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The map label for this gene is 77458535

Identifier: 77458535

GI number: 77458535

Start: 2662060

End: 2662986

Strand: Reverse

Name: 77458535

Synonym: Pfl01_2308

Alternate gene names: NA

Gene position: 2662986-2662060 (Counterclockwise)

Preceding gene: 77458536

Following gene: 77458534

Centisome position: 41.36

GC content: 64.29

Gene sequence:

>927_bases
ATGAAACGAGTACACGTCATTGATTCCCACACCGGCGGCGAGCCCACGCGTCTGGTGATGAAAGGTTTTCCCGATCTGCC
CGGCCACACCATGGCCGAGAAGCGCGATGCCCTGCGCAACCAGCATGACCAATGGCGCCGCGCCTGCCTGCTGGAACCGC
GTGGCAACGATGTGCTGGTGGGCGCGCTGTATTGCGAGCCGGTGTCGCCGGACGCCACCTGCGGGGTGATCTTCTTCAAC
AACGCCGGTTACCTCGGCATGTGCGGCCACGGCACCATCGGTCTGGTCGCATCGCTGCAGCACCTGGGGCTGATCGCGCC
GGGGGTGCACAAGATCGACACCCCGGTCGGCCCGGTCAGCGCAACGTTGCATGAAGACGGTGCCGTGACTCTGGGCAACG
TGCCGGCTTATCGATTTCGTAAGCAGGTGGCGGTGGAAGTGCCGGGATACGGTCGTTTCCTCGGCGACGTGGCCTACGGC
GGCAACTGGTTTTTCCTGGTCTCCGAACACGGCCAGACCCTGACGATGGACAACGTCGAAACCCTGACCGACCTCACCTG
GAAAATGCTCAAGGCCCTCGAAGAGCAAGGCATCCATGGCGAGGACGGCGCGCTCATCGACCATATCGAACTGTTCGCCG
ATGACGCCGAAGCCGACAGCCGCAACTTCGTCATGTGCCCCGGCAAAGCCTACGACCGCTCCCCTTGCGGCACCGGCACC
AGCGCCAAACTGGCGTGCCTGGCCGCCGACGAAAAACTCGCGCCCGGCGAGCGCTGGGTGCAGGCGAGCATCACCGGCAG
CCAGTTTGAAGGCCGCTTTGAATGGGAAGGCGAACGCATCCGCCCGTACATCACCGGCCGCGCCCACATGACCGCCGACA
GCACGCTGCTGATCGACGAAACCGATCCGTTCGCGTGGGGCATCTGA

Upstream 100 bases:

>100_bases
TCCGAAGAGGATGAAAGCGAAGTCGCTTCGCCGTCCCCCGCCTCCACCGCCAATCCTCGCGCCGCCGGCGCTTACTGAAA
TCACTTAACGGGACCTGTCC

Downstream 100 bases:

>100_bases
GCCGCTGCGCTGTTTTTTCAACCCCCTCTGAAAGACCGTTCCAAGGAGAACAATAATGAGCGACAACATCTTCACCGGCT
GCATGCCCGCCCTGATGACC

Product: proline racemase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; PaHyPRE [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKRVHVIDSHTGGEPTRLVMKGFPDLPGHTMAEKRDALRNQHDQWRRACLLEPRGNDVLVGALYCEPVSPDATCGVIFFN
NAGYLGMCGHGTIGLVASLQHLGLIAPGVHKIDTPVGPVSATLHEDGAVTLGNVPAYRFRKQVAVEVPGYGRFLGDVAYG
GNWFFLVSEHGQTLTMDNVETLTDLTWKMLKALEEQGIHGEDGALIDHIELFADDAEADSRNFVMCPGKAYDRSPCGTGT
SAKLACLAADEKLAPGERWVQASITGSQFEGRFEWEGERIRPYITGRAHMTADSTLLIDETDPFAWGI

Sequences:

>Translated_308_residues
MKRVHVIDSHTGGEPTRLVMKGFPDLPGHTMAEKRDALRNQHDQWRRACLLEPRGNDVLVGALYCEPVSPDATCGVIFFN
NAGYLGMCGHGTIGLVASLQHLGLIAPGVHKIDTPVGPVSATLHEDGAVTLGNVPAYRFRKQVAVEVPGYGRFLGDVAYG
GNWFFLVSEHGQTLTMDNVETLTDLTWKMLKALEEQGIHGEDGALIDHIELFADDAEADSRNFVMCPGKAYDRSPCGTGT
SAKLACLAADEKLAPGERWVQASITGSQFEGRFEWEGERIRPYITGRAHMTADSTLLIDETDPFAWGI
>Mature_308_residues
MKRVHVIDSHTGGEPTRLVMKGFPDLPGHTMAEKRDALRNQHDQWRRACLLEPRGNDVLVGALYCEPVSPDATCGVIFFN
NAGYLGMCGHGTIGLVASLQHLGLIAPGVHKIDTPVGPVSATLHEDGAVTLGNVPAYRFRKQVAVEVPGYGRFLGDVAYG
GNWFFLVSEHGQTLTMDNVETLTDLTWKMLKALEEQGIHGEDGALIDHIELFADDAEADSRNFVMCPGKAYDRSPCGTGT
SAKLACLAADEKLAPGERWVQASITGSQFEGRFEWEGERIRPYITGRAHMTADSTLLIDETDPFAWGI

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=331, Percent_Identity=30.8157099697885, Blast_Score=141, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 33577; Mature: 33577

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVHVIDSHTGGEPTRLVMKGFPDLPGHTMAEKRDALRNQHDQWRRACLLEPRGNDVLV
CCEEEEEECCCCCCCEEEHEECCCCCCCCHHHHHHHHHHCHHHHHHHHEEECCCCCEEEE
GALYCEPVSPDATCGVIFFNNAGYLGMCGHGTIGLVASLQHLGLIAPGVHKIDTPVGPVS
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCE
ATLHEDGAVTLGNVPAYRFRKQVAVEVPGYGRFLGDVAYGGNWFFLVSEHGQTLTMDNVE
EEEECCCCEEECCCCHHHEEEEEEEECCCCCHHHHHEEECCCEEEEEECCCCEEEECCHH
TLTDLTWKMLKALEEQGIHGEDGALIDHIELFADDAEADSRNFVMCPGKAYDRSPCGTGT
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCC
SAKLACLAADEKLAPGERWVQASITGSQFEGRFEWEGERIRPYITGRAHMTADSTLLIDE
CCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEECCCEEEEEEECCEEECCCCEEEEEC
TDPFAWGI
CCCCCCCC
>Mature Secondary Structure
MKRVHVIDSHTGGEPTRLVMKGFPDLPGHTMAEKRDALRNQHDQWRRACLLEPRGNDVLV
CCEEEEEECCCCCCCEEEHEECCCCCCCCHHHHHHHHHHCHHHHHHHHEEECCCCCEEEE
GALYCEPVSPDATCGVIFFNNAGYLGMCGHGTIGLVASLQHLGLIAPGVHKIDTPVGPVS
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCE
ATLHEDGAVTLGNVPAYRFRKQVAVEVPGYGRFLGDVAYGGNWFFLVSEHGQTLTMDNVE
EEEECCCCEEECCCCHHHEEEEEEEECCCCCHHHHHEEECCCEEEEEECCCCEEEECCHH
TLTDLTWKMLKALEEQGIHGEDGALIDHIELFADDAEADSRNFVMCPGKAYDRSPCGTGT
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCC
SAKLACLAADEKLAPGERWVQASITGSQFEGRFEWEGERIRPYITGRAHMTADSTLLIDE
CCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEECCCEEEEEEECCEEECCCCEEEEEC
TDPFAWGI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]