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The map label for this gene is mdtN [H]

Identifier: 77458365

GI number: 77458365

Start: 2421073

End: 2422170

Strand: Reverse

Name: mdtN [H]

Synonym: Pfl01_2138

Alternate gene names: 77458365

Gene position: 2422170-2421073 (Counterclockwise)

Preceding gene: 77458366

Following gene: 77458364

Centisome position: 37.62

GC content: 65.21

Gene sequence:

>1098_bases
ATGAGTGATGAAGCGCCGCCGGATCCGGCGAAAAAAGGCATCCGCTGGGTGCTGCTGGTGATTGTGCTGAGCCTGGTCTG
GTATCTGCTGGCCGACCGTTTTACGCCCTACACGCAGCAGGCGCGGGTCGGCGCGTTCGTGATTCCGGTGGCGGCGGAAG
TCGCGGGCCGGGTGATCAAGGTCAACGTGCGCAACAATCAGGACGTGCAGGCCGGCGACATTCTCTTCGAGCTCGATCCG
CAGCCGCTGCAGATCGCCGTCGACCGGGCCCGCGCCGATCTGGAAAACACCCGGCGCACGGTCGGCGCCAGCACCGCCGG
CATCGCGTCGGCTCAGGCATCGTTGCGTGCCGCGCAAGCCAATGAACTCAAAACGCGCCAGGACAATCGACGGCTGGAAG
GTTTGTACAAAGAAGATCCGGGCACGGTTTCGGTTCGGCTGCTGGAAGTGTCCCGGGCCAACCACGAGGCCGCCGTCAGC
CAGGTCGCCGCCGCCCGGGCCGAAGTGCTGCGTGCGCAGGAGCAGGAAGGCGGCAACACCGACACCAACGCCAAGCTGCT
CAGCGCCGCCGCCACGCTGGCCAAGGCCGAACTGGATCTGGCCAACACCCGCATTGGCGCGCGTTCGGCGGGCTTGATCA
CCGACCTGCGCACCGACGTCGGCCAGTTCGCCGCTGTCGGCAGTCCGGTAATGACCCTGATCACGATCCAGGACGTGTGG
ATCAGCGCCGACCTCACCGAGAACAACCTCGGCCGGATCAAGCCCGGCACGCCGGTGTCGATCATCCTCGACGCCCTGCC
CGGCGAAGTGCTCGACGGCCGGGTACGCAGCATCGGTTACGGTGTCAGCGTCGGCCAGACGCCGCCGCCCGGAACACTGC
CGACGATCCAGAACAGTCGCGACTGGCTACGTCCGGCCCAGCGCTTTCCGGTGATCATCGAGTTCAGCGAAGAGGCGAAA
AAGCGCCTGTTCGAGAGTCGTTCGATTCGCGCTGGCGGGCAGGCGGAAGTCATGGCGTTTCCGAGCGAGGGCAATCTGCT
CAATCCACTCGGGCGGATGTTTGTCTGGTTGATGAGTTGGCTGTCGTATGCCTATTGA

Upstream 100 bases:

>100_bases
GCGACCCGACAGCAGATGCAGCAACGCACCGACTGGGGCGATCTGCTGAGCGCCCCGCCGCCCCGACCGACCTATCCGAT
TCCCTCGCAGGTAGACCGCC

Downstream 100 bases:

>100_bases
GCGCAGCGTTCCGGCGCAACGGGCCTTGCGCCTGGCTTGCGGCACGGCGTTGTGCACCGCCGCCAGTTACGGCCTCGCCT
TGCCGCTGTCGTTTTTGTCT

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSDEAPPDPAKKGIRWVLLVIVLSLVWYLLADRFTPYTQQARVGAFVIPVAAEVAGRVIKVNVRNNQDVQAGDILFELDP
QPLQIAVDRARADLENTRRTVGASTAGIASAQASLRAAQANELKTRQDNRRLEGLYKEDPGTVSVRLLEVSRANHEAAVS
QVAAARAEVLRAQEQEGGNTDTNAKLLSAAATLAKAELDLANTRIGARSAGLITDLRTDVGQFAAVGSPVMTLITIQDVW
ISADLTENNLGRIKPGTPVSIILDALPGEVLDGRVRSIGYGVSVGQTPPPGTLPTIQNSRDWLRPAQRFPVIIEFSEEAK
KRLFESRSIRAGGQAEVMAFPSEGNLLNPLGRMFVWLMSWLSYAY

Sequences:

>Translated_365_residues
MSDEAPPDPAKKGIRWVLLVIVLSLVWYLLADRFTPYTQQARVGAFVIPVAAEVAGRVIKVNVRNNQDVQAGDILFELDP
QPLQIAVDRARADLENTRRTVGASTAGIASAQASLRAAQANELKTRQDNRRLEGLYKEDPGTVSVRLLEVSRANHEAAVS
QVAAARAEVLRAQEQEGGNTDTNAKLLSAAATLAKAELDLANTRIGARSAGLITDLRTDVGQFAAVGSPVMTLITIQDVW
ISADLTENNLGRIKPGTPVSIILDALPGEVLDGRVRSIGYGVSVGQTPPPGTLPTIQNSRDWLRPAQRFPVIIEFSEEAK
KRLFESRSIRAGGQAEVMAFPSEGNLLNPLGRMFVWLMSWLSYAY
>Mature_364_residues
SDEAPPDPAKKGIRWVLLVIVLSLVWYLLADRFTPYTQQARVGAFVIPVAAEVAGRVIKVNVRNNQDVQAGDILFELDPQ
PLQIAVDRARADLENTRRTVGASTAGIASAQASLRAAQANELKTRQDNRRLEGLYKEDPGTVSVRLLEVSRANHEAAVSQ
VAAARAEVLRAQEQEGGNTDTNAKLLSAAATLAKAELDLANTRIGARSAGLITDLRTDVGQFAAVGSPVMTLITIQDVWI
SADLTENNLGRIKPGTPVSIILDALPGEVLDGRVRSIGYGVSVGQTPPPGTLPTIQNSRDWLRPAQRFPVIIEFSEEAKK
RLFESRSIRAGGQAEVMAFPSEGNLLNPLGRMFVWLMSWLSYAY

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=295, Percent_Identity=34.5762711864407, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790012, Length=353, Percent_Identity=28.328611898017, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790024, Length=262, Percent_Identity=32.824427480916, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081951, Length=296, Percent_Identity=28.3783783783784, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789637, Length=310, Percent_Identity=25.8064516129032, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788711, Length=280, Percent_Identity=28.2142857142857, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789041, Length=332, Percent_Identity=23.7951807228916, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39556; Mature: 39424

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEAPPDPAKKGIRWVLLVIVLSLVWYLLADRFTPYTQQARVGAFVIPVAAEVAGRVIK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEEHHHHHCCEEEE
VNVRNNQDVQAGDILFELDPQPLQIAVDRARADLENTRRTVGASTAGIASAQASLRAAQA
EEECCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
NELKTRQDNRRLEGLYKEDPGTVSVRLLEVSRANHEAAVSQVAAARAEVLRAQEQEGGNT
HHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DTNAKLLSAAATLAKAELDLANTRIGARSAGLITDLRTDVGQFAAVGSPVMTLITIQDVW
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEHE
ISADLTENNLGRIKPGTPVSIILDALPGEVLDGRVRSIGYGVSVGQTPPPGTLPTIQNSR
EEEECCCCCCCCCCCCCCHHHHEECCCCHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCH
DWLRPAQRFPVIIEFSEEAKKRLFESRSIRAGGQAEVMAFPSEGNLLNPLGRMFVWLMSW
HHHCHHHHCCEEEEECHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
LSYAY
HHHCC
>Mature Secondary Structure 
SDEAPPDPAKKGIRWVLLVIVLSLVWYLLADRFTPYTQQARVGAFVIPVAAEVAGRVIK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEEHHHHHCCEEEE
VNVRNNQDVQAGDILFELDPQPLQIAVDRARADLENTRRTVGASTAGIASAQASLRAAQA
EEECCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
NELKTRQDNRRLEGLYKEDPGTVSVRLLEVSRANHEAAVSQVAAARAEVLRAQEQEGGNT
HHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DTNAKLLSAAATLAKAELDLANTRIGARSAGLITDLRTDVGQFAAVGSPVMTLITIQDVW
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEHE
ISADLTENNLGRIKPGTPVSIILDALPGEVLDGRVRSIGYGVSVGQTPPPGTLPTIQNSR
EEEECCCCCCCCCCCCCCHHHHEECCCCHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCH
DWLRPAQRFPVIIEFSEEAKKRLFESRSIRAGGQAEVMAFPSEGNLLNPLGRMFVWLMSW
HHHCHHHHCCEEEEECHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
LSYAY
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]