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The map label for this gene is cobC [H]

Identifier: 77457872

GI number: 77457872

Start: 1835882

End: 1836889

Strand: Direct

Name: cobC [H]

Synonym: Pfl01_1645

Alternate gene names: 77457872

Gene position: 1835882-1836889 (Clockwise)

Preceding gene: 77457871

Following gene: 77457873

Centisome position: 28.51

GC content: 65.67

Gene sequence:

>1008_bases
ATGCTTGAGCACGGTGGCCGGTTGCGCAGGGCGGCGCTCGAATACGGCATCGCGGAAGAAGACTGGCTCGACCTGTCTAC
GGGCCTGGCGCCGTGGCCGTTTCCGGTCCCGGACATCCCGCTGCGGGCCTGGGCGCGTTTGCCGGAAAACGATGACGGCC
TGGAGCAGGCCGCCTGCGATTACTACGGCGCCAGCCAGGTGTTGCCAGTGGCCGGTTCGCAGATGGCCATTCAGTTGCTG
CCGCGTTTGCGTAGGGCCGGCAAGGTCGGCGTGCTGTCGCCGTGTTATGCCGAACATGCCGAAGCCTGGCGGCGCAGCGG
CTATATCGTCCGCGAAGTGCTGGAGCAGGAAGTCGACTTCTTTCTCGACAGCCTCGACGTGCTGGTGGTGGTCAATCCGA
ACAATCCAACAGGCCTGAACCTGACCCCGGCGCGCCTGCTCGACTGGCACGCACGGCTGGCCCAGCGCGGCGGCTGGCTG
GTGGTCGACGAAGCGTTCATGGACAACACGCCGCAGTTGAGCCTTGCCCCGCATGCGCATCAAGTGGGGTTGATCGTGTT
GCGCTCGTTCGGCAAGTTTTTCGGTCTGGCCGGTGTGCGGCTGGGCTTCGTGCTGGCCGAGCGCAAGTTGCTCCGGTTGC
TGGCCGAACAGGTCGGGCCCTGGGCAGTCAGCGGACCGACGCGGGTGCTGGGGCAGGCTTGTCTGCGCGACACCGAAGGC
CATACCCGCCAGCGCATCCGCAGCGACGAGGCCAGCGAACGATTGGCTGCGCTACTTGAGCGGCACGGCTTCAAACCGCA
GGGCGGCTGCGCACTGTTTCAGTGGCTGATCACCGAACAGGCCGCCGCGCTGCACGAATTCATGGCCCGCCGCGGCATTC
TTCTGCGCCTGTTCGCGCACAACAGCAGCCTGCGTTTTGGGCTGCCCGCCGATGCCGCCGACGAGGCGCGTCTTGAGCAA
GCCCTGCAAGCATTCGCCAAGCATTGCTCCATGGAAAAACCAGCATGA

Upstream 100 bases:

>100_bases
GGCGCGCCGGCGGATGCCGATTCCATTGATCGCGGCTGGCAATTGGTCCAGCGCGGGGTATGGTTATGGCTGCTGATTCT
CTGCGTGGGGGCTGAATTCT

Downstream 100 bases:

>100_bases
CCACATTAATGGTGCAGGGCACCACCTCCGACGCCGGCAAAAGCACGCTGGTGACGGCGCTGTGCCGCTGGGCCACCCGT
CAGGGCGTTGCGGTGGTGCC

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MLEHGGRLRRAALEYGIAEEDWLDLSTGLAPWPFPVPDIPLRAWARLPENDDGLEQAACDYYGASQVLPVAGSQMAIQLL
PRLRRAGKVGVLSPCYAEHAEAWRRSGYIVREVLEQEVDFFLDSLDVLVVVNPNNPTGLNLTPARLLDWHARLAQRGGWL
VVDEAFMDNTPQLSLAPHAHQVGLIVLRSFGKFFGLAGVRLGFVLAERKLLRLLAEQVGPWAVSGPTRVLGQACLRDTEG
HTRQRIRSDEASERLAALLERHGFKPQGGCALFQWLITEQAAALHEFMARRGILLRLFAHNSSLRFGLPADAADEARLEQ
ALQAFAKHCSMEKPA

Sequences:

>Translated_335_residues
MLEHGGRLRRAALEYGIAEEDWLDLSTGLAPWPFPVPDIPLRAWARLPENDDGLEQAACDYYGASQVLPVAGSQMAIQLL
PRLRRAGKVGVLSPCYAEHAEAWRRSGYIVREVLEQEVDFFLDSLDVLVVVNPNNPTGLNLTPARLLDWHARLAQRGGWL
VVDEAFMDNTPQLSLAPHAHQVGLIVLRSFGKFFGLAGVRLGFVLAERKLLRLLAEQVGPWAVSGPTRVLGQACLRDTEG
HTRQRIRSDEASERLAALLERHGFKPQGGCALFQWLITEQAAALHEFMARRGILLRLFAHNSSLRFGLPADAADEARLEQ
ALQAFAKHCSMEKPA
>Mature_335_residues
MLEHGGRLRRAALEYGIAEEDWLDLSTGLAPWPFPVPDIPLRAWARLPENDDGLEQAACDYYGASQVLPVAGSQMAIQLL
PRLRRAGKVGVLSPCYAEHAEAWRRSGYIVREVLEQEVDFFLDSLDVLVVVNPNNPTGLNLTPARLLDWHARLAQRGGWL
VVDEAFMDNTPQLSLAPHAHQVGLIVLRSFGKFFGLAGVRLGFVLAERKLLRLLAEQVGPWAVSGPTRVLGQACLRDTEG
HTRQRIRSDEASERLAALLERHGFKPQGGCALFQWLITEQAAALHEFMARRGILLRLFAHNSSLRFGLPADAADEARLEQ
ALQAFAKHCSMEKPA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=181, Percent_Identity=34.2541436464088, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 37157; Mature: 37157

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGRLRRAALEYGIAEEDWLDLSTGLAPWPFPVPDIPLRAWARLPENDDGLEQAACD
CCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
YYGASQVLPVAGSQMAIQLLPRLRRAGKVGVLSPCYAEHAEAWRRSGYIVREVLEQEVDF
HCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
FLDSLDVLVVVNPNNPTGLNLTPARLLDWHARLAQRGGWLVVDEAFMDNTPQLSLAPHAH
HHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCEEECCCHH
QVGLIVLRSFGKFFGLAGVRLGFVLAERKLLRLLAEQVGPWAVSGPTRVLGQACLRDTEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
HTRQRIRSDEASERLAALLERHGFKPQGGCALFQWLITEQAAALHEFMARRGILLRLFAH
HHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
NSSLRFGLPADAADEARLEQALQAFAKHCSMEKPA
CCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLEHGGRLRRAALEYGIAEEDWLDLSTGLAPWPFPVPDIPLRAWARLPENDDGLEQAACD
CCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHH
YYGASQVLPVAGSQMAIQLLPRLRRAGKVGVLSPCYAEHAEAWRRSGYIVREVLEQEVDF
HCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
FLDSLDVLVVVNPNNPTGLNLTPARLLDWHARLAQRGGWLVVDEAFMDNTPQLSLAPHAH
HHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCEEECCCHH
QVGLIVLRSFGKFFGLAGVRLGFVLAERKLLRLLAEQVGPWAVSGPTRVLGQACLRDTEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
HTRQRIRSDEASERLAALLERHGFKPQGGCALFQWLITEQAAALHEFMARRGILLRLFAH
HHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
NSSLRFGLPADAADEARLEQALQAFAKHCSMEKPA
CCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]