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The map label for this gene is gltR [H]

Identifier: 77457630

GI number: 77457630

Start: 1574237

End: 1575148

Strand: Reverse

Name: gltR [H]

Synonym: Pfl01_1403

Alternate gene names: 77457630

Gene position: 1575148-1574237 (Counterclockwise)

Preceding gene: 77457635

Following gene: 77457626

Centisome position: 24.46

GC content: 61.18

Gene sequence:

>912_bases
ATGAACCTGAAGTTTCTCGAAACGTTCGTCTGGGTCGCCCGGCTGAAAAGTTTTCGCCTGACCGCCGACAAGCTGTTCAC
CACTCAGGCCTCGATCTCAAGCCGGATCGCGGTGCTCGAAGGCGAGCTCGGGGTGAAGCTGTTCCTGCGTGATTCACGCG
GCGTCAGCCTGACGCCCGAAGGTTTGAAAGTGCTGGACTATGCCGAGCAGATGCTCGACACGATGCAGGCGCTGAAGCAG
TCGATCGAGACCCGATCGAGCAAGGTCGGCCGGGTGCGCATCGGGGTGATGGACACGGTGATCCACACCTGGCTCAGCCC
GCTGGTGGCGCAGATGACCGATCTGTACCCACGGGTGGAAATCGAGCTGGTGGCGGATACCTCGCTGAACCTCTGCGATC
AGCTGCAAAAAGGCTTTCTCGATCTGATCCTGCAAACCGATCTGGTGCGCCAGGAAAGCGTGCGCAGCCTGGAGCTGGCC
AGCCACCCCATCGGCTGGATCGTCGCCAGCAACTCGATCTACAACCGCGATTACCAGAGCCTCGCCGACCTGGCCCAGGA
ACGGATCATCACCTACTCGAAAAACTCCCGGCCGCACCAGGACATCCTGGCGTTGATGCAGGCCCAAGGTGTGTTGGCGC
CACGGTTGAACTGTGTGAATTCGGTATCGGCGATTACCCGGCTGTTACGCGACGGGTTCGGCATTGGCGCGTTGCCGCCG
GTGCTGGTGGCCGAGGAGCTGACGCGGGGCGAACTGACCCTGCTCGACATCGAACAGCGCCCGCCGAACCTCCAGGTCGT
GGTGTCGTGGCGGGTCGGCGTGGAATGGGTCGAGGAAATTGTGACGCTGTGTCAGCAGGTGCTGGAGGGGTATACGCGCA
AGGTGGGCAAGGATTACATCGCTTTAAGTTGA

Upstream 100 bases:

>100_bases
ACGCCTATCGTGGGAACCGGATGCGTCGATTCTTGGGTGCGTCACCCGGTCGCGTCCAACGAATAAAAACCCGCCCAAGA
CATAAGAAAAATTTGTTGCC

Downstream 100 bases:

>100_bases
TCGTTCCCACTGCGTGGGAACGATGCATCGAAGCTTACAGCCCTCGCACATCCCGGTCTTCGATCGGCCGGCTCTGGCGC
AGGCGCTTGCCGCCCAGCAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNLKFLETFVWVARLKSFRLTADKLFTTQASISSRIAVLEGELGVKLFLRDSRGVSLTPEGLKVLDYAEQMLDTMQALKQ
SIETRSSKVGRVRIGVMDTVIHTWLSPLVAQMTDLYPRVEIELVADTSLNLCDQLQKGFLDLILQTDLVRQESVRSLELA
SHPIGWIVASNSIYNRDYQSLADLAQERIITYSKNSRPHQDILALMQAQGVLAPRLNCVNSVSAITRLLRDGFGIGALPP
VLVAEELTRGELTLLDIEQRPPNLQVVVSWRVGVEWVEEIVTLCQQVLEGYTRKVGKDYIALS

Sequences:

>Translated_303_residues
MNLKFLETFVWVARLKSFRLTADKLFTTQASISSRIAVLEGELGVKLFLRDSRGVSLTPEGLKVLDYAEQMLDTMQALKQ
SIETRSSKVGRVRIGVMDTVIHTWLSPLVAQMTDLYPRVEIELVADTSLNLCDQLQKGFLDLILQTDLVRQESVRSLELA
SHPIGWIVASNSIYNRDYQSLADLAQERIITYSKNSRPHQDILALMQAQGVLAPRLNCVNSVSAITRLLRDGFGIGALPP
VLVAEELTRGELTLLDIEQRPPNLQVVVSWRVGVEWVEEIVTLCQQVLEGYTRKVGKDYIALS
>Mature_303_residues
MNLKFLETFVWVARLKSFRLTADKLFTTQASISSRIAVLEGELGVKLFLRDSRGVSLTPEGLKVLDYAEQMLDTMQALKQ
SIETRSSKVGRVRIGVMDTVIHTWLSPLVAQMTDLYPRVEIELVADTSLNLCDQLQKGFLDLILQTDLVRQESVRSLELA
SHPIGWIVASNSIYNRDYQSLADLAQERIITYSKNSRPHQDILALMQAQGVLAPRLNCVNSVSAITRLLRDGFGIGALPP
VLVAEELTRGELTLLDIEQRPPNLQVVVSWRVGVEWVEEIVTLCQQVLEGYTRKVGKDYIALS

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=305, Percent_Identity=24.5901639344262, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789639, Length=261, Percent_Identity=29.5019157088123, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790262, Length=242, Percent_Identity=26.0330578512397, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI48994962, Length=172, Percent_Identity=30.2325581395349, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI145693193, Length=252, Percent_Identity=26.5873015873016, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787128, Length=155, Percent_Identity=32.258064516129, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786401, Length=254, Percent_Identity=27.5590551181102, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788626, Length=248, Percent_Identity=24.5967741935484, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787601, Length=142, Percent_Identity=26.7605633802817, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=147, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=123, Percent_Identity=30.8943089430894, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787879, Length=254, Percent_Identity=25.1968503937008, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787530, Length=231, Percent_Identity=22.5108225108225, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1788887, Length=172, Percent_Identity=33.7209302325581, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33994; Mature: 33994

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKFLETFVWVARLKSFRLTADKLFTTQASISSRIAVLEGELGVKLFLRDSRGVSLTPE
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCEEEEECCCCEEEEEECCCCCEECCC
GLKVLDYAEQMLDTMQALKQSIETRSSKVGRVRIGVMDTVIHTWLSPLVAQMTDLYPRVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEE
IELVADTSLNLCDQLQKGFLDLILQTDLVRQESVRSLELASHPIGWIVASNSIYNRDYQS
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
LADLAQERIITYSKNSRPHQDILALMQAQGVLAPRLNCVNSVSAITRLLRDGFGIGALPP
HHHHHHHHHEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
VLVAEELTRGELTLLDIEQRPPNLQVVVSWRVGVEWVEEIVTLCQQVLEGYTRKVGKDYI
HHHHHHHCCCCEEEEEECCCCCCEEEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALS
CCC
>Mature Secondary Structure
MNLKFLETFVWVARLKSFRLTADKLFTTQASISSRIAVLEGELGVKLFLRDSRGVSLTPE
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCEEEEECCCCEEEEEECCCCCEECCC
GLKVLDYAEQMLDTMQALKQSIETRSSKVGRVRIGVMDTVIHTWLSPLVAQMTDLYPRVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCEE
IELVADTSLNLCDQLQKGFLDLILQTDLVRQESVRSLELASHPIGWIVASNSIYNRDYQS
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
LADLAQERIITYSKNSRPHQDILALMQAQGVLAPRLNCVNSVSAITRLLRDGFGIGALPP
HHHHHHHHHEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
VLVAEELTRGELTLLDIEQRPPNLQVVVSWRVGVEWVEEIVTLCQQVLEGYTRKVGKDYI
HHHHHHHCCCCEEEEEECCCCCCEEEEEEEHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]