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The map label for this gene is gltP [H]

Identifier: 77458469

GI number: 77458469

Start: 2571829

End: 2573088

Strand: Direct

Name: gltP [H]

Synonym: Pfl01_2242

Alternate gene names: 77458469

Gene position: 2571829-2573088 (Clockwise)

Preceding gene: 77458468

Following gene: 77458470

Centisome position: 39.95

GC content: 56.9

Gene sequence:

>1260_bases
ATGAAACGTATTCCCCTGGTGTGGCAAATCGTTGCCGGGCTGTTGCTTGGCGTGCTCGTTGGTTGGTACTTCAACACCCA
TCCGCAGTATCAGTCGTGGGTCAGTGCGGAGATCCTGAAACCGCTTGGCGATATCTTCATCAAGATGATGAAGATGGTGG
TCGTGCCCATCGTGTTGTGTTGCATGATCCTGGGTATCGCCGGTGGCGGGGATAACAAGTCGTTCGGCCGGATGGGCATC
AAGTCGCTGGGCTATTTCTTTGCGATCACCGGCCTGGCCATCGTGATCGGCCTGTGTTTCGCGAACCTCTTCGAACCCGG
TACGGGCACCGATATTTCGGGCATCGCGCATGGTGCTACCGCCATCACGATGGAGCCTTCGAAGGGCGCGCTCGTGATTA
TGCAAAACATCGTTCCGGATAACGTTCTGGTGGCGATGTCCGAGGCGAAGCTGCTTTCGGTCCTGTTCTTCGCGGTGTTG
TTCGGTGTCGCGCTGAACGCATTGCCCAAGGAAAAAAGTGCACCTGTGGTTGCGCTGGTCCAAGGCATTTCGGATGCGAT
GTTCAGGATCGTCTCGATCGTCATGGCCTATGCCCCGATAGGGGTGTTCGGCATGATCGGTGCGACCGTCGCGACCTTCG
GTTTTGCCTCGTTGTTGCCCCTGCTCAAGTTGATTGGTGTGGTTTATCTGGCGCTGATCGTCTTCGCATTGGTAGTGCTC
GGAGGAATCAGTTACCTGATCGGCGAGAACATCTTCAAGTTGATCAGGTATTTCCGCGACGAGTTGATTCTTGCGTTCTC
CAGTGCTGCCTCTGCAGCGGTCATGCCGCAGTTGATGAGCAAGCTGGAGAACTACGGCGTACCACGGCGCATTGTCAGTT
TTGTGGTGCCAGTGGGGTACGCGTTCAACCTTGATGGCGCGTCGATCTTCCTCGGGGTGGCGACAATCTTTATCGCCCAG
CTTTATGGAATCGATCTGTCGCTTTCTCAGGAAATCCTGCTGGTGGTGACCATGGTGCTGACCTCCAAAGGTGCTGCCGG
GGTGCCTGGATTCGCCATCGTCATCCTGTCGGCCACATTGGCGTCTGCCGGTCTTCCGCTGGAGGGCGTGGCACTGATCG
CCGGCATCTTCAGGATTATCGACAGCGGCACCACCACCCTGAATGTGTTGGGCAATGCGATCGCGCCCCTGGTGATCGCC
AAATGGGAGAGGGTGACTCTTGAGCCTTCGCGCACCCGCCCGGACGTACAAAAGGCCTGA

Upstream 100 bases:

>100_bases
CAACGGCGTTGTGCCATTTGATCTCAAGTGAGCTGGAAGCTCATGACTCTAGCAACTGCCGAATTGATGCAGTCCTTTCA
TTCCAACAAAAAGGCTAGAC

Downstream 100 bases:

>100_bases
CGATCACAAGGAGCACTGACGGCGCTGCACGAGTAAACGCCTGCTGAATGTACAGGCGATTTTTTTCATCAAGTTACTAG
ACGACCGGTCTGATATTGAA

Product: Sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKRIPLVWQIVAGLLLGVLVGWYFNTHPQYQSWVSAEILKPLGDIFIKMMKMVVVPIVLCCMILGIAGGGDNKSFGRMGI
KSLGYFFAITGLAIVIGLCFANLFEPGTGTDISGIAHGATAITMEPSKGALVIMQNIVPDNVLVAMSEAKLLSVLFFAVL
FGVALNALPKEKSAPVVALVQGISDAMFRIVSIVMAYAPIGVFGMIGATVATFGFASLLPLLKLIGVVYLALIVFALVVL
GGISYLIGENIFKLIRYFRDELILAFSSAASAAVMPQLMSKLENYGVPRRIVSFVVPVGYAFNLDGASIFLGVATIFIAQ
LYGIDLSLSQEILLVVTMVLTSKGAAGVPGFAIVILSATLASAGLPLEGVALIAGIFRIIDSGTTTLNVLGNAIAPLVIA
KWERVTLEPSRTRPDVQKA

Sequences:

>Translated_419_residues
MKRIPLVWQIVAGLLLGVLVGWYFNTHPQYQSWVSAEILKPLGDIFIKMMKMVVVPIVLCCMILGIAGGGDNKSFGRMGI
KSLGYFFAITGLAIVIGLCFANLFEPGTGTDISGIAHGATAITMEPSKGALVIMQNIVPDNVLVAMSEAKLLSVLFFAVL
FGVALNALPKEKSAPVVALVQGISDAMFRIVSIVMAYAPIGVFGMIGATVATFGFASLLPLLKLIGVVYLALIVFALVVL
GGISYLIGENIFKLIRYFRDELILAFSSAASAAVMPQLMSKLENYGVPRRIVSFVVPVGYAFNLDGASIFLGVATIFIAQ
LYGIDLSLSQEILLVVTMVLTSKGAAGVPGFAIVILSATLASAGLPLEGVALIAGIFRIIDSGTTTLNVLGNAIAPLVIA
KWERVTLEPSRTRPDVQKA
>Mature_419_residues
MKRIPLVWQIVAGLLLGVLVGWYFNTHPQYQSWVSAEILKPLGDIFIKMMKMVVVPIVLCCMILGIAGGGDNKSFGRMGI
KSLGYFFAITGLAIVIGLCFANLFEPGTGTDISGIAHGATAITMEPSKGALVIMQNIVPDNVLVAMSEAKLLSVLFFAVL
FGVALNALPKEKSAPVVALVQGISDAMFRIVSIVMAYAPIGVFGMIGATVATFGFASLLPLLKLIGVVYLALIVFALVVL
GGISYLIGENIFKLIRYFRDELILAFSSAASAAVMPQLMSKLENYGVPRRIVSFVVPVGYAFNLDGASIFLGVATIFIAQ
LYGIDLSLSQEILLVVTMVLTSKGAAGVPGFAIVILSATLASAGLPLEGVALIAGIFRIIDSGTTTLNVLGNAIAPLVIA
KWERVTLEPSRTRPDVQKA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=459, Percent_Identity=26.1437908496732, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI21314632, Length=396, Percent_Identity=27.5252525252525, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI169790839, Length=462, Percent_Identity=24.8917748917749, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI5032093, Length=409, Percent_Identity=28.361858190709, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI40254478, Length=445, Percent_Identity=23.5955056179775, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=30.9963099630996, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI223468566, Length=271, Percent_Identity=30.9963099630996, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI194239697, Length=287, Percent_Identity=29.2682926829268, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4827012, Length=263, Percent_Identity=32.6996197718631, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI301601644, Length=168, Percent_Identity=35.7142857142857, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI262359914, Length=407, Percent_Identity=23.5872235872236, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=49.1525423728814, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=35.8910891089109, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789473, Length=371, Percent_Identity=25.8760107816712, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788024, Length=394, Percent_Identity=25.1269035532995, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983106, Length=447, Percent_Identity=27.2930648769575, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71983099, Length=447, Percent_Identity=27.2930648769575, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71996953, Length=457, Percent_Identity=25.8205689277899, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=449, Percent_Identity=26.0579064587973, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17537407, Length=427, Percent_Identity=24.5901639344262, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193206654, Length=403, Percent_Identity=23.3250620347395, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=412, Percent_Identity=22.8155339805825, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583025, Length=462, Percent_Identity=24.6753246753247, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17137668, Length=462, Percent_Identity=24.6753246753247, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583023, Length=462, Percent_Identity=24.6753246753247, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281360483, Length=453, Percent_Identity=23.841059602649, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137666, Length=453, Percent_Identity=23.841059602649, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281360481, Length=456, Percent_Identity=24.5614035087719, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44330; Mature: 44330

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIPLVWQIVAGLLLGVLVGWYFNTHPQYQSWVSAEILKPLGDIFIKMMKMVVVPIVLC
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CMILGIAGGGDNKSFGRMGIKSLGYFFAITGLAIVIGLCFANLFEPGTGTDISGIAHGAT
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCE
AITMEPSKGALVIMQNIVPDNVLVAMSEAKLLSVLFFAVLFGVALNALPKEKSAPVVALV
EEEECCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
QGISDAMFRIVSIVMAYAPIGVFGMIGATVATFGFASLLPLLKLIGVVYLALIVFALVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGISYLIGENIFKLIRYFRDELILAFSSAASAAVMPQLMSKLENYGVPRRIVSFVVPVGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCE
AFNLDGASIFLGVATIFIAQLYGIDLSLSQEILLVVTMVLTSKGAAGVPGFAIVILSATL
EECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ASAGLPLEGVALIAGIFRIIDSGTTTLNVLGNAIAPLVIAKWERVTLEPSRTRPDVQKA
HHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MKRIPLVWQIVAGLLLGVLVGWYFNTHPQYQSWVSAEILKPLGDIFIKMMKMVVVPIVLC
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CMILGIAGGGDNKSFGRMGIKSLGYFFAITGLAIVIGLCFANLFEPGTGTDISGIAHGAT
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCE
AITMEPSKGALVIMQNIVPDNVLVAMSEAKLLSVLFFAVLFGVALNALPKEKSAPVVALV
EEEECCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
QGISDAMFRIVSIVMAYAPIGVFGMIGATVATFGFASLLPLLKLIGVVYLALIVFALVVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGISYLIGENIFKLIRYFRDELILAFSSAASAAVMPQLMSKLENYGVPRRIVSFVVPVGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCE
AFNLDGASIFLGVATIFIAQLYGIDLSLSQEILLVVTMVLTSKGAAGVPGFAIVILSATL
EECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ASAGLPLEGVALIAGIFRIIDSGTTTLNVLGNAIAPLVIAKWERVTLEPSRTRPDVQKA
HHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]