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The map label for this gene is cobD [H]

Identifier: 77457871

GI number: 77457871

Start: 1834981

End: 1835889

Strand: Direct

Name: cobD [H]

Synonym: Pfl01_1644

Alternate gene names: 77457871

Gene position: 1834981-1835889 (Clockwise)

Preceding gene: 77457870

Following gene: 77457872

Centisome position: 28.5

GC content: 65.02

Gene sequence:

>909_bases
ATGAGTGTGGCGTTGCTGAGTGCCGCCGCGGTTGCGCTGGATGCGCTGCTGGGTGAACCGAAACGCTGGCATCCGCTGGT
GGCGTTCGGCAATTTCGCCGGGCGCATCGAGCAACGTTTCAATAGCGCTGGTCGTGGTTGGCGCAGCCATGGCGTCACCG
CGTGGGTGATCGCGGTGTTGCCGCTGACCCTGCTGGCCACCGCGTTTTCCTGGGCGCCGTATGTGGGCTGGATCGTCGAG
ATTCTTGCGCTGTATTGCGCCCTCGGCATGCGCAGCCTGGGTGAGCACGTCGAGCCGGTGGCCAAGGCTTTGCGCGCCGA
TGATCTAGAGGAGGCGCGCAAGCGTGTGGGTTATCTGGTCAGCCGTCAGACCGATGAGCTGGACAGCACCGCCGTCGCCC
GCGCCGCCACCGAGTCGGTGCTGGAAAACGGCAGCGATGCAGTGTTCGCCGCGCTGTTCTGGTTTGCCGTGGCCGGTGCG
CCGGGCGTGGTGCTCTATCGTCTGAGCAATACGCTCGACGCGATGTGGGGCTATCGCAACGAACGCTTCGAGCGTTTCGG
CTGGGCAGCGGCAAAAATCGACGACGTCCTCAACTACATTCCTGCACGGCTGGTGGCGTTGACCTACGCCTTGCTCGGCA
AAACCCGACTGGCGTTGAAATGCTGGCGCACCCAGGCGCCGAAATGGGACAGCCCGAACGCCGGCCCGGTGATGGCCGCT
GGCGCGGGTGCCTTGGGCGTCGAGCTGGGTGGCCCGGCGATTTACCACGGCGAGCTGCACGAGCGTCCGCAACTGGGCGA
GGGCGCGCCGGCGGATGCCGATTCCATTGATCGCGGCTGGCAATTGGTCCAGCGCGGGGTATGGTTATGGCTGCTGATTC
TCTGCGTGGGGGCTGAATTCTATGCTTGA

Upstream 100 bases:

>100_bases
TCAAGGCATTCTATCCGGCGCCGATGCTGGTACTCGAAGGGTGGGCGCAGGCGCGTCCGCTGAATGAGCTGCTGTACGAA
AATTTCTGGGGAGTGAGTCA

Downstream 100 bases:

>100_bases
GCACGGTGGCCGGTTGCGCAGGGCGGCGCTCGAATACGGCATCGCGGAAGAAGACTGGCTCGACCTGTCTACGGGCCTGG
CGCCGTGGCCGTTTCCGGTC

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSVALLSAAAVALDALLGEPKRWHPLVAFGNFAGRIEQRFNSAGRGWRSHGVTAWVIAVLPLTLLATAFSWAPYVGWIVE
ILALYCALGMRSLGEHVEPVAKALRADDLEEARKRVGYLVSRQTDELDSTAVARAATESVLENGSDAVFAALFWFAVAGA
PGVVLYRLSNTLDAMWGYRNERFERFGWAAAKIDDVLNYIPARLVALTYALLGKTRLALKCWRTQAPKWDSPNAGPVMAA
GAGALGVELGGPAIYHGELHERPQLGEGAPADADSIDRGWQLVQRGVWLWLLILCVGAEFYA

Sequences:

>Translated_302_residues
MSVALLSAAAVALDALLGEPKRWHPLVAFGNFAGRIEQRFNSAGRGWRSHGVTAWVIAVLPLTLLATAFSWAPYVGWIVE
ILALYCALGMRSLGEHVEPVAKALRADDLEEARKRVGYLVSRQTDELDSTAVARAATESVLENGSDAVFAALFWFAVAGA
PGVVLYRLSNTLDAMWGYRNERFERFGWAAAKIDDVLNYIPARLVALTYALLGKTRLALKCWRTQAPKWDSPNAGPVMAA
GAGALGVELGGPAIYHGELHERPQLGEGAPADADSIDRGWQLVQRGVWLWLLILCVGAEFYA
>Mature_301_residues
SVALLSAAAVALDALLGEPKRWHPLVAFGNFAGRIEQRFNSAGRGWRSHGVTAWVIAVLPLTLLATAFSWAPYVGWIVEI
LALYCALGMRSLGEHVEPVAKALRADDLEEARKRVGYLVSRQTDELDSTAVARAATESVLENGSDAVFAALFWFAVAGAP
GVVLYRLSNTLDAMWGYRNERFERFGWAAAKIDDVLNYIPARLVALTYALLGKTRLALKCWRTQAPKWDSPNAGPVMAAG
AGALGVELGGPAIYHGELHERPQLGEGAPADADSIDRGWQLVQRGVWLWLLILCVGAEFYA

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 32802; Mature: 32671

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVALLSAAAVALDALLGEPKRWHPLVAFGNFAGRIEQRFNSAGRGWRSHGVTAWVIAVL
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHH
PLTLLATAFSWAPYVGWIVEILALYCALGMRSLGEHVEPVAKALRADDLEEARKRVGYLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SRQTDELDSTAVARAATESVLENGSDAVFAALFWFAVAGAPGVVLYRLSNTLDAMWGYRN
HCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCHH
ERFERFGWAAAKIDDVLNYIPARLVALTYALLGKTRLALKCWRTQAPKWDSPNAGPVMAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
GAGALGVELGGPAIYHGELHERPQLGEGAPADADSIDRGWQLVQRGVWLWLLILCVGAEF
CCCCCEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YA
CC
>Mature Secondary Structure 
SVALLSAAAVALDALLGEPKRWHPLVAFGNFAGRIEQRFNSAGRGWRSHGVTAWVIAVL
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHH
PLTLLATAFSWAPYVGWIVEILALYCALGMRSLGEHVEPVAKALRADDLEEARKRVGYLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SRQTDELDSTAVARAATESVLENGSDAVFAALFWFAVAGAPGVVLYRLSNTLDAMWGYRN
HCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCHH
ERFERFGWAAAKIDDVLNYIPARLVALTYALLGKTRLALKCWRTQAPKWDSPNAGPVMAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
GAGALGVELGGPAIYHGELHERPQLGEGAPADADSIDRGWQLVQRGVWLWLLILCVGAEF
CCCCCEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]