCAGTGACCGACCGATGCAGC
AGACTGAACGCATCGCCCCCACCAGCCTGGCCAGCAGCATCAACGTGGCGCTGCCCCGCGACCGGCTCAAAGCCATGCGC
GCGGTGACCGCCAGCGAGGGCGAATTCATGTGTGTCAGCGACGCGAGCATCGTCGCCGCCGCATCGAAGCTTGCCGCCAG
CACCGGCGTGTTTCCCGAAGCCGGCGCCGCCAGTGCCTTCGCCGGCCTGCTGAAGTACGCCGAACAACACCCCGACACCG
CGCAAACCGCCGTGATCCTGATCACCGGCAGCGGCTTGAAAGACACCTCCATTTTTCTCTCCGACACGGCCGCGAGCCCG
TCACGTGTGTTCCCTCATCACGTGCCGACCACGCTGACCGAAACGCTTGCACAAGGAATCACCGCATGA

Upstream 100 bases:

>100_bases
TGGTCTGAAACACCGTCTGTCAGCAGTGCCCGCCGGTCCGTTTTTTCGGACCGGCGTTGGCAGGGAATGCACCCGCACAG
CGTACTTCCAGGGGATGGCC

Downstream 100 bases:

>100_bases
GCCTGCAAAATTTCGACCCCGCCATTGCCCGCCTGATCGACCGCGAACGCAATCGCCAGGAAACTCACCTGGAACTGATC
GCCTCGGAAAACTACGTCAG

Product: L-threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKNSYREYVLQCLVCDRSYQPHEVSYFCPHCKVDGALDALYDYPTLRREWPKESLAHHQARGMWRYDRLMPLSSTQFIPP
LLVGNTPLYAPTDLLGKGSRIKVLIKDESRQPTGSLKDRASALAVAHAMQSGARTVAVASTGNAASALAGMSASLGLHNV
IYLPRSAPREKRAQMQGYGAEIVLVDGQYDEAFEQCLNACERYGWYNRTTGINSYMSEGKKTVAFEICEQLHWQVPDLVF
VPVGNGCILGSVYKGFFDLLQLGWIERIPRLIGVQAEHSNFMYRAWRSDRPMQQTERIAPTSLASSINVALPRDRLKAMR
AVTASEGEFMCVSDASIVAAASKLAASTGVFPEAGAASAFAGLLKYAEQHPDTAQTAVILITGSGLKDTSIFLSDTAASP
SRVFPHHVPTTLTETLAQGITA

Sequences:

>Translated_422_residues
MKNSYREYVLQCLVCDRSYQPHEVSYFCPHCKVDGALDALYDYPTLRREWPKESLAHHQARGMWRYDRLMPLSSTQFIPP
LLVGNTPLYAPTDLLGKGSRIKVLIKDESRQPTGSLKDRASALAVAHAMQSGARTVAVASTGNAASALAGMSASLGLHNV
IYLPRSAPREKRAQMQGYGAEIVLVDGQYDEAFEQCLNACERYGWYNRTTGINSYMSEGKKTVAFEICEQLHWQVPDLVF
VPVGNGCILGSVYKGFFDLLQLGWIERIPRLIGVQAEHSNFMYRAWRSDRPMQQTERIAPTSLASSINVALPRDRLKAMR
AVTASEGEFMCVSDASIVAAASKLAASTGVFPEAGAASAFAGLLKYAEQHPDTAQTAVILITGSGLKDTSIFLSDTAASP
SRVFPHHVPTTLTETLAQGITA
>Mature_422_residues
MKNSYREYVLQCLVCDRSYQPHEVSYFCPHCKVDGALDALYDYPTLRREWPKESLAHHQARGMWRYDRLMPLSSTQFIPP
LLVGNTPLYAPTDLLGKGSRIKVLIKDESRQPTGSLKDRASALAVAHAMQSGARTVAVASTGNAASALAGMSASLGLHNV
IYLPRSAPREKRAQMQGYGAEIVLVDGQYDEAFEQCLNACERYGWYNRTTGINSYMSEGKKTVAFEICEQLHWQVPDLVF
VPVGNGCILGSVYKGFFDLLQLGWIERIPRLIGVQAEHSNFMYRAWRSDRPMQQTERIAPTSLASSINVALPRDRLKAMR
AVTASEGEFMCVSDASIVAAASKLAASTGVFPEAGAASAFAGLLKYAEQHPDTAQTAVILITGSGLKDTSIFLSDTAASP
SRVFPHHVPTTLTETLAQGITA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790207, Length=305, Percent_Identity=26.5573770491803, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI2367138, Length=329, Percent_Identity=25.8358662613982, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508781, Length=155, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46201; Mature: 46201

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSYREYVLQCLVCDRSYQPHEVSYFCPHCKVDGALDALYDYPTLRREWPKESLAHHQA
CCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHCCCHHHHHCCHHHHHHHHH
RGMWRYDRLMPLSSTQFIPPLLVGNTPLYAPTDLLGKGSRIKVLIKDESRQPTGSLKDRA
CCCHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHCCCCEEEEEEECCCCCCCCCHHHHH
SALAVAHAMQSGARTVAVASTGNAASALAGMSASLGLHNVIYLPRSAPREKRAQMQGYGA
HHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHCCCCEEEECCCCCCHHHHHHHCCCCC
EIVLVDGQYDEAFEQCLNACERYGWYNRTTGINSYMSEGKKTVAFEICEQLHWQVPDLVF
EEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEE
VPVGNGCILGSVYKGFFDLLQLGWIERIPRLIGVQAEHSNFMYRAWRSDRPMQQTERIAP
EECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHCCH
TSLASSINVALPRDRLKAMRAVTASEGEFMCVSDASIVAAASKLAASTGVFPEAGAASAF
HHHHCCCEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHH
AGLLKYAEQHPDTAQTAVILITGSGLKDTSIFLSDTAASPSRVFPHHVPTTLTETLAQGI
HHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCC
TA
CC
>Mature Secondary Structure
MKNSYREYVLQCLVCDRSYQPHEVSYFCPHCKVDGALDALYDYPTLRREWPKESLAHHQA
CCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHCCCHHHHHCCHHHHHHHHH
RGMWRYDRLMPLSSTQFIPPLLVGNTPLYAPTDLLGKGSRIKVLIKDESRQPTGSLKDRA
CCCHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHCCCCEEEEEEECCCCCCCCCHHHHH
SALAVAHAMQSGARTVAVASTGNAASALAGMSASLGLHNVIYLPRSAPREKRAQMQGYGA
HHHHHHHHHHCCCCEEEEEECCCHHHHHHCCHHHCCCCEEEECCCCCCHHHHHHHCCCCC
EIVLVDGQYDEAFEQCLNACERYGWYNRTTGINSYMSEGKKTVAFEICEQLHWQVPDLVF
EEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCEEE
VPVGNGCILGSVYKGFFDLLQLGWIERIPRLIGVQAEHSNFMYRAWRSDRPMQQTERIAP
EECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHCCH
TSLASSINVALPRDRLKAMRAVTASEGEFMCVSDASIVAAASKLAASTGVFPEAGAASAF
HHHHCCCEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHH
AGLLKYAEQHPDTAQTAVILITGSGLKDTSIFLSDTAASPSRVFPHHVPTTLTETLAQGI
HHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]