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The map label for this gene is glyA

Identifier: 77458539

GI number: 77458539

Start: 2666047

End: 2667285

Strand: Reverse

Name: glyA

Synonym: Pfl01_2312

Alternate gene names: 77458539

Gene position: 2667285-2666047 (Counterclockwise)

Preceding gene: 77458540

Following gene: 77458536

Centisome position: 41.43

GC content: 62.55

Gene sequence:

>1239_bases
ATGAGCCTGCAAAATTTCGACCCCGCCATTGCCCGCCTGATCGACCGCGAACGCAATCGCCAGGAAACTCACCTGGAACT
GATCGCCTCGGAAAACTACGTCAGTGAAGAAGTGCTCCAGGCCCAGGGCTCGCTGCTCACCAACAAGTACGCCGAAGGCT
ATCCGGGCCGGCGCTATTACGGCGGCTGCAAGGTCGTCGACGAGATCGAGAACCTGGCCATCGAACGCGCCCGCAAACTG
TTCGGTTGCGAGTACGTCAACGTCCAGCCGCACTCTGGTTCACAGGCCAATCAGGCGGTGTTCCTGGCGGTGCTTGAGCC
CGGCGACAGGATACTGGGCATGTCCCTGGCCCACGGCGGGCACCTGACCCACGGTGCCTCGGTGAATTTCTCCGGGAAGT
TTTTCCAGGCCTTCACCTATGGGCTGGAGAAGGACAGCGAAACCCTCGACTACGATCAGATGGAAGACCTGGCCCGCGAA
CACCGGCCGAAGATGATCATCGCCGGCGCTTCAGCCTATTCGCGCGTCATCGACTTCCCGCGCTTTCGCAAAATCTGCGA
TGAAATCGGCGCTTACCTGATGGTCGACATGGCCCACTACGCCGGTCTCATCGCGGCGGGCGTGTACCCTTCGCCGGTGG
GCATCGCCGACTTCATCACCTCGACCACGCACAAGACCCTGCGCGGCCCGCGCGGCGGCCTGATTCTGGCCAAGGCCGAA
TACGCTGCCGTGCTCGACAAGACGATCTTCCCGGTTTATCAGGGCGGCCCGCTGATGCACGTGATCGCCGCCAAGGCTGT
GGCGTTCAACGAAGCTCTGGGCGACGAGTTCAAGCATTACCAGCAACGGGTGATCAACAACGCCCGGACCATGGCCGACG
TGCTGACCCGACGCGGATTGCGCGTGGTGTCCGGCGGCACCGACTGCCACATGTTCCTGCTCGACCTGCGCGCGATGAAC
ATCACCGGCAAGGACGCCGAAGCCCTGCTGGAAAGCGCTCACATCACGCTGAACAAGAACGCGATCCCCGATGACCCGCA
GAAACCGGCGATCACCAGCGGCATCCGCATCGGCACGCCGGCACTGACCACTCGCGGTTTCGGTGAGGCCGAATGCGCCG
AAGTGGCCAACCTGATCGCCGACCTGCTGGAGCAACCGGACAACACCGCGCGGGTGGAAAACATCCGCCGTCGAGTGATG
CACCTGTGCGAATGCTTTCCGGTGTACCTGCTGACGTGA

Upstream 100 bases:

>100_bases
CCTCCATTTTTCTCTCCGACACGGCCGCGAGCCCGTCACGTGTGTTCCCTCATCACGTGCCGACCACGCTGACCGAAACG
CTTGCACAAGGAATCACCGC

Downstream 100 bases:

>100_bases
CGAGTAGGCCGGCCGCTCAGTTCTTGCACTTGGCCAGCACCACCTGGCAAGTGTCGGGTGTGCCACCGGAGCGGCCGGCA
TAACGAATGCAGTTGTTCAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSLQNFDPAIARLIDRERNRQETHLELIASENYVSEEVLQAQGSLLTNKYAEGYPGRRYYGGCKVVDEIENLAIERARKL
FGCEYVNVQPHSGSQANQAVFLAVLEPGDRILGMSLAHGGHLTHGASVNFSGKFFQAFTYGLEKDSETLDYDQMEDLARE
HRPKMIIAGASAYSRVIDFPRFRKICDEIGAYLMVDMAHYAGLIAAGVYPSPVGIADFITSTTHKTLRGPRGGLILAKAE
YAAVLDKTIFPVYQGGPLMHVIAAKAVAFNEALGDEFKHYQQRVINNARTMADVLTRRGLRVVSGGTDCHMFLLDLRAMN
ITGKDAEALLESAHITLNKNAIPDDPQKPAITSGIRIGTPALTTRGFGEAECAEVANLIADLLEQPDNTARVENIRRRVM
HLCECFPVYLLT

Sequences:

>Translated_412_residues
MSLQNFDPAIARLIDRERNRQETHLELIASENYVSEEVLQAQGSLLTNKYAEGYPGRRYYGGCKVVDEIENLAIERARKL
FGCEYVNVQPHSGSQANQAVFLAVLEPGDRILGMSLAHGGHLTHGASVNFSGKFFQAFTYGLEKDSETLDYDQMEDLARE
HRPKMIIAGASAYSRVIDFPRFRKICDEIGAYLMVDMAHYAGLIAAGVYPSPVGIADFITSTTHKTLRGPRGGLILAKAE
YAAVLDKTIFPVYQGGPLMHVIAAKAVAFNEALGDEFKHYQQRVINNARTMADVLTRRGLRVVSGGTDCHMFLLDLRAMN
ITGKDAEALLESAHITLNKNAIPDDPQKPAITSGIRIGTPALTTRGFGEAECAEVANLIADLLEQPDNTARVENIRRRVM
HLCECFPVYLLT
>Mature_411_residues
SLQNFDPAIARLIDRERNRQETHLELIASENYVSEEVLQAQGSLLTNKYAEGYPGRRYYGGCKVVDEIENLAIERARKLF
GCEYVNVQPHSGSQANQAVFLAVLEPGDRILGMSLAHGGHLTHGASVNFSGKFFQAFTYGLEKDSETLDYDQMEDLAREH
RPKMIIAGASAYSRVIDFPRFRKICDEIGAYLMVDMAHYAGLIAAGVYPSPVGIADFITSTTHKTLRGPRGGLILAKAEY
AAVLDKTIFPVYQGGPLMHVIAAKAVAFNEALGDEFKHYQQRVINNARTMADVLTRRGLRVVSGGTDCHMFLLDLRAMNI
TGKDAEALLESAHITLNKNAIPDDPQKPAITSGIRIGTPALTTRGFGEAECAEVANLIADLLEQPDNTARVENIRRRVMH
LCECFPVYLLT

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=45.2538631346578, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=45.2538631346578, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=45.2538631346578, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=45.2538631346578, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=44.5916114790287, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=46.3840399002494, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI22547189, Length=386, Percent_Identity=45.5958549222798, Blast_Score=309, Evalue=3e-84,
Organism=Escherichia coli, GI1788902, Length=412, Percent_Identity=58.495145631068, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI25144732, Length=402, Percent_Identity=44.0298507462687, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=402, Percent_Identity=44.0298507462687, Blast_Score=338, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=43.30900243309, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6323087, Length=429, Percent_Identity=41.7249417249417, Blast_Score=332, Evalue=7e-92,
Organism=Drosophila melanogaster, GI24640005, Length=449, Percent_Identity=44.988864142539, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=453, Percent_Identity=44.8123620309051, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA1_PSEPF (Q3KDV1)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_348044.1
- ProteinModelPortal:   Q3KDV1
- SMR:   Q3KDV1
- STRING:   Q3KDV1
- GeneID:   3715536
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_2312
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   WTAIQDE
- ProtClustDB:   PRK00011
- BioCyc:   PFLU205922:PFL_2312-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45463; Mature: 45331

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQNFDPAIARLIDRERNRQETHLELIASENYVSEEVLQAQGSLLTNKYAEGYPGRRYY
CCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHCCCCCCEEC
GGCKVVDEIENLAIERARKLFGCEYVNVQPHSGSQANQAVFLAVLEPGDRILGMSLAHGG
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCC
HLTHGASVNFSGKFFQAFTYGLEKDSETLDYDQMEDLAREHRPKMIIAGASAYSRVIDFP
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHCCH
RFRKICDEIGAYLMVDMAHYAGLIAAGVYPSPVGIADFITSTTHKTLRGPRGGLILAKAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHH
YAAVLDKTIFPVYQGGPLMHVIAAKAVAFNEALGDEFKHYQQRVINNARTMADVLTRRGL
HHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RVVSGGTDCHMFLLDLRAMNITGKDAEALLESAHITLNKNAIPDDPQKPAITSGIRIGTP
EEEECCCCHHHHEEHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCCCCCCHHCCCEECCC
ALTTRGFGEAECAEVANLIADLLEQPDNTARVENIRRRVMHLCECFPVYLLT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLQNFDPAIARLIDRERNRQETHLELIASENYVSEEVLQAQGSLLTNKYAEGYPGRRYY
CCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHCCCCCCEEC
GGCKVVDEIENLAIERARKLFGCEYVNVQPHSGSQANQAVFLAVLEPGDRILGMSLAHGG
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEEEECCCC
HLTHGASVNFSGKFFQAFTYGLEKDSETLDYDQMEDLAREHRPKMIIAGASAYSRVIDFP
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHCCH
RFRKICDEIGAYLMVDMAHYAGLIAAGVYPSPVGIADFITSTTHKTLRGPRGGLILAKAE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHH
YAAVLDKTIFPVYQGGPLMHVIAAKAVAFNEALGDEFKHYQQRVINNARTMADVLTRRGL
HHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RVVSGGTDCHMFLLDLRAMNITGKDAEALLESAHITLNKNAIPDDPQKPAITSGIRIGTP
EEEECCCCHHHHEEHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCCCCCCHHCCCEECCC
ALTTRGFGEAECAEVANLIADLLEQPDNTARVENIRRRVMHLCECFPVYLLT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA