Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 77458013

GI number: 77458013

Start: 1987618

End: 1988637

Strand: Direct

Name: pyrD [H]

Synonym: Pfl01_1786

Alternate gene names: 77458013

Gene position: 1987618-1988637 (Clockwise)

Preceding gene: 77458004

Following gene: 77458015

Centisome position: 30.87

GC content: 64.02

Gene sequence:

>1020_bases
ATGTACACCCTGGCCCGTCAGCTGTTGTTCAAACTTTCCCCGGAAACCTCCCACGATCTGTCGCTGGATCTGATCGGCGC
GGGCGGGCGTTTGGGCCTCAACGGTTTGCTGTGCAAGGCCCCGGCGTCGCTGCCGGTGAATGTCATGGGCTTGCAATTCC
CAAATCCTGTGGGGCTGGCGGCCGGTCTGGACAAGAACGGCGCGGCCATCGACGGCTTCGCGCAACTGGGTTTCGGTTTT
GTCGAAATCGGCACCGTGACTCCGCGCCCGCAGCCGGGCAACCCGAAACCACGGATTTTCCGTCTGCCGGAAGCCGAGGC
GATCATCAATCGCATGGGGTTCAACAACCTCGGTGTGGATAACCTGCTGGCGCGGGTGGCGGCGGCCAAATACAAGGGCG
TGCTGGGGATCAACATCGGCAAGAACTTCGACACCCCGGTCGAGCGCGCTGTAGACGACTACCTGATCTGCCTGGACAAG
GTCTACGCCCACGCCAGTTACGTCACGGTCAACGTCAGCTCGCCGAACACTCCGGGCCTGCGCAGCCTGCAATTCGGCGA
TTCGCTCAAGCAATTGCTGGCGGACCTGGCCACGCGCCGCGCCGAACTGGCCCTGCGCCACGGCAAGCATGTACCGCTGG
CGATCAAGATCGCGCCGGACATGACCGACGAAGAAACCGCGCAAGTCGCCCAGGCGCTGATCGAAACCGGGATGGACGCG
GTGATCGCCACCAACACCACCCTCAGCCGCGTGGGCGTCGAAGGCATGGAACATGGTGACGAGGCGGGCGGTCTGTCCGG
CGCGCCAGTGCGTGAAAAGAGTACCCATACCGTGAAAGTGCTGGCGTCCGAGCTGGGCGGCAAGCTGCCGATCATCGCGG
CGGGCGGTATCACCGAAGGCAAGCATGCGGCTGAGAAGATCGCTGCCGGCGCGAGCCTGGTGCAGATCTACTCCGGCTTC
ATCTACAAGGGCCCGGCGCTGATTCGCGAGTCCGTGGACGCGATCGCCGCCAAGCGCTGA

Upstream 100 bases:

>100_bases
GCATATGCCATGCGCACCGATTTACCCGTGCGCCTCGCGCGGTGGGGCGATGCCCGGCTATAATCGTCGCCTCTTTTCGC
CGCCCGAGTCATAGCCGCCC

Downstream 100 bases:

>100_bases
TTTGCGGATTTAAAAGGCAGGCATAAAAAAGGGCTCCTCGAAGGAGCCCCTGGGCCGTAGCCCGCCGTCCGGGAAGGACG
TGCATGGTGATCAGGTCGTT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MYTLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLCKAPASLPVNVMGLQFPNPVGLAAGLDKNGAAIDGFAQLGFGF
VEIGTVTPRPQPGNPKPRIFRLPEAEAIINRMGFNNLGVDNLLARVAAAKYKGVLGINIGKNFDTPVERAVDDYLICLDK
VYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLADLATRRAELALRHGKHVPLAIKIAPDMTDEETAQVAQALIETGMDA
VIATNTTLSRVGVEGMEHGDEAGGLSGAPVREKSTHTVKVLASELGGKLPIIAAGGITEGKHAAEKIAAGASLVQIYSGF
IYKGPALIRESVDAIAAKR

Sequences:

>Translated_339_residues
MYTLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLCKAPASLPVNVMGLQFPNPVGLAAGLDKNGAAIDGFAQLGFGF
VEIGTVTPRPQPGNPKPRIFRLPEAEAIINRMGFNNLGVDNLLARVAAAKYKGVLGINIGKNFDTPVERAVDDYLICLDK
VYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLADLATRRAELALRHGKHVPLAIKIAPDMTDEETAQVAQALIETGMDA
VIATNTTLSRVGVEGMEHGDEAGGLSGAPVREKSTHTVKVLASELGGKLPIIAAGGITEGKHAAEKIAAGASLVQIYSGF
IYKGPALIRESVDAIAAKR
>Mature_339_residues
MYTLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLCKAPASLPVNVMGLQFPNPVGLAAGLDKNGAAIDGFAQLGFGF
VEIGTVTPRPQPGNPKPRIFRLPEAEAIINRMGFNNLGVDNLLARVAAAKYKGVLGINIGKNFDTPVERAVDDYLICLDK
VYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLADLATRRAELALRHGKHVPLAIKIAPDMTDEETAQVAQALIETGMDA
VIATNTTLSRVGVEGMEHGDEAGGLSGAPVREKSTHTVKVLASELGGKLPIIAAGGITEGKHAAEKIAAGASLVQIYSGF
IYKGPALIRESVDAIAAKR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=44.2424242424242, Blast_Score=251, Evalue=5e-67,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=56.5868263473054, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17509475, Length=325, Percent_Identity=43.6923076923077, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI281361352, Length=294, Percent_Identity=41.156462585034, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI17137316, Length=294, Percent_Identity=41.156462585034, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 35586; Mature: 35586

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLCKAPASLPVNVMGLQFPNPVGLA
CHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCC
AGLDKNGAAIDGFAQLGFGFVEIGTVTPRPQPGNPKPRIFRLPEAEAIINRMGFNNLGVD
CCCCCCCCEECHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCHH
NLLARVAAAKYKGVLGINIGKNFDTPVERAVDDYLICLDKVYAHASYVTVNVSSPNTPGL
HHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCC
RSLQFGDSLKQLLADLATRRAELALRHGKHVPLAIKIAPDMTDEETAQVAQALIETGMDA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCE
VIATNTTLSRVGVEGMEHGDEAGGLSGAPVREKSTHTVKVLASELGGKLPIIAAGGITEG
EEECCCHHHHHCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
KHAAEKIAAGASLVQIYSGFIYKGPALIRESVDAIAAKR
HHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYTLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLCKAPASLPVNVMGLQFPNPVGLA
CHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCC
AGLDKNGAAIDGFAQLGFGFVEIGTVTPRPQPGNPKPRIFRLPEAEAIINRMGFNNLGVD
CCCCCCCCEECHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCHH
NLLARVAAAKYKGVLGINIGKNFDTPVERAVDDYLICLDKVYAHASYVTVNVSSPNTPGL
HHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCC
RSLQFGDSLKQLLADLATRRAELALRHGKHVPLAIKIAPDMTDEETAQVAQALIETGMDA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCE
VIATNTTLSRVGVEGMEHGDEAGGLSGAPVREKSTHTVKVLASELGGKLPIIAAGGITEG
EEECCCHHHHHCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
KHAAEKIAAGASLVQIYSGFIYKGPALIRESVDAIAAKR
HHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA